Programme The Wellcome Trust Waddington Symposium Epigenetics: in dialogue with the genome Supported by EpiGeneSys - www.epigenesys.eu and The University of Edinburgh - www.ed.ac.uk/schools-departments/biology Organisers: Robin Allshire University of Edinburgh Adrian Bird University of Edinburgh Wendy Bickmore University of Edinburgh Tom Collins The Wellcome Trust David Tollervey University of Edinburgh Registration Open - 10:00 at venue Dynamic Earth, Holyrood Road, Edinburgh EH8 8AS
Programme Monday, June 1 st 14:00 Welcome and Opening Remarks Session 1: RNA to Chromatin Chair: Robin Allshire 14:15-14:40 David Tollervey - WT Centre for Cell Biology, University of Edinburgh RNA polymerase II is trapped in an initiation state on non-coding RNA transcripts 14:40-15:05 Caroline Dean - John Innes Centre, Norwich Polycomb-based epigenetic switching 15:05-15:30 Rob Martienssen - HHMI, Cold Spring Harbor Laboratories, New York Inheritance and reprogramming of heterochromatin with small RNA 15:30-16:00 Session 2: small RNA and Chromatin Chair: Elizabeth Bayne 16:00-16:15 Araceli Castillo Dept. Genetics, University of Malaga Geminivirus rep protein interferes with the plant DNA methylation machinery and suppresses transcriptional gene silencing 16:15-16:40 Eric Miska - WT/CRUK Gurdon Institute, Cambridge Transgenerational epigenetic inheritance and RNAe 16:40-17:05 David Baulcombe Dept. Plant Sciences, University of Cambridge Heritable epigenetic variation triggered by small RNA in plants 17:05-17:20 Nick Gilbert - MRC HGU & IGMM, University of Edinburgh SAF-A (hnrnp-u) regulates transcriptionally active large-scale chromatin structures through its ATPase activity 17:20-17:35 Julie Ahringer - WT/CRUK Gurdon Institute, Cambridge Genome organization revealed through chromatin state mapping 18:00 Welcome Reception 19:30 Dinner in Dynamic Earth
Programme Tuesday, June 2 nd Session 3: Self-renewal and Senescence Chair: Neil Brockdorff 09:00-09:25 Ian Chambers - MRC Centre for Regenerative Medicine, University of Edinburgh Transcription factor control of transitions in pluripotent cell states 09:25-09:50 Andrea Brand - WT/CRUK Gurdon Institute, Cambridge Nutritional control of neural stem cells 09:50-10:15 Peter Adams - CRUK Beatson Institute, Glasgow The dynamic epigenome - a challenge to healthy aging 10:15-10:30 Pumi Perera - Institute for Molecular Plant Sciences, University of Edinburgh Novel roles for the proteasome and a domesticated transposase in regulating plant Polycomb-group protein activity 10:30-11:00 Session 4: Epigenetic Plasticity in Development & Disease Chair: Adrian Bird 11:00-11:25 Doug Higgs - Weatherall Institute of Molecular Medicine, Oxford Switching genes on and off during hematopoiesis 11:25-11:50 Olivier Delaneau - Genetic Medicine & Development, University of Geneva Genetic control of chromatin in a human population 11:50-12:15 Stefan Beck - Cancer Institute, University College London Insights from methylome analysis 12:15-12:30 Jane Skok - Langone Medical Center, New York University The role of 53BP1 in shaping chromosome conformation and its impact on changing accessibility during Class switch recombination 12:30-14:00 Lunch Session 5: Genome to Epigenome Chair: Anne Ferguson-Smith 14:00-14:25 Adrian Bird WT Centre for Cell Biology, University of Edinburgh DNA methylation and other CpG signalling 14:25-14:50 Rob Klose - Dept Biochemistry, University of Oxford Interpreting the CpG island signal 14:50-15:15 Dirk Schübeler - Friedrich Miescher Institute, Basel Sequence and chromatin determinants of DNA methylation 15:15-15:30 Philippe Arnaud - CNRS, Clermont-Ferrand Université Bivalent chromatin signature is the default state of imprinting control regions (ICRs) 15:30 16:00
Programme Session 6: Cancer Epigenetics Chair: Irina Stancheva 16:00-16:25 Duncan Sproul - MRC HGU & IGMM, University of Edinburgh Genomic analysis of cancer hypomethylated domains 16:25-16:50 Peter Jones - Van Andel Research Institute, Grand Rapids, USA How DNA Methylation Organizes The Cancer Epigenome 16:50-17:05 Philipp Voigt - WT Centre for Cell Biology, University of Edinburgh Asymmetrically Modified Nucleosomes and their Role in the Establishment and Function of Bivalent Domains 17:05-17:20 Ho-Ryun Chung - Max Planck Institute for Molecular Genetics, Berlin The Tale of Two Tails 17:30-19:30 Refreshments & Poster Session 1 19:30 Dinner in Dynamic Earth
Programme Wednesday, June 3rd Session 7: Transgenerational Inheritance Chair: Rob Martienssen 09:00-09:25 Emma Whitelaw - Institute for Molecular Science, La Trobe University, Melbourne Reflections on an ENU screen for modifiers of epigenetic reprogramming 09:25-09:50 Antoine Peters - Friedrich Miescher Institute, Basel Chromatin inheritance and dynamics at the onset of life: mechanisms and functional implications 09:50-10:15 Andrew Pospisilik - Max Planck Institute of Immunology & Epigenetic Freiburg Chromatin and Metabolism: Disease switches and integrational control 10:15-10:30 Juliane Glaser - INSERM/CNRS Institut Curie, Paris The Liz/Zdbf2 locus in the early mouse embryo: epigenetic programming with life-long consequences 10:30-11:00 Session 8: Epigenetic Transmission Chair: Emma Whitelaw 11:00-11:25 Anne Ferguson-Smith - Dept of Genetics, University of Cambridge Parental-origin effects and epigenetic inheritance 11:25-11:50 Oliver Rando - UMMS, Worcester, MA, USA Mechanical disassembly and reassembly of reproduction in mammals 11:50-12:05 Nick Burton - HHMI, MIT, Cambridge, MA, USA C. elegans sensory neurons regulate a transgenerational developmental response to osmotic stress via insulin and MAP kinase signaling 12:05-12:30 Robin Allshire - WTCCB, University of Edinburgh Establishment, maintenance and transmission of specialised chromatin 12:30-14:00 Lunch Session 9: Maintenance and Disruption 14:00-14:25 Mick Tuite - School of Biosciences, University of Kent Prions as natural modifiers of complex phenotypes in fungi 14:25-14:50 Fred van Leeuwen Netherlands Cancer Institute, Amsterdam Histone turnover and its relationship with histone methylation and variants 14:50-15:05 Marta Radman-Livaja - CNRS, Institute of Molecular Genetics, Montpelier Timeline of nucleosome positioning dynamics after DNA replication 15:05-15:30 Anja Groth - BRIC & Centre for Epigenetics, University of Copenhagen Chromatin Replication and Epigenome Maintenance 15:30 16:00 Chair: Edith Heard
Programme Session 10: Specialised States Chair: Bill Earnshaw 16:00-16:15 Ross Fennessy - Centre for Gene Regulation & Expression, University of Dundee Genome-wide mapping of nascent chromatin provides evidence for distinct replication and transcription coupled pathways for nucleosome organisation 16:15-16:40 Patrick Heun - WT Centre for Cell Biology, University of Edinburgh Dissection of centromere chromatin and components 16:40-17:05 Elaine Dunleavy - CCB, National University of Ireland, Glaway Centromere Assembly and Maintenance in Male Meiosis in Drosophila 17:05-17:20 Sigurd Braun - Ludwig-Maximilians - University of Munich The nuclear membrane protein Lem2 coordinates localization and silencing of heterochromatin at the nuclear periphery 17:20-19:30 Refreshments & Poster Session 2 19:30 Free Evening
Programme Thursday, June 4 th Session 11: Regulation of States Chair: Wendy Bickmore 09:00-09:25 Wolf Reik - Epigenetics Programme, Babraham Institute, Cambridge Epigenetic reprogramming in mammalian development 09:25-09:50 Richard Meehan - MRC HGU & IGMM, University of Edinburgh The regulatory potential of DNA methylation; dialing into the genome 09:50-10:15 Vincent Colot - CNRS/INSERM, Institut de Biologie de l'ens, Paris Demystifying trans-generational epigenetics 10:15-10:30 Muhammad Zoabi - Technion Institute of Technology, Haifa RNA-dependent chromatin localization of KDM4D lysine demethylase promotes H3K9me3 demethylation 10:30-11:00 Session 12: Dosage compensation Chair: Doug Higgs 11:00-11:25 Neil Brockdorff - Dept Biochemistry, University of Oxford Identification of novel factors required for Xist RNA mediated chromosome silencing 11:25-11:40 Tahsin Stefan Barakat - Erasmus MC, University Medical Center, Rotterdam RNF12 is essential for X-inactivation in female mouse embryonic stem cells 11:40-12:05 Edith Heard - CNRS/INSERM, Institut Curie, Paris The relationship between X-chromosome structure and gene activity during X inactivation 12:05-12:20 Céline Vallot - CNRS, Université Paris Diderot, Sorbonne Paris Cité XACT and instability of X chromosome inactivation in human pluripotent stem cells 12:30-14:00 Lunch & Posters Session 13: Right Time and Place Chair: Anja Groth 14:00-14:25 Greg Hannon - CRUK Cambridge Institute & HHMI, CSHL, New York pirna-dependent co-transcriptional silencing 14:25-14:50 Wendy Bickmore MRC HGU & IGMM, University of Edinburgh Transcription, chromatin structure and nuclear organisation: cause and consequence 14:50-15:15 Bing Zhu HHMI, Institute of Biophysics, Chinese Academy of Sciences, Beijing, Preferential further oxidation of 5-hydroxymethylcytosine at distinct chromatin regions 15:15-15:30 Sara Buonomo - Mouse Biology Unit, EMBL Monterotondo, Italy Rif1 establishes DNA replication timing by three-dimensional control of chromatin contacts 15:30 16:00
Programme Session 14: Modifiers and Manipulation Chair: David Tollervey 16:00-16:25 Rich Roberts - New England Biolabs, Ipswich, MA, USA Bacterial Methylomes 16:25-16:50 Geeta Narlikar Biochemistry & Biophysics, UCSF, CA, USA Mechanisms of ATP-dependent Chromatin Remodeling Motors 16:50-17:15 Bill Earnshaw WTCCB, University of Edinburgh Epigenetic Engineering the Human Centromere 17:15-17:40 Tony Kouzarides - WT/CRUK Gurdon Institute, University of Cambridge Epigenetic modification pathways: their function and misconduct in cancer 17:40-18:00 Discussion & Concluding Remarks 18:00 End of Final Session 19:00 Arrive at the Hub (www.thehub-edinburgh.com) 19:30 Dinner called 19:50 Guests seated 20:00 Dinner served 22:00 Ceilidh begins 00:00 Finish