Telemedicine Resuscitation & Arrest Trials (TreAT)
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1 Telemedicine Resuscitation & Arrest Trials (TreAT) Telemedicine within the ED for treating Severe Sepsis: A Hub and Spoke Telemedicine pilot SUMR Intern: Karole Collier Mentor: Dr. Brendan Carr & Dr. Anish Agarwal
2 Agenda: 1.What is sepsis? 2.How do you treat it? 3.Uptake of best practices? 4.Telemedicine Pilot - Literature review - Database development - Chart review & data entry - Feasibility pilot 5.Next steps = TRIAL 6.Lessons learned 2 Sepsis Early Goal Directed Therapy (EGDT) Telemedicine
3 What is Sepsis? WHAT: Sepsis is a deadly medical condition characterized by a whole-body inflammatory state ; or in laymen s term a severe full body infection i. There is often confusion between sepsis, septicemia, and bacteremia ii. Bacteremia To keep consistency, think of the aforementioned as a spectrum of medically relatedly medical conditions Septicemia Sepsis SIRS 3
4 Prevalence: Severe Sepsis in the US Sepsis is the 11 th leading cause of death in the US, affecting over 750,000 patients per year ($17 billion/year) Its estimated that one patient present to an emergency dept. in the US with severe sepsis or septic shock every minute Mortality [or incidence of death] ranges from 25%- 50% 4
5 Imagine Your Sick? What s the progression In the same way that you recognize sickness, physicians are trained specially to notice key vital or clinical encounters that allow them to diagnose disease Reason or clinical encounter How You Know A clinical response fulfilling certain criteria What infection tells you about what is wrong. SICK Body Dysfunction, Person may be at the brink of serious damage or death Infection Diagnosis REALLY SICK!
6 Identification of Sepsis in the ED To understand how the problem of Sepsis can be solved one has to understand the process by which it develops and is diagnosed within a clinical setting. Reason or clinical encounter Infection/ Trauma SIRS Criteria A clinical response arising from a nonspecific resulting in 2 of the following : 2 SIRS Criteria met + Source of Infection Sepsis Severe Sepsis Organ Dysfunction, hypotension, or Hypoperfusion Severe Sepsis w. hypotension, despite fluid resuscitation Septic Shock Heart Rate: > 90 Respiratory Rate: >20 or PaCO2 > 32 mmhg Temperature: <98.6 F or>100.4 F WBC >12,000/mm 3 >, < 4,000/mm 3 >, or Bands >10% 6
7 Sepsis How do you treat it? EGDT Early assessment on the basis of physical findings, vital signs, central venous pressure, and urinary output fails to detect persistent global tissue hypoxia. Global tissue hypoxia is an indicator of serious illness, and a key development preceding multiorgan failure and death. Early Goal Directed Therapy [EGDT] = a more definitive resuscitation strategy to detect persistent global tissue hypoxia Resuscitation End Points: End points used to confirm the balance between oxygen delivery and oxygen demand. Arterial Lactate Concentration Base Deficit Mixed Venous Oxygen Saturation ph During the first 6 hr in the ED, the EGDT patients receive significantly more fluid therapy, red-cell transfusion, and inotropic agent (dobutamine) prior to ICU Admission 7
8 Sepsis
9 Sepsis Relative risk of in-hospital, 28 day, and 60 day mortality was substantially reduced (roughly a third) in Rivers 2001.
10 EGDT+ ED & Sepsis Mortality Despite the many proven prehospital and hospital based therapies for resuscitation care, multiple commentaries, uptake remains poor. WHY? Questions about how to develop hospital protocols, The time window Hospitals with inter-facility transport after initial stabilization Specifically for EGDT & Sepsis Increasing the adherence to evidence based guidelines throughout the country is a slow and arduous task 10
11 Even HERE! Using the most liberal definition do you perform goal directed therapy for patient with severe sepsis more often than not?, 66% of Pennsylvania EDs said yes. (Carr 2013) 11
12
13 The Study: USING REAL-TIME TELEMEDICINE TO IMPROVE QUALITY AND OUTCOMES
14 Aims Telemedicine has been shown to improve the odds of appropriate treatment decision-making by nearly 11-fold for acute ischemic stroke proving telemedical consultation to be an effective and feasible option. Given that Sepsis: +Time Sensitive +Missed too often +Would Benefit from examination from an onsite expert = may aid in narrowing the observed variation in survival and in the improvement of patient outcomes by utilizing TELEmedicine.
15 Telemedicine: Within the ED We proposed to use real-time telemedicine to develop a novel care delivery system for patients with Severe Sepsis It provides a way to replace or augment existing education and system design efforts for unplanned critical illnesses Dissemination Issues Could serve as a powerful model for improving care in other disease states and critical conditions. Innovation of the ED with Man to Man coverage 15
16 Overview: What: Decrease sepsis related mortality How: Establish a baseline (chart review) Prove feasibility of an intervention (real time coaching via telemedicine) Perform a large scale randomized trial Pre-Telemedicine (1) Telemedicine Intervention (2) Post Intervention (3) 16
17 Methods Develop a network of hospitals arranged in a hub (typically an academic medical center) and spoke (typically smaller community hospitals) that will enable us to trial the virtual resuscitation of patients in need of critical care. UPHS Trial Hub & Spoke: Hospital of the University of Pennsylvania [HUB] PENN Presbyterian Medical Center Pennsylvania Hospital
18 Technology (REACH Health) was used to build an internal telemedical network which included: mobile telemedical carts placed in each ED equipped with a laptop computer, hidefinition pan-tilt-zoom video camera, and high-speed wireless connectivity. Both hub and spoke providers could control the camera and view/enter/edit patient information through HIPAA secure connections in real-time.
19 HUP Florida? Kids Baseball Game Center City
20 Severe Sepsis Management
21 21
22 Home (3 am) US guided IV placement
23 Study Design: Pilot & Trial (1) 23 Assess the practical and technologic feasibility of using a real-time video based telemedical consultation to treat and manage critically ill patients within the ED (i.e. severe sepsis and post-cardiac arrest care). 1. Obtain all data on Sepsis Patient in UPHS Network in the last year 2. Create a database to organize the data obtained 3. Analyze the UPHS Sepsis mortality rate and utilization of EGDT comparatively within the 3 hospitals of UPHS 4. Obtain provider perceptions regarding telemedical platforms within the ED Telemedicine Intervention (2) 1. Create and Utilize a network of resuscitation experts to take telemedicine consults. 2. Consult critically ill (i.e severe sepsis) patients and utilize EGDT via a telemedical platform 3. Continually assess and gather data on telemedicine intervened patients Post Intervention (3) 1. Obtain data on all Sepsis patients in UPHS network during the study/ 2. Utilize the created database to compare patients receiving telemedical platform and not. 3. Obtain provider perceptions & monitor use or uptake of EGDT 4. Gain funding to roll out intervention on large scale RT.
24 My Role within the Telemedicine Pilot Quantify and describe the epidemiology of severe sepsis within the UPHS spoke network Create a database and analyze a database of severe sepsis cases treated in the ED within the UPHS institutions 165 Chart Reviews & Data Abstraction Help in ease implementation of telemedicine consultation by creating a standardized entry system - Functional Data Dictionary. Ultimately help create the baseline for the larger Telemedicine & Sepsis Trial 24
25 How I achieved these goals: Red Cap? Data Entry? Medview Chart review Deciphering through the varying ways in which a chart is completed in the ED 25
26 How I made the Database: I had to learn the thought process of both clinicians and researchers to best design the database and execute data entry. My database had to mirror the clinical process by which clinicians came to the conclusion of sepsis. Red Cap 26
27 Many, many, MANY Charts to read! 27
28 Limitations? Understanding the extreme variety within healthcare Standardization of Charts is not often not a very feasible solution. Though it would better reflect the patient information (particularly for this study) within the ED, as ED physicians, dept., and ED coding varies drastically even within the UPHS system. Telemedicine, though innovative is not quite at the point that it is readily available, or adequately compensated for. Technology : though innovative and quite exciting, the expectations of the technology used is not quite up to speed with the technology readily available to patients outside of healthcare (i.e Facetime & Skype but with clinical capabilites) 28
29 The Surreal Experience Lessons Learned My Father s experience with Severe Sepsis after serious surgical complications in the SICU. Letter Specifically to PCORI My Hopes for Telemedicine and its capabilities in solving Patient Centeredness. Medical Abbreviations!!! 29
30 Thank YOU! DR. CARR DR. AGARWAL KATIE! JOANNE SAFA & SHANAE LDI COHORT 13
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