CURRICULUM VITAE of Dick Frans SWAAB

CURRICULUM VITAE of Dick Frans SWAAB Contents Abbreviated curriculum vitae 2 Full Curriculum vitae Education 7 Professional career 7 Awards and honors 7 Functions and committees 8 Chairs held by NIBR members 11 Member editorial boards 11 Courses 12 Ph.D. theses 12 supervisor 12 promotor 12 co-promotor 16 co-referent/external referent 16 Ph.D. committee member 16 International conferences organized 19 Dutch meetings organized 20 Some work visits abroad 21 Guest collaborators 22 Some external funds 26 Teaching 28 students 28 university lectures 34 Publications 48 Monographs 49 Articles in journals 50 Book chapters 71 Books edited 83 Reports and columns 85 Abstracts 91 Papers read (type of lecture indicated 1997-present) 120 Meetings with the press 141 Swaab's/NIN research in national and international television/radio programmes 151 Dick Swaab's work referred to in the media 153 Matters relating to Wij Zijn ons Brein (reviews etc.) 156 1

Abbreviated Curriculum Vitae for Dick F. Swaab Name: Dick Frans Swaab Date of birth: 17-12-1944 Education: 1963 Final examination Amsterdams Lyceum 1968 MD (Medicine, UvA) 1970 Ph.D. Thesis: Factors influencing neurosecretory activity of the supraoptic and paraventricular nuclei in rat. A histochemical and cytochemical study. Mentor: Prof. dr. J. Ariëns Kappers. 1972 general physician Professional career 1975-1978 Acting director of the Netherlands Institute for Brain Research, an institute of the Royal Netherlands Academy of Arts and Sciences (KNAW) 1978-2005 Director of the Netherlands Institute for Brain Research 1979- now Professor of Neurobiology at the Medical Faculty, UvA. 1985 Founder and, until 2005, Director of the Netherlands Brain Bank 1978- now Leader Research team Neuropsychiatric Disorders, Neth. Inst for Neuroscience. Editorial activities (selected) Neurobiology of Aging, Progress in Brain Research, Brain Research Series (Elsevier), series Editor of the 3 rd new series of the Handbook of Clinical Neurology (24 volumes published, > 30 volumes planned), Elsevier, Editorial board of Encyclopedic Reference of Neuroscience (Field editor of Neuroendocrinology), Springer Awards and Honors 1976 'Snoo-van 't Hoogerhuijs' prize (together with Dr. W.J. Honnebier) for work in the field of fetal neuroendocrinology. 1987 Holst lecture', T.U. Eindhoven and N.V. Philips 'De klok in onze hersenen', December 12. 1990 'Hugo van Poelgeest' prize for the Netherlands Brain Bank as an alternative for animal experiments, June 26.Journal of Neural Transmission (36, 195-215, 1975) paper awarded "Citation Classic" status in Current Contents 33, no. 30, p. 16. 1995 Nature paper on transsexuality discussed in Nature 378, 15-16, 1995, "Another important organ". Selected by Discover for the top 100 science stories of 1995. 1996 Emil Kraepelin Guest Professorship 1996, Max-Planck-Institut für Psychiatrie, Munich, Germany. 1998 Royal Honour, Knight in the Order of the Netherlands Lion bestowed by her Royal Highness Queen Beatrix of the Netherlands. 1998/now Guest Professor of Anhui Medical University, Hefei, Anhui, PR China. 1999/now Guest Professor of Capital University of Medical Sciences, Beijing, P.R. China. 2000 10 th David de Wied lecture Alzheimer research, the beginning of a better end (in Dutch) at the Educatorium, University of Utrecht, 14 April 2000. Gynaecongres lecture 2000, "The clever but vulnerable head of the unborn child" Millennium Gynaecongres, May 23 and 26, 2000, Beatrixtheater, Jaarbeurs, Utrecht Federa Prize 2000, Federation of Medical Scientific Societies, November 17, 2000, RAI, Amsterdam, for scientific work in biomedical determinants of Alzheimer s disease 2002 GIRES (Gender Identity Research and Education Society) award 2002 for the article Male-to-Female Transsexuals Have Female Neuron Numbers in a Limbic Nucleus. (Kruijver et al., J. Clin. Endocrinol. Metabol. 2034-2041 Alzheimer s Association Award: Lifetime Achievement Award in Alzheimer s Disease Research. Received at the 8 th International Conference on Alzheimer s Disease and Related Disorders in Stockholm, Sweden, 21 July 2003 School of Behavioral and Cognitive Neurosciences New Year s Lecture 2003. Exploring the brain: a search for our selves Honorary member of the installation committee of the journal on Gender Identity Disorders, the GID Journal 2004 The Brain Foundation Lecture Sexual Differentiation of the Human Brain. June1, Doorwerth,the Netherlands. 2005/6 Visiting Professorship in Sleep Medicine (Amer.Ass.of Sleep Med.& Pfizer) at Stanford, CA, USA. Guest Professor at the Beijing Institute of Radiation Medicine from 1 October 2005 to 31 December 2008 2

2007 Guest Professor at Zhejiang University, Hangzhou, PR China. 2008 Academy medal for his role in national and international neuroscience (fundamental to applied), for his initiative to start the Netherlands Brain Bank, and for his research in Alzheimer's disease. Two lectures for the opening of the Academic Year on the invitation of Gezondheids- en Levenswetenschappen, Faculty of Aard- en Levenswetenschappen, Vrije Universiteit, Amsterdam. Title: Education and Environment have only a minor effect on us. Most of our characteristics are inborn. 2009 The "Prof. Nico Bakker Lecture" van de Nederlandse Vereniging voor Urologie, 14 November, Martini Plaza, Groningen. 2010 Honorary member of Brein in Beeld 2011-14 Chao Kuang Piu Chair of Zhejiang University, Hangzhou, P.R. China. Ph.D. theses D.F. Swaab was mentor of 77 Ph.D students, 14 of whom became full professor. The following PhD students received an award or other accolades: 1989 A. Kalsbeek Incentive Prize of the Amsterdam Neurological Society, Professor of Experimental Neuroendocrinology, University of Amsterdam, 2012 1991 E. Goudsmit Sandoz Prize for Endocrinology 1992 1993 H.B.O.M. Honnebier Cum Laude. Organon Prize for Endocrinology 1994 1993 E. Aronica Cum Laude 1995 P.J. Lucassen Cum Laude, Organon Prize for Endocrinology 1996, appointed Professor of Structural & Functional Plasticity of the Nervous System at the University of Amsterdam in 2011 1996 J.N. Zhou The Netherlands Society for Endocrinology Thesis Prize 1997 1996 A. Salehi Boerhaave Aanmoedigingsprijs 1998. 1997 E.J.W. van Someren Cum Laude. Young Investigators Award by the International Society for Chronobiology in 1997. 1998 B.A.Th.F. Gabreëls Organon Prize for Endocrinology 1999. 1998 W.J.G. Hoogendijk Ramaermedaille for Psychiatry 1999 and the International Society for Biological Psychiatry Scientific Award for Young Scientists, 1999. 1999 Paul Dijkhuizen Greiner Award for best Ph.D. thesis on gene therapy of 1999. 2000 Tatjana Ishunina Russian thesis (2003) Summa Cum Laude. 2004 F.P.M. Kruijver GIRES research award 2004 Publications D.F. Swaab has published over 490 papers in SCI journals and 200 chapters in books. He is editor of 24 books. He is series editor (3 rd series) of the renowned Elsevier Handbook of Clinical Neurology, of which over 30 volumes are planned and of which 24 volumes have already appeared. Swaab's H-factor is: 70 He is author of: - The Human Hypothalamus. Basic and Clinical Aspects. Part I: Nuclei of the Hypothalamus, Handbook of Clinical Neurology, Elsevier, Amsterdam, approx. 1000 pp, 2003/2004. - The Human Hypothalamus. Basic and Clinical Aspects. Part II: Neuropathology of the Hypothalamus and Adjacent Brain Structures. Handbook of Clinical Neurology, Elsevier, Amsterdam, approx. 1000 pp, 2003/2004. - Wij zijn ons brein: van baarmoeder tot Alzheimer. Uitgeverij Contact, Amsterdam 2010. The book has appeared in Chinese and German translations and English and Italian translations are being prepared and are expected to be published in 2012. A few key topics and publications: Sexual differentiation of the brain - Swaab, D.F. and E. Fliers - A sexually dimorphic nucleus in the human brain. Science 228, 1112-1115, 1985. - Swaab, D.F. and M.A. Hofman - An enlarged suprachiasmatic nucleus in homosexual men. Brain Res. 537, 141-148, 1990. - Zhou, J.N., Hofman, M.A., Gooren, L.J.G. and Swaab, D.F. - A sex difference in the human brain and its relation to transsexuality. Nature 378: 68-70, 1995. 3

- Garcia-Falgueras, A. and Swaab, D.F. - A sex difference in the hypothalamic uncinate nucleus: relationship to gender identity. Brain 131: 3132-3146, 2008. - Swaab, D.F. - Sexual orientation and its basis in brain structure and function. Proc. Natl. Acad. Sci. USA 105: 10273-10274, 2008. Alzheimer's disease - Swaab, D.F. - Brain aging and Alzheimer's disease: "wear and tear" versus "use it or lose it". Neurobiol. Aging, 12, 317-324, 1991. - Salehi, A., Verhaagen, J., Dijkhuizen, P.A., Swaab, D.F. - Colocalization of high affinity neurotrophin receptors in nucleus basalis of Meynert neurons and their differential reduction in Alzheimer's disease. Neuroscience 75: 373-378, 1996. - Salehi, A., Dubelaar, E.J.G., Mulder, M., Swaab, D.F. - Decreased activity of nucleus basalis neurons in Alzheimer s disease is ApoE type dependent. PNAS 95: 11445-11449, 1998. - Scherder, E.J.A., Sergeant, J.A., Swaab, D.F. - Pain processing in dementia and its relation to neuropathology. Lancet Neurol. 2: 677-686, 2003. - Ishunina, T.A., Swaab, D.F., Fischer, D.F. - Estrogen receptor alpha splice variants in the medial mamillary nucleus of Alzheimr's disease patients: identification of a novel MS1 isoform. J. Clin. Endocrin. Metab. 90: 3757-3765, 2005. Submission of sequence data to GenBank, nucleotide sequence bankit651211 AY750962 - Dubelaar, E.J.G., Mufson, E.J., Ter Meulen, W., Van Heerikhuize, J.J., Verwer, R.W.H., Swaab, D.F. Increased metabolic activity in nucleus basalis of Meynert neurons in elderly individuals with mild cognitive impairment as indicated by the size of the Golgi apparatus. J. Neuropathol. Exptl. Neurol. 65: 257-266, 2006. - Ishunina, T.A. and Swaab, D.F. - Age-dependent ERα MB1 splice variant expression in discrete areas of the human brain. Neurobiol. Aging 29: 1177-1189, 2008 - Wu, Y.-H., Fischer, D.F., Kalsbeek, A., Garidou-Boof, M.-L., Van der Vliet, J., Pirovano, C., Liu, R.-Y., Zhou, J.N., Swaab, D.F. - Pineal clock gene oscillation is disturbed in Alzheimer's disease, due to functional disconnection from the "master clock". FASEB J. 20: E1171-E1180, 2006 - Riemersma-van der Lek, R.F., Swaab, D.F., Twisk, J., Hol, E.M., Hoogendijk, W.J., Van Someren, E.J. - Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial. JAMA 299: 2642-2655, 2008 Parkinson s disease - Hoogendijk, W.J.G., Pool, C.W., Troost, D., Van Zwieten, E.J. and Swaab, D.F. - Image-analyzer-assisted morphometry of the locus coeruleus in Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Brain, 118, 131-143, 1995 * Material from this paper was selected by the journal to serve as cover illustration. - Hoogendijk, W.J.G., Purba, J.S., Hofman, M.A., De Vos, R.A.I., Jansen, E.N.H., Swaab, D.F. - Depression in Parkinson s disease is not accompanied by more corticotropin-releasing hormone expressing neurons in the hypothalamic paraventricular nucleus. Biol. Psych. 43: 913-917, 1998. - Scherder, E.J.A., Wolters, E., Polman, C., Sergeant, J., Swaab, D. - Pain in Parkinson's disease and multiple sclerosis; its relation to the medial and lateral pain systems. Neuroscience and Biobehavioral Rev. 29: 1047-1056, 2005. - Fronczek, R., Overeem, S., Lee, S.Y.Y., Hegeman, I.M., Van Pelt, J., Van Duinen, S.G., Lammers, G.J., Swaab, D.F. - Hypocretin (orexin) loss and sleep disturbances in Parkinson's disease. Brain 130: 1577-1585, 2007. - Bossers, K., Meerhoff, G., Balesar, R., Van Dongen, J.W., Kruse, C.G., Swaab, D.F., Verhaagen, J. - Analysis of gene expression in Parkinson's disease: possible involvement of neurotrophic support and axon guidance in dopaminergic cell death. Brain Pathol. 19: 91-107, 2008 Depression - Raadsheer, F.C., Van Heerikhuize, J.J., Lucassen, P.J., Hoogendijk, W.J.G., Tilders, F.J.H., D.F. Swaab - Increased corticotropin-releasing hormone (CRH) mrna in the paraventricular nucleus of patients with Alzheimer's disease or depression. Am. J. Psychiatry 152, 1372-1376, 1995. - Zhou, J.N., Riemersma, R.F., Unmehopa, U.A., Hoogendijk, W.J.G., Van Heerikhuize, J.J., Hofman, M.A. and Swaab, D.F. - Alterations in arginine vasopressin neurons in the suprachiasmatic nucleus in depression. Arch. Gen. Psychiatry 58: 655-662, 2001. - Lucassen, P.J., Müller, M.B., Holsboer, F., Bauer, J., Holtrop, A., Wouda, J., Hoogendijk, W.J.G., De Kloet, E.R., Swaab, D.F. - Hippocampal apoptosis in major depression is a rare event and absent from subareas at risk for glucocorticoid overexposure. Am. J. Pathol. 158: 453-468, 2001. 4

- Bao, A.-M., Hestiantoro, A., Van Someren, E.J.W., Swaab, D.F., Zhou, J.N. Colocalization of corticotrophin releasing hormone and estrogen receptor-α in the paraventricular nucleus of the hypothalamus in mood disorders. Brain 128: 1301-1313, 2005. - Meynen, G., Unmehopa, U.A., Van Heerikhuize, J., Hofman, M.A., Swaab, D.F. - Increased arginine vasopressin mrna expression in the human hypothalamus in depression: a preliminary report. Biol. Psychiatry 60: 892-895, 2006 - Meynen, G., Unmehopa, U.A., Hofman, M.A., Swaab, D.F., Hoogendijk, W.J. - Hypothalamic oxytocin mrna expression and melancholic depression. Mol. Psychiatry 12: 118-119, 2007 - Wang, S.S., Kamphuis, W., Zhou, J.N., Swaab, D.F. - Gene expression analysis in the human hypothalamus in depression by Laser Micro-Dissection and Real Time PCR: the presence of multiple receptor imbalances. Mol. Psychiatry 13: 786-799, 2008. - Chen, X.N., Meng, Q.Y., Bao, A.M., Swaab, D.F., Wang, G.H., Zhou, J.N. - The involvement of retinoic acid receptor-α in corticotropin-releasing hormone gene expression and affective disorders. Biol. Psychiatry 66: 832-839, 2009. Eating disorders and metabolism - Goldstone, A.P., Unmehopa, U.A., Swaab, D.F. - Hypothalamic NPY and AGRP are increased in human illness but not in Prader-Willi syndrome and other obese subjects. J. Clin. Endocrinol. Metab. 87: 927-937, 2002. - Swaab, D.F., Purba, J.S. and Hofman, M.A. - Alterations in the hypothalamic paraventricular nucleus and its oxytocin neurons (putative satiety cells) in Prader-Willi syndrome: A study of five cases. J. Clin. Endocrin. Metab. 80(2):573-579, 1995. - Alkemade, A., Unmehopa, U.A., Wiersinga, W.M., Swaab, D.F., Fliers, E. - Glucocorticoids decrease TRH mrna expression in the paraventricular nucleus (PVN) of the human hypothalamus. J. Clin. Endocrin. Metab. 90: 323-327, 2005. - Unmehopa, U.A., Van Heerikhuize, J.J., Spijkstra, W., Woods, J.W., Howard, A.D., Zycband, E., Feighner, S.D., Hreniuk, D.L., Palyha, O.C., Guan, X.-M., MacNeil, D.J., Van der Ploeg, L.H.T., Swaab, D.F. - Increased melanin concentrating hormone receptor type I (MCH1R) in the human hypothalamic infundibular nucleus in cachexia. J. Clin. Endocrin. Metab. 90: 2412-2419,2005. - Fronczek, R., Lammers, G.J., Balesar, R., Unmehopa, U., Swaab, D.F. - Hypothalamic hypocretin (orexin) system is not affected in Prader-Willi syndrome. J. Clin. Endocr. Metab. 90: 5466-5470. MS - Huitinga, I., De Groot, C.J.A., Van der Valk, P., Kamphorst, W., Tilders, F.J.H., Swaab, D.F. - Hypothalamic lesions in multiple sclerosis. J. Neuropath. Exptl. Neurol. 60: 1208-1218, 2001. - Huitinga, I., Erkut, Z.A., Van Beurden, D., Swaab, D.F. - Impaired hypothalamus-pituitary-adrenal axis activity and more severe multiple sclerosis with hypothalamic lesions. Ann. Neurol. 55: 37-45, 2004. - Koning, N., Swaab, D.F., Hoek, R.M., Huitinga, I. - Distribution of the immune inhibitory molecules CD200 and CD200R in the normal central nervous system and multiple sclerosis lesions suggests neuron-glia and glia-glia interactions. J. Neuropathol. Exp. Neurol. 68: 159-167, 2009 Human postmortem cell culture - Dai, J.P., Swaab, D.F., Buijs, R.M. - Recovery of axonal transport in dead neurons. Lancet 351: 499-500, 1998. - Verwer, R.W.H., Hermens, W.T.J.M.C., Dijkhuizen, P.A., Ter Brake, O., Baker, R.E., Salehi, A., Sluiter, A.A., Kok, M.J.M., Müller, L.J., Verhaagen, J., Swaab, D.F. - Cells in human post-mortem brain tissue slices remain alive for several weeks in culture. FASEB J. 16: 54-60, 2002. - Wu, L., Sluiter, A.A., Guo, H.F., Balesar, R.A., Swaab, D.F., Zhou, J.N., Verwer, R.W.H. - Neural stem cells improve neuronal survival in cultured postmortem brain tissue from aged and Alzheimer patients. J. Cellular and Mol. Med. 12: 1611-1621, 2008 Huntington's Disease - Timmers, H.J.L.M., Swaab, D.F., Van de Nes, J.A.P., and Kremer, H.P.H. - Somatostatin 1-12 immunoreactivity is decreased in the hypothalamic lateral tuberal nucleus of Huntington's disease patients. Brain Res. 728: 141-148, 1996. - Aziz, N.A., Swaab, D.F., Pijl, H., Roos, R.A.C. - Hypothalamic dysfunction and neuroendocrine and metabolic alterations in Huntington's disease: clinical consequences and therapeutic implications. Revs. Neurosci 18: 223-251. 5

- Aziz, N.A., Fronczek, R., Maat-Schieman, M.L.C., Unmehopa, U.A., Roelandse, F.W.C., Overeem, S., Van Duinen, S.G., Lammers, G.J., Swaab, D.F., Roos, R.A.C. - Hypocretin and melanin-concentrating hormone in patients with Huntington disease. Brain Pathology 18: 474-483, 2008 Hypertension - Goncharuk, V.D., Van Heerikhuize, J.J., Swaab, D.F., Buijs, R.M. - Paraventricular nucleus of the human hypothalamus in primary hypertension: activation of corticotropin-releasing hormone neurons. J. Comp. Neurol. 443: 321-331, 2001. - Goncharuk, V.D., Buijs, R.M., Swaab, D.F. - Corticotropin-releasing hormone neurons in hypertensive patients are activated in the hypothalamus but not in the brainstem. J. Comp. Neurol. 503: 148-168, 2007. Miscellaneous - Erkut, Z.A., Klooker, T., Endert, E., Huitinga, I., Swaab, D.F. - Stress of dying is not suppressed by high-dose morphine or by dementia. Neuropsychopharmacology 29: 152-157, 2004. - Overeem, S., Van Vliet, J.A., Lammers, G.J., Zitman, F.G., Swaab, D.F., Ferrari, M.D. The hypothalamus in episodic brain disorders. Lancet Neurol. 1: 437-444, 2002. - Verwer, R., Sluiter, A., Balesar, R., Baayen, J., Noske, D., Dirven, C.,Wouda, J., Van Dam, A., Lucassen, P., Swaab, D. - Mature astrocytes in the adult human neocortex express the early neuronal marker doublecortin. Brain 130: 3321-3335, 2007. - Raymann, R.J.E.M., Swaab, D.F., Van Someren, E.J.W. - Skin deep: enhanced sleep depth by cutaneous temperature manipulation, Brain 131: 500-513, 2008. - Kreier, F., Swaab, D.F. - History of neuroendocrinology: 'the spring of primitive existence'. In: Finger, S, Boller, F. Tyler, K.L., Eds. Handbook of Clinical Neurology, vol. 95 (3 rd series) History of Neurology, chapter 23, p. 335-360. 6

CURRICULUM VITAE of Dick Frans Swaab, born December 17, 1944, Amsterdam, The Netherlands H-Factor: 70 Education 1963 Final examination 'Amsterdams Lyceum' 1966 Bachelor of Medicine, UvA 1966 Student assistant Netherlands Central Institute for Brain Research NCIBR), Amsterdam 1968 M.D. and doctoral assistant at the NCIBR 1968/71 Internships university clinics of Amsterdam 1970 Ph.D. Thesis, 'Factors Influencing Neurosecretory Activity of the Supraoptic and Paraventricular Nuclei in Rat, a Histochemical and Cytochemical Study' (supervisor: J. Ariëns-Kappers). 1972 General physician (registration 69024173801 as of 31-12-97) Professional career 1975/78 Acting director of the NCIBR (renamed the Netherlands Institute for Brain Research, NIBR, in 1977) 1978-2005 Director of the Netherlands Institute for Brain Research 1979 Professor of Neurobiology at the Medical Faculty, UvA (1 December). 1980 Oratie: Bederven wij de hersenen van onze kinderen reeds voor hun geboorte? (Are we ruining our children's brains even before they are born?) Inaugural lecture, 28 April 1980. Faculteit der Geneeskunde van de Universiteit van Amsterdam. 1985 Initiator and, until 2005, Director of the Netherlands Brain Bank 1978 Team leader of the work group Neuropsychiatric Diseases at the Netherlands Institute for Brain Research/Neuroscience Awards and Honors 1976 'Snoo-van 't Hoogerhuijs' prize (together with Dr. W.J. Honnebier) for work in the field of fetal neuroendocrinology. 1987 'Holst lecture', T.U. Eindhoven and N.V. Philips 'De klok in onze hersenen', December 12. 1990 'Hugo van Poelgeest' prize for the Netherlands Brain Bank as an alternative for animal experiments, June 26. Journal of Neural Transmission (36, 195-215, 1975) paper awarded "Citation Classic" status in Current Contents 33, no. 30, p. 16. 1995 Nature paper on transsexuality discussed in Nature 378, 15-16, 1995, "Another important organ". Selected by Discover for the top 100 science stories of 1995. 1996 Emil Kraepelin Guest Professorship 1996, Max-Planck-Institut für Psychiatrie, Munich, Germany. 1998 Royal Honour, Companion in the Order of the Dutch Lion bestowed by her Royal Highness Queen Beatrix of the Netherlands. 1998 Guest Professor of Anhui Medical University, Hefei, Anhui, PR China. 1999 Guest Professor of Capital University of Medical Sciences, Beijing, P.R. China. 2000 10 th David de Wied lecture Alzheimer research, the beginning of a better end (in Dutch) at the Educatorium, University of Utrecht, 14 April 2000. Gynaecongres lecture 2000, "The clever but vulnerable head of the unborn child" Millennium Gynaecongres, May 23 and 26, 2000, Beatrixtheater, Jaarbeurs, Utrecht Federa Prize 2000, Federation of Medical Scientific Societies, November 17, 2000, RAI, Amsterdam, for scientific work in biomedical determinants of Alzheimer s disease. 2002 GIRES (Gender Identity Research and Education Society) award 2002 for the article Male-to- Female Transsexuals Have Female Neuron Numbers in a Limbic Nucleus. (Kruijver et al., J. Clin. Endocrinol. Metabol. 2034-2041. Alzheimer s Association Award: Lifetime Achievement Award in Alzheimer s Disease Research. Received at the 8 th International Conference on Alzheimer s Disease and Related Disorders in Stockholm, Sweden, 21 July. 2003 School of Behavioral and Cognitive Neurosciences Groningen New Year s Lecture 2003. Exploring the brain: a search for our selves. 2003 Honorary member of the installation committee of the journal about Gender Identity Disorders, 7

the GID Journal 2004 Hersenstichting Lecture, 3 rd Dutch Endo-Neuro-Psycho Meeting, June 1-4, 2004, Doorwerth. "Sexual differentiation of the human brain". 2005/6 Visiting Professorship in Sleep Medicine at Stanford Medical Center, CA, USA (American Academy of Sleep Medicine and Pfizer Inc.). Selected as one of the 200 Dutch scientists for the Keur der Wetenschap ( Cream of Science ), 10 May 2005 KNAW (www.keurderwetenschap.nl). Honorary editor of Neuroendocrinology Letters. Visiting Professorship in Sleep Medicine (Amer.Ass.of Sleep Med.& Pfizer) at Stanford, CA, USA. Guest Professor at the Beijing Institute of Radiation Medicine from 1 October 2005 to 31 December 2008. 2007 Guest Professor at Zhejiang University, Hang Zhou, PR China. 2008 Academy medal for his role in national and international neuroscience (fundamental to applied), for his initiative to start the Netherlands Brain Bank, and for his research in Alzheimer's disease Two lectures for the opening of the Academic Year on the invitation of Gezondheids- en Levenswetenschappen, Faculty of Aard- en Levenswetenschappen, Vrije Universiteit, Amsterdam. Title: Education and Environment have only a minor effect on us. Most of our characteristics are inborn. Chairman International MS audit of MS Center Rotterdam (27 November) and MS Center Amsterdam, with Prof. J.P. Andel (Canada), Prof. A. Compston (UK) and Prof. J. Kesselring (Switzerland). 2009 The "Prof. Nico Bakker Lezing" van de Nederlandse Vereniging voor Urologie, 14 November, Martini Plaza, Groningen. 2011-14 Chao Kuang Piu Chair of Zhejiang University, Hangzhou, P.R. China Functions and committees Netherlands Institute for Brain Research 1971/1973 Secretary of the NCIBR Institute Council 1976/1977 Member RECON-committee 1977 Leader of research team 'Interaction of the Nervous System and Hormones during Maturation' at the NIBR 1982 Secretary-treasurer of the "Van den Houtenfonds" Foundation for the NIBR 1985 Initiator and director of the Netherlands Brain Bank in the Netherlands Institute for Brain Research 1986 Member board of governors of the 'Stichting tot Ondersteuning van de Hersenbank, beheerd door het Nederlands Instituut voor Hersenonderzoek' 1986 Founding member ALS Brain Bank and member board ALS-Bank foundation 1989 Founding member MS Brain Bank Dutch Societies and Committees 1976/1977 Member of the board of the Dutch Society for Endocrinology 1976/ Secretary of the Netherlands 'International Brain Research Organization' (IBRO) Committee of the Royal Academy of Arts and Sciences 1977/1980 Vice-president of the Dutch Society for Endocrinology 1979/1985 Member committee on 'Teratology of Chemical Compounds' (Health Council, The Hague) 1980/1981 President of the Dutch Society for Endocrinology 1980/1989 Member 'ZWO-dwarsverband' committee of Gerontological Research 1981 Member 'FUNGO-dwarsverband' committee of Gerontology Member committee of the Helffer-Kootkar Prize Foundation 1984/1990 Member committee 'Neurosciences' of FUNGO/Medigon 1985/ Member 'Amsterdamsche Neurologenvereeniging' 1985/ Member 'FUNGO/MEDIGON-dwarsverband' committee on 'Etiology of Aging' 1985/ Chairman committee on the assignment of subsidized aged animals (NWO) 1986/1990 Member NWO/ZWO committee of Neurosciences 1987 Member MEDIGON committee of 'Dementia/Alzheimer's Disease' 1987/2003 Member scientific council Netherlands Organization for Scientific Research of Multiple Sclerosis 8

1989/ Member Policy Committee Neuropathology 1990 Member committee incentive prize 'Amsterdamsche Neurologenvereeniging' 1990 Member committee incentive prize 'Sandoz' 1990/ Member advisory board "Veldwijk" Psychiatric Hospital 1990/2003 Member scientific advisory council of the Netherlands Brain Foundation 1991/1992 Member scientific committee NWO 'The Decade of the Brain'. 1994 Consultant commissie "Wetenschap en Beleid" van de Alzheimer Stichting. 1995/2002 Member Scientific Council Dutch Alzheimer's Foundation 1997/ Chairman of De Arnold Oosterbaan Brain Foundation. 1997-2007 Member of the Program Committee Aging Successfully (Succesvol Ouder Worden), NWO. 1998 Lid Wetenschappelijke Adviesraad Stichting Onderzoek Licht en Gezondheid (TU Eindhoven, Philips). 1999 Lid Raad van Aanbeveling voor de Stichting Medisch Interfacultair Congres t.b.v. het 10e Medisch Interfacultair Congres met als onderwerp Experimentele Geneeskunde, Universiteit Leiden. 1999 Member Health Council Committee Dementia (#655). 2000 Lid Adviesraad Stichting Vrijwillig Leven (Dutch Society for Dignified Voluntary Death) 2000 Lid Hoogleraren Dispuut UvA Unitas Multiplex. 2002 Lid Comité van Aanbeveling van het Nederlands Centrum Hersenletsel 2003 Member Health Council Committee Brain Damage due to Sports (#627) 2008 NVVE, Perspectieven op waardig sterven, werkgroep Dementie (Dying with Dignity workgroup) 2008 Curatorium herbenoeming 3 e vijfjaarstermijn Prof. Dr. H.B.M. Uylings (Morfometrie en ontwikkeling van het zenuwstelsel, Vrije Universiteit Amsterdam) 2008-2009 Medische Adviesraad Science Museum Corpus, Oegstgeest, The Netherlands. 2008/ Member Program Advice Committee, Council for Civilian-Military Care and Research (Ministry of Defence) 2009 Ministerie van Justitie: commissie en adviesrapport De Hersenen in Beeld. Neurobiologisch onderzoek en vraagstukken op het gebied van verklaring, reductie en preventie van criminaliteit. 2009-2010 Member of Civilian Initiative on Completed Life (Burgerinitiatief Voltooid Leven). 2010 Treasurer of the Stichting Vrienden van de Neurofederatie. International Societies and Committees 1978 Charter member of the International Society for Developmental Neurocience (ISDN) 1979/84 Member of the International Scientific Committee of the European Science Foundation, ESF (European training programme in Brain and Behavior Research, ETP, Strasbourg, France) 1983/84 Regional secretary of the International Society for Developmental Neuroscience (ISDN) 1984 Member selection committee for neuroendocrinology posts at the Edinburgh MRC Reproductive Biology Unit 1984/93 Founding member of the Research Group on Dementias of the World Federation of Neurology and member of the Executive Committee. 1984 Coordinator for the Netherlands of the European project on aging (EURAGE) 1985/88 Director of the IBRO Workshop Programme (Paris) 1987/ Member external advisory committee of the Lab for Pregnancy and Newborn Research, Cornell University, Ithaca, NY, USA., Center for Pregnancy and Newborn Research, University of Texas Health Sciences Center Medical School, Dept. Obstetrics and Gynecology-MSC 7836, Dallas, Texas. 1988 Dutch representative in EC working party 'Age-related Health Problems' of the EC Medical and Health Research Programme (EUROMED, Brussels) 1988/89 Chairman EURAGE subgroup on Tissue Banking 1989/97 Member of the International Medical Advisory Board of the International Federation of Multiple Sclerosis Societies 1990/95 Council member European Neuroscience Association (Panel Neuroendocrinology) 1990/ Member scientific advisory board of the Croatian Brain Research Institute 1991/92 Chairman Peter Debye-Prize on 'Aging of the Brain' 1992/ Member 'Interim Steering Group' European Dementia Research Network 1992/ Member Scientific Committee EUROSPES Foundation 1992/ Member advisory board The European Graduate School of Child Neuropsychology - Graduate Programme 9

1992/ Consultant "Molecular Geriatrics" (Chicago, USA) 1993 Committee member "Einrichtung eines Referenzzentrums für neurodegenerative Erkrankungen" (Bonn, Germany) 1993 Member of the New York Academy of Sciences. 1994/2003 Member scientific board International Alzheimer Research. 1994 Member Audit Committee projects PO1 HD 28014-03 ("Ontogeny of fetal behavior; P.L. Dr. P.W. Nathanielsz) and PO1 HD 21350 ("Parturition and fetal primate hypothalamic function; P.L. Dr. P.W. Nathanielsz). October 3-5, 1994, Cornell University, Ithaca, New York, USA. Member advisory board of the Society for Behavioral Neuroendocrinology and member of the journal committee Hormones and Behavior. 1996 Member panel for the 1996 Parker-Davis Award for Alzheimer's disease. New York, USA, 10 February 1996. 1998 Member review committee German Reference Center for Diseases of the Central Nervous System (GRCC) BrainNet and member International Advisory Board of the GRCC 2001 Chairman Scientific advisory and review board for the German Reference Center for Diseases of the Central Nervous System BrainNet. 2002 Member Forensic Sciences Expert Centre 2003 Member of the International Scientific Advisory Board of the Croatian Institute for Brain Research. 2004 Evaluation of the competence networks in medicine. Funding measure of the German Federal Ministry of Education and Research (BMBF). Consultant for the "Alzheimer's Disease Discovery Workshop", September 29-30, 2004, Cambridge, MA, USA. 2005 Member of the External Advisory Board of the Center for Pregnancy and Newborn Research, University of Texas Health Sciences Center, Medical School, Department of Obstetrics and Gynecology, Houston, Texas, USA 2008 Chairman International MS Audit of MS Center Rotterdam (Nov. 27) and MS Center Amsterdam, with Prof. J.P. Andel (Canada), Prof. A. Compston (UK) and Prof. J. Kesselring (Switzerland). 2009 Member of program-advice committee Research (Programma adviescommissie Onderzoek) of the RZO (Raad voor civiel-militaire Zorg en Onderzoek). 2010 Advisory Board Member Study Protocol Effects of sex steroid hormones on human brain function, structure and connectivity. (PI Rupert Lanzenberger). 2012 Member Advisoryl Board of Functional Neurology and New Trends in Neurosciences. UvA/AMC/Free University/KNAW 1979 Member committee Neurobiology (2nd Phase Education, Faculty of Biology) Member committee Neurological Sciences (2nd Phase, Faculty of Medicine) 1979/81 Member committee Childpsychology (UvA) 1982/2007 Founding member and member scientific advisory board of the Graduate School Neurosciences Amsterdam (ONWA) 1984/ Member 'Vaste Doctoraalexamencommissie Vrije Studierichting Medische Biologie' 1985/89 Chairman committee extra-ordinary professorate Clinical Pharmacology 1985/88 Member selection committee professorate Neurosurgery 1986 Founding member workgroup of clinicians and scientists on 'Brain Development and its disturbances', in collaboration with Dr. P.G. Barth 1987 Founding member of the Amsterdam workgroup of clinicians and scientists on 'Aging and Dementia' 1987/ Co-initiator and member of the board of the Amsterdam Neuroscience Network (since 1992 Research Institute Neurosciences Amsterdam) 1987-88 Member selection committee professorate Pharmacology, specifically Neuroendocrinology (Faculty of Medicine, Free University, Amsterdam) 1988/93 Curator chair Inborn and Hereditary Diseases of the Nervous System (UvA) Prof. Dr. P.G. Barth 1988 Member selection committee personal ordinary professorate Neurosurgery (UvA) 1989/02 Member evaluation committee and scientific advisory board Psychosis-project Adolescents clinic, Psychiatric Center AZUA (Dr. D.H. Linszen) 1990/ One of the three coordinators Research Institute for the Neurosciences of the Medical Faculty (UvA) 1990 Member selection committee ordinary professorate Neurology (UvA) 10

1990/ Coordinator new curriculum block XIII (Faculty of Medicine, UvA, together with Dr. J. Stam) 1991/95 Curator chair Gerontopsychiatry Free University, Amsterdam (P. Eikelenboom) 1992/2000 Curator chair Comparative Neurobiology, Free University, Amsterdam 1992/93 chairman selection committee 'Ordinariaat Verloskunde' 1992/2002 Member advisory committee for the integration of the Medical Faculty of the UvA and the Academic Medical Centre 1992 Co-initiator and Board member Graduate School Neurosciences Amsterdam, and member Research Institute for Neurosciences of the Medical Faculty (UvA) 1993/94 Member selection committee chair Neurology, in particular MS. Free University. 1994 Member project team reorganization Netherlands Ophthalmic Institute. 1994-2005 Member of the committee of the Van Leersum Fund (KNAW). 1994 Member of selection committee ordinary professorate Histology and Cell Biology (UvA) 1997/ Acting member Advisory Committee External Research Projects (Advies Commissie Externe Onderzoeksproject) AMC 1998 Member Curatorium chair Immunological aspects of chronic inflammation of the nervous system Prof. Dr. C. Lucas. Free University, Amsterdam. 1999 Member Advisory Committee appointment Professor of Social Psychiatry (AMC) 2000 Member Committee appointment Professor of Neurology, in particular dementias. 2001 Chairman committee MS programme applications. 2008 Curatorium Bijzondere Leerstoel Prof. dr. H.B.M. Uylings 2012 Member Scientific Advisory Board EU project Prenatal exposure to stress and the effect on (aging) of the brain. Chairs held by NIBR members (PhDs of D.F. Swaab are indicated by an *) 1986-1998 M.A. Corner: Extraordinary chair in Developmental Physiology at the Faculty of Mathematics and Natural Sciences of the UvA (Van den Houten-Foundation), September 1 1987-1996 N.E. van den Poll: Extraordinary chair in Comparative Psychobiology of Emotions at the Subfaculty of Psychology of the UvA (Van den Houten-Foundation), November 1 *1991 R.M. Buijs: Prof. of Medicine, Medical Faculty, Univ. of Ottawa, Canada 1991 H.B.M. Uylings: Extraordinary chair in Morphometry and Development of the Nervous System at the faculty of medicine of the Free University, Amsterdam, January 1 1991 I. Kostovic' (Zagreb, Yugoslavia): Spinoza Chair, UvA 1995 W.J. Freeman (Berkeley CA, USA): Spinoza Chair, UvA *1995 G.J. de Vries (Amherst, MA, USA): Professor of the Department of Psychology 1996-1998 D.F. Swaab: Emil Kraepelin Guest Professorship. Max-Planck-Institut für Psychiatrie, Munich, Germany. 1996 M. Mirmiran: Visiting Professor, Dept. of Pediatrics, Div. Neonatal. & Devel. Medicine, Stanford University, USA. 1996-1997 M. Mirmiran: Visiting Professor, Dept. Physiology, Lab. Pregnancy & Newborn Research, Cornell University, Ithaca, USA. *1997 R.M. Buijs. Extraordinary Chair in Neuroendocrinology, Faculty of Biology, UvA *1997 J.N. Zhou. Professor of Neuroscience, Department of Psychiatry and Neuroscience, First Affiliated Hospital of Anhui Medical University, P.R. China. 1998 J. Verhaagen. Extraordinary Chair in Molecular Biology, Faculty of Biology, Free University, Amsterdam 1999 D.F. Swaab, Visiting Professor at Capitol University of Medical Sciences, Beijing, P.R. China *1999 H.P.H. Kremer, Professor in Neurology, Faculty of Medicine, University of Nijmegen. 1999 R.M. Buijs, Visiting Professor at the University of Strasbourg, France 1999 A. Kalsbeek, Visiting Professor at the University of Strasbourg, France *2000 W.A. van Gool, Professor of Neurology, especially the Dementias, UvA *2000 D. Troost, Professor of Neuropathology, AMC, Amsterdam 2001 Prof. dr. F. Holsboer, Spinoza Chair, Amsterdam University Ver. for the Faculty of Medicine of the UvA *2002 Prof. dr. E.J.A. Scherder, Bijzonder Hoogleraar Klinische Neuropsychologie, in het bijzonder het onderzoek naar de diagnostiek en behandeling van neuropsychologische stoornissen van de ouder wordende mens. Vrije Universiteit, Amsterdam, faculteit der Psychologie en Pedagogiek. *2002 Prof. R.Y. Liu, Professor of Internal Medicine, Geriatric Department, First Affiliated Hospital of Anhui Medical University, Hefei, P.R. China 2002 Prof. dr. C.M.A. Pennartz, Special Professor in Cognitive Neurobiology at the UvA. 11

*2003 Prof. dr. W.J.G. Hoogendijk. Professor of Biological Psychiatry at the Free University, Amsterdam *2005 Prof. dr. E. Fliers, Professor of Endocrinology, Neuroendocrinology in particular, at the UvA *2006 Prof. dr. J.A.M. van der Post, Strategic Professor of Obstetrics, at the UvA *2008 T.A. Ishunina. Associate Professor at the Department of Histology, Kursk State Medical University, Russia. *2009 Prof. dr. E.J.W. Van Someren, Special Professor "Humane Hersenactiviteit van Slaap, Rust en Vigilantie", Vrije Universiteit, Amsterdam *2009 Prof. A. Salehi, Clinical Associate Professor, Stanford University Medical Center, CA, USA *2011 P.J. Lucassen. Structural and Functional Neuroanatomy, Faculteit der Natuurwetenschappen, Wiskunde en Informatica, Swammerdam Institute of Life Sciences, Universiteit van Amsterdam *2012 G. Meynen, Special Professor Forensic Psychiatry, University of Tilburg, Stichting Koningsheide *2012 A. Kalsbeek, Professor of Experimental Neuroendocrinology, University of Amsterdam. Member editorial boards 1975/1986 Acta Endocrinologica 1976/1983 Journal of Neural Transmission 1978/1987 Journal of Developmental Physiology 1978/1998 Journal of Neuroscience Methods 1981/1990 Peptides 1982/1986 Molecular and Cellular Endocrinology 1983/1991 Journal of Neurological Sciences 1987/now Neuroendocrinology Letters (Associate Editor as of January 2003) 1987/1992 Journal of Chemical Neuroanatomy 1988/1996 Journal of Neuroendocrinology 1988/1990 Advances in Neurosciences 1988/1992 Neuroendocrinology 1990/now Neurobiology of Aging 1990/now Progress in Brain Research 1991/now Brain Research 1997/now Neuropraxis 1997/2000 Neuroscience News 1999/2000 Inaugural Editorial Board of Brain and Mind 2002/2005 Associate Editor & Editorial Board Member, XX vs XY 2002/now Associate Editor of Neuroendocrinology Letters 2002/now Associate Editor of the Journal of Prenatal and Perinatal Psychology and Medicine. 2006 Deputy Chief Editor of International Journal of Prenatal and Perinatal Psychology and Medicine 2002/now Series Editor of the Handbook of Clinical Neurology series (new third series), Elsevier. 2005/now Field editor for Neuroendocrinology, Springer's "Encyclopedic Reference of Neurosciences" 2006 Editor of Biogenic Amines. 2008 Member of the Founding Editorial Board of the International Journal of Physiology, Pathophysiology and Pharmacology (IJPPP). 2008 Member of the Editorial Board of the International Journal of Physiology, Pathophysiology and Pharmacology (IJPPP) 2010 Editor (together with Gerard Nuovo) of Methods Vol. In Situ Hybridization. Elsevier, Amsterdam. 2011 Member of the Editorial Board of Neuroscience Bulletin, Shanghai, China. Courses 1968/70 Course 'Methods of medical-biological research', Department of Medicine, Leiden 1969/70 Course 'Medical statistics' (H. de Jonge), Nederlands Instituut voor Preventieve Geneeskunde, Leiden 1975 4th Training Course on 'Radioimmunoassay and Radioreceptor Techniques'. National Institutes of Health, Bethesda, Maryland, USA (March 17-21) Ph.D.-Theses Supervisor of Ph.D. projects 1974 W.J. Honnebier: 'The fetal brain in intrauterine growth and parturition, the role of the 12

hypothalamohypophysial systems', (cum laude) 1976 G.J. Boer: 'The role of pituicytes in the rat neurohypophysis; an exploratory investigation using histo- and microchemistry' K. Boer: 'The rat hypothalamo-neurohypophysial system; its involvement in the onset and course of labour' 1977 J. Dogterom: 'The release and presence of vasopressin in plasma and cerebrospinal fluid as measured by radioimmunoassay; studies on vasopressin as a mediator of memory processes in the rat' (in collaboration with the Rudolf Magnus Institute, Utrecht) "Promotor" (supervisor) of Ph.D. Students 1980 1 F.W. van Leeuwen: 'Light and electronmicroscopical immunocytochemical localization of neuropeptides in the rat brain', together with Prof. J. Joosse and Dr. J.G. Streefkerk ('co-promotors'), Free Univ. of Amsterdam (Faculty of Mathematics and Natural Sciences). 2 R.M. Buijs: 'Vasopressin and oxytocin innervation of the rat', together with Prof. D. de Wied ('copromotor') and Dr. F.H. Lopes da Silva ('co-referent'), Univ. of Amsterdam (Faculty of Medicine). R.M. Buijs has become Professor of Neuroendocrinology 1981 3 J.G.M. van Oyen: 'Reactions to novel and aversive stimuli in female and male rats', together with Prof. J.L. Slangen, Univ. of Utrecht (Faculty of Social Sciences). 1982 4 M. Mirmiran; 'Experimental studies on the significance of active (c.q. rem)-sleep for maturation of brain and behavior in the rat', together with Dr. M.A. Corner ('co-promotor') and Prof. M. Jouvet (Univ. of Lyon) ('co-referent'), Univ. of Amsterdam (Faculty of Medicine). 1984 5 M.A. Hofman: 'Towards a general theory of encephalization', together with Dr. H.B.M. Uylings and Dr. M.A. Corner ('co-promotors'), Univ. of Amsterdam (Faculty of Mathematics and Natural Sciences). 1985 6 G.J. de Vries: 'The vasopressinergic innervation of the brain. a target for gonadal hormones', together with Dr. R.M. Buijs, ('co-promotor'), Univ. of Amsterdam (Faculty of Medicine). G.J. de Vries has become Professor in Amherst, Massachusetts 7 C.G. van Eden: 'Postnatal development of the prefrontal cortex in the rat', together with Dr. H.B.M. Uylings ('co-promotor'), Univ. of Amsterdam (Faculty of Mathematics and Natural Sciences) 8 E. Fliers: 'Hypothalamic changes in aging and Alzheimer's disease' (31 Oct.), together with Prof. H. van Crevel, Univ. of Amsterdam (Faculty of Medicine). In 1997 E. Fliers was awarded the Organon Nederland Prize for Thyroid Research. In 2005 E. Fliers was made Professor of Neuroendocrinology 9 H.P. Oosterbaan: 'Amniotic oxytocin and vasopressin in the human and rat. Alterations during pregnancy, parturition and intra-uterine growth retardation' (21 Nov.), together with Prof. P.E. Treffers and Dr. G.J. Boer ('co- promotor'), Univ. of Amsterdam (Faculty of Medicine). 1986 10 F. van Huizen: 'Significance of bioelectric activity for synaptic network formation. A quantitative electronmicroscopic study on rat cerebral cortex cultures' (17 April), together with Dr. H.J. Romijn and Dr. M.A. Corner ('co-promotors'), Univ. of Amsterdam (Faculty of Medicine). 1987 11 J. Kruisbrink: 'Accurel polymer as an implantable new device for rate-controlled delivery of peptides' (21 May), together with Dr. G.J. Boer ('co- promotor'), Univ. of Amsterdam (Faculty of Medicine). 12 W.A. van Gool: 'Aging of the brain: circadian sleep-wakefulness rhythms and environmental influences in the rat' (4 Jun.), together with Prof. H. van Crevel ('promotor') and Dr. M. Mirmiran ('copromotor'), Univ. of Amsterdam (Faculty of Medicine). W.A. van Gool has become Professor of Neurology. 13 E.M. Brenner; 'Functions of the noradrenergic innervation of the rat brain' (4 June), together with Prof. M.A. Corner ('promotor') and Dr. M. Mirmiran ('co-promotor'), Univ. of Amsterdam (Faculty of Medicine). 14 A.R. Caffé: 'Intra- and extrahypothalamic vasopressin systems in the rat and monkey brain' (8 Oct.), together with Dr. F.W. van Leeuwen ('co-promotor'), Univ. of Amsterdam (Faculty of Medicine). 1988 15 F.G.M. Snijdewint: 'Vasopressin and brain development: the brattleboro rat as a model' (1 Sept.), together with Dr. G.J. Boer (co-promotor), Univ. of Amsterdam (Faculty of Medicine). 13

1989 16 A. Kalsbeek : 'The role of dopamine in the development of the rat prefrontal cortex' (27 Jan.), together with Dr. H.B.M. Uylings ('co-promotor'), Univ. of Amsterdam (Faculty of Medicine). This thesis was awarded the 1989 Incentive Prize of the Amsterdam Neurological Society. 17 B.M. de Jong: 'Cultured rat cerebral cortex explants and their application in the study of spect scan radiopharmaceuticals' (June 23), together with Prof. dr. J.B. van der Schoot ('promotor'), dr. J.M. Ruijter ('co-promotor'), Dr. E.A. van Royen ('co-promotor'), Univ. of Amsterdam (Faculty of Medicine). 1990 18 M.L.H.J. Hermes: 'Functional significance of central vasopressin and oxytocin in rodents' (December 14) 'Examinateur' together with Dr. P. Pévet (Directeur de Recherche) and Dr. R.M. Buijs, University of Straatsburg (Lab of Zoology and Embryology); (December 21) 'promotor' together with Dr. R.M. Buijs ('co-promotor'), UvA (Faculty of Medicine) 1991 19 E. Goudsmit: 'Neural activation during aging and in Alzheimer's disease; the role of sex steroids and osmotic stimulation' (February 14), Univ. of Amsterdam (Faculty of Medicine). This thesis was awarded the SANDOZ PRIZE for endocrinology in 1992. 20 F.J.C.M. van Eerdenburg: 'Postnatal development of some nuclei in the pig hypothalamus' (April 11) together with Prof.dr. C.J.G. Wensing (promotor) and Dr. F.W. van Leeuwen (co-promotor), State Univ. Utrecht (Faculty of Veterinary Medicine). 21 G.J.A. Ramakers: 'Development of fetal rat cerebral cortex in primary tissue culture and the role of bioelectric activity' (June 21) together with Prof.dr. M.A. Corner (promotor) and Prof.dr. W.H. Gispen (promotor), UvA (Faculty of Medicine). 1992 22 D. Troost: 'Inflammatory changes in amyotrophic lateral sclerosis; a neuropathologic immunocytochemical study' (February 6) together with Prof. J.M.B.V. de Jong (promotor) and Dr. J.J. Van de Oord (co-promotor), UvA (Faculty of Medicine). D. Troost has become Professor of Neuropathology. 23 B.H.W. Erdtsieck-Ernste: 'ß-adrenoceptors in rat brain development' (March 26) together with Dr. M.G.P. Feenstra (co-promotor), UvA (Faculty of Medicine). 24 H.A. Griffioen: 'Suprachiasmatic nucleus transplants in rats; growth and functional development' (February 19) together with Dr. G.J. Boer (co-promotor), UvA (Faculty of Medicine). 25 J.M. de Brabander: 'Sparing of function following damage to the prefrontal cortex. What can we learn from the developing brain?' (May 21) together with Prof.dr. H.B.M. Uylings (promotor) and Dr. J.P.C. de Bruin and Dr. C.G. van Eden (co-promotores), UvA (Faculty of Medicine). 26 H.P.H. Kremer: 'The lateral hypothalamus in Huntington's, Alzheimer's and Parkinson's disease' (September 24) together with Prof. dr. G.W. Bruyn (promotor) and Dr. R.A.C. Roos (co-promotor), University of Leiden (Faculty of Medicine). H.P.H. Kremer has become Professor of Neurology. 1993 27 M.B.O.M. Honnebier: 'The role of the circadian system during pregnancy and labor in monkey and man' (February 3) together with Prof. P.W. Nathanielsz (promotor) and Dr. M. Mirmiran (co-promotor), UvA. Cum Laude. Dr. Honnebier was also awarded the Organon prize for Endocrinology in 1993, and the Snoo van 't Hoogerhuys prize in 1996. 28 E. Aronica: 'Excitatory amino acids in nerve cell development and neuronal plasticity' (June 1) together with Prof.dr. F. Nicoletti (promotor) and R. Balázs (co-promotor), UvA. Cum Laude. 29 C.J.C. Boersma: 'Neuron-glia interactions in the rat neurohypophysis; the role of opioids, other neuropeptides and their receptors' (November 26) together with Dr. F.W. van Leeuwen (co-promotor), UvA. 1994 30 F.C. Raadsheer: 'Increased activity of hypothalamic corticotropin-releasing hormone neurons in aging, Alzheimer's disease and depression: a study on human postmortem material' (June 13), together with Prof. dr. F.J.H. Tilders (promotor), UvA. 31 M.J.A. van Veldhuizen: 'In vivo noradrenaline overflow in rat brain' (September 13), together with Dr. M.G.P. Feenstra (co-promotor), Univ. of Amsterdam. 32 J.S. Purba: 'The paraventricular nucleus of the human hypothalamus during aging and in several pathologies: a morphometric study on postmortem material'; (September 19), together with Dr. M.A. Hofman (co-promotor), Univ. of Amsterdam. 33 A.M. Resink: 'Trophic and toxic influences of excitatory amino acids in cerebellar granule cell cultures: regulation of N-methyl-D-aspartate receptors'; (December 23), together with Dr. R. Balázs and Dr. G.J. Boer (co-promotors), UvA 14

1995 34 N.J. Hack: 'Excitatory amino acids and the development of cerebellar granule cells in vitro'; (February 9), together with Dr. R. Balázs (co-promotor), UvA 35 E.J.A. Scherder: 'Peripheral nerve stimulation in Alzheimer's disease; Effects on memory and affective behavior'; (May 15), together with Prof. dr. T.L. Holdstock (promotor) and Dr. J.M. Bouma (copromotor), Free University, Amsterdam 36 E.J. Van Zwieten: 'Vasopressin systems in aging and Alzheimer's disease: a study on rat and human brain'; (November 9), together with Dr. R. Ravid (co-promotor), UvA. 37 J.A.P. Van de Nes: 'Independent occurrence of -protein deposits and cytoskeletal changes in the brain of Alzheimer's disease patients: a study in the human hypothalamus with anti-a a nd Alz-50'; (December 6), together with Dr. W. Kamphorst and Dr. C. Jonker (co-promoters). Free University, Amsterdam. 1996 38 P.J. Lucassen: 'The relationship between neuronal activity, brain aging and Alzheimer's disease'. (18 March). UvA. Cum Laude. Dr. Lucassen was also awarded the Organon Prize for Endocrinology 1996. In 2011 he became Professor of Structural and Functional Neuroanatomy. 39 P.A. Piosik: 'Influence of thyroid hormones on gene expression in goat brain during development'. (17 April), together with Prof. Dr. J.J.M. de Vijlder (promotor) en Dr. F. Baas (co-promotor). UvA. 40 J.N. Zhou: Vasoactive intestinal polypeptide in the human hypothalamus. Relationship to development, sex, aging and Alzheimer s disease, rhythmicity and depression. (4 October). UvA. In 1997 The Netherlands Society for Endocrinology awarded this thesis with the Thesis Prize. 41 A. Salehi: Relationship between neuropathological hallmarks and neuronal activity in Alzheimer s disease. A postmortem study on the human hypothalamus and hippocampus. (7 November). UvA. Dr. Salehi was awarded the Boerhaave Aanmoedigingsprijs (Dfl. 10.000) on 20 November 1998. 42 A.J.G.D. Holtmaat: Functional analysis of B-50/GAP-43 in transgenic mice and by viral vectormediated gene transfer. (9 December). University of Utrecht. 1997 43 W. Witting: Aging of the circadian system. Chronobiological effects of light. (15 January). UvA. 44 J.A.M. van der Post: Preeclampsia: relation with vasopressin and activation of thrombocytes. (25 April). UvA. 45 W.T.J.M.C. Hermens: Viral vectors. Towards application in neuroregeneration research. (19 June). University of Utrecht. 46 E.J.W. van Someren: Rest-activity rhythms in aging, Alzheimer s disease and Parkinson s disease. Methodological developments and therapeutic interventions. (4 July). UvA. Cum Laude. E.J.W. van Someren was awarded the Young Investigators Award by the International Society for Chronobiology in 1997. He was made a Special Professor of Human Brain Activity in Sleep, Rest and Vigilance in 2010. 1998 47 B.A.Th.F. Gabreëls: Vasopressin secretion disorders in: Diabetes insipidus, Prader-Willi syndrome, Wolfram syndrome. (16 April). UvA. Dr. Gabreëls was awarded the Organon Prize for Endocrinology 1999. 48 W.J.G. Hoogendijk: Brain changes in depression. A combined clinical and post-mortem study in depressed patients with or without Alzheimer s or Parkinson s disease. (12 June), together with Prof. dr. P. Eikelenboom. Free University, Amsterdam. Dr. Hoogendijk was awarded the Ramaermedaille for Psychiatry on 17 April 1999 and the International Society for Biological Psychiatry Scientific Award for Young Scientists, 3-4 June 1999. 49 J.P. Dai: The anatomical organization of the human hypothalamus in relation to circadian rhythms. Immunocytochemical and postmortem tracing studies. (4 November), together with Prof. Dr. R.M. Buijs, UvA. 1999 50 Lisette van Esseveldt: Transplantation of the rat suprachiasmatic nucleus. Functional studies and ex vivo adenoviral vector-mediated gene transfer. (1 June), together with Prof. Dr. W.J. Rietveld, UvA. 51 Paul Dijkhuizen: Viral vectors as tools for neurotrophin gene delivery to the injured nervous system (21 September), together with Prof. dr. J. Verhaagen en Prof. dr. W.H. Gispen. This thesis was awarded the Greiner Award for best Ph.D. thesis on gene therapy for the year 1999. 2000 52 Jeroen Pasterkamp: Chemorepulsive semaphorins in neural regeneration. (20 June), together with Prof. Dr. J. Verhaagen, Free University, Amsterdam. 53 Simone Lunshof: Circadian rhythms in the normal and growth-retarded fetus and infant (21 June), together with Prof. Dr. O.P. Bleker, UvA. 15

54 Tatjana Ishunina: "Functional sex differences in the human hypothalamus and nucleus basalis of Meynert: relation to ageing and Alzheimer's disease" (Dec. 1) together with Prof. dr. A. Zavialov, UvA. Russian thesis (2003) summa cum laude. 2001 55 R.-Y. Liu: Circadian system rhythm disorders in aging and AD (4 July). UvA. 56 B. Blits: Cell and gene therapy: experimental strategies for spinal cord regeneration (26 February). Free University, Amsterdam 2002 57 T.H.K. Heinen: Timing and functional implications of GABA A receptor maturation during visual cortex development. (19 December). Free University, Amsterdam, together with Prof. dr. A.B. Brussaard 2003 58 W.C.J. Chung: Sexual differentiation of the human and rodent forebrain. (15 January). UvA, together with Prof. dr. G.J. de Vries. 59 M.J. Ruitenberg: Experimental spinal cord injury. Emerging cell and gene therapeutic strategies for neuroregeneration. (22 May). Free University, Amsterdam, together with Prof. J. Verhaagen. 2004 60 Z.A. Erkut: The stress-axis in multiple sclerosis. Effects of sepsis, morphine and corticosteroids. (11 mei). UvA. 61 F. de Winter: Secreted semaphorins: chemorepulsive control of neural regeneration? (27 mei). Free University, Amsterdam, together with Prof. J. Verhaagen. 62 F.P.M. Kruijver: "Sex in the brain. Gender differences in the human hypothalamus and adjacent areas. Relationship to transsexualism, sexual orientation, sex hormone receptors and endocrine status". (22 October). UvA, together with Prof.dr. L.J.G. Gooren. Won the GIRES research award 2004. 63 J. de Wit: "Truncated TrKB and semaphorin 3A: a role in restricting structural plasticity in the adult nervous system?" (29 November). Free University, Amsterdam, together with Prof. dr. J. Verhaagen. 2005 64 F. de Vrij: "Mutant ubiquitin and the proteasome in Alzheimer's disease" (10 February). UvA, together with Prof. dr. J. Verhaagen 65 A. Alkemade: "Central components of the human hypothalamus-pituitary-thyroid axis and their role in nonthyroidal illness" (27 September). UvA, together with Prof. dr. W. Wiersinga and Prof. dr. E. Fliers. 66 M.W. Luijpen: "Transcutaneous electrical nerve stimulation in mild cognitive impairment." (8 December) Vrije Universiteit, Amsterdam, together with Prof. dr. E.J.A. Scherder. 2007 67 Y. Wu: The human circadian timing system in aging, Alzheimer s disease and depression (30 January). UvA, together with Prof.dr. J.N. Zhou. 68 G. Meynen: "Neurobiological characteristics of depression" (22 May). Vrije Universiteit, Amsterdam, together with Prof. dr. W.J.G. Hoogendijk. 69 R. Riemersma-Van der Lek: "Keep it bright. Deterioration and reactivation of the biological clock in dementia" (5 July). UvA. 70 L. Eggermont: "Neurorehabilitation in dementia on the move. Influences of physical activity on cognition, mood, and the rest-activity rhythm" (21 December). Vrije Universiteit Amsterdam, together with Prof. E.J.A. Scherder. 2008 71 R. Fronczek: "Hypocretin deficiency. Neuronal loss and functional consequences" (30 January). Universiteit Leiden, together with Prof. dr. J.G. van Dijk. 72 P. van Tijn: "The effect of mutant ubiquitin on proteasome function in relation to neurodegenerative disease" (7 November). UvA. 73 N. Koning: "Imbalanced immunity in multiple sclerosis" (12 March). UvA, together with Prof. Dr. R.A.W. van Lier. 2009 74 C.A.M. Bossers: "Spot the difference. Microarray analysis of gene expression changes in Alzheimer's and Parkinson's disease." (10 November). Vrije Universiteit Amsterdam, together with Prof. Dr. J. Verhaagen and Prof. Dr. C.G. Kruse. 2010 75 E. Altena: "Mapping insomnia: brain structure, function and sleep intervention", together with Prof. dr. E.J.W. van Someren, Dr. Y.D. van der Werf, Prof.dr. Ph. Scheltens. 76 J. Middeldorp: "Astrocytes in development, aging and disease", together with Dr. E. Hol, copromotor. 2011 77 S. van den Berge: The endogenous repair capacity of the Parkinson brain, together with Prof. Dr. 16

E. Hol. "Co-promotor" (co-supervisor) of Ph.D. Students 1985 W. Kamphorst: 'Glial cells. An immunocytochemical and morphological study', together with Prof. F.C. Stam (promotor) and Prof. E.J. Essels (referent), Free Univ., Amsterdam (Faculty of Medicine). 1996 M.J.Th. Koenderink: 'Postnatal neuronal maturation of the human prefrontal cortex'; (February 6) Together with Prof. Dr. H.B.M. Uylings (promotor) and Prof. A. Ruiz Marcos (referent) Free University, Amsterdam (Faculty of Medicine). 1991 O. Van Reeth (Brussels, Belgium) "Manipulation pharmacologique et comportementale de l'horloge circadienne des mammifères". "(Co-)referent" / "External Referent" of Ph.D. Theses 1979 J. Assies: 'Neuroendocrine aspects of prolactinomas. a clinical study', Univ. of Amsterdam (Faculty of Medicine). 1981 M.J. van der Horn: 'De radioimmunologische bepaling van vasopressine in urine', Univ. of Amsterdam (Faculty of Medicine). 1984 L.P.C. Schot: 'Immunocytochemical studies on peptidergic neurons in the pond snail lymnaea stagnalis', Free Univ., Amsterdam (Faculty of Mathematics and Natural Sciences). 1990 J.M. Rozemüller-Kwakkel: 'Amyloid Formation in Alzheimer's Disease. An immunocytochemical study' (19 Jan.) Free Univ., Amsterdam (Faculty of Medicine). 1990 M. Najimi (Lyon, France) on the development of the hypothalamus and SIDS 1992 I. Huitinga: 'The role of macrophages in the pathogenesis of experimental allergic encephalomyelitis' (13 Nov.) Free Univ., Amsterdam (Faculty of Medicine). 2003 S. Overeem: Narcolepsy. From clinical entity to hypocretin deficiency (28 May) University of Leiden (Faculty of Medicine). 2004 S. Perreau-Lenz: Control of the daily melatonin rhythm. (9 June). UvA (Faculty of Medicine). Rapporteur externe.. Ph.D. Committee member 1978 A.F.M. Moorman: 'Synthesis of mythochondrial proteins - identification and localization of genes on yeast mitochondrial DNA', Univ. of Amsterdam (Faculty of Mathematics and Natural Sciences). 1979 O.P. Bleker: 'On human intrauterine growth', Univ. of Amsterdam (Faculty of Medicine). A. ter Maat: 'Integrative properties of a group of neuro-endocrine cells in the pond snail', Univ. of Amsterdam (Faculty of Mathematics and Natural Sciences). 1980 W.L. Lamers: 'Multihormonal control of enzyme clusters in liver ontogeny', Univ. of Amsterdam (Faculty of Medicine). C.W. Pool: 'An immune- and enzyme-histochemical determination of striated muscle fibre characteristics', Univ. of Amsterdam (Faculty of Mathematics and Natural Sciences). 1981 M.F. Schutte: 'Over de behandeling van dreigende vroeggeboorte', Univ. of Amsterdam (Faculty of Medicine). P.W.J. Peters: 'Induced congenital malformations of the central nervous system. a teratological study', Univ. of Utrecht (Faculty of Medicine). 1982 H.J.L.A. Ruis: 'Borstvoeding. in het bijzonder over het afkolven van moedermelk', Cath. Univ. of Nijmegen (Faculty of Medicine). H.W.M. Steinbusch: 'Serotonergic neurons in the central nervous system of the rat', Cath. Univ. of Nijmegen (Faculty of Medicine). G. Schmitt-Ehret: 'Les cellules opiocortico-melanotropes du lobe intermediaire de l'hypophyse. etude au cours de l'ontogenese et apres perturbations du metabolisme hydromineral chez la souris', Strasbourg, Univ. Louis Pasteur (Faculty of Mathematics and Natural Sciences). 1985 J. Overweg: 'Withdrawal of antiepileptic drugs seizure-free adult patients. Prediction of outcome', Univ. of Amsterdam (Faculty of Medicine), 24 October. P. Room: 'Connections of the parahippocampal cortex. A neuroanatomical tracing study in the cat', Free Univ. of Amsterdam (Faculty of Medicine), 25 October. J.A. Poulis: 'Circadian urinary excretion rhythms in rats', Univ. of Leyden (Faculty of Medicine), 4 December. 1986 F.H. de Jonge: 'Sexual and agressive behavior in female rats. Psychological and endocrine factors', Univ. of Utrecht (Faculty of Social Sciences), 14 February. 1987 L.J.A. van Putten: 'The prolactin cells and plasma prolactin levels in the aging rat: an immunocytochemical and biochemical study', Univ. Nijmegen (Faculty of Mathematics and Natural 17

Sciences), 3 December. 1988 N.E.P. Deutz: 'Pathological aspects of acute hepatic encephalopathy in the rat. An electroencephalographic, biochemical and in vivo brain NMR spectroscopic study', Univ. of Amsterdam (Faculty of Medicine), 10 March. B.T. Poll-The: 'Genetic Peroxisomal disorders', Univ. of Amsterdam (Faculty of Medicine), 6 October. 1989 F.T.M. Rotteveel: 'Clonal analysis of human lymphocyte functions: implications for the study of the immunopathology of multiple sclerosis', Univ. of Amsterdam (Faculty of Medicine), 9 February. J.M.H.H. van Hest: 'Behavorial differences between male and female rats: learning and memory', Univ. of Amsterdam (Faculty of Psychology), 9 May. E. Mullaart: 'DNA damage and repair in relation to aging', University of Leiden (Faculty of Mathematics and Natural Sciences), 13 September J. Scholtens: 'Behavioral consequences of agonistic experiences in S3 rats', 1 December. 1990 T.A.M. Voorhuis: 'Vasotocin in the canary brain', University of Utrecht (Faculty of Medicine), 29 March R.P.W. Heinsbroek: 'Sex differences in behavioral and biochemical consequences of aversive stimulation', Univ. of Amsterdam, Faculty of Mathematics and Natural Sciences, 31 May. 1992 C.M. Van Duijn: 'Risk factors for Alzheimer's disease; a genetic epidemiologic study'. Erasmus Univ. Rotterdam, Faculty of Medicine, January 29 C.J.A. de Groot: 'Characterization and function of brain macrophages and neuroglial cells'. Free University, Amsterdam, Faculty of Medicine, 15 May J.A. Gorter: 'Chronic neonatal neurotransmitter interference and adult brain function: effects of clonidine and MK-801'. UvA, Faculty of Medicine, 4 June P.A.E. Sillevis Smitt: 'Amyotrophic lateral sclerosis. Experimental Animal, Immunocytochemical and Biochemical Studies'. Univ. of Amsterdam, Faculty of Medicine, 30 June D. Terwel: 'Vasopressin in the brain and plasma of the aging rat. A radioimmunoassay study'. University of Maastricht, Faculties II, 5 November 1993 D. Jaarsma: Glutamate and related substances in the brain: histochemical methodology and Alzheimer's pathology. University of Groningen, Faculty of Medicine, 31 March N.P.L.G. Verhoeff: Neuroreceptor ligand imaging by Single Photon Emission Computerised Tomography (SPECT). UvA, Faculty of Medicine, 1 April. Cum Laude. M.M.B. Breteler: Cognitive decline in the elderly. Erasmus University Rotterdam, Faculty of Medicine, 18 June. R. Adriaanse: Pulsatile and circadian TSH release in health and disease. UvA, Faculty of medicine, 1 July. M.P. van Veen: Dynamic mechanisms of neuronal outgrowth. Free University, Faculty of Medicine, 1 September. S.A. Scherjon: The brainsparing effect: flow velocity waveforms in the fetal and neonatal period and their relation to intracranial pathology and neurological outcome. UvA, Faculty of Medicine, 19 October. D.H. Linszen: Recent onset schizophrenic disorders: outcome, prognosis and treatment. UvA, 16 November. 1994 A.J.W. van der Does: Symptomatology and cognition in recent onset schizophrenia. UvA, 20 January. E.M. van der Beek: Circadian regulation of the hypothalamus-pituitary-gonadal axis in the female rat. University of Utrecht, 22 February. A.M.W. van Dam: Production and action of immunomodulators in the rat brain. Free UvA, 25 November. J. Bauer: Macrophages and glial cells in the pathogenesis of experimental autoimmune encephalomyelitis. UvA, 2 December. R.H.M. Hermans: Behavioural sequelae of perinatal hypoxia in the rat. University of Maastricht, 21 October. M.H. Godfried: Soluble receptors for tumour necrosis factor in HIV infection. UvA, 23 December. 1995 R.L.A.W. Bleys: Innervation of the basal cerebral arteries: pathways and densities. University of Utrecht, 28 February. K. Gerritse: Antibody formation and immunomodulation in experimental allergic encephalomyelitis and multiple sclerosis. Erasmus University of Rotterdam, 28 September. A.P. Evans: Somatic mutations in vasopressin neurons. Identification of mutant transcripts and precursors. University of Utrecht, 3 October. 1996 J. Bakker: Sexual differentiation of the brain and partner preference in the male rat. Erasmus University Rotterdam, 6 March. J.B. Derks: The effects of antenatal glucocorticoid administration on the fetus. University of Utrecht, 31 May. W. Hesen: Corticosteroid receptor mediated modulation of serotonergic and cholinergic responsiveness 18

in rat hippocampal CA1 neurons. UvA, 13 September. A.B. Dessens: Prenatal exposure to phenobarbital and diphantoin. A study on long-lasting consequences. UvA, 18 September. 1998 B.M.J. Uitdehaag: Cytokines and glucocorticoids in experimental allergic encephalomyelitis and multiple sclerosis. Free University, Amsterdam, 9 January. I. Dijksta: Glucocorticoids and adaptive changes in the hypothalamic-pituitary-adrenal system. Free University, Amsterdam, 18 February. L. Heijink: Hexanedione toxicity and neurofilament metabolism. UvA, 22 April. G. Kwakkel: Dynamics in functional recovery after stroke. Vrije Universiteit, Amsterdam, 2 December. M. van Stipdonk: The immune response to -crystallin: self, non-self and phosphorylation. UvA, 17 March 1999 Y.G.H. Maas: Early neurological development, growth and nutrition in very preterm infants. UvA, 11 November. 2001 I.F. Palm: Timing of female reproduction. Role of the suprachiasmatic nucleus. UvA, 13 March. J. Lavalaye: SPECT imaging in young patients with schizophrenia. UvA, 25 April. J. Ratsma: Biological vulnerability to alcoholism in children of alcoholics. UvA, 30 November L. Reneman: Investigating the potential neurotoxicity of ecstacy (MDMA). An imaging approach. UvA, 6 December. (cum laude) J. Grootendorst: Stress effects on cognitive performance of apolipoprotein E knockout mice. University of Leiden, 13 June. 2002 L.J.S. Brokken: The TSH receptor in the pituitary and its clinical relevance. UvA, 14 May. 2002 T. Rinne: The Neuro-endocrine scars of sustained childhood abuse in adult female patients with borderline personality disorder. UvA, 28 May. 2002 M. Kromkamp: Homeobox genes and thalamic pathology in schizophrenia. A postmortem study. University of Utrecht, 17 October. 2003 R.C. Sival: Aggressive behaviour in dementia. University of Utrecht, 18 November. 2004 N.D. Prins: Cerebral Small Vessel Disease in Dementia and Depression. Erasmus University Rotterdam, 24 March. V.M. Heine: Adult hippocampal cell birth and death in relation to stress, aging and the vasculature. UvA, 28 September. I. van Welie: Activity-dependent plasticity of neuronal excitability. A role for short-term modulation of voltage-gated ion channels in neuronal function. UvA, 30 November. Swaab added to promotion committee due to request for Cum Laude. 2005 K.R.A. van Dijk: Peripheral electrical nerve stimulation in Alzheimer's disease. Vrije Universiteit, Amsterdam, 6 September. F. Kreier: Autonomic nervous control of white adipose tissue. UvA, 7 September. J.P. Brouwer: Thyroid and adrenal axes in major depression. UvA, 18 October. R.J.L. Lindauer: Effects of psychotherapy on the biology of posttraumatic stress disorder: brain imaging and neurophysiological correlates. UvA, 16 December. 2006 F.J. Stam: Exploring the regenerative response to peripheral nervous system injury: a genomics and proteomics approach. Vrije Universiteit, Amsterdam, 29 May. K. Boekhoorn: Microtubule associated proteins and plasticity in the developing and diseased brain. University of Amsterdam, 26 September. 2007 S.R. de Rooij: Metabolic consequences of prenatal exposure to the Dutch famine. UvA, 8 February. J.M. Oosterman: Aging matters. White matter and age-related conditions: a focus on cognition, pain, and the rest-activity rhythm. 2008 W.T.J.H. Hendriks: Gene therapy for neurotrophic factors in experimental neurotrauma. Vrije Universiteit Amsterdam, 20 June. M.R. Tannemaat: Molecular nerve repair. Vrije Universiteit Amsterdam, 3 December E.H.P. Franssen: Olfactory ensheathing glia as a source of neuroregeneration-promoting molecules. Vrije Universiteit Amsterdam, 5 December 2009 T.E. Hartog: Singing on steroids. A story of neuronal plasticity and blood vessels. Vrije Universiteit Amsterdam, 2 September. F.M.J. Jacobs: Pitx3 and Nurr1 in control of terminal differentiation of Meso-diencephalic dopamine neurons. Universiteit Utrecht, 3 September 2010 N.A. Aziz: Huntington's disease. Hypothalamic, endocrine and metabolic aspects. Universiteit Leiden, 31 maart. 2011 T.T. Vo: Studies on semaphorin 3A in the neuromuscular junction and in perineuronal nets. Vrije Universiteit, 8 September 2011 19

M. Sinnema: Prader-Willi syndrome: genotype and phenotype at adult age. University of Maastricht, 9 December 2011. 2012 A.F.M. van Abeelen: Undernutrition and chronic disease. The 1944-1945 Dutch famine. University of Amsterdam, 15 June 2012. International conferences organized (* = post-academic teaching) 1973* 8th International Summer School of Brain Research, 'Integrative Hypothalamic Activity' (The role of the hypothalamus in development, reproduction, growth and behavior), together with Dr. J.P. Schadé, Baarn, June 25-29. 1974 Symposium, 'Brain Development and Thyroid Deficiency', together with Prof. A. Querido (Leyden), Royal Academy, Amsterdam. 1975* 9th International Summer School of Brain Research, 'Perspectives in Brain Research', together with Dr. M.A. Corner, Amsterdam, July 28 - August 1. Member local committee of the Xth Acta Endocrinologica Congress, Amsterdam. 1976 Symposium, 'Melanocyte Stimulating Hormone: Control, Chemistry and Effects', together with Prof. P.G. Smelik and Dr. F.J.H. Tilders, Free Univ., Amsterdam, July 14-16. 1977* 10th International Summer School of Brain Research, 'Maturation of the Nervous System', together with Drs. M.A. Corner, H.B.M. Uylings and N.E. van de Poll and Ir. K. Kuijpers, Amsterdam, July 11-15. 1980* EMBO Practical Course, 'Immunocytochemistry and its Application in Brain Research', together with Dr. G.J. Boer et al., Amsterdam, May 27-30. 1981* 12th International Summer School of Brain Research, 'Chemical Transmission in the Brain. The Role of Amines, Aminoacids and Peptides', together with Drs. R.M. Buijs and P. Pévet, Amsterdam, August 31 - September 4. 1982* Second EMBO Practical Course, 'Immunocytochemistry and its Application in Brain Research', together with Drs. F.W. van Leeuwen and R.M. Buijs, Amsterdam, May 24-28. Member Program-committee 3rd International Meeting of the International Society for Developmental Neurosciences (ISDN), Patras, Greece. 1982/83 Advisory member Program committee Symposium, 'Aging, Dementia and Memory', Cath. Univ. of Nijmegen. 1983* 13th International Summer School of Brain Research, 'Sex Differences in the Brain. Relation between Structure and Function', together with Dr. J.P.C. de Bruin, Dr. H.H. Swanson, G.J. de Vries and J. Sels. 1984* ETP Winter School 'New Developments in the Investigation of the Human Brain', together with Prof. G. Berluchi (Pisa, Italy) and T. Crow (London, U.K.), Zuoz, Switzerland, January 7-14. 1983/84 Member local Committee European Neuroscience Association (ENA), meeting The Hague, September 11-15. 1985* Co-organizer Practical Course on Morphometry and Stereology in Neurosciences, Amsterdam, May 20-24. 1985* 14th International Summer School of Brain Research, 'Aging of the Brain and Senile Dementia', together with E. Fliers, W.A. van Gool, F.P.A.J. van Haaren and M. Mirmiran, Amsterdam, August 26-30. 1986 Member Scientific committee 3rd International Symposium 'Trace Elements and Health', Free Univ., Amsterdam, September 5-6. 1987 Member organizing committee of the International Symposium on Alzheimer's Disease, Free Univ., Amsterdam, May 7-9. 1987* 15th International Summer School of Brain Research, 'Neurochemistry of Functional Neuroteratology; permanent Effects of Chemicals on the Developing Brain', together with G.J. Boer, M.G.P. Feenstra, M. Mirmiran and F. van Haaren, Amsterdam, August 31-September 4. 1988 XIXth Congress of the ISPNE Annual Meeting, together with B. Bohus, University of Groningen, August 21-25. 1990 British-Dutch MS-meeting in NIBR, Amsterdam, 16 March. 1990 Second International Conference on Alzheimer's Disease & related disorders. 15-20 July, Toronto, Canada. 1991* 17th International Summer School of Brain Research, 'The human hypothalamus in health and disease', together with F.W. van Leeuwen, M. Mirmiran, R. Ravid, Amsterdam, 26-30 August 1991. 1991 Member of committee of recommendation for the Alzheimer's Disease International (ADI) Congress 1991. 1992 Member Scientific Committe Third International Conference on Alzheimer's Disease & related disorders. Padua, Italy. 20