Scientific Programme
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1 Day 1: Thursday, 7 March 2013 Scientific Programme Session 1: Meeting overview and experimental background Welcome and meeting logistics D. Miller (London, UK) Historical background and meeting aims Overview of the understanding and management of pregnancy and hormonal factors in MS Hormonal factors in experimental models of MS and related disorders What do we know, what has the contribution of EAE been to the understanding of MS? Discussion X. Montalban (Barcelona, SP) H. Offner (Portland, US) Coffee Break Session 2: Preparing for Pregnancy with MS Risk counselling for parents with MS How to guide parents about risks of pregnancy to the mother with MS, complications of MS for child-rearing, and risk of MS in offspring Discussion D. Sadovnick (Vancouver, CA) Fertility treatments and risk of MS relapses What we know about contemporary fertility treatment and impact on MS disease course in women K. Hellwig (Bochum, DE)
2 Discussion Effect of disease modifying therapies (DMTs) on fertility of women and men with MS, effect of DMTs on foetal viability Does prior therapy with DMTs affect the development and viability of a foetus? M. Clanet (Toulouse, FR) Discussion Lunch Break Session 3: Impact of Pregnancy on MS Disease Course Short-term (relapse risk) and long-term (progression of disability) impact of pregnancy in MS Current data on change in disease relapse characteristics during pregnancy and post-partum; do single (or multiple) pregnancies have an impact on long-term outcomes? Discussion C. Confavreux (Lyon, FR) MRI during pregnancy and post-partum Are changes in MS disease course during pregnancy and postpartum reflected in pathology detected by MRI? F. Fazekas (Graz, AT) Discussion Pregnancy and NMO-spectrum disorders Pregnancy outcomes in NMO-spectrum disorders and whether it differs from MS M. Leite (Oxford, UK) Discussion
3 Coffee Break Session 4: Treatment During Pregnancy When and how to treat an MS relapse during pregnancy Best current relapse management strategies Data from clinical practice and clinical trials P. Soelberg-Sorensen (Copenhagen, DK) Discussion Older disease modifying treatment during pregnancy Outcomes from clinical trials and in clinical practice; how to manage M. Sandberg-Wollheim (Lund, SE) Discussion Newer disease modifying treatments during pregnancy Outcomes from clinical trials and in clinical practice; how to manage R. Gold (Bochum, DE) Discussion Symptomatic management during pregnancy Data from clinical trials and practice M. Hutchinson (Dublin, IR) Discussion Workshop Dinner at the Foundling Museum
4 Day 2: Friday, 8 March Session 5: Panel Discussion What can we recommend as the best ways to manage MS during pregnancy, for both the health of the mother and of the foetus/new-born? What is data driven, what is speculation? What is needed to provide missing data? Session 6: Delivery and Beyond Facilitator: S. Reingold (Salisbury, US) Panel Members: E. Havrdova (Prague, CZ) L. Kappos (Basel, CH) A. Miller (New York, US) S. Tennebaum (Buenos Aires, AR) E. Waubant (San Francisco, US) Obstetric management for women with MS Case studies and best practices D. Williams (London, UK) Discussion Delivery and neonatal outcomes Problems associated with delivery for women with MS; considerations for neonatal health and management H. Tremlett (Vancouver, CA) Discussion Coffee Break Breast feeding and MS Impact of breast feeding on disease course; impact of MS disease modifying and symptomatic therapies on breast milk A. Langer-Gould (California, US)
5 Discussion
6 Geographical variations in gender ratio trends over time in MS The utility of international MS registries for gender issues M. Trojano (Bari, IT) Discussion Lunch Break Session 7: Non-Pregnancy-Related Hormonal Factors and MS Disease Course Menopause and MS Effect of menopause on MS disease course and therapeutic implications T. Chitnis (Boston, US) Discussion Experimental basis, current status and future prospects for repurposing hormones as DMTs for MS Oestriol and testosterone clinical trials in MS R. Voskuhl (California, US) Discussion Impact of an add-on oral contraceptive to beta interferon in MS Does oral contraception affect MS? C. Pozzilli (Rome, IT) Discussion Summing up What have we learned, where are we headed? D. Miller (London, UK) Meeting end
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