ÖZGEÇMİŞ. Görev Unvanı Görev Yeri Yıl. Ar.Gör. Biyoloji Bölümü, Orta Doğu Teknik Üniversitesi

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1 ÖZGEÇMİŞ Adı Soyadı : Veli Cengiz Özalp Doğum Tarihi: Unvanı : Doç. Dr. Öğrenim Durumu: Derece Bölüm/Program Üniversite Yıl Doktora Biyoloji Ortadoğu Teknik Üniversitesi 2000 Y. Lisans Biyoloji Ortadoğu Teknik Üniversitesi 1993 Lisans Biyoloji Ortadoğu Teknik Üniversitesi 1990 Görevler: Görev Unvanı Görev Yeri Yıl Ar.Gör. Biyoloji Bölümü, Orta Doğu Teknik Üniversitesi Ar.Gör. Department of Biotechnology, Texas Tech University, Lubbock, Texas, ABD Genetik ve Moleküler Biyoloji Bölümü, Bilkent Üniversitesi Phytobiology, University of Bourgogne, Dijon, Fransa Molecular and Cell Biology, University of Illinois at Urbana-Champain, ABD Nanobiotechnology Institute, University of Rovira i Virgili, Tarragona, İspanya Department of Molecular Biology, University of Southern Denmark, Odense, Danimarka Polymat (Institute for Polymers), University of the Basque Country, San Sebastian, İspanya Biyoloji Bölümü, Orta Doğu Teknik Üniversitesi Burslar : 2012 TÜBİTAK Doktora sonrası geri dönüşüm burs programı-bideb Marie Curie Intra-european Mobility Fellow (GLUSENS (Reagentless Electrochemical & Fluorescent Biosensor Formats for Detection of Coeliac Disease Toxic Gluten (Gliadins and Glutenins) in Raw and Processed Foodstuffs), FP7_PEOPLE IEF 2007 Generalitat de Catalunya (İspanya) for a PIV (professors investigadors visitants ) Visiting scholarship (2007PIV00032) 1998 TÜBİTAK, A2 Doktora Araştırma Bursu

2 1995 Texas Tech University Biotechnology Fellowship 1994 UNESCO short-term Biotechnology Fellowship YAYINLAR Uluslararası hakemli dergilerde yayımlanan makaleler : 1. Ozalp, V.C., Bilecen, K., Kavruk, M., Oktem, H.A Antimicrobial aptamers for detection and inhibition of microbial pathogen growth. Future Microbiology. 8 (3): Hernandez, F.J., Hernandez, L.I., Pinto, A., Schäfer, T., Özalp, V.C Targeting Cancer Cells with Controlled Release Nanocapsules based on Single Aptamer. Chemical Communications. 49, Serrano-Santos, M. B., E. Llobet, Ozalp, V.C., Schafer, T "Characterization of Structural Changes in Aptamer Films for Controlled Release Nanodevices." Chemical Communications. 48 (81): Hernandez, F.J. and Ozalp, V.C Garaphene and Other Nanomaterial-based Electrochemical Aptasensors. Biosensors, 2 (1): Ytting, C.K., Fuglsang, A.T., Hiltunen, K., Kastaniotis, A.J., Ozalp, V.C., Nielsen, L.J., and Olsen, L.F Measurements of intracellular ATP provide new insight into the regulation of glycolysis in the yeast Saccharomyces cerevisiae. Integrative Biology. 4(1): Ozalp, V.C Dual Polarization Interferometry for Quantification of Small Molecules Using Aptamers. Analytical and Bioanalytical Chemistry. 402(2): Ozalp, V.C Acoustic Quantification of ATP Using Quartz Crystal Microbalance with Dissipation. Analyst. 136 (23): Ozalp, V.C., Eyidogan, F., Oktem, H.A Aptamer-Gated Nanoparticles for Smart Drug Delivery. Pharmaceuticals. 4(8): Ozalp, V.C. and Schafer, T Aptamer-based Switchable Nanovalves for Stimuli-Responsive Drug Delivery. Chemistry-A European Journal. 17(36): Ozalp, V. C., Nielsen, L. J., Olsen, L. F An Aptamer-based Nanobiosensor for Real-Time Measurements of ATP Dynamics. ChemBioChem. 11(18): Ozalp, V. C., Pedersen, T. R., Nielsen, L. J., Olsen, L. F Time-Resolved Measurements of Intracellular ATP in the Yeast Saccharomyces cerevisiae Using A New Type of Nanobiosensor. Journal of Biological Chemistry. 285(48):

3 12. Nielsen, L. J., Olsen, L. F., Ozalp, V. C Aptamers Embedded in Polyacrylamide Nanoparticles: A Tool for in Vivo Metabolite Sensing. ACS Nano. 4 (8): Nasef H, Ozalp VC, Beni V, O'Sullivan CK Melting temperature of surfacetethered DNA. Analytical Biochemistry, 406 (1): Nasef H, Beni V, Ozalp VC, O'Sullivan CK Cystic fibrosis: a label-free detection approach based on thermally modulated electrochemical impedance spectroscopy. Analytical and Bioanalytical Chemistry. 396(7): Naqvi, S. M. S., Raza, S. Q., Hyder, M. Z., Ozalp, C. V., Oktem, H. A., Yucel, M Sub-cellular distribution of two salt-induced peptides in roots of Oryza sativa L. var Nonabokra. African Journal of Biotechnology, 8 (18): Pinto, A., Bermudo Redondo, M. C., Ozalp, V. C., O Sullivan, C. K Real-time apta-pcr for fold improvement in detection limit. Molecular Biosystems. 5 (5): Hernandez, F. J., Dondapati, S. J., Ozalp, V. C., Pinto, A., O'Sullivan, C. K., Klar, T. A., Katakis, I Label free optical sensor for Avidin based on single gold nanoparticles functionalized with aptamers. Journal of Biophotonics, 2 (4): Ozalp, V.C., Nygren, A.O.H., and C.K. O Sullivan Fluorescent Resonance Energy Transfer (FRET) Based Detection of Multiplex Ligation-dependent Probe Amplification assay (MLPA) Product. Molecular Biosystems. 4 (9): Mairal, T., Ozalp, C., Lozano, P., Mir, M., Katakis, I. and O Sullivan, C Aptamers: molecular tools for analytical applications. Analytical and Bioanalytical Chemistry. 390 (4): Oktem, H. A., Bayramoglu, G., Ozalp, V. C., Arica, M. Y Single-Step Purification of Recombinant Thermus aquaticus DNA Polymerase Using DNA- Aptamer Immobilized Novel Affinity Magnetic Beads. Biotechnology Progress, 23 (1): Roeser T, Ritzi M, Drese KS, Laureyn W, Liu C, O Sullivan CK, Ozalp VC, Fermer C, Nilsson O, Hauch S, Albert W, Borgen E, Nygre AO Lab-on-chip for the isolation and characterization of circulating tumor cells. IEEE Engineering in Medicine and Biology Society, Ozalp, C., Szczesna-Skorupa, E., Kemper, B Identification of Membrane- Contacting Loops of the Catalytic Domain of Cytochrome P450 2C2 by Tryptophan Fluorescence Scanning. Biochemistry, 45 (14): Ozalp, C., Szczesna-Skorupa, E., Kemper, B Bimolecular Fragment Complementation Analysis of Cytochrome P450 2C2, 2E1 and NADPH-Cytochrome P450 Reductase Molecular Interactions in Living Cells. Drug Metabolism and Disposition, 33(9): Bhalla, S., Ozalp, C., Fang, S., Xiang, L., Kemper, J. K Ligand-activated Pregnane X Receptor Interferes with HNF-4 Signaling by Targeting a Common Coactivator PGC-1. Journal of Biological Chemistry, Oct 2004; 279:

4 25. Daniel Reisen, Nathalie Leborgne-Castel, Cengiz Özalp, François Chaumont and Francis Marty Expression of a cauliflower tonoplast aquaporin tagged with GFP in tobacco suspension cells correlates with an increase in cell size. Plant Molecular Biology. 52 (2): Ozalp, VC., Naqvi, SMS, Öktem, HA., Yücel, M Photosystem II and Cellular Membrane Stability Evaluation in Hexaploid Wheat Seedlings under Salt Stress Conditions. Journal of Plant Nutrition, 23 (2): Naqvi, SMS, Ozalp, VC., Öktem, HA., Yücel, M Salt-induced Synthesis of New Proteins in the Roots of Rice Varieties. Journal of Plant Nutrition, 18(6): Naqvi, SMS., Ozalp, VC., Öktem, HA., Yücel, M Two-dimensional Electrophoresis with a Different Approach to Isoelectric Focusing. Analyst, 119: Naqvi, S.M.S., Ozalp, V. C., Oktem, H. A., Yücel, M Study of proteins synthesized in rice roots under salt stress conditions. International Rice Research Newsletter, 15 (6): Uluslararası bilimsel toplantılarda sunulan ve bildiri kitabında (Proceedings) basılan bildiriler : 1. Schäfer, T., Özalp, V.C., Hernandez, F.J., Hernandez, L.I., Pinto, A. Stimuli-responsive DNA nanovalves for controlled delivery and nanodevices. NanoBioMed2013, Bilbao, Spain, A. Pinto, F.J. Hernandez, L.I. Hernandez, M.B. Serrano Santos, V.C. Özalp, T. Schäfer. Aptavalves for Stimulus-Responsive Hybrid Nanodevices, Third International Conference on Multifunctional, Hybrid and Nanomaterials Hybrid Materials 2013, 3-7 March 2013 in Sorrento, Italy. 3. I. Machado, V.C. Ozalp, T. Schafer. Aptamers as Molecular Probes for Molecular Recognition and Elucidating Interactions of Ionic Liquids with DNA, EUCHEM Molten salts and ionic liquids XXIV, Celtic Manor, Wales, August 5-10, Schäfer, T. and V.C. Özalp "Small-molecule Stimulus Responsive Membrane with Reversible Gating Function", 8 th European Congress of Chemical Engineering and 1 st European Congress of Applied Biotechnology (ECCE/ECAB), Berlin, Germany, September 25-29, Machado, I., Serrano Santos, M.B., Özalp, V.C. and Schäfer, T. "Investigation of the applicability of oligonucleic acids as biomolecular recognition sites in stimuli-responsive membranes", 8 th European Congress of Chemical Engineering and 1 st European Congress of Applied Biotechnology (ECCE/ECAB), Berlin, Germany, September 25-29, Schäfer, T. and V.C. Özalp "Small-Molecule Stimulus Responsive Membrane with Reversible Gating Function", International Congress on Membranes and Membrane Processes (ICOM), Amsterdam, The Netherlands, July 23-29, Machado, I., Serrano Santos, M.B., Özalp, V.C. and Schäfer, T. "Stimuli-Responsive Membranes Based on Oligonucleic Acids as Biomolecular Recognition Sites", International Congress on Membranes and Membrane Processes (ICOM), Amsterdam, The Netherlands, July 23-29, 2011.

5 8. Schäfer, T. and V.C. Özalp "Small-Molecule Stimulus Responsive Membrane with Reversible Gating Function", 2011 International Conference on Materials for Advanced Technologies (ICMAT), Singapore, June 26-July 1, Schäfer, T. and V.C. Özalp "Small-Molecule Stimulus Responsive Membrane with Reversible Gating Function", 2011 International Conference on Materials for Advanced Technologies (ICMAT), Singapore, June 26-July 1, Schäfer, T. and Özalp, V.C. "Stimulus-Responsive Membrane with Reversible Gating Function upon Small Molecule Recognition", Meeting of the North American Membrane Society (NAMS), Las Vegas, June 4-6, Machado, I., Serrano Santos, M.B., Özalp, V.C. and Schäfer, T. "Oligonucleic Acids as Biomolecular Recognition Sites for the Design of Stimuli-Responsive Membranes", Meeting of the North American Membrane Society (NAMS), Las Vegas, June 4-6, Schäfer, T., Özalp, C. "Aptamers as molecular recognition sites for stimuli-responsive membranes", CITEM 2010, Sintra, Portugal, April 10-14, Lise Junker Nielsen, Veli Cengiz Ozalp, Lars Folke Olsen. Peptide mediated delivery of optical nanosensors into S. cerevisaes. Nanoparticles 2009, Micro and Nano Encapsulations, July 2009, Berlin, Germany. 14. Veli Cengiz Ozalp, Lise Junker Nielsen, Lars Folke Olsen. Aptamer embedded polyacrylamide nanoparticles used as nanosensors for metabolite detection in vivo. Nanoparticles 2009, Micro and Nano Encapsulations, July 2009, Berlin, Germany. 15. Schäfer, T., Schäfer, M., Özalp, C. "Exploring the Potential of Oligonucleic Acids ( Aptamers ) for Designing Stimuli-Responsive Membranes", Euromembrane 2009, Montpellier, France, September 7-10, Schäfer, T., Schäfer, M., Özalp, C. "Oligonucleic Acids Acids for Tunable Interfaces in Sensing and Membrane Separations, Engineering Conferences International (ECI): Membrane Advanced Membrane Technology IV, Trondheim, Norway, June 7-12, A.Pinto, M.Svobodova, M.C. Bermudo, P. Nadal Polo, C.V.Ozalp, C.K.O Sullivan. Towards the aptamers meadiated detection of wheat high molecular weight glutenin. XIV. Trobado Transfronterera sobre Sensores i Biosensors (XIV. Cross-Border Meeting on Sensors and Biosensors), Banyul Sur Mer, France, P. Nadal Polo, V. Cengiz Ozalp, N. Canela, I. Katakis, C. K. O Sullivan. Preparation of aptamers against lupine potential allergens. XIV. Trobado Transfronterera sobre Sensores i Biosensors (XIV. Cross-Border Meeting on Sensors and Biosensors), Banyul Sur Mer, France, Schäfer, T., Schäfer, M., Özalp, C. "Oligonucleic Acids for Tunable Interfaces in Sensing and Membrane Separations", Engineering with Membranes 2008: Membrane Processes: Development, Modelling and Monitoring from the Nano to the Macro Scale, Faro, Portugal, May 25-28, Schäfer, T., Özalp, C. "Tunable Interfaces for Selective Sensing and Separation based Oligonucleic Acids", Engineering Conferences International: The Role of Structure in Biological, Chemical and Environmental Separations: From the Molecular to the Macro, Puntarenas, Costa Rica, January 6-11, T. Roeser, M. Ritzi, K.S. Drese, W. Laureyn, C. Liu, C.K. O Sullivan, V.C. Ozalp, C. Fermér,O. Nilsson, S. Hauch, W. Albert,E. Borgen, A.O.H. Nygre. Lab-on-chip system for the isolation and characterization of circulating tumor cells. 10 Jahre Statusseminar

6 Chiptechnologien, Stand der Forschung und Zukunftsperspektiven (31. Januar 1. Februar 2008). DECHEMA-Haus Frankfurt am Main. 22. Pedro Nadal Polo, Cengiz Veli Ozalp, Ciara O'Sullivan. Extraction, Isolation and Characteization of Lupin potential allergens.xiii Encuentro Transfronterizo sobre Sensores i Biosensores. Centro de Congresos de Andorra la Vella. Andorra, Svobodova, M.;Ozalp C.; O Sullivan C.K. Selection of DNA aptamers against PSA aptamer for biosensor aplication. XIII Encuentro Transfronterizo sobre Sensores i Biosensores. Centro de Congresos de Andorra la Vella. Andorra, Röser, T., Ritzi, M., Drese, K.S., Laureyn, W., Liu, C., O' Sullivan, C.K., Ozalp, V.C., Fermér, C., Nilsson, O., Hauch, S., Borgen, E., Nygren, A.O.H. Lab-On-Chip for the Isolation and Characterization of Circulating Tumor Cells. 29th IEEE EMBS Annual International Conference, August 23-26, 2007, Cité Internationale, Lyon, France. EMBC07 Paper Abstract, Paper SuA Laureyn, W., Liu, C., O'Sullivan, C.K., Ozalp, V.C., Nilsson, O., Fermer, C., Drese, K.S., Roeser, T., Ritzi, M.,Hauch, S., Albert, W., Borgen, E., Nygren, A.O.H. Lab-onchip for the isolation and characterization of circulating tumor cells (2007) 2007 NSTI Nanotechnology Conference and Trade Show, Santa Clara, California, U.S.A. - NSTI Nanotech 2007, Technical Proceedings, 2, pp Bermudo-Redondo, M.C.; Pinto, A.; Ozalp, C.; O Sullivan, C.K. A sensitive ELONA application for detection of thrombin. XII Encuentro Transfronterizo sobre Sensores i Biosensores (XII. Cross-Border Meeting on Sensors and Biosensors), Ceret, France, Pinto, A., Hernandez Hincapia, F.L.; Ozalp, C.; O Sullivan, C.K. When aptamers meet enzymes: a detection system based on nucleases protection assay. XII Encuentro Transfronterizo sobre Sensores i Biosensores (XII. Cross-Border Meeting on Sensors and Biosensors), Ceret, France, Svobodova, M.; Ozalp, V.C.; O Sullivan, C. Aptamer selection against PSA for Biosensors applications. XII Encuentro Transfronterizo sobre Sensores i Biosensores (XII. Cross-Border Meeting on Sensors and Biosensors), Ceret, France, Nadal, P.; Ozalp, V.C.; O Sullivan, C. Extraction, isolation and characterization of globulin proteins from Lupinus Albus for SELEX application. XII Encuentro Transfronterizo sobre Sensores i Biosensores (XII. Cross-Border Meeting on Sensors and Biosensors), Ceret, France, Nasef, H., Ozalp, C., O'Sullivan, C. Biosensor for Cystic Fibrosis Mutant Detection. 5th Poster Exhibition, Chemical and Process Engineering, October, 20th, Tarragona, Spain. 31. Ozalp, V.C. An SPR-based Biosensor for MLPA products. Transfronterizo sobre Sensores i Biosensores (XII. Cross-Border Meeting on Sensors and Biosensors), Ceret, France, Yazılan uluslararası kitaplar veya kitaplarda bölümler : 1. Schafer, T. and Ozalp, V.C. Stimuli-responsive membranes in Responsive Membranes and Materials. (Editors: Wickramasinghe, R., Daunert, S. and Schafer, T.), John Wiley Publishing, Ozalp, V.C. and Schafer, T. Aptamer-Nanoparticle Bioconjugates for Drug Delivery, in Nanoparticles. (Editor: Hashimi, A.), Intech publishing, 2012.

7 Ulusal hakemli dergilerde yayımlanan makaleler : 1. Gundoguş, N., Sayilir, C., Ozalp, VC., Ozkan, F., Yücel, M., Criss, EW Effects of Polyamine Stimulated Casein Kinase II from Rat Brain on Cellular Oncogene Activities. Turkish Journal of Medical Sciences, 23: Oktem, HA., Ozkan, F., Ozalp, VC., Yücel, M Agrobacterium mediated Gene Transfer. Turkish Journal of Botany, Vol.18, Oktem H.A., Özalp V.C., Nalbant D., Özkan F., Naqvi S.M.S., Memon A.R., Yücel M. Identification of stress induced proteins in different varieties of poppy (Papaver Somniferum L.). Turkish Journal of Botany, 16: , Ulusal bilimsel toplantılarda sunulan ve bildiri kitaplarında basılan bildiriler: 1. Özalp V.C., Öktem H.A., Yücel M, Genetic Diversity of Gluten Protein patterns of Wheat Cultivars. "Second Balkan Botanical Congress, Mayıs, 2000, Istanbul",, (2000), p Ozalp VC., Saglan S.M.S., Oktem H.A., Yücel M. "Characterization of salt induced proteins in wheat cultivars." MED Campus, Enzymes as Industrial Tools, Ege Univ. Biotech. Center, IzmirTurkey (Lecture Notes) s. 3134, Ozalp V.C., Inci F., Naqvi S.M.S., Ozkan F., Oktem H.A., Göktürk H.A., Yücel M.(1992) "Effect of air pollutant SO2 on photosynthetic activity in different wheat varieties" Journal of Biochemistry (Turkish Biochemical Society) Vol XVII,pp B12. Diğer yayınlar : 1. Patent; Nucleic acid nanobiosensors. Inventors: Lars Folke Olsen, Cengiz Ozalp, Lise Junker Nielsen, University of Southern Denmark. US Patent App. 13/382, ; WO/2011/003424, ; EP Patent 2,451,