Laure BINDELS, PharmD, PhD

Transcription

1 Laure BINDELS, PharmD, PhD PLACE AND DATE OF BIRTH: Etterbeek, 23/08/1985 NATIONALITY: Belgian EDUCATION March 2013 April 2012 March 2010 June 2009 June 2008 June 2007 June 2006 June 2005 June 2004 PhD in Biomedical and Pharmaceutical Sciences (UCL) Thesis: Role of gut microbiota modulation in the control of cancer progression and associated cachexia. Thesis director: Prof. Nathalie Delzenne, Université catholique de Louvain (UCL), Belgium. First Nutrimetabonomics Workshop (University of Reading) Biopark formation on Flow Cytometry, Belgium Master in Animal Experimentation (UCL) Doctor of Pharmacy (UCL) Research option Thesis: "Interest of the multiplex immunoassay in the study of the nutritional modulation of inflammation and insulin signaling Director: Prof. Nathalie Delzenne, UCL, Brussels, Belgium. Second year for the Doctor of Pharmacy (UCL) First year for the Doctor of Pharmacy (UCL) With high honors Bachelor in Pharmaceutical Sciences (UCL) First year for the Bachelor in Pharmaceutical Sciences (UCL) PROFESSIONAL POSITIONS HELD October March 2013 April June 2013 July ongoing PhD student in Biomedical and Pharmaceutical Sciences (UCL) Post-doctoral Researcher (UCL) Post-doctoral Research Associate (University of Nebraska-Lincoln, Nebraska, USA) 1

2 PRIZES, AWARDS AND FELLOWSHIPS Early Career Investigator Travel Fellowship from the New York Academy of Sciences (2013) Heritage Fellowship, UCL, Belgium (October 2012-Mars 2013) Keystone Symposium Scholarship, grant from the NIH, Colorado, U.S. (2012) FNRS fellowship, Belgium (October 2008-October 2012) Prize of Excellence for the research activities conducted during the Doctor of Pharmacy s studies, UCL, Belgium (2008) Pharmacist & Doctor Nedeljkovitch Award, Belgian Society of Pharmaceutical Sciences, Belgium (2008) INTERNATIONAL COLLABORATIONS April 2011 June 2012 Prof. Bruno Pot and Dr. Corinne Grangette Lactic Acid Bacteria and Mucosal Immunity, Center for Infection and Immunity of Lille, INSERM U1019-CNRS UMR 8204, Institut Pasteur de Lille, Université Lille Nord de France, Lille, France Participated to the culture and quantification of lactobacilli for in vivo experiments. July 2010 Dr. Karen Scott Gut Health Division, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, United Kingdom Performed gut microbiota analysis by PCR-denaturing gradient gel electrophoresis. MEMBERSHIPS IN PROFESSIONAL ASSOCIATIONS Member of the Belgian Nutrition Society since Member of the Students and Fellows Association (SFA) of the International Scientific Association for Probiotics and Prebiotics (ISAPP) since Involved in the writing of articles for the newsletter since Finance Executive of the SFA Committee since July Member of the New York Academy of Sciences ( ) 2

3 SERVICES PROVIDED TO STUDENTS AND THE HOME INSTITUTION Organized student events (October 2005-May 2006) Followed up 3 Master students for a research traineeship ( ) Actively contributed to the management of a 2-year Master s thesis (January 2011-June 2013) Represent the scientific members at the Council of the Louvain Drug Research Institute, UCL (February 2010 June 2013) COMMUNITY SERVICE Participated to a humanitarian project in Burkina-Faso, including reforestation in collaboration with local teenagers, with the NGO Défi Belgique Afrique, DBA (July 2002) Ran weekly activities for Belgian children, with a two-week summer camp (September 2002 September 2006) Organized, as responsible-in-chief, a humanitarian stay in Romania for a group of 15 girl scouts (17-year-old) with the non-profit organisation Partenariat Villages Roumains (September 2006 September 2007) LANGUAGES French: mother tongue Dutch: I personally evaluate my competence level in speaking and writing as fair and in reading as good. English: I personally evaluate my competence level in speaking and writing as good and in reading as excellent. I obtained a C1 level at an English test last year. C1 is the second highest level on the six-level scale of the CEFR (Common European Framework of Reference for Languages, Council of Europe, 2001). 3

4 PUBLICATIONS IN PEER-REVIEWED JOURNALS AS FIRST OR JOINT FIRST AUTHOR Bindels LB and Delzenne NM. Muscle wasting: The gut microbiota as a new therapeutic target?, Int J Biochem Cell Biol, 2013 Bindels LB, Dewulf EM, Delzenne NM. GPR43/FFA2: physiopathological relevance and therapeutic prospects, Trends Pharmacol Sci, 2013: Bindels LB, Porporato P, Dewulf EM, Verrax J, Neyrinck AM, Martin JC, Scott KP, Buc CP, Feron O, Muccioli GG, Sonveaux P, Cani PD, Delzenne NM. Gut microbiota-derived propionate reduces cancer cell proliferation in the liver, Br J Cancer, 2012: Bindels LB, Beck R, Schakman O, Martin JC, De Backer FC, Sohet FM, Dewulf EM, Pachikian BD, Neyrinck AM, Thissen JP, Verrax J, Calderon PB, Pot B, Grangette C, Cani PD, Delzenne NM. Restoring Specific Lactobacilli Levels Decreases Inflammation and Muscle Atrophy Markers in an Acute Leukemia Mouse Model, PLoS One, 2012: e Neyrinck AM, Bindels LB, De Backer FC, Pachikian BD, Cani PD, Delzenne NM. Dietary supplementation with chitosan derived from mushrooms changes adipocytokine profile in diet-induced obese mice, a phenomenon linked to its lipid-lowering action, Int Immunopharmacol, 2009: (AMN and LBB contributed equally to this work) AS AUTHOR Everard A, Belzer C, Geurts L, Ouwerkerk JP, Druart C, Bindels LB, Guiot Y, Derrien M, Muccioli GG, Delzenne NM, de Vos WM, Cani PD. Crosstalk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci U S A (in press) Dewulf EM, Ge Q, Bindels LB, Sohet FM, Cani PD, Brichard SM, Delzenne NM. Evaluation of the relationship between GPR43 and adiposity in human, Nutr Metab (Lond), 2013: 11- Dewulf EM, Cani PD, Claus SP, Fuentes S, Puylaert PG, Neyrinck AM, Bindels LB, de Vos WM, Gibson GR, Thissen JP, Delzenne NM. Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women, Gut, Neyrinck AM, Van Hee VF, Bindels LB, De Backer F, Cani PD, Delzenne NM. Polyphenol-rich extract of pomegranate peel alleviates tissue inflammation and hypercholesterolaemia in high-fat diet-induced obese mice: potential implication of the gut microbiota, Br J Nutr, 2012: 1-8. Dewulf EM, Cani PD, Neyrinck AM, Possemiers S, Van Holle A, Muccioli GG, Deldicque L, Bindels LB, Pachikian BD, Sohet FM, Mignolet E, Francaux M, Larondelle Y, Delzenne NM. Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARgamma-related adipogenesis in the white adipose tissue of high-fat diet-fed mice, J Nutr Biochem, 2011: Pachikian BD, Neyrinck AM, Deldicque L, De Backer FC, Catry E, Dewulf EM, Sohet FM, Bindels LB, Everard A, Francaux M, Guiot Y, Cani PD, Delzenne NM. Changes in Intestinal 4

5 Bifidobacteria Levels Are Associated with the Inflammatory Response in Magnesium-Deficient Mice, J Nutr, 2010 Neyrinck AM, Cani PD, Dewulf EM, De Backer FC, Bindels LB, Delzenne NM. Critical role of Kupffer cells in the management of diet-induced diabetes and obesity, Biochem Biophys Res Commun, 2009: Sohet FM, Neyrinck AM, Pachikian BD, De Backer FC, Bindels LB, Niklowitz P, Menke T, Cani PD, Delzenne NM. Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation associated with diet-induced obesity in mice, Biochem Pharmacol, 2009: Sohet FM, Neyrinck AM, Dewulf EM, Bindels LB, Portois L, Malaisse WJ, Carpentier YA, Cani PD, Delzenne NM. Lipid peroxidation is not a prerequisite for the development of obesity and diabetes in high-fat-fed mice, Br J Nutr, 2009: Pachikian BD, Neyrinck AM, Cani PD, Portois L, Deldicque L, De Backer FC, Bindels LB, Sohet FM, Malaisse WJ, Francaux M, Carpentier YA, Delzenne NM. Hepatic steatosis in n-3 fatty acid depleted mice: focus on metabolic alterations related to tissue fatty acid composition, BMC Physiol, 2008 Neyrinck AM, De Backer F, Cani PD, Bindels LB, Stroobants A, Portetelle D, Delzenne NM. Immunomodulatory properties of two wheat bran fractions - aleurone-enriched and crude fractions - in obese mice fed a high fat diet, Int Immunopharmacol, 2008:

6 SCIENTIFIC COMMUNICATIONS IN CONGRESSES 6/10-14/13 SFA-ISAPP meeting (students and fellows association of the international scientific association for probiotics and prebiotics) New York, USA Poster communication: Synbiotic approach leads to prolonged survival in cachectic mice with leukemia SFA and NYAS grants 10/29-3/12 SFA-ISAPP meeting (students and fellows association of the international scientific association for probiotics and prebiotics) Cork, Ireland Oral communication (late breaking news): Increasing serum propionate by prebiotics reduces cancer cell proliferation in the liver Associated with poster presentation SFA grant 5/8-10/12 Exploring Human Host-Microbiome Interactions in Health and Disease (Wellcome Trust Scientific Conference) Hinxton, United Kingdom Poster communication : Restoring gut lactobacilli levels reduces muscle atrophy and inflammation in an acute leukemia model FNRS grant, organizer committee bursary 4/20/12 Third annual meeting of the Belgian Nutrition Society (BNS) Brussels, Belgium Poster communication, with oral presentation : Prebiotic and probiotic approaches in an acute leukemia mouse model 3/3-9/12 The microbiome (Keystone Symposia) Keystone, Colorado, USA Poster communication, after selection : Prebiotic and probiotic approaches in an acute leukemia mouse model NIH Grant based on poster interest, FNRS grant 12/1-2/11 Microbes for Health (2 nd international symposium) Paris, France Poster communication : Selected probiotic approach lessens inflammation and muscle atrophy markers in a model of acute leukemia 4/29/11 Second annual meeting of the Belgian Nutrition Society (BNS) Brussels, Belgium Poster communication : Link between gut microbiota and host cachexia in a mouse model of cancer 10/26/10 5 th GCNAS symposium Brussels, Belgium Oral communication & poster communication : Gut microbiota modulation modifies the progression of cancer cells in a mouse model 9/23/10 12 th Gut Day Symposium Gent, Belgium Poster communication, with oral presentation : Gut microbiota modifications in leukemic mice 12/5-8/09 5 th Cancer Cachexia Conference 6

7 Barcelona, Spain Poster communication, with oral presentation : Gut microbiota modifications are associated with cancer-induced cachexia Abstract published in J Cachexia Sarcopenia Muscle (2010) 1: /2-3/07 5 th Planet Xmap Europe Seminar Amsterdam, the Netherlands Poster communication: Multiplex assays to assess inflammation and insulin response upon acute LPS challenge in mice SCIENTIFIC SKILLS Protein analyses (Elisa, Western blot, multiplex immunoassays of cytokines, proteins and phosphorylated proteins) Nucleic acids biology (RNA and DNA extraction, real-time PCR on cdna and bacterial DNA, bioanalyzer, PCR-denaturing gradient gel electrophoresis) In vivo experiments with mice (animal care, injection [intraperitoneal, intravenous, retroorbital, subcutaneous], dissection, blood leucocytes isolation, mesenteric lymph nodes (MLN) purification and T cell isolation, TD-NMR) Histological and biochemical analysis (whose SCFA measurement in mice serum) In vitro experiments on cancer cell lines (cell culture, proliferation assays, pharmacological inhibition, GTPγS) 7