Imaging Science Prof. Dr. rer. nat. Bernd Pichler
Department Radiologie Diagnostic and lnterventional Radiology Prof. Nikolaou Diagnostic and lnterventional Neuroradiology Prof. Ernemann Nuclear Medicine Prof. la Fougere Preclinical lmaging and Radiopharmacy Prof. Pichler Biomedical Magnetic Resonance Prof. Scheffler Experimental Radiology Prof. Schick
X-Strahlen: Eine neue Art von Strahlen Wilhelm Conrad Röntgen 1845-1923 1895: Entdeckung der X-Strahlen 1901: Nobelpreis für Physik
Neurosciences Immunology Infection Medicine Microbiology Imaging Cardiology Vascular Medicine Oncology Biomedical engineering Radiation Therapy
Der Grundstein der Nuklearmedizin Henri Becquerel 1852-1908 1896: Entdeckung der Radioaktivität 1903: Nobelpreis für Physik George de Hevesy 1885-1923 1913: Radiotracer-Experiment 1943: Nobelpreis für Chemie
Positron-Elektron Annihilation POSITRON 511 kev PHOTON POSITRON-EMITTING RADIONUCLIDE Positron-Electron ANNIHILATION 180 o Positron path-length depends on tissue density and positron energy The two 511 kev gamma rays are emitted in an angle of 180 o 511 kev PHOTON
PET-Prinzip H 2 C H OH O H H OH O H H O H 18 F 18 F markierter Zucker 2-deoxy-2-[ 18 F]fluoro-D-glucose (FDG) Injektion & Anreicherung Detektion
Kleintierbildgebungs-Modalitäten Optische CT MRI PET Bildgebung Morphologie Morphologie (Funktion) Funktion Funktion
Datamining/Machine Learning Bildgebungs-Modalitäten Radio graphy CT MRI PET Optical Imaging Omics SPECT Ultra sound
pre CTx 1. CTx cycle CTx final Positronen Emissions Tomographie (PET) RESPONDER 52a, male NSCLC re. OL ct4 cn0 cm0
pre CTx 1. CTx cycle CTx final Positronen Emissions Tomographie (PET) NON-RESPONDER 51a, male NSCLC li. OL ct4 cn3 cm0
Positronen Emissions Tomographie (PET) pre CTx 1. CTx cycle CTx final
Radiofrequenzablation (RFA)
Brain Function as a Result of Receptor Activation 14 Department of H.F. Wehrl, et al.; J Mucl Med; 2014
H.F. Wehrl, et al.; Nature Medicine; accepted
Resting state PET H.F. Wehrl, et al.; Nature Medicine; accepted
R R Tracer specific Connectivity Matrixes [ 18 F]FDG [ 15 O]H 2 O [ 11 C]DASB BOLD-fMRI 1.0 0 Rat R 2 threshold Network Construction R 2 0.25-1.0 1.0 R 2 n=8 n=29 n=8 n=4 0 1.0 0 Mouse R 2 threshold Network Construction R 2 0.25-1.0 1.0 R 2 n=23 n=12 n=16 0
6-OHDA mouse model of PD DVR (healthy) = 2.04 DVR (sham les) = 2.06 DVR (healthy) = 2.09 DVR (les) = 1.56 DVR (healthy) = 1.97 DVR (les) = 1.38 K. Fischer, et al.; Neuroimage; 2012
Backwards Inference: Gaussian Distribution Histology Probability Map 20
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Blood Vessel FASN Molecular Imaging Targets 18 F-FET 11 C-Met 18 F-FLT 18 F-FAZA 18 F-FMISO 18 F-FDG CNT ENT 18 F-Gln Protein Biosynthesis TK I Nitroreductase HK II Trapping Glutaminolysis Cancer Associated Fibroblast αvβ3 Integrin DNA Synthesis Tumor Cell 18 F-ICMT11 Caspase 3/7 SA-αL-Fuc Phosphatidylserin H+ H+ H+ Lysosome FAP 18 F-Annexin 5 18 F-FASN-Inhib. 18 F-SA-αL-Fuc-Inhib. 64 Cu-FAP-AB 23
PET-Detektor Strip encoding Crystal _ ID = max(s1 i ) Çmax(S2 j ) æ Crystal _ ID = S1 ö æ 1 ç Ç S2 ö 1 è SS1 ç i ø è SS2 j ø S1 DOI = i SS1 DOI = i S1 i + S2 j S S1 i + S2 j ( ) E = S1 i + S2 j E = S(S1 i + S2 j ) 24 Department of Preclinical Imaging and Radiopharmacy
PET-Detektor Strip encoding
PET-Detektor Strip encoding
PET-Insert PET-System Cooling Microcontroller High Voltage NTC Filter board Quicksilver Acquisition Software Inveon System Monitor and Control Data Acquisition 27 Department of Preclinical Imaging and Radiopharmacy
Graphical User Interface (A) PET rings current status (temperature, high voltage) (B) Temperature of secondary electronics (e.g. microcontroller, filter board, cooling board, digitizer), (C) Temperature of individual detector module (D) High voltage monitoring and controll (E) Cooling system controll and monitor A D B C E 28 Department of Preclinical Imaging and Radiopharmacy
Cooling System NECESITY APD Gain is Temperature Dependent GOAL Cold Stream Compressed Air Hot Stream Stable Fast Vortex Tube Cheap ACHIEVEMENT Air Cooling Maintenance free Automatic or manual Cheap But Stable (15 ±0.02 C) and fast 29 Department of Preclinical Imaging and Radiopharmacy
5. Semester (WS) 168 h Präsenzzeit
Detectorphysics Radiation Safety Clincal PET/MR MRI basics/ Spectroscopy Hyperpolarization Comparison Master vs. Bachelor Med. Tech. Bioimaging Preclinical Imaging PET/MR MRI Clinical Imaging Labeling of Biomolecules Imaging of Inflammation Spatial Encoding in MRI fmri Image Reconstruction Angiography Advanced Clincal PET Pharmacol. Modelling Adv. Image Analysis NMR Spectroscopy Image Contrast in MRI Diffusion- Imaging Perfusion- Imaging Appl. PET/MRI Preclinical Imaging PET/MR MRI Clinical Imaging MRI CT PET Organ specific MRI Organ specific CT Radiopharmacy SPECT Optical Imaging Basic PET Ultrasound
Vorläufiger Stundenplan Kontakt & Info: Dr. Carsten Calaminus Tel: 07071-29-87532
locations Berg Internal Medicine Nuclear Medicine MR/PET MR center Zentrales Röntgen PET/CT ER Pediatric Imaging
locations Tal Preclinical Imaging Radiopharmacy Women Imaging