Projects: 1. Regulation of immune/inflammatory responses 2. Development and maintenance of a mouse model as a research tool

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1 BOREN LIN, PhD RESEARCH INTEREST Biomaterials for bone regeneration and repair Inflammatory responses and its regulators Cancer-induced bone diseases and its treatment PROFESSIONAL EXPERIENCE Postdoctoral Fellow, 2013-present Engineering Center for Orthopaedic Research Excellence The University of Toledo, Toledo, OH Projects: 1. Research in bone regeneration induced by drugs and stem cells 2. Development of synthetic bone graft used in orthopaedic surgery (technology transferred to OsteoNovus Inc.) 3. Development of sensing technology for rapid detection of bacterial infection (technology transferred to Intellisenze Inc.) Postdoctoral Fellow, The Leaman Laboratory, Department of Biological Sciences The University of Toledo, Toledo, OH Projects: 1. Regulation of immune/inflammatory responses 2. Development and maintenance of a mouse model as a research tool Postdoctoral Fellow, The Tsai Laboratory, Department of Chemistry Kent State University/Summa Health System/IC-MedTech Inc. Projects: 1. Cancer drug development Teaching Assistant,

2 Kent State University, Department of Chemistry EDUCATION M. S., General Engineering, 2013 Department of Engineering Technology, the University of Toledo, Toledo, OH Ph.D., Biomedical Sciences (Cellular and Molecular Biology), 2006 School of Biomedical Sciences, Kent State University/Cleveland Clinic Foundation Collaborative Doctoral Program M. S., Chemistry, 2003 Department of Chemistry, Kent State University, Kent, OH B. S., Chemical Engineering, 1995 Department of Chemical Engineering, Tung Hai University, Taichung, Taiwan PATENTS 1. Injectable Biodegradable Bone Matrix For Multiple Myeloma Lesion Augmentation and Osteoporosis US: US A1 China: CN A Europe: EP A2 World Intellectual Property Organization: WO A2 Other inventors: Agarwal AK, Goel VK, Kim D-S, Bhaduri SB Licensed to OsteoNovus Inc. 2. A Biosensor Device to Target Analytes in Situ, in Vivo, and/or in Real Time, and Methods of Making and Using the Same US: US China: CN A

3 Europe: EP A1 World Intellectual Property Organization: WO A1 Other inventors: Agarwal AK, Goel VK, Kim D-S, Yoon D-Y, Feyzizarnagh H. 3. Citation in patent: Lin B. "A Novel Resveratrol Analog: Its Cell Cycle Inhibitory, Pro-Apoptotic and Anti-Inflammatory Activities on Human Tumor Cells" (Dissertation) Hydroxylated tolans and related compounds in the treatment of a cancer US: US A1 World Intellectual Property Organization: WO A2 Inventor: Tsai C-c. PUBLICATIONS Published: Materials Science and Engineering C: Materials for Biological Applications Zhou H, Nabiyouni M, Lin B, Bhaduri SB. Fabrication of novel poly(lactic acid)/amorphous magnesium phosphate bionanocomposite fibers for tissue engineering applications via electrospinning May 1;33(4): (14 citations) Lin B, Zhou H, Leaman DW, Goel VK, Agarwal AK, Bhaduri SB. Sustained release of small molecules from carbon nanotube-reinforced monetite calcium phosphate cement Oct 1;43:92-6. (2 citations) Babaie E, Zhou H, Lin B, Bhaduri SB. Influence of ethanol content in the precipitation medium on the composition, structure and reactivity of magnesium-calcium phosphate Aug;53: Under revision: Lin B, McGuire K, Liu B, Jamison J, Tsai C-c. Structure-activity relationship, synthesis and biological activity of a hydroxytolan series. Journal of Medicinal Chemistry

4 Lin B, Xu D, Leaman DW. Negative regulation of TNFα-induced NFκB activation by XAF1 via inhibition of the TRADD/TRAF2/RIP1 signal complex. FEBS Letters Babaie E, Lin B, Bhaduri S. Evaluation of Amorphous Magnesium Phosphate (AMP) Based Non-exothermic Orthopedic Cements. Biomedical Materials Babaie E, Lin B, Bhaduri S. A New Method to Produce Macroporous Mg-phosphate Bone Growth Substitutes. Materials Science and Engineering C: Materials for Biological Applications CONFERENCE ABSTRACTS 1. Lin B. Multiple bioactivities of a novel resveratrol analog. Midwest Taiwanese Symposium on Science and Technology, Ohio, USA, 2005 Excellent Presentation Award 2. Fan W, Lin X, Hsieh Y-W, Lin B, Baker JW, Tsai C-c. Chemical structure-activity relationship visualization using structure-activity maps. IEEE Computational Systems Bioinformatics Conference, California, USA, Fan W, Hsieh Y-W, Lin X, Lin B, Baker JW, Tsai C-c. Structure-activity relationship (SAR) analysis using structure-activity maps (SAMs). Ohio Collaborative Conference on Bioinformatics Conference, Ohio, USA, Lin B, Aboelzahab A, Azad A-M, Goel VK, Leaman DW, Biyani A, Ebraheim N, Serhan H. Infrared radiation activated-nanostructured titania did not induce inflammatory responses in human cells". Annual Meeting of the International Society for the Study of the Lumbar Spine, Sweden, Lin B, Zhou H, Leaman DW, Goel VK, Agarwal AK, Bhaduri SB. Carbon nanotube-reinforced calcium phosphate cement for drug delivery in multiple myeloma bone disease treatment. Annual Meeting of the International Society for the Study of the Lumbar Spine, Arizona, USA, Agarwal AK, Kodigudla M, Desai D, Jones AD, Lin B, Goel VK, Schlossber B.

5 Biomedical evaluation of polymerized biodegradable cement vs PMMA cement in kyphoplasty for vertebral compressive fractures. American Society of Mechanical Engineers Summer Bioengineering Conference, Oregon, USA, Lin B, Zhou H, Leaman DW, Goel VK, Agarwal AK, Bhaduri SB. Sustained release of small molecules from a calcium phosphate-based bone cement. 60 th Annual Meeting of the Orthopaedic Research Society, Louisiana, USA, Lin B, Xu D, Leaman DW. Negative regulation of TNFα-induced NFκB activation by XAF1 via inhibition of the TRADD/TRAF2/RIP1 signal complex. American Association of Cancer Research Annual Meeting, California, USA, Agarwal AK, Lin B, Feyzizarnagh H, Kim D-S, von Sigler W, Ahmadi K, Goel VK. Rapid detection of methicillin-resistant Staphylococcus aureus in orthopaedic surgery. 3 rd International Conference and Exhibition on Biosensors & Bioelectronics, Texas, USA, Lin B, Ke Q, Leaman DW, Goel VK, Agarwal AK. RING Finger Protein RNF114 Inhibits RANKL-induced Osteoclast Maturation. 61 st Annual Meeting of the Orthopaedic Research Society, Nevada, USA, Lin B, Feyzizarnagh H, Kim D-S, von Sigler W, Ahmadi K, Gholami M, Goel VK, Agarwal AK. Rapid Detection of Methicillin-resistant Staphylococcus aureus in Orthopaedic Surgery. Ohio Branch American Society for Microbiology Spring Meeting, Ohio, USA, Lin B, Yoho S, Leaman DW, Goel VK, Agarwal AK. Counteractive Effects of a RING Finger Protein RNF114 on Ca2+-regulated Mesenchymal Stem Cell Proliferation and Osteogenic Differentiation. 62st Annual Meeting of the Orthopaedic Research Society, Florida, USA, 2016 FUNDING SOURCES NSF Center for Disruptive Musculoskeletal Innovations, Industrial Partnership Funds Title: Prevention of bacterial infection during spinal fusion Role: Principal Investigator OTHER ACTIVITIES IN SCIENTIFIC SOCIETIES

6 Manuscript peer review: Materials Science and Engineering C: Materials for Biological Applications (since 2014, 8 papers) Editorial board member: Scientific Journal of Genetics and Gene Therapy OTHER PROFESSIONAL EXPERIENCE Petrochemical Department, Ho Tung Chemical Corp., Taipei, Taiwan Engineer and Sales Representative, Marketing, production and shipping management, fuel oil trading Project Specialist and Special Assistant to General Manager, Project 1: New petrochemical factory complex and logistic center Project 2: Business diversification (service station network and international trading of petroleum products in Taiwan and China)