NATIONAL FEDERAL GRANTS CONFERENCE & WEBCAST ADVANCING HIGHER EDUCATION, SCIENCE & OUTREACH

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1 NATIONAL FEDERAL GRANTS CONFERENCE & WEBCAST ADVANCING HIGHER EDUCATION, SCIENCE & OUTREACH OCTOBER 21, 2011 MIAMI, FL Lawrence A. Tabak, DDS, PhD Principal Deputy Director, NaLonal InsLtutes of Health (NIH) Department of Health and Human Services (DHHS) A little background about me "Open the doors to all. Let the children of the rich and the poor take their seats together and know of no distinction save that of industry, good conduct and intellect, declared Townsend Harris, president of the city s Board of Education, upon his founding of the Free Academy in a single building at Lexington Avenue and 23rd Street in Manhattan. His bold idea: to offer a free education to the children of immigrants and poorer city residents based on academic worth, not wealth. 1

2 NIH: Steward of Medical and Behavioral Research for the Nation Science in pursuit of fundamental knowledge about the nature and behavior of living systems... and the applicalon of that knowledge to extend healthy life and reduce the burdens of illness and disability. Why Does Research Matter? Chilies, cactus and treatment of chronic pain 2

3 One of the aclve ingredients in spicy hot foods is capsaicin ConLnuous exposure causes desensilzalon - in other words if you eat chilies regularly, your tolerance to their burning taste increases A receptor, VR1, that decorates the cell membranes of nerves throughout the body, senses capsaicin - this is why spicy foods can make your fingers (or eyes!) irritated Hottness scale: jalapeno chilies 10 3 units, habanero chilies 10 5 units, pure capsaicin 10 7 units, VR1 A Novel Approach for the Management of Chronic Pain A compound related to capsaicin has been found in a cactus, found in Mororco, termed resiniferatoxin (RTX) It binds to the same receptors that capsaicin binds to, the VR1 receptors that decorate heat/pain sensing neurons 3

4 RTX-treatment selectively destroys cells that are decorated with the VR1 receptor CONTROL 0.1 µg RTX 0.2 µg RTX Cervical DRG Why Does Research Matter? Research prevents disease and leads to new treatments 4

5 NIH Extramural & Intramural Funding FY 2011 Enacted: $30.9 Billion* Spending at NIH $5.0 B 16% $3.3 B Intramural Research $1.5 B Research Management & Support $0.2 B Buildings and Facilities, Other $321M less than FY2010 Spending Outside NIH $25.9 B 84% Supports over 325,000 Scientists & Research Personnel Supports over 3,000 Institutions * Total includes $150 million from the Special type 1 Diabetes appropriation and excludes estimated $8 million transfer from HHS for NLM Program Evaluation. How Do You Decide How To Spend All That Money And How Can I Get Some? 5

6 Top 10 NIH Funded Florida Institutions Ins&tu&on FY2010 Total NIH $ Awarded* University of Miami School of Medicine M University of Florida M H. Lee MoffiJ Cancer Ctr & Res Inst 39.2 M University of South Florida 30.3 M Florida State University 20.9 M Florida Interna&onal University 18.8 M Jaeb Center For Health Research, Inc M University of Miami Coral Gables 10.9 M Mayo Clinic Jacksonville 7.3 M University of Central Florida 7.2 M *Figures are approximate dollars awarded to each insltulon. hjp://report.nih.gov/award/trends/state_congressional/statedetail.cfm?state=florida&lon= &Lat=

7 Approaches to Supporting Research, Research Training and Career Development NIH funds grants, coopera&ve agreements, and contracts that support the advancement of fundamental knowledge about the nature and behavior of living systems to meet the NIH Mission. Research Grants Career Development Awards Ins&tu&onal Research Training Grants Fellowships Loan Repayment Awards Small Business Awards (SBIR/STTR) 13 Principles of Success Understand the peer review process. Understand the agency mission. Every IC is different! Secure collaborators (mentors) to complement your exper&se and experience. Don t compete collaborate! Learn and prac&ce the skills of wri&ng applica&ons for grant funds. 14 7

8 Understand the Institute/Center Mission Mission of each of the 24 NIH ICs able to fund grants is based and defined in law Authoriza&ons (periodic) Appropria&ons (annual) ICs establish specific research emphases Legisla&ve mission Current state of science Use the Web to find out!

9 The Mission 17 Getting to the Top: Writing Great Grants Components of successful applica&ons Strong Idea Strong Science Strong Team Strong Presenta&on Match idea/science to the NIH Ins&tute Every IC has specific mission Hone high- quality grant wri&ng skills Communicate scien&fic content compellingly Follow all the instruc&ons START EARLY & PLAN! 18 9

10 Tips from NIH Program Staff Monitor Ins&tute websites and the NIH Guide (hjp://grants.nih.gov/grants/guide/) Get to know the Program Director for your scien&fic area Contact them about your research ideas Fit with ins&tute mission and priori&es Best grant mechanism or program Best study sec&on for review Par&cipate in workshops and symposia Stay abreast of the latest NIH & OER news Par&cipate in review of grant applica&ons (study sec&ons) 19 NIH Loan Repayment Program 20 10

11 NIH Loan Repayment Programs (LRP) NIH Loan Repayment Programs are a vital component of our na&on's efforts to ajract health professionals to careers in research. How they work: You: Commit to perform research for 2 years NIH: Repays up to $35,000 per year of your qualified educational debt and covers the resulting taxes Result: Increase the number of biomedical and behavioral research scien&sts Five Extramural LRPs Clinical Research Pediatric Research Health Dispari&es Research Contracep&on and Infer&lity Research Clinical Research for Individuals from Disadvantaged Backgrounds Note: NIH employees in research posi&ons are eligible for Intramural LRPs

12 Eligibility Doctoral degree (M.D., D.D.S., Ph.D., or equivalent) EXCEPTION: Eligibility for the Contracep&on and Infer&lity Research LRP includes nurses, physician assistants, graduate students, and postgraduate research fellows training in the health professions Funding for research at any domes&c nonprofit, university, or government organiza&on Educa&onal loan debt must be at least 20% of applicant s annual salary Must conduct qualifying research for at least 20 hours/week U.S. Ci&zen or permanent resident **NIH grant or award support NOT required** Online Information and Application Application Deadline November

13 Research Training and Career Awards 25 Research Training and Career Awards Training Grants T Ins&tu&onal Predoctoral and Postdoctoral Fellowships F Individual Predoctoral F30, F31 F30 for Individual Predoctoral MD/PhD and other Dual Doctoral Degree Fellows F31 to promote Diversity in Health- Related Research Postdoctoral F32 hjp://grants.nih.gov/training/nrsa.htm Career Development Awards K 26 13

14 Underrepresented MinoriLes Demographics 2006 (in %) Expanding Minority Participation: American s Science and Technology Talent at the Crossroads, NAS Report, 2011 Where are Opportunities for Improvement? Awarded Degrees in Biological Sciences, Chemistry and Physics to CiLzens and Permanent Residents by US InsLtuLons ( ) - NSF Web Caspar BS PhD Non-URM: ~8.8% URM: ~4.1% Need to more than double the number of URMs to maintain proporlon of PopulaLon 10/11/

15 Grant Programs To Consider Bachelorette Granting Institutions Don t stop here Keep in contact with NIH 15

16 NIH Turning Discovery into Health 16