Curriculum Vitae Peter K. Plinkert, M.D.



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Curriculum Vitae Peter K. Plinkert, M.D. Department of Otorhinolaryngology, Head and Neck Surgery (ORL-HNS) University of Heidelberg Professor and Chairman Address Office Univ. Hals-Nasen- und Ohrenklinik Im Neuenheimer Feld 400

Peter K. Plinkert Page 2 Personal Information Date of birth: November 26, 1956 Education 1962 1978 German Elementary, Middle- and High School at the Rheingau- Gymnasium in Geisenheim; Diploma from German secondary school qualifying for university admission and matriculation Conscription duty in the Medical Corps Apprenticeship training as pharmaceutic-technical assistant 1978 1985 Medical School at the University of Goettingen 1985 State medical examination for human medicine and receipt of License to Practice Medicine. 1981-1985 Doctorial thesis, Department of Chemistry and Neurotoxicology, University of Goettingen Training and Qualification 1985 1986 Residency at the Department of General Surgery, Krankenhaus der Borromäerinnen Trier, University Mainz 1986 1990 Residency at the Department of ORL-HNS, University Wuerzburg (Professor Dr. J. Helms) Professional Career 1988 Consultant surgeon at the Department ORL-HNS, University Tuebingen (Professor Dr. Dr. H. P. Zenner) 1989 Post-doctorial fellowship from the Deutsche Forschungsgemeinschaft (DFG) at the Institute for Neurochemistry and Neurotoxicology, University Stockholm (Prof. Dr. E. Heilbronn, WS1989/90): Innervation of cochlear hair cells 1992 Venia Legendi for ORL-HNS, University Tuebingen (Assistant professorship) 1992 Additional specialist designation Plastic Surgery 1993 Additional specialist designation Allergology

Peter K. Plinkert Page 3 1994-2000 Vice Director at the Department of ORL-HNS, Eberhard-Karls- University Tuebingen 1996 Additional specialist designation Special ORL-HNS 1998 Guest Professor at the MD Anderson Cancer Center, University of Texas, Houston 2000 Appointed the position of chairman of the Department of ORL-HNS, University Greifswald (declined) 2000 2004 Chairman and Director of the Department of ORL-HNS, Saarland University 2001 2004 Member of the Board of Directors of the Cancer Center Saarland 2002 2004 Dean (Vice) of the Medical Faculty, Saarland University Since October 2004 Chairman and Director of the Department of ORL-HNS, University Heidelberg 2005 Member of the Board of Directors of the Department Kopfklinik, University Heidelberg 2007 Granting of a honorary doctorate (Honoris causa) Universitas Medicinae et Scientiae Pharmaceuticae Victor Babes Timisiensis, Timisoara Rumania 2009 Re-elected as member of the Board of Directors of the Department Kopfklinik, University Heidelberg Interdisciplinary structures established during the chairmanship at the Department of ORL-HNS at the Saarland University (2000-2004) Establishing a general screening program for a SNHL in all newborns in the Saarland Area Interdisciplinary Center of Skull Base Surgery at the Saarland University (Speaker) Rehabilitation Center for Children with Cochlear Implants in Saarland

Peter K. Plinkert Page 4 Awards, Stipendiates 1994 Anton von Töltsch Prize of the German Society for ORL-HNS on merits of scientific studies in inner ear biology. 1889 Stipendiate from DFG at the Institute for Neurochemistry and Neurotoxicology, University Stockholm 1993 Stipendiate from DAAD for being a Guest lecturer at Kidwai Memorial Institute of Oncology, Bangalore India (Prof. Dr. Ashok Shenoy) and for the implementation of modern reconstructive surgical procedures in head and neck oncology. Memberships German Society for ORL-HNS German Society for Base Scull Surgery German Society for Plastic and Reconstructive Surgery Association for Research in Otolaryngology (ARO), USA Association for Endoscopy in the German Society for ORL-HNS (member of the board of directors) President of the Association for German speaking Audiologists and Neurootologists (ADANO) Member of Collegium Oto-Rhino-Laryngologicum Amicitae Sacrum (CORLAS) Clinical and Research Fellowships Washington University, School of Medicine, Department of Otolaryngology, Prof. Dr. R. Thalmann, St. Louis, Missouri, USA: Experimental studies on endolymphatic hydrops (7-8/ 1988). Institute for Neurochemistry and Neurotoxicology, University Stockholm, Sweden, Prof. Dr. E. Heilbronn (DFG-Stipendiate, WS 1989/90): Research project about the efferent innervation of the cochlea. Department of ORL-HNS, Kantonsspital Basel, Switzerland, Prof. Dr. R. Probst (WS 1991/92): Suppression experiments in distorsion product otoacoustic emissions.

Peter K. Plinkert Page 5 Emphasis: Otology, lateral skull base surgery and functional and reconstructive ORL-HNS. The following visits were conducted to acquire special surgical techniques. Department of ORL-HNS, University Wuerzburg (Prof. Dr. J. Helms): Middle ear and skull base surgery, July 1992 Department of ORL-HNS, Kantonsspital Zuerich (Prof. Dr. U. Fisch): Techniques in skull base surgery procedures, February 1995 MD Anderson Cancer Center, University of Texas, Houston, USA (Prof. Dr. H. Goepfert) SS 1998. Current Scientific Emphases Skull Base Surgery and Robotics (DFG-Project 1124 Medical Navigation and Robotics): - Multi sensor technology for automated milling in skull base surgery - New technical developments in endoscopic surgical techniques among other things vibrotactile sensor, facial neuromonitoring via milling head. - Implementation of operative ultrasound in robotics Audiology - Optimised speech processor fitting in cochlear implant patients with the help of subjective scaling of electrical and acoustical stimuli. - Examination of the relation between otoacoustic emissions (OAE) parameters and the amount of inner ear hearing loss in consideration to age. - Objective determination of hearing threshold from input/output function of transitory evoked otoacoustic emissions (TEOAE). Otology - Examination of treatment options in auditory or vestibular dysfunctions of the inner ear via gene therapy - Pilot study of the plasticity in auditory cortex with long-lasting relative deprivation

Peter K. Plinkert Page 6 Oncology (in cooperation with Dr. Simon, Dr. Herold-Mende and Dr. Dyckhoff) - Investigation of molecular mechanisms underlying cancer cell invasion and metastasis - Anti-tumor vaccination with autologous virus-modified tumor cells and bi-specific antibodies - Functional role of angiogenic growth factors and clinical implications - Pre-clinical testing of new therapeutical substances in a NOD/SCID-mouse model