European Educational Programme in Epidemiology

Transcription

1 European Educational Programme in Epidemiology 29 th RESIDENTIAL SUMMER COURSE FLORENCE, ITALY Pre-courses JUNE /13

2 European Educational Programme in Epidemiology Pre-Course: Introduction to Genetic and Molecular epidemiology June /13

3 Introduction to Genetic and Molecular epidemiology June 2016 Dave M Evans and Gib Hemani Program Monday 13 June :00 10:30 Session 1 Course Outline / Introduction Basic Genetics Theory (DE): Molecular and biological basis of inheritance; Mendelian inheritance; Hardy-Weinberg Law; Complex traits and Diseases. 11:00 12:30 Session 2 History of Genetic Epidemiology (DE): Founding figures; Methods of gene mapping; Landmark genetic projects; Successes and failures. 12:30 14:00 Lunch 14:00 15:15 Session 3 Introduction to R (GH): Practical session; Basics of R, Using packages; Simple plotting. 15:15 15:45 Coffee point available 15:45 17:00 Session 4 Basic statistics and genetics (GH): Practical session; Refresher on statistical testing; Regression; Using R for linear models. 3/13

4 Program Tuesday 14 June :00 10:30 Session 1 Genetic Association Studies and GWAS (DE): Overview; Metaanalysis; Phasing and Imputation; Follow up of findings. 11:00 12:30 Session 2 Population stratification (DE): Using genetic data to uncover underlying population structure; Impact of structure on GWAS. 12:30 14:00 Lunch 14:00 15:15 Session 3 Introduction to genetic data (GH): Practical session; Genetic data formats; PLINK software; Quality control. 15:15 15:45 Coffee point available 15:45 17:00 Session 4 GWAS practical (GH): Practical session; Performing GWAS; Visualising results. 4/13

5 Program Wednesday 15 June :00 10:30 Session 1 Statistics of GWAS (DE): Statistical Power; Significance; Type I error; Mini-practical. 11:00 12:30 Session 2 Mendelian randomization (DE): Basic concepts; Two sample design; Online tools; Demonstration and Mini-practical. 12:30 14:00 Lunch 14:00 15:15 Session 3 Quantitative Genetics Theory (GH): Quantitative Genetics; The classical twin design; Liability Threshold Model; Risk models. 15:15 15:45 Coffee point available 15:45 17:00 Session 4 Polygenic approaches (GH): GCTA; LD Score regression; Polygenic scores; GCTA Mini practical. 5/13

6 Program Thursday 16 June :00 10:30 Session 1 Bioinformatics and Fine Mapping (GH): Identifying the causal variant; Methods and pitfalls for enrichment. 11:00 12:30 Session 2 Next Generation Sequencing (GH): Technological methods; Bioinformatic challenges. 12:30 14:00 Lunch 14:00 15:15 Session 3 Rare Variant Association Tests (DE): Motivation; SKAT; Interpretation. 15:15 15:45 Coffee point available 15:45 17:00 Session 4 Genomics in Medicine (DE): Genetic testing; Genomic profiling in complex diseases; Pharmacogenomics; Using genetics in drug discovery. 6/13

7 Program Friday 17 June :00 10:30 Session 1 Introduction to epigenetics (DE): Gene regulation; DNA methylation; EWAS theory. 11:00 12:30 Session 2 EWAS practical (GH): DNA methylation data; Quality control; Performing EWAS and visualisation. 12:30 14:00 Lunch 14:00 15:15 Session 3 The Future of Genetic Epidemiology (DE) 7/13

8 Pre-Course: GIS (Geographic Information Systems) in Epidemology June /13

9 GIS (Geographic Information Systems) in Epidemology June 2016 Danielle Vienneau and Kees de Hoogh Program Wednesday 15 June :30 10:30 Course intro (15min KdH) Quick start to GIS Intro (15min DV) Exercise 1 (1h30min) 11:00 13:00 Projections and geocoding Intro (15min DV) Exercise 2 (1h45min) 13:00 14:30 Lunch 14:30 15:30 Lecture 1 GIS in Epidemiology (1h DV) 15:30 16:00 Coffee point available 16:00 18:30 Spatial analysis and relationships Intro (15min KdH) Exercise 3 (2h15min) 9/13

10 Program Thursday 16 June :30 10:30 Working with raster data Intro (15min KdH) Exercise 4 (1h45min) 11:00 13:00 Automating processes Intro (15min DV) Exercise 5 (1h45min) 13:00 14:30 Lunch 14:30 15:30 Lecture 2 Exposure assessment using GIS (1h KdH) 15:30 16:00 Coffee point available 16:00 18:30 Risk assessment Intro (15min DV) Exercise 6 (2h15min) 10/13

11 Program Friday 17 June :30 10:30 Open source GIS Intro (15min KdH) Exercise 7 (1h45min) 11:00 13:00 Decision making with Route Analysis Intro (15min KdH) Exercise 8 (1h45min) 13:00 14:30 Lunch 14:30 15:30 Lecture 3 Mapping and Communication (1h KdH/DV) 15:30 16:00 Coffee point available 16:00 18:30 Mapping Exercise 9 (2h15min) Wrap up (15min DV) 11/13

12 European Educational Programme in Epidemiology FACULTY MEMBERS 12/13

13 Faculty Members Kees de Hoogh Swiss Tropical and Public Health Institute Socinstrasse Basel Switzerland Danielle Vienneau Swiss Tropical and Public Health Institute Socinstrasse Basel Switzerland David M Evans University of Queensland Brisbane St Lucia, QLD 4072 Australia [email protected] Gib Hemani University of Bristol Senate House Tyndall Avenue Bristol, BS8 1TH United Kingdom [email protected] Manolis Kogevinas (Director of the course) Centre for Research in Environmental Epidemiology Doctor Aiguader Barcelona Spain [email protected] Rodolfo Saracci (Founder Director of the course) Istituto di Fisiologia Clinica del CNR Via Trieste Pisa Italy [email protected] Secretariat Mar Ferrer Centre for Research in Environmental Epidemiology Doctor Aiguader Barcelona Spain [email protected] 13/13