DIaMICOM Network Spring School 2014
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1 DIaMICOM Network Spring School 2014 GrK 1874 Diabetic Microvascular Complications: DIaMICOM Mannheim Groningen (Hans-Peter Hammes, Han Moshage) GrK 1566 Protecting the Heart from Ischemia: PrOMISE Giessen - Barcelona (Klaus T. Preissner) GrK 1508 arterial remodeling: EuCar Aachen - Maastricht (Jürgen Bernhagen)
2 Organizing committee Prof. Dr. H.-P. Hammes V. Med. Klinik, Universitätsmedizin Mannheim Prof. Dr. H. Moshage Director of Graduate School GUIDE, Medical Dept., UMCG Prof. Dr. J.-L. Hillebrands Dept. of Pathology & Medical Biology - Pathology, UMCG Dr. G. Krenning Dept. of Pathology & Medical Biology Medical Biology, UMCG Prof. Dr. J. Kroll Dept. of Vascular Biology & Tumorangiogenesis Universitätsmedizin Mannheim Prof. Dr. B. Yard V. Med. Klinik, Universitätsmedizin Mannheim S. Englert Dekanat, Medizinische Fakultät Mannheim Venue Internationales Wissenschaftsforum Heidelberg Universität Heidelberg Hauptstraße Heidelberg Tel.: (06221) Fax: (06221) [email protected]
3 Programme Sunday, March 30, Welcome & Introduction DIAMICOM: Hans-Peter Hammes PROMISE: Klaus T. Preissner EuCAR: Jürgen Bernhagen Moderation: Hot Topic I Robin Jonas & Vincenzo Terlizzi Glyoxalase-1 and microvascular complications in diabetes Caspar Schalkwijk (EuCAR) Session 1 Kidney - Sweet dreams for kidneys, a nightmare for renal cells The function of the Rac1 regulator ELMO1 in the vasculature and in renal development under high glucose in zebrafish and in human diabetic nephropathy Krishna R. Sharma (DIAMICOM) Oxidative protein modification in diabetic nephropathy friend or foe? Tanja Wiedenmann (DIAMICOM) Carnosinase in hyperglycemia: Influence on CN-1 secretion and relevance for damage to glomerular endothelial cells Shiqi Zhang (DIAMICOM) Diabetic nephropathy in the BTBR Ob/Ob mouse as a pre-clinical model for therapeutic interventions Thomas Albrecht (DIAMICOM) Dinner Moderation: Klaus Preissner Keynote lecture Novel potential mediators and biomarkers in diabetic nephropathy Gabriella Gruden
4 Programme Monday, March 31, 2014 Session 2 More than meets the Eye Moderation: Thomas Albrecht & Bettina Müller Keynote lecture How do policy-makers decide which treatments for diabetic retinopathy to fund? Issues and experience from NICE Amanda Adler Hyperglycemic memory mechanisms relevant to the diabetic retina Patrick Friedrichs (DIAMICOM) ADSC: up a Notch to support retinal capillaries Vincenzo Terlizzi (DIAMICOM / Groningen) MicroRNA-induced microangiopathy in diabetes Julian Friedrich (DIAMICOM) Glucose-induced mitochondrial dysfunction in ADSC implications for pericyte function Ghazaleh Hajmousa (DIAMICOM / Groningen) Coffee break Session 3 Vascular I - The bigger not the better Moderation: Siqi Zhang & Bastian Schlickenrieder Long-term inhibition of AP-1 by JDP2 overexpression prevents cardiac hypertrophy after unilateral kidney stenosis but provokes cardiac dysfunction Gerhild Euler (PROMISE) A background Ca2+ entry pathway mediated by TRPC1/ TRPC4 is critical for development of cardiac hypertrophy Marc Freichel (SFB 1118) The calcium-sensing receptor in experimental models of pressure-induced cardiac hypertrophy Elena Dyukova (PROMISE) Role of endothelial junctional adhesion molecule-a (JAM-A) in inflammatory cell recruitment in atherosclerosis Martin Schmitt (EuCAR) A glimpse on IMI SUMMIT Work package 4 activities at Sanofi Thomas Hübschle (Sanofi) Lunch
5 Programme Session 4 Neuropathy - To feel or not to feel Moderation: Krishna R. Sharma & Julian Friedrich Keynote lecture Diagnosing and managing diabetic neuropathy: Can we do better? Rayaz Malik Altered cell-cell interaction in experimental diabetic neuropathy contributing to pain? Divija Deshpande (DIAMICOM) Diabetic thin fiber neuropathy - objective assessment and mechanism Robin Jonas (DIAMICOM) Identification of tissue specific changes within the nociceptive system in diabetic peripheral neuropathy contribution of TRP channels Bastian Schlickenrieder (DIAMICOM) Coffee break Session 5 Vascular II - Lost in translation Moderation: Jaspal Garg & Nadine Volk Protective versus exacerbating roles of MIF in cardiovascular and metabolic disease Jürgen Bernhagen (EuCAR) The damaging nature of extracellular RNA in atherosclerosis and cardiovascular disease Hector A. Cabrera-Fuentes (PROMISE) Cytoprotective actions of the anti-diabetic drug metformin Han Moshage (DIAMICOM / Groningen) Inflammatory activities of extracellular RNA in the vasculature Silvia Fischer (PROMISE) Predictive value of vascular function for individual susceptibility to end-organ damage: does it also hold in diabetes? Hendrik Buikema (DIAMICOM / Groningen) Dinner Moderation: Hans-Peter Hammes Candlelight lecture Of mice and men: what did we not (yet) learn about diabetes Hans-Georg Joost
6 Programme Tuesday, April 1, 2014 Session 6 Mechanisms - Highway to hell Moderation: Tanja Wiedenmann & Divija Deshpande Keynote lecture Climate change at sites of diabetic complications: Just looking for alternative fuel sources?, Josephine Forbes Detoxifying enzymes in diabetic target tissues mitochondrial dependent and independent effects of methylglyoxal, Nadine Volk (DIAMICOM) Dysfunction of compartmentalized cyclic AMP signaling in the diabetic vasculature, Jaspal Garg (DIAMICOM) Coffee break Hyperglycemia-induced monocyte-macrophage differentiation, Kondaiah Moganti (DIAMICOM) Kv channels in myogenic and perivascular fat-dependent autoregulation and small artery diabetic dysfunction, Bettina Müller (DIAMICOM) Monocyte differentiation and macrophage plasticity in diabetic conditions, Sarah Riemann (DIAMICOM) Hot Topic II Moderation: Jürgen Bernhagen Development of an accelerated and reliable model of diabetic nephropathy in mice, Tammo Ostendorf (EUCAR) Concluding remarks Lunch & Farewell End of Meeting & Departure
7 Participants Chairmen Prof. Dr. H.-P. Hammes V. Med. Klinik, Universitätsmedizin Mannheim Prof. Dr. H. Moshage Graduate School GUIDE, Medical Dept., University Medical Center Groningen (UMCG) Speakers Dr. A. Adler Addenbrooke s Hospital, University of Cambridge Prof. Dr. J. Bernhagen Institute of Biochemistry and Molecular Cell Biology RWTH Aachen University Prof. Dr. H. Buikema Department of Clinical Pharmacology, UMCG Prof. Dr. G. Euler Department of Physiology, Justus-Liebig-University Gießen Dr. S. Fischer Institute for Biochemistry, Justus-Liebig-University Gießen Prof. Dr. M. Freichel Institute of Pharmacology, Heidelberg University Prof. Dr. J. Forbes Department of Medicine, University of Melbourne Prof. Dr. G. Gruden Department of Internal Medicine, University of Turin Dr. T. Hübschle Diabetes Division, Sanofi-Aventis Deutschland GmbH, Frankfurt a.m. Prof. Dr. H.-G. Joost German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal Prof. Dr. R. Malik School of Clinical & Laboratory Sciences, University of Manchester Prof. Dr. H. Moshage GUIDE, Medical Dept., UMCG Prof. Dr. T. Ostendorf Department of Internal Medicine II, RWTH Aachen University Prof. C. Schalkwijk CARIM, Maastricht University
8 DIAMICOM Network Spring School 2014
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