Curriculum Vitae. Dario Riccardo Valenzano, PhD. BSc and MSc in Biology at the University of Pisa, Pisa, Italy

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1 Curriculum Vitae Dario Riccardo Valenzano, PhD Work Address Max-Planck Institute for Biology of Ageing Evolutionary and Experimental Biology of Ageing Joseph-Stelzmann-Str 9b Cologne, Germany Tel: +49-(0) Tel: +49-(0) Fax: +49-(0) Education October 2001 December 2002 April 2006 BSc and MSc in Biology at the University of Pisa, Pisa, Italy Diploma in Biology at Scuola Normale Superiore, Pisa, Italy Ph.D. in Neuroscience Department of Neuroscience Scuola Normale Superiore, Pisa, Italy Research Experience Aug 2000 Dec 2002 Jan 2003 Apr 2006 May May Undergraduate Thesis Research ISTC of the CNR, Rome, Italy Advisor: Dr. Elisabetta Visalberghi Undergraduate Thesis research title: Facial expressions in tufted capuchins (Cebus apella) Graduate Student in Neurobiology at Scuola Normale Superiore, Pisa, Italy Advisor: Dr. Alessandro Cellerino Thesis Title: Aging in Nothobranchius furzeri, a new vertebrate model of extremely short lifespan Postdoctoral Fellow Stanford University, Department of Genetics Advisor: Dr. Anne Brunet Developing genetic and genomic tools to identify the genes associated with longevity in the short-lived fish Nothobranchius furzeri Research Associate Stanford University, Department of Genetics (Brunet laboratory) 1

2 Research Theme: Developing genetic and genomic tools to identify the genes associated with longevity in the shortlived fish Nothobranchius furzeri Jun 2013 present Max Planck Research Group Leader Max Planck Institute for Biology of Ageing, Cologne, Germany Awards and Honors 1999 Scuola Normale Superiore undergraduate scholarship 2002 University of Pisa Gold Medal for outstanding curricular achievements 2003 Young Researcher Scuola Normale Superiore Award 2004 Young Researcher Scuola Normale Superiore Award 2005 Young Researcher Scuola Normale Superiore Award 2006 First prize at the Stanford Genetics Retreat poster session Stanford Center on Longevity postdoctoral fellowship Ellison/AFAR postdoctoral fellowship Publications 1. Genade T, Benedetti M, Terzibasi E, Roncaglia P, Valenzano DR, Cattaneo A, Cellerino A. (2005). Annual fish of the genus Nothobranchius as a model system for aging research. Aging Cell. 4(5): Valenzano DR, Terzibasi E, Genade T, Cattaneo A, Domenici L, Cellerino A. (2006). Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr Biol. 16(3): Valenzano DR, Cellerino A. (2006). Resveratrol and the pharmacology of aging: a new vertebrate model to validate an old molecule. Cell Cycle. 5(10): Valenzano DR, Mennucci A, Tartarelli G, Cellerino A (2006). Shape analysis of female facial attractiveness. Vision Res. 46(8-9): Valenzano DR, Terzibasi E, Cattaneo A, Domenici L, Cellerino A. (2006). Temperature affects longevity and age-related locomotor and cognitive decay in the short-lived fish Nothobranchius furzeri. Aging Cell. 5(3): Visalberghi E, Valenzano DR, Preuschoft S. (2006). Facial displays in tufted capuchins. Int. J. Primatol. 27(6): Terzibasi E, Valenzano DR, Cellerino A. (2006). The short-lived fish Nothobranchius furzeri as a new model system for aging studies. Exp Gerontol. 42(1-2): Cellerino A, Borghetti D, Valenzano DR, Tartarelli G, Mennucci A, Murti L, Sartucci F. (2006). Neurophysiological correlates for the perception of facial 2

3 sexual dimorphism. Brain Res Bull. 71(5): Terzibasi E*, Valenzano DR*, Benedetti M, Roncaglia P, Cattaneo A, Domenici L and Cellerino A. (2008). Large differences in aging phenotype between strains of the short-lived annual fish Nothobranchius furzeri. PLoS One: 3(12): e3866. * Both authors contributed equally to this work. 10. Valenzano DR*, Kirschner J*, Kamber RA, Zhang E, Weber D, Cellerino A, Englert C, Platzer M, Reichwald K, Brunet A. (2009). Mapping the loci associated with tail color and sex determination in the short-lived fish Nothobranchius furzeri. Genetics. 183(4): * Both authors contributed equally to this work. 11. Valenzano DR, Sharp S, Brunet A (2011). Transposon-mediated transgenesis in the short-lived fish Nothobranchius furzeri, a vertebrate model for aging. G3 (Bethesda), Dec 1(7): (cover article). 12. Origlia N, Valenzano DR, Moretti M, Gotti C, Domenici L. (2012). Visual acuity is reduced in alpha-7 nicotinic receptor knock-out mice. Invest Ophthalmol Vis Sci. Mar 9; 53(3): Harel I, Benayoun BA, Machado B, Singh PP, Hu CK, Pech MF, Valenzano DR, Zhang E, Fullhart SC, Artandi SE, Brunet A. (2015). A platform for rapid exploration of aging and diseases in a short-lived vertebrate, the African killifish. Cell, 160, 1 14, Feb Cellerino A, Valenzano DR, Reichard M. (2015). From the bush to the bench: the annual Nothobranchius fishes as a new model system in biology. Biological Review, doi: /brv/ Reichard M, Cellerino A, Valenzano DR. (2015). Turquoise Killifish. Current Biology. Aug;25(17): R Valenzano DR*,1, Benayoun B 1, Singh PP 1, Zhang E, Etter PD, Hu CK, Clement-Ziza M, Willemsen D, Cui R, Harel I, Machado B, Yee MC, Sharp SC, Bustamante CD, Beyer A, Johnson EA, Brunet A*. (2015). The African Turquoise Killifish genome provides insights into evolution and genetic architecture of lifespan. Cell, Dec 3;162(6): co-first author; *corresponding author. 17. Kim Y, Nam HG, Valenzano DR. (2016). The short-lived African Turquoise Killifish: an Emerging Model for Ageing. DMM Feb 3;9(2): (cover article). Teaching Experience 2003 Undergraduate orientation school. Scuola Normale Superiore di Pisa, San Miniato Pisa, Italy Undergraduate course Longevity, Stanford University, USA. 3

4 2009 Undergraduate course Longevity, Stanford University, USA Graduate course Genomics for the Neurosciences. Scuola Normale Superiore di Pisa, Italy Master module Functional Genomics. University of Cologne, Cologne, Germany Graduate course Neurogenomics. Scuola Normale Superiore di Pisa, Pisa, Italy. Presentations 2002 Associazione Italiana di Primatologia, Rome, Italy 2004 Evolution and Human Behavior meeting, Berlin, Germany 2004 Italian Organization of Science Teachers (ANISN), Viareggio, Italy 2005 International Symposium on Neuroplasticity, Pisa, Italy 2008 Aging Symp: Linking Evolution to Mechanisms, Fribourg, Switzerland 2009 Stanford Current Issues in Genetics, Stanford, CA 2009 Lunch Bunch UC Riverside Seminar Series, Riverside, CA 2009 Stanford Center on Longevity, Stanford, CA 2010 Stanford Current Issues in Genetics, Stanford, CA 2010 Bay Area Aging Meeting Club, San Francisco, CA 2010 Longevity Consortium, Washington D.C Molecular Genetics of Aging, Cold Spring Harbor, NY 2010 Bay Area Population Genetics Meeting, Stanford, CA 2011 Buck Institute for Aging Research, Novato, CA 2011 Scuola Normale Superiore, Pisa, Italy 2011 University of Pisa, Dept. Biologia Cellulare, Pisa, Italy 2011 Max-Planck Institute for the Biology of Ageing, Cologne, Germany 2012 Harvard University, Department of MCB, Cambridge, MA, USA 2012 UC Berkeley, Department of MCB, Berkeley, CA, USA 2012 Max-Planck Institute for the Biology of Ageing, Cologne, Germany 2012 American Kllifish Association, WKW, Portland, OR, USA 2012 University of Alabama at Birmingham, NORC, Birmingham, AL, USA 2012 ENDO 2012, Houston, Tx, USA 2012 DGIST, Hyeonpung-Myeon, Daegu, South Korea 2013 Max-Planck Institute for the Biology of Ageing, Cologne, Germany 2014 Symposium series: I Nothobranchius Symposium, Pisa, Italy 2014 Poppelsdorfer Schlossgespräche: University of Bonn, Germany 2014 SFB670 Cell-autonomous Immunity CECAD, Cologne, Germany 2014 IRB, Barcelona, Spain 2015 ERIBA, Groningen, The Netherlands 2015 MPI Molecular Biomedicine, Münster, Germany 2015 SFB680, Institute fort Theoretical Physics, Cologne, Germany 2015 King s College, MCR Centre for Dev Neurobiol, London, UK 2015 Babraham Institute, University of Cambridge, Cambridge, UK 2015 Max Planck Institute for Plant Breeding, Cologne, Germany 2015 Francis Crick Institute, London, UK 2015 Department of Zoology, University of Cambridge, Cambridge, UK Press coverage 4

5 2006 Eat less, live more, The Economist URL: A model for ageing, Max Planck Gesellshaft news URL: Short-lived fish may hold clues to human ageing 5