Imaging Science. Prof. Dr. rer. nat. Bernd Pichler
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1 Imaging Science Prof. Dr. rer. nat. Bernd Pichler
2 Department Radiologie Diagnostic and lnterventional Radiology Prof. Nikolaou Diagnostic and lnterventional Neuroradiology Prof. Ernemann Nuclear Medicine Prof. la Fougere Preclinical lmaging and Radiopharmacy Prof. Pichler Biomedical Magnetic Resonance Prof. Scheffler Experimental Radiology Prof. Schick
3 X-Strahlen: Eine neue Art von Strahlen Wilhelm Conrad Röntgen : Entdeckung der X-Strahlen 1901: Nobelpreis für Physik
4 Neurosciences Immunology Infection Medicine Microbiology Imaging Cardiology Vascular Medicine Oncology Biomedical engineering Radiation Therapy
5 Der Grundstein der Nuklearmedizin Henri Becquerel : Entdeckung der Radioaktivität 1903: Nobelpreis für Physik George de Hevesy : Radiotracer-Experiment 1943: Nobelpreis für Chemie
6 Positron-Elektron Annihilation POSITRON 511 kev PHOTON POSITRON-EMITTING RADIONUCLIDE Positron-Electron ANNIHILATION 180 o Positron path-length depends on tissue density and positron energy The two 511 kev gamma rays are emitted in an angle of 180 o 511 kev PHOTON
7 PET-Prinzip H 2 C H OH O H H OH O H H O H 18 F 18 F markierter Zucker 2-deoxy-2-[ 18 F]fluoro-D-glucose (FDG) Injektion & Anreicherung Detektion
8 Kleintierbildgebungs-Modalitäten Optische CT MRI PET Bildgebung Morphologie Morphologie (Funktion) Funktion Funktion
9 Datamining/Machine Learning Bildgebungs-Modalitäten Radio graphy CT MRI PET Optical Imaging Omics SPECT Ultra sound
10 pre CTx 1. CTx cycle CTx final Positronen Emissions Tomographie (PET) RESPONDER 52a, male NSCLC re. OL ct4 cn0 cm0
11 pre CTx 1. CTx cycle CTx final Positronen Emissions Tomographie (PET) NON-RESPONDER 51a, male NSCLC li. OL ct4 cn3 cm0
12 Positronen Emissions Tomographie (PET) pre CTx 1. CTx cycle CTx final
13 Radiofrequenzablation (RFA)
14 Brain Function as a Result of Receptor Activation 14 Department of H.F. Wehrl, et al.; J Mucl Med; 2014
15 H.F. Wehrl, et al.; Nature Medicine; accepted
16 Resting state PET H.F. Wehrl, et al.; Nature Medicine; accepted
![R R Tracer specific Connectivity Matrixes [ 18 F]FDG [ 15 O]H 2](/docs-images/39/18665185/images/17-0.jpg "O [ 11 C]DASB BOLD-fMRI 1.")
17 R R Tracer specific Connectivity Matrixes [ 18 F]FDG [ 15 O]H 2 O [ 11 C]DASB BOLD-fMRI Rat R 2 threshold Network Construction R R 2 n=8 n=29 n=8 n= Mouse R 2 threshold Network Construction R R 2 n=23 n=12 n=16 0
18 6-OHDA mouse model of PD DVR (healthy) = 2.04 DVR (sham les) = 2.06 DVR (healthy) = 2.09 DVR (les) = 1.56 DVR (healthy) = 1.97 DVR (les) = 1.38 K. Fischer, et al.; Neuroimage; 2012
19
20 Backwards Inference: Gaussian Distribution Histology Probability Map 20
21 21
22 22
23 Blood Vessel FASN Molecular Imaging Targets 18 F-FET 11 C-Met 18 F-FLT 18 F-FAZA 18 F-FMISO 18 F-FDG CNT ENT 18 F-Gln Protein Biosynthesis TK I Nitroreductase HK II Trapping Glutaminolysis Cancer Associated Fibroblast αvβ3 Integrin DNA Synthesis Tumor Cell 18 F-ICMT11 Caspase 3/7 SA-αL-Fuc Phosphatidylserin H+ H+ H+ Lysosome FAP 18 F-Annexin 5 18 F-FASN-Inhib. 18 F-SA-αL-Fuc-Inhib. 64 Cu-FAP-AB 23
24 PET-Detektor Strip encoding Crystal _ ID = max(s1 i ) Çmax(S2 j ) æ Crystal _ ID = S1 ö æ 1 ç Ç S2 ö 1 è SS1 ç i ø è SS2 j ø S1 DOI = i SS1 DOI = i S1 i + S2 j S S1 i + S2 j ( ) E = S1 i + S2 j E = S(S1 i + S2 j ) 24 Department of Preclinical Imaging and Radiopharmacy
25 PET-Detektor Strip encoding
26 PET-Detektor Strip encoding
27 PET-Insert PET-System Cooling Microcontroller High Voltage NTC Filter board Quicksilver Acquisition Software Inveon System Monitor and Control Data Acquisition 27 Department of Preclinical Imaging and Radiopharmacy
28 Graphical User Interface (A) PET rings current status (temperature, high voltage) (B) Temperature of secondary electronics (e.g. microcontroller, filter board, cooling board, digitizer), (C) Temperature of individual detector module (D) High voltage monitoring and controll (E) Cooling system controll and monitor A D B C E 28 Department of Preclinical Imaging and Radiopharmacy
29 Cooling System NECESITY APD Gain is Temperature Dependent GOAL Cold Stream Compressed Air Hot Stream Stable Fast Vortex Tube Cheap ACHIEVEMENT Air Cooling Maintenance free Automatic or manual Cheap But Stable (15 ±0.02 C) and fast 29 Department of Preclinical Imaging and Radiopharmacy
30 5. Semester (WS) 168 h Präsenzzeit
31 Detectorphysics Radiation Safety Clincal PET/MR MRI basics/ Spectroscopy Hyperpolarization Comparison Master vs. Bachelor Med. Tech. Bioimaging Preclinical Imaging PET/MR MRI Clinical Imaging Labeling of Biomolecules Imaging of Inflammation Spatial Encoding in MRI fmri Image Reconstruction Angiography Advanced Clincal PET Pharmacol. Modelling Adv. Image Analysis NMR Spectroscopy Image Contrast in MRI Diffusion- Imaging Perfusion- Imaging Appl. PET/MRI Preclinical Imaging PET/MR MRI Clinical Imaging MRI CT PET Organ specific MRI Organ specific CT Radiopharmacy SPECT Optical Imaging Basic PET Ultrasound
32 Vorläufiger Stundenplan Kontakt & Info: Dr. Carsten Calaminus Tel:
33 locations Berg Internal Medicine Nuclear Medicine MR/PET MR center Zentrales Röntgen PET/CT ER Pediatric Imaging
34 locations Tal Preclinical Imaging Radiopharmacy Women Imaging
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