HERMES MEDICAL SOLUTIONS

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1 HERMES MEDICAL SOLUTIONS Solutions for your medical imaging needs! HERMES Fusion for Oncology HERMES CardioClick HERMES NeuroClick for Cardiology for Neurology HERMES Explorer for bridging Radiology, Nuclear Medicine & PET State-of-the-Art Medical Imaging Software by HERMES Clinically driven MultiModality medical imaging software for diagnosis, staging & treatment of disease!

2 HERMES software - designed for your clinical imaging needs Fighting illness & disease requires state-of-the-art imaging modalities & software in order to diagnose accurately, stage disease appropriately & select the best treatment available. HERMES partners with the best institutions globally to continually deliver customized diagnostic software packages to meet your ever-changing medical imaging needs. Whether it be longitudinal tumor tracking in Oncology, database design to differentiate Alzheimer s Disease & Fronto - Temporal Dementia, advances in cardiac PET imaging or bridging Radiology, Nuclear Medicine & PET, HERMES is leading the way. HERMES Fusion for Oncology Fusion features: MultiModality Fusion & Volume Display HERMES MultiModality Image Fusion is the most advanced automatic image registration sofware toolkit for co-registration, analysis, comparison & fusion of image data from any modality: PET, SPECT, CT, MRI & Ultrasound HERMES Volume Display provides all the tools necessary for reporting PET-CT & other volume datasets efficiently Fuse Multiple Modalities PET-CT-MRI Fusion Report PET-CT Efficiently PET-CT Fusion PET-CT study co-registered with an MRI study using MultiModality and viewed in Volume Display. Head & Neck Cancer. Case Courtesy of Children s Hospital Boston, Department of Nuclear Medicine, Boston, MA, USA. Register the PET/CT scan to other modalities such as MRI, SPECT, standalone CTs & Radiotherapy Planning CTs See SUV values on the PET scan immediately as you move the cursor over the images Lymphoma case courtesy of Brigham & Women s Hospital, Department of Nuclear Medicine, Boston, MA, USA. View up to 4 studies in synchrony with a linked cursor in Transverse/Coronal/Sagittal (TCS) style Volume display with triangulation & automatic zoom Generate/save MIP movies from transverse slices as animated GIF or as DICOM multiscreen captures for viewing from PACS exquisite tissue characterization HERMES in Drug Development PET PET-CT Fusion CT Improve Tumor Localization PET-CT, Misaligned Aligned with HERMES Patient with gastrointestinal stromal tumor (GIST), before drug treatment. PET-CT with motion artifact, FUSION ONLY Solitary Pulmonary Nodule (SPN). Case Courtesy of Athens Regional Medical Center, Athens, GA, USA. After HERMES co-registration & FUSION. (Up to 15% of PET-CT hardware fusion lung cases require image registration software for motion correction) Draw ROIs & display SUV average & max ROI values Send VOIs & registered studies to a radiotherapy planning station (RTP) 1 month after drug treatment. Case courtesy of Dana-Farber Cancer Institute, Nuclear Medicine Dept., Boston, MA, USA. Longitudinal Tumor Tracking: Register, fuse & compare serial scans on the same patient, e.g. before & after drug treatment Automatic seed ROI for quick & easy definition of lesions & display of SUV values

3 HERMES NeuroClick for Neurology NeuroClick features: HERMES BRASS Improve Differential Diagnosis HERMES Explorer for bridging Radiology, Nuclear Medicine & PET Explorer features: HERMES JADE & HERMES RAPID PACS DICOM Gateway FDG PET Normal Template Alzheimer s Disease Fronto - Temporal Dementia PET-CT Fusion The images above show deviation maps of the patient studies in relation to the normal database. The red-colored regions on the two right images represent the regions of the patient s brain that are more than 2.5 standard deviations away from normal. Cases courtesy of Dr. Stephen R. Bunker, M.D. Clinical Dir. Nuclear Medicine, California Pacific Medical Center & Medical Director, Fusion Diagnostic Group, San Francisco, CA, USA HERMES BRASS empowers the clinician with state-ofthe-art brain quantification software in order to perform automatic coregistration & direct comparison of the patient s neuro-pet study to a normal template (database) HERMES offers more than 52 databases HERMES BRASS quantification tools improve differential diagnosis of Fronto-Temporal Dementia & Alzheimer s Disease & specifically display the affected brain regions, accompanied by the severity/deviation away from normal Voxel-based & volume-region-based quantification techniques PET-CT Image Fusion on HERMES Explorer with HERMES JADE HERMES JADE is a windows based patient browser with multi frame viewing, which displays & fuses medical images from Radiology, Nuclear Medicine & PET, including dynamic PET & Gated MRI HERMES JADE has DICOM gateway functionality which enables direct import from DICOMDir CD s & connectivity with HERMES GOLD Mediator & existing PACS Report from Anywhere PET-CT Fusion statistically significant rather than visually apparent PET-CT Image Fusion on HERMES Explorer with HERMES RAPID case courtesy of Brigham & Women s Hospital, Department of Nuclear Medicine, Boston, MA, USA. HERMES CardioClick for Cardiology CardioClick features: PERFIT - Cardiac Perfusion Analysis Fit & Quantify Perfusion Scans HERMES PERFIT, Bullseye Analysis HERMES JADE interfaces with HERMES GOLD Mediator & other DICOM servers via the web to access, store & view DICOM & Interfile studies securely from anywhere over the Internet HERMES RAPID PC is a standalone application for image fusion display & analysis of PET, PET-CT & other volumetric studies with TCS Display, SUV Calculations, VOI Measurements & MIP movie generation Distribute Image Fusion (e.g. PET-CT) Automatic fitting of myocardial PET & PET-CT perfusion scans to model databases with HERMES PERFIT Display deviation from normal databases & stress/rest differences HERMES RAPID CD enables distribution of studies along with an application for display, analysis & fusion of PET, PET-CT & other volumetric studies with TCS Display, SUV Calculations, VOI Measurements & MIP movie generation Packaged as a standalone PC application together with patient data on an AES (256-bit) encrypted CD, created on HERMES GOLD, to provide a secure, self-contained viewing & analysis package for distribution to referring physicians, etc.

4 HERMES Packages HERMES offers a dynamic range of custom designed software & hardware packages for utilizing medical imaging for Oncology, Cardiology & Neurology etc. HERMES offers a Classic line of software applications for the UNIX platform and an Explorer line of software packages for the Windows platform. HERMES Classic line is installed on HERMES recommended hardware for optimal performance, maximum availability & uptime. HERMES Software HERMES Classic Line (Unix-based) - Select one or more Classic packages to add to Hermes Hardware HERMES Fusion HERMES Fusion Deluxe HERMES NucMed Click HERMES NM/PETClick Designed for comprehensive any modality image fusion & PET-CT reading. Designed for comprehensive any modality image fusion, PET-CT reading & RAPID CD distribution. Designed for your comprehensive Nuclear Medicine processing needs. Designed for your Nuclear Medicine Processing & Image Fusion needs. Quantification Motion correction Suite, including Quantification Motion correction Suite, including HReviewer HERMES RAPID CD burning Image Display Suite Image Analysis Suite Suite, including Renal applications CardioClick applications Image Display & Analysis Suite Suite, including Renal applications CardioClick applications HERMES RAPID CD burning HERMES NeuroClick HERMES NeuroClick Deluxe HERMES CardioClick HERMES RAPID CD Advanced brain quantification software suite for registration, analysis & comparison to normal databases. HERMES NeuroClick with Image Fusion, Volume Display & RAPID CD Distribution. State-of-the-art Cardiac Nuclear Medicine Software Suite for all your cardiac Nuclear Medicine needs. Designed for burning password protected PET, CT, PET-CT & MRI studies together with image viewer on CD s BRASS Brain Registration Analysis Software Suite 1 x HERMES BRASS Database of your selection. Suite, including BRASS Brain Registration Analysis Software Suite 3 x HERMES BRASS Databases of your selection. Suite, including HERMES RAPID CD burning Suite, including gated gated PERFIT - Automatic Cardiac Perfusion Analysis FUGA - Gated Heart Analysis First Pass Shunt Analysis Optional: Cedar Sinai (BPGS, QGS, QPS) or 4DM SPECT TCS Display SUV voxel values Automatic VOI growing with SUV & volume measurements Image Fusion MIP Movie Generation Packaged as a standalone PC application together with patient data on an AES (256-bit) encrypted CD, to provide a secure, self-contained viewing & analysis package for distribution to referring physicians, etc

5 HERMES Explorer Line (Windows-based) HERMES JADE HERMES RAPID PC HERMES JADE -RAPID Bundle HERMES JARVIS A patient browser designed as a PACS DICOM Gateway and Viewing application for Radiology, Nuclear Medicine & PET. Any Modality Image Fusion Viewing application designed especially for PET-CT fusion with TCS, SUV, VOI & MIP tools. Designed to provide a robust suite of image communication, analysis & fusion tools, a combination of the best of JADE & RAPID. Designed to access, manipulate, fuse & report studies from the patient archive using a web browser with no additional client software required. Multiple frame viewing environment which can display images from any modality (CT, MRI, Planar Radiography, Ultrasound, NM & PET) HERMES JADE communicates with HERMES Classic and/or DICOM Servers HERMES JADE interfaces with HERMES GOLD Mediator & other DICOM servers to access, store & view DICOM & Interfile studies securely from anywhere via the web Interfile & DICOM file import & connectivity, standalone or through HERMES JADE Manual manipulation, thresholding, triangulation and full standard uptake value (SUV) capabilities for PET studies, including 3D automatic region growing Fusion of two studies with variable overlay, triangulation of two studies in synchrony and Maximum Intensity Projection (MIP) movie generation Complete image analysis tool for viewing planar, volumetric & gated data Modality independent viewing & synchronized fusion DICOM server capability Access, store & view DICOM & Interfile studies securely from anywhere via the web Manual manipulation, thresholding, triangulation, distance measurement, VOI & ROI, annotation & many other features Secure web-based remote viewing and reporting access to your HERMES studies Interactive viewing controls including display and processing of static, dynamic, gated, wholebody, tomographic images & fusion Customized remote reporting using annotated images, text and voice notes Suitable for other modalities such as CT & MRI User-dependent access privileges HERMES Connectivity, Integration & Archiving HERMES Services HERMES GOLD Mediator Designed as a one-stop solution platform to your department s connectivity & image storage needs GOLD (Global OnLine Database) Native and/or DICOM storage Any protocol connection to PET, NM, CT, CR, MRI, Ultrasound, PACS & HIS / RIS (Worklist SCP/SCU) Provides DICOM Query / Retrieve (SCP/SCU), DICOM Import/Export, DICOM CD Reading and Writing, DICOM Basic Worklist (SCP/SCU). Can act as an interface & gateway to many non- DICOM systems. HERMES RAID-5 Storage HERMES RAID-5 Storage is a fault-tolerant, failure-safe, digital online archiving solution for Nuclear Medicine & Radiology departments. 1 high capacity storage management workstation 1 x external RAID5 Disk Array with up to 8 hard drives including two hotswap drives (variable capacity/ availability configurations to 2.4 Terabytes (Tb)) Expandable to any size required HERMES Experts Online Clinical services (via HERMES secure GOLD and/or VPN) for your needs called Experts Online. HERMES Experts Online includes: Remote processing and/or remote reading by our imaging experts Remote backup storage offsite for your studies Database creation Teaching/Education Consulting HERMES Hardware HERMES Servers and Clients HERMES Laptop HERMES Tandem Server HERMES Displays HERMES hardware platform is based on the latest generation of PC s with flexible display capabilities and mirrored internal drives for hosting Hermes Classic line server applications. HERMES servers & clients can be integrated into existing image communication, storage & security infrastructure, or can provide a complete solution in itself. HERMES Laptop may host the entire HERMES product line all in one optimized portable, state-of-the-art, multimodality, diagnostic imaging workstation for the modern mobile life. HERMES Laptop is based on the latest generation of PC s HERMES Tandem Server consists of two mirrored HERMES Servers where all user settings and patient data are duplicated. Should the first system become inoperable for any reason, the second system can be switched to take over the complete functionality of the first system, with no loss of patient data and minimal loss of up time. HERMES server & client configuration is flexible & the systems can be deliveered with one, two or four displays of any size, resolution or orientation.

6 HERMES MEDICAL SOLUTIONS Hermes Medical Solutions (Nuclear Diagnostics AB) was established in Stockholm, Sweden in 1976 by Jan Bertling (Founder, CEO & President). In the same year, the company was the first to develop commercial SPECT reconstruction software collaboratively with Dr. Stig Larsson of Karolinska, Stockholm, Sweden. Since 1976, Hermes Medical Solutions has grown into an international company with worldwide headquarters in Stockholm, Sweden. HERMES experience, proven history and success comes from playing a leading role in the development of cutting-edge medical imaging software solutions for Radiology, Nuclear Medicine & PET Departments. HERMES is the oldest and most well established of any Fusion vendor in the world. In November 2004, the International Museum of Surgical Science, in Chicago, Illinois, USA recognized Hermes Medical Solutions to be featured in an exhibit called MILESTONES IN MEDICAL IMAGING: from X-Ray to Nuclear Medicine which runs from November 30th, 2004 thru December HERMES was recognized due to its unique contribution as the first company globally to commercially introduce medical image fusion software to the marketplace in 1992 together with collaborator/inventor Piotr Slomka. The ability to seamlessly integrate CT, MRI, PET, SPECT and other imaging modalities has made HERMES the choice of more than 1,200 hospitals worldwide in over 30 countries. FDA aproved since 2000 MDD aproved since 2000 HIPAA compliant Advancing the Art of Fusion Hermes Medical Solutions AB Stockholm, SWEDEN Tel: +46 (0) Contact us info@hermesmedical.com Explore more at Hermes Medical Solutions Ltd. London, United Kingdom Tel Hermes Medical Solutions Inc. Greenville, NC, USA Tel +1 (252) Hermes Medical Solutions Canada Inc. Montréal, Québec, Canada Tel: +1 (877) Manufactured by Nuclear Diagnostics AB. Hermes Medical Solutions reserves the right to make changes in specifications and features shown herein, or discontinue the product described at any time without notice or obligation. Contact your Hermes Representative for the most current information.

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