BRAIN INJURY MEDICATIONS by Daniel Gardner, M.D. (copyright 9/94, 8/98)
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1 BRAIN INJURY MEDICATIONS by Daniel Gardner, M.D. (copyright 9/94, 8/98) (This article may be reprinted and distributed freely provided the text is unchanged and full attribution is given to the author.) *** PLEASE CONSULT WITH YOUR PHYSICIAN BEFORE MAKING ANY CHANGES IN YOUR CURRENT MEDICATION OR ADDING ANY NEW MEDICATIONS!*** The following list of medications used for brain injury-related problems is based on the medical literature and my clinical experience. CLINICAL INDICATIONS: Disorders in the following areas: Aggression, Anxiety, Arousal, Autonomic regulation, Cognition, Conceptual disorder, Eating, Headache, Mood Movement, Obsessions-compulsions, Perception, Seizures, Sexual function, Sleep, Speech-language AGGRESSION: Anticonvulsants Carbamazepin, Valproic acid, Clonazepam, Gabapentin, Lamictal, Topiramate, Neuroleptics, Fluphenazine, Pimozide (especially for negative symptoms; check EKG at start and each dose increase over 10 mg/day), Clozaril (no extra-pyramidal side effects (EPS), but hypotension, hypersalivation, sedation, agranulocytosis) Risperidone (low EPS), Olanzepine, Quetiapine Medroxyprogesterone Lithium carbonate Amantadine (100 mg up to 100mg qid) Beta adrenergic blockers Inderal, Pindolol (up to 60 mg daily; less hypotension secondary to intrinsic sympathomimetic activity) Calcium Channel Blockers Verapamil (up to 80 mg. qid), Diltiazem, Nifedipine, Nimodipine (selective for cerebral vasculature) Antidepressants Fluoxetine, Sertraline, Paroxetine, Trazodone, Nortriptyline, Desipramine Amoxapine (metabolized to a neuroleptic), Nefazodone, Mirtazapine Anti-anxiety medications Buspirone, Alprazolam, Clonazepam, Lorazepam Clonidine (hypotension and sedation; mg bid--starting dose. Increase by.1 mg/d, maximum dose = 2.4 mg/d) Stimulants Methylphenidate, Dextroamphetamine, Magnesium Pemoline, Adderall Antihistamines Hydroxyzine Anticholinergics Benztropine, Scopolamine Dextromethorphan (sustained release) (60-90mg bid) ANXIETY : ANXIETY, SOMATIC PREOCCUPATION, HYPOCHONDRIASIS: Antidepressants, Buspirone, Alprazolam, Clonazepam, Lorazepam POST-TRAUMATIC STRESS DISORDER: Tricyclic antidepressants: Imipramine, Nortriptyline Selective serotonin reuptake inhibitor antideptressants: Fluoxetine, Sertraline, Paroxetine Monoamine oxidase inhibitor antidepressants: Phenylzine, Parnate
2 Anti-anxiety agents: Alprazolam, Lorazepam Beta-adrenergic blockers: Propranolol, Atenolol Anticonvulsants: Carbamazepine AROUSAL: COMA RECOVERY: L-Dopa, Amphetamine, Hyperbaric oxygen, Naloxone "Coma Cocktail" Neurotransmitter precursors Vitamin C 100 mg, Co-Enzyme Q mg tid, L-Tyrosine 2000 mg/day for one week then add Bromocriptine 2.5 mg tid up to 30 mg/d (check bp) (or may use L-Dopa), then Dextroamphetamine 5 mg twice daily up to 20 mg/day,then Scopolamine patch (to block muscarinic receptors) behind alternating ears q3d (.5 mg/d) (Allen Childs, unpublished) LACK OF INITIATIVE, APATHY, IMPAIRED ATTENTION AND MEMORY, HYPERACTIVITY: Amphetamine (avoid abrupt withdrawal, leading to depression) Bromocriptine, Pergolide, L-Dopa/Carbidopa Amantadine ( mg. per day, especially in patients with Parkinsonian symptoms of bradykinesia, rigidity, tremor, reduced spontaneity and initiation) Fluoxetine, Sertraline, Paroxetine, Selegiline 5 mg bid, Risperidone (for negative symptoms in psychosis) Methylphenidate, Dextroamphetamine, and L-Dopa give best results in mild to moderate impairments such as mild post-concussion syndrome. Psychostimulants are best for mild impairment with decreased attention and memory, apathy and anergy. Other dopamine agonists are useful in more severe impairments. Presynaptic dopamine agonists: Methylphenidate, Dextroamphetamine, Adderall, L-Dopa Postsynaptic dopamine agonists: Bromocriptine (mixed), Pergolide, Amantadine (mixed) Other antidepressants: Imipramine, Desipramine, Amitriptyline ATTENTION DEFICIT / HYPERACTIVITY: Bupropion, Buspirone, Other antidepressants, Carbamazepine Psychostimulants Methylphenidate, Dextroamphetamine, Adderall, Magnesium pemoline Beta-adrenergic blockers Inderal, Pindolol, Clonidine.05-.1mg bid, increasing by.1mg/d to 2.4 mg/d maximum (hypervigilance, hyperactivity) HYPERVIGILANCE AND HYPERACTIVITY: Clonidine EMOTIONAL INCONTINENCE/PATHOLOGICAL LAUGHING OR CRYING: Amitriptyline, Amantadine, L-Dopa, Fluoxetine, Carbamazepine AUTONOMIC DYSREGULATION: (hyperthermia, diaphoresis, tachycardia, tachypnea) Bromocriptine, Dantrolene sodium COGNITION: Cognitive impairment in TBI. First evaluate side effects of current medications-- anticholinergic, antihistaminic, sedative. These could lead to impaired memory, attention and concentration. Naltrexone, Ergoloid mesylates, Nimodipine, Nicotine, Donepezil CONCEPTUAL DISORDERS: PSYCHOSIS: Neuroleptics Fluphenazine, Clozaril, Risperidone, Olanzepine, Quetiapine
3 Anticonvulsants MONOSYMPTOMATIC DELUSIONS, PATHOLOGICAL JEALOUSY: Pimozide, Fluoxetine EATING DISORDERS: OVEREATING: Fluoxetine, Trazodone, Naltrexone, Sibutramine LACK OF APPETITE : Cyproheptadine EXCESSIVE WATER DRINKING : Demeclocycline (600 mg bid), Lithium carbonate, Captopril (12.5 mg/d) MOOD DISORDERS: DEPRESSION: Incidence of post-tbi depression:15-25%. Depression may occur without a feeling of sadness. It may manifest as agitation, irritability, lack of pleasure, impaired cognition. Antidepressants: Desipramine (not sedating), Nortriptyline (sedating), Bupropion (low anticholinergic and antihistaminic side effects; activating), Trazodone (sedating), Fluoxetine, Sertraline, Paroxetine (low anticholinergic and antihistaminic side effects; activating), Amoxapine (metabolized to neuroleptic), Nefazodone (lower incidence of insomnia, GI upset, weight gain), Mirtazapine, Venlafaxine, Selegiline (MAOI, no dietary restriction when used at Parkinson's Disease doses of 5-10mg/d; antidepressant doses, mg/d, require low tyramine diet; metabolized to amphetamine) Psychostimulants Methylphenidate, Dextroamphetamine, Magnesium pemoline, Adderall TREATMENT- RESISTANT OR PARTIALLY RESPONSIVE DEPRESSIONS: (a) Increase dose until benefits or side effects appear (b) Change to another antidepressant (c) Add a second antidepressant (d) Augment antidepressants with: Buspirone, Lithium Carbonate, Thyroxine, Tri-iodothyronine, Atypical Neuroleptic, Anticonvulsant, Pindolol MANIC DISORDER : Lithium Carbonate Anticonvulsants Carbamazepine, Valproic acid, Clonazepam, Gabapentin, Lamotrigine Calcium Channel Blockers Verapamil, Diltiazem, Nifedipine, Nimodipine Neuroleptics (If single agent ineffective, consider low dose Lithium + anticonvulsants +/or neuroleptic) POST-TRAUMATIC HEADACHES: Nonsteroidal anti-inflammatories (NSAIDs) Antidepressants (tricyclic) Calcium channel blockers Verapamil, Diltiazem, Nifedipine, Nimodipine (selective for cerebral vasculature) Phenylzine (MAOI antidepressant) MOVEMENT DISORDERS: ABSENCE OF MOVEMENTS AFTER TBI: Neostigmine, Physostigmine, Bromocriptine, Amantadine INCOORDINATION L-trytophan, Thyrotropin-releasing hormone (oral), Propranolol, Gamma-vinyl GABA, Acetazolamide, Phthalazinol DYSTONIA : Dopamine agonists: Bromocriptine, L-dopa Anticholinergics: Benztropine, Trihexyphenidyl Baclofen Benzodiazepines: Diazepam, Alprazolam, Lorazepam Carbamazepine
4 TREMORS: Beta-adrenergic blockers: Propranolol, Atenolol, Pindolol Benzodiazepines, Dopamine agonists, Valproic acid, Anticholinergics, Isoniazide PARKINSONISM: (bradykinesia, dysarthria, decreased facial expression, rigidity) Selegiline, L-Dopa, Pergolide, Bromocriptine AKATHISIA: Bromocriptine, Propranolol,Cyproheptadine MYOCLONUS: Clonazepam,Trazodone, L-Tryptophan, Valproic acid, Primidone, Piracetam DYKINESIAS: Dopamine agonists, Anticonvulsants NEUROGENIC HETEROTOPIC OSSIFICATION: Etidronate disodium, Nonsteroidal anti-inflammatory meds (NSAIDs) OBSESSIVE-COMPULSIVE DISORDER: Fluoxetine, Sertraline, Paroxetine, Clomipramine (May add Buspirone or atypical neuroleptic to antidepressant ) PERCEPTUAL DISORDERS: HEMI-INATTENTION / NEGLECT: Bromocriptine SEIZURE DISORDERS: Carbamazepine (partial seizures, simple or complex) Valproic acid (multi-focal or generalized seizures), Gabapentin (metabolized by kidneys), Lamotrigine, Topiramate SEXUAL DISORDERS: HYPOSEXUALITY: Antidepressants, Yohimbine, Testosterone, Sildenafil HYPERSEXUALITY: Females: (Sexual assault, frequent masturbation, violent erotic dreams, with normal testosterone levels) Cyproterone acetate (androgen receptor blocker) mg/d (days 5-15 of menstrual cycle) Ethinyl estradiol 50 mcg/day (days 5-25 of menstrual cycle) Males: Medroxyprogesterone im: approx. 200 mg im/week decreasing to 200mg/mo with testosterone level maintained at 100 po: mg/d (fewer side effects with low dose p.o. than i.m.) Depo-leuprolide acetate 7.5 mg im/mo, Cyproterone acetate 50mg bid, Conjugated estrogens Both males and females: fluoxetine and other serotonin re-uptake inhibitors ( reduced sex drive and function in 30% ) SLEEP DISORDERS: NARCOLEPSY: Fluoxetine, Psychostimulants INSOMNIA: Antidepressants (sedating), Valproic acid, Zolpidem, Clonazepin SPEECH - LANGUAGE DISORDERS: MUTISM: Physostigmine 1 mg i.m. one time weekly x three weeks Bromocriptine mg twice daily up to 45 mg/day (increase the dose about every one month) Imipramine DYSPHAGIA: L-dopa DYSPHASIA: Bromocriptine DYSARTHRIA: Clonazepam About the author: Daniel Gardner, MD is in the private practice of psychiatry, psychoanalysis, and neurobehavioral medicine in San Diego and Solana Beach, California. He provides treatment (problem solving, skill building, and medication management) and consults on quality of care issues with TBI
5 survivors, their families, health care providers, health care organizations, and insurance companies. He is Assistant Clinical Professor of Psychiatry, UCSD School of Medicine and faculty member, San Diego Psychoanalytic Society and Institute. He was formerly medical director of NeuroCare at Stone Mountain, a post-acute brain injury rehabilitation program and is currently medical director of Hidden Valley Rehabilitation Services, a neurologic disabilities rehabilitation program in Ramona, California Kearny Villa Rd., Ste. 214 San Diego, CA E Lomas Santa Fe Drive Solana Beach, CA Phone/fax: [email protected] website:
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