S C I E N T I F I C P R O G R A M M E Face-to-Face HIV and COINFECTIONS 2nd INTERCOHORTS MEETING Scientific Coordinators: Andrea Antinori Antonella d Arminio Monforte Antonella Castagna Francesca Ceccherini-Silberstein Alessandro Cozzi-Lepri Enrico Girardi Sergio Lo Caputo Cristina Mussini Massimo Puoti ROME January 29-30, 2016 Auditorium Via Veneto Italian Cohort I. C O. N A. Naive Antiretrovirals Fondazione Icona I T A L I A N C O H O R T N A I V E A N T I R E T R O V I R A L S Founded by Professor Mauro Moroni
Face-to-Face HIV and COINFECTIONS 2nd INTERCOHORTS MEETING ROME January 29-30, 2016 Auditorium Via Veneto CME Provider and Organizing Secretariat Effetti Srl Via Gallarate, 106-20151 Milan, Italy Ref. Barbara Bocciardi Phone +39 02 3343281 - Fax +39 02 38002105 Mail: barbara.bocciardi@effetti.it www.effetti.it - www.fondazioneicona.org Italian Cohort I. C O. N A. Naive Antiretrovirals Fondazione Icona I T A L I A N C O H O R T N A I V E A N T I R E T R O V I R A L S Founded by Professor Mauro Moroni
Promoted by the ICONA Foundation Study, the Face-to-Face 2nd Intercohorts Meeting is a closed-workshop dedicated to ICONA researchers which also involve representatives of some of the major European Cohorts enrolling patients with HIV and coinfections (CRNS, France - EuroSIDA, Denmark - GeSIDA, Spain - ICONA, Italy - HepaICONA, Italy - Swiss Cohort, Switzerland - Piter, Italy). The aim of the workshop is pursuing new findings, analyses as well as works in progress and allows open discussions among European Experts on cutting-edge issues in HIV and coinfections. For this reason, the scientific program of this two-day Meeting has been structured into two sections: Day one, January 29 Based on five themes, interactive round tables among cohorts representatives on the following main topics: Long-term outcomes in the treatment of HIV Future settings of HIV/HCV coinfection Long-term outcomes in the treatment of HCV New perspectives in hepatitis B and Delta Scientific evidence and new research project by ICONA and HepaICONA Cohort in the treatment of HIV and HIV/HCV coinfection Official language of this section is English. S C I E N T I F I C R AT I O N A L E Day two, January 30 Based on ICONA Foundation latest data and scientific projects discussion among all researchers from ICONA clinical sites only. Official language of this section is Italian.
ADRIANA AMMASSARI IRCCS INMI Lazzaro Spallanzani, Rome I MASSIMO ANDREONI University of Tor Vergata, Rome I GIOACCHINO ANGARANO University Hospital of Bari I ANDREA ANTINORI IRCCS - INMI Lazzaro Spallanzani, Rome I JUAN BERENGUER Gregorio Marañón University Hospital, Madrid E RAFFAELE BRUNO University of Pavia I FA C U LT Y STEFANIA CARRARA IRCCS INMI Lazzaro Spallanzani, Rome I ANTONELLA CASTAGNA San Raffaele Scientific Institute, Milan I ROBERTO CAUDA Catholic University, Rome I FRANCESCA CECCHERINI-SILBERSTEIN University of Tor Vergata, Rome I ANTONIO CHIRIANNI Domenico Cotugno Hospital, Naples I ANTONELLA CINGOLANI Catholic University, Rome I ALESSANDRO COZZI-LEPRI Royal Free & University College Medical School - University College of London UK ANTONELLA D ARMINIO MONFORTE San Paolo Hospital, University of Milan I IURI FANTI Catholic University, Rome I GIOVANNI DI PERRI University of Turin I GIOVANNI BATTISTA GAETA Second University of Naples I ROME January 29-30, 2016 Auditorium Via Veneto
Face-to-Face HIV and COINFECTIONS 2nd INTERCOHORTS MEETING MASSIMO GALLI Luigi Sacco Hospital, University of Milan I ENRICO GIRARDI IRCCS - INMI Lazzaro Spallanzani, Rome I GIUSEPPE IPPOLITO IRCCS - INMI Lazzaro Spallanzani, Rome I HELEN KOVARI University Hospital Zurich CH ADRIANO LAZZARIN University Vita-Salute San Raffaele, Milan I MIRIAM LICHTNER Sapienza University of Rome, Polo Pontino, Latina I SERGIO LO CAPUTO University Hospital of Bari I GIULIA MARCHETTI San Paolo Hospital, University of Milan I SIMONE MARCOTULLIO NADIR Onlus, Rome I CRISTINA MUSSINI University Hospital of Modena and Reggio Emilia, Modena I CARLO FEDERICO PERNO University of Tor Vergata, Rome I FA C U LT Y LARS PETERS University of Copenhagen DK MASSIMO PUOTI Niguarda Ca Granda Hospital, Milan I DOMINIQUE SALMON Cochin Hospital, Rene Descartes University, Paris F ANNALISA SARACINO University Hospital of Bari I MILENSU SHANYINDE Royal Free & University College Medical School - University College of London UK GLORIA TALIANI Sapienza University, Rome I ALESSANDRO TAVELLI San Paolo Hospital, University of Milan I STEFANO VELLA Istituto Superiore di Sanità, Rome I
FRIDAY JANUARY 29, 2016 10.00-11.15 Registration 11.15-11.30 Introduction: rationale and aims of the 2nd Icona Intercohorts Meeting A. Antinori, A. d Arminio Monforte, M. Puoti P R E L I M I N A R Y P R O G R A M M E 11.30-11.45 The role of Italian infectious diseases specialists in the International setting A. Chirianni 11.45-13.45 Interactive Round Table among European Cohorts Insights HIV/HCV coinfection: future scenarios, what Cohorts are doing, what we can do together Chairs: A. Antinori, A. d Arminio Monforte, M. Puoti (Icona Cohort) 13.45-14.30 Lunch Participants: Dominique Salmon Lars Peters Juan Berenguer Helen Kovari Stefano Vella CRNS France EuroSIDA Denmark GeSIDA Spain Swiss Cohort Switzerland Piter Italy ROME January 29-30, 2016 Auditorium Via Veneto
Face-to-Face HIV and COINFECTIONS 2nd INTERCOHORTS MEETING 14.30-15.50 Meet the Experts Chairs: G. Di Perri, G. Taliani 14.30-14.50 Lecture Retention in care: role of cohort studies C. Mussini 14.50-15.10 Lecture Long term outcome in HIV treatment M. Andreoni 15.10-15.30 Lecture Long term outcome in HCV treatment M. Puoti 15.30-15.50 Lecture New perspectives in hepatitis B and Delta treatment G.B. Gaeta P R E L I M I N A R Y P R O G R A M M E 15.50-16.10 Discussion 16.10-16.30 Coffee break
FRIDAY JANUARY 29, 2016 P R E L I M I N A R Y P R O G R A M M E 16.30-17.20 SESSION 1 ICONA research in HIV and HIV-HCV coinfection Chairs: G. Ippolito, A. Lazzarin 16.30-16.40 Low-level viremia (LLV) ranging from 50 to 500 copies/ml is associated to an increased risk of AIDS events A. Antinori 16.40-16.50 PrecART proinflammatory milieu, microbial translocation (MT) and risk of disease progression in HIV Infected patients starting their first cart G. Marchetti 16.50-17.00 Risk and determinants of failure of a monopi/r simplification strategy with LPV/r or DRV/r in clinical practice M. Andreoni 17.00-17.10 HIV-positive subjects treated with EVG/COBI based regimens - preliminary data A. Cozzi-Lepri 17.10-17.20 CD4 explosion after effective HAART in HIV people: the hidden meaning M. Lichtner 17.20-17.40 Discussion ROME January 29-30, 2016 Auditorium Via Veneto
Face-to-Face HIV and COINFECTIONS 2nd INTERCOHORTS MEETING 17.40-18.30 SESSION 2 ICONA research in HIV and HIV-HCV coinfection Chairs: G. Angarano, C.F. Perno 17.40-17.50 Survival in HIV-1 positive and HIV negative individuals with diagnosis of lymphoma A. Cingolani 17.50-18.00 Increased risk of virological failure to the first antiretroviral regimen in HIV-infected migrants compared to natives A. Saracino 18.00-18.10 Correlations of pre-art HIV-DNA with outcome in 1st-line treated ART patients F. Ceccherini-Silberstein 18.10-18.20 Determinants and impact of late HCV diagnosis among persons with newly diagnosed HIV infection M. Shanyinde 18.20-18.30 Challenges of anti HCV treatment in persons living with HIV in the era of Directly Acting Antivirals (DAA) M. Puoti P R E L I M I N A R Y P R O G R A M M E 18.30-18.50 Discussion 18.50-19.00 Final conclusions A. Antinori, A. d Arminio Monforte, M. Puoti
SATURDAY JANUARY 30, 2016 SESSIONE 3 Moderatori: R. Bruno, R. Cauda, M. Galli 09.00-09.20 Il valore di ICONA nello scenario internazionale A. Castagna P R E L I M I N A R Y P R O G R A M M E 09.20-10.20 Presentazione del report ICONA ed HepaICONA ICONA HepaICONA S. Lo Caputo A. Ammassari 10.20-11.20 Questionario ICONA-PRO A. Cingolani, E. Girardi, S. Marcotullio 11.20-11.50 Coffee break 11.50-13.30 Spazio di discussione con i Centri Conducono: S. Carrara, I. Fanti, A. Tavelli 13.30-13.45 Considerazioni conclusive e chiusura dei lavori A. Antinori, A. d Arminio Monforte, M. Puoti ROME January 29-30, 2016 Auditorium Via Veneto
Face-to-Face HIV and COINFECTIONS 2nd INTERCOHORTS MEETING Dates January 29-30, 2016 Venue Auditorium Via Veneto Via Veneto, 89-00187 Rome I www.auditoriumviaveneto.it Crediti ECM La Commissione Nazionale per la Formazione Continua in Medicina ha assegnato n. 11 crediti formativi al Meeting (N. ECM 150-143229), per Biologi, Farmacisti ospedalieri e territoriali e Medici Specialisti in Malattie Infettive, Microbiologia e Virologia, Igiene, Epidemiologia e Sanità Pubblica, Direzione Medica di Presidio Ospedaliero, Allergologia e Immunologia Clinica, Medicina Interna e Gastroenterologia. L assegnazione dei crediti formativi è subordinata alla presenza al 100% dei lavori e alla corretta compilazione di almeno il 75% delle domande proposte all interno del questionario di valutazione finale. È inoltre obbligatoria la rilevazione delle presenze e la compilazione del questionario di valutazione e di gradimento dell evento formativo. G E N E R A L I N F O R M AT I O N
ICONA FOUNDATION STUDY GROUP Board of Directors A. d Arminio Monforte (Vice-President), M. Andreoni, G. Angarano, A. Antinori, F. Castelli, R. Cauda, G. Di Perri, M. Galli, R. Iardino, G. Ippolito, A. Lazzarin, C.F. Perno, F. von Schlösser, P. Viale Presidential Commitee A. Antinori, A. d Arminio Monforte, G. Ippolito, A. Lazzarin, C.F. Perno Scientific Secretary A. d Arminio Monforte, A. Antinori, A. Castagna, F. Ceccherini-Silberstein, A. Cozzi-Lepri, E. Girardi, S. Lo Caputo, C. Mussini, M. Puoti Steering Committee A. Ammassari, M. Andreoni, A. Antinori, C. Balotta, A. Bandera, P. Bonfanti, S. Bonora, M. Borderi, A. Calcagno, L. Calza, M.R. Capobianchi, A. Castagna, F. Ceccherini-Silberstein, A. Cingolani, P. Cinque, A. Cozzi-Lepri, A. d Arminio Monforte, A. De Luca, A. Di Biagio, N. Gianotti, E. Girardi, A. Gori, G. Guaraldi, G. Lapadula, M. Lichtner, S. Lo Caputo, G. Madeddu, F. Maggiolo, G. Marchetti, S. Marcotullio, L. Monno, C. Mussini, S. Nozza, M. Puoti, E. Quiros Roldan, R. Rossotti, S. Rusconi, M. Santoro, A. Saracino, M. Zaccarelli Statistical and Monitoring Team A. Cozzi-Lepri, I. Fanti, L. Galli, P. Lorenzini, A. Rodano, M. Shanyinde, A. Tavelli Biological Bank INMI F. Carletti, S. Carrara, A. Castrogiovanni, A. Di Caro, F. Petrone, G. Prota, S. Quartui Italian Cohort I. C O. N A. Naive Antiretrovirals Fondazione Icona I T A L I A N C O H O R T N A I V E A N T I R E T R O V I R A L S Founded by Professor Mauro Moroni