Product list Version September 2010

Transcription

1 Product list Version September 2010

2 Introduction Since 1914, Katwijk Chemie has been successfully producing high quality Active Pharmaceutical Ingredients and Fine chemicals. We offer our customers the following benefits: More than 90 years Dutch reliability igh and consistent product quality Quick and accurate QA and QC support, FDA/EDQM inspected Small (90 staff), fast and flexible World-wide local sales contacts, including Japan Privately owned and fully independent In this product list, you will find the variety of products that we are currently supplying, split into three different sections: 1. Active Pharmaceutical Ingredients (API s) (page 4) The Anti-epileptics form a major part of our API s. owever, we also cover other therapeutic categories like anti-inflammatory, anti-bacterial and CS stimulant (page 6). For every API, the approved indications for a pharmaceutical formulation have been given. All API s are produced under cgmp conditions. Drug Master Files (DMF) are available for many countries and several Certificates of Suitability (CoS, CEP) for the European Pharmacopoeia have been issued. 2. Bulk Fine Chemicals (page 9) The Bulk Fine Chemicals are used in a wide variety of fields, the most important of them being the pharmaceutical and the agrochemical industries. These chemicals are produced under cgmp conditions, in volumes between 1 and 100 metric tons. 3. ther Fine Chemicals (page 12) The applications for these chemicals also lie mostly in the pharmaceutical and agrochemical area. More specifically, we offer you a range of substituted Pyrimidines (page 12), Pyridines (page 14) and Pyrazoles (page 15). These chemicals are produced under cgmp conditions, in volumes between 5 kg and 2 metric tonnes. For your convenience, all products are listed alphabetically at the back of this Product list (page 22), followed by a cross reference table with the corresponding CAS numbers

3 Custom chemical synthesis Katwijk Chemie is also a strong partner in Custom chemical synthesis, producing exclusive products for specific customers, with a focus on volumes between 100 kg and 50 metric tonnes. We guarantee full confidentiality, a quick scaling up from Lab to Commercial, and a long term relationship based on mutual trust. Chemical Experience The following types of organic reactions fall within our current scope: Additions with Isocyanates or Sodium cyanide Aminations with Ammonia Condensations Types: Aldol, Benzoin, Claisen and Knoevenagel Malonic ester synthesis Syntheses of heterocycles (e.g. pyrimidines, pyrrolidines, imidazolidines and phthalimides) Derivatisations Esterification to n-alkyl esters Preparations of imines Preparations of phthalimides Pinner reaction Eliminations with ydazine xidations with ydrogen peroxide or Potassium permanganate Equipment Katwijk Chemie is using the following equipment: - Glass lined reactors with volumes of 0.1 m 3 to 4 m 3, equipped with fractionating columns - Stainless steel reactors with volumes of 1 m 3 to 8 m 3 - Stainless steel fractionating installations, with volumes of 3 m 3, a minimum pressure of 5 Torr, and a maximum bottom temperature of 170º C. ne of these installations has been equipped for the distillation of solidifying liquids (melting points up to 55º C) - Stainless steel centrifuges and astelloy centrifuges - Spray dryer, fluid bed dryers, mixing screw vacuum dryers, vacuum paddle dryer. - Elevated temperature storage (to melt solid raw materials) - 3 -

4 Active Pharmaceutical Ingredients Anti-epileptics Calcium Valproate Calcium Dipropylacetate hydrate CAS: , EIECS: , REAC: exempted o DMF available [(C 3 -C 2 -C 2 ) 2 CC - ] 2 Ca ++ Therapeutic category: anti-epileptic, anti migraine, treatment of bipolar mood disorder Divalproex sodium Sodium divalproate CAS: , EIECS: not registered, REAC: exempted DMF: USA, Canada, Europe, India (C 3 -C 2 -C 2 ) 2 CC - (C 3 -C 2 -C 2 ) 2 CC a+ Therapeutic category: anti-epileptic, anti migraine, treatment of bipolar mood disorder Ethosuximide 2-Ethyl-2-methylsuccinimide CAS: , EIECS: , REAC: exempted DMF: USA, Europe, Japan, Australia, ew Zealand, India 3 C C 2 5 Therapeutic category: anti-epileptic Magnesium Valproate Magnesium Dipropylacetate hydrate CAS: , EIECS: , REAC: exempted DMF: Europe, (Mexico) [(C 3 -C 2 -C 2 ) 2 CC - ] 2 Mg ++ Therapeutic category: anti-epileptic, anti migraine, treatment of bipolar mood disorder - 4 -

5 Active Pharmaceutical Ingredients Phenylethylacetylurea Pheneturide, Ethylphenacemide CAS: , EIECS: , REAC: exempted o DMF available Therapeutic category: anti-epileptic C Phenytoin 5,5-Diphenylhydantoin CAS: , EIECS: , REAC: exempted C 6 5 DMF : USA, Canada, Europe, Japan, Australia, ew Zealand, South Africa Therapeutic category: anti-epileptic, ulcer treatment C 6 5 Phenytoin Calcium 5,5-Diphenylhydantoin Calcium Salt CAS: , EIECS: , REAC: exempted o DMF available C 6 5 C Ca 2+ Therapeutic category: anti-epileptic Phenytoin Sodium 5,5-Diphenylhydantoin Sodium Salt CAS: , EIECS: , REAC: exempted C 6 5 a + DMF: USA, Canada, Europe, Australia, ew Zealand, South Africa, India, Moldova, Singapore C 6 5 Therapeutic category: anti-epileptic Sodium Valproate Sodium Dipropylacetate CAS: , EIECS: , REAC: exempted DMF: USA, Canada, Europe, Europe CoS (R1-CEP and R0-CEP ), Japan, Australia, ew Zealand, India, Singapore (C 3 -C 2 -C 2 ) 2 CC - a + Therapeutic category: anti-epileptic, anti migraine, treatment of bipolar mood disorder - 5 -

6 Active Pharmaceutical Ingredients Valdisoval A mixture of Sodium Valproate and valproic acid (2 : 1 molar) CAS, EIECS: not registered, REAC: exempted DMF available ((C 3 -C 2 -C 2 ) 2 CC - ) 2 a 2 (C 3 -C 2 -C 2 ) 2 CC Therapeutic category: anti-epileptic, anti migraine, treatment of bipolar mood disorder Valproic Acid Dipropylacetic Acid CAS : , EIECS: , REAC: exempted DMF : USA, Canada, Europe, Europe CoS (R1-CEP ), South Africa, India (C 3 -C 2 -C 2 ) 2 CC Therapeutic category: anti-epileptic, anti migraine, treatment of bipolar mood disorder Valpromide Dipropylacetamide CAS: , EIECS: , REAC: exempted (C 3 -C 2 -C 2 ) 2 CC 2 o DMF available Therapeutic category: anti-epileptic ther Therapeutic Categories Deferiprone 1,2-Dimethyl-3-hydroxy-4-pyridone CAS: , EIECS: not registered, REAC: exempted DMF: USA, Europe, India C 3 Therapeutic category: oral iron chelator C 3-6 -

7 Active Pharmaceutical Ingredients Magnesium Pemoline CAS: , EIECS: not registered, REAC: exempted Mixture of Magnesium hydroxyde and Pemoline C o DMF available Therapeutic category: CS-stimulant. Mg() 2 Controlled substance xaprozin 3-(4,5-Diphenyl-2-oxazolyl)propionic Acid C 6 5 CAS: , EIECS: , REAC: exempted C 2 C 2 C DMF: USA, Canada, India C 6 5 Therapeutic category: anti-inflammatory (SAID), analgesic (arthritis) Pemoline 4-xo-2-imino-5-phenyloxazolidine, Phenylpseudohydantoin CAS: , EIECS: , REAC: exempted C DMF: USA, Canada, Europe, Japan Therapeutic category: CS-stimulant Controlled substance Phthalylsulfacetamide 1 -Acetyl- 4 -phthalylsulfanilamide CAS: , EIECS: , REAC: exempted o DMF available S 2 CC 3 C Therapeutic category: anti-bacterial Sulfacetamide 1 -Acetylsulfanilamide CAS: , EIECS: , REAC: exempted DMF: USA, Canada, Europe Therapeutic category: anti-bacterial 2 S 2 CC 3-7 -

8 Active Pharmaceutical Ingredients Sulfacetamide Sodium 1 -Acetylsulfanilamide Monosodium Salt Monohydrate CAS: , ; EIECS: , REAC: exempted 2 S 2 acc 3 DMF: USA, Canada, Europe, Europe CoS (R0-CEP ), ew Zealand Therapeutic category: anti-bacterial (acne, dermatitis, ocular inflammations) - 8 -

9 Fine Chemicals Bulk Fine Chemicals Benzil 1,2-Diphenyl-1,2-ethanedione CAS: , EIECS: REAC: preregistered, reference nr Intermediate for API production, photo initiator Regulated under PCW Benzilic Acid Diphenylglycolic Acid CAS: , EIECS: REAC: preregistered, reference nr Minimum purity 99.5 % Intermediate for API production Regulated under PCW C Benzoin 2-ydroxy-1,2-diphenylethanone, Benzoyl phenyl carbinol CAS: , EIECS: REAC: preregistered, reference nr Intermediate for production of actives, used in powder coatings, photo initiator - 9 -

10 Fine Chemicals 2-Bromoethanesulfonic Acid Sodium Salt Sodium 2-bromoethanesulfonate CAS: , EIECS: REAC: preregistered, reference nr Br-C 2 -C 2 -S 3 a Minimum purity 98.0 % Intermediate for production of APIs, photochemicals and buffer substances -(2-Bromoethyl)-phthalimide CAS: , EIECS: REAC: preregistered, reference nr Minimum purity 99.5 % Intermediate for API production Br -(3-Bromopropyl)-phthalimide CAS: , EIECS: REAC: preregistered, reference nr Minimum purity 99.5 % Intermediate for API production Br Ethyl Benzilate Benzilic Acid Ethyl Ester, Ethyl Diphenylglycolate CAS: , EIECS: REAC: preregistered, reference nr Minimum purity 96.0 % Intermediate for API production Regulated under PCW CC 2 5 -(2-ydroxyethyl)-phthalimide 2-Phthalimidoethanol CAS: , EIECS: REAC: preregistered, reference nr Intermediate for API production

11 Fine Chemicals Methyl Benzilate Benzilic Acid Methyl Ester, Methyl Diphenylglycolate CAS: , EIECS: REAC: preregistered, reference nr C 3 Intermediate for API production Regulated under PCW -Phthaloylglycine Phthalimidoacetic Acid CAS: , EIECS: REAC: preregistered, reference nr Minimum purity 99.5 % Intermediate for production of active for X-ray contrast fluids C Sulfanilamide 4-Aminobenzenesulfonamide CAS: , EIECS: REAC: preregistered, reference nr S 2 2 Intermediate for API production, API (antibacterial)

12 Fine Chemicals ther Fine Chemicals - Pyrimidines 5-Amino-4,6-dihydroxy-2-methylpyrimidine CAS: , EIECS: not registered REAC: preregistered, reference nr Minimum purity 98.0 % C 3 5-Amino-4,6-dihydroxypyrimidine CAS: , EIECS: not registered REAC: preregistered, reference nr Minimum purity 95.0 % 2-Amino-4,6-dimethylpyrimidine C 3 CAS: , EIECS: REAC: preregistered, reference nr C Amino-4-hydroxy-6-isopropyrimidine CAS: , EIECS: not registered, REAC: preregistered, reference nr Amino-4-hydroxy-6-methylpyrimidine 6-Methyl-isocytosine CAS: , EIECS: REAC: preregistered, reference nr C

13 Fine Chemicals 4-Amino-6-hydroxy-2-methylpyrimidine Dihydrate 6-Amino-2-methyl-4-pyrimidinol 2 CAS: , EIECS: REAC: preregistered, reference nr Minimum purity 98.0 % 2 2 C 3 4,6-Dihydroxy-2-methylpyrimidine CAS: , EIECS: REAC: preregistered, reference nr C 3 2,4-Dimethyl-6-hydroxypyrimidine C 3 CAS: , EIECS: REAC: preregistered, reference nr C 3 4,6-Dimethyl-2-hydroxypyrimidine 4,6-Dimethyl-2-pyrimidinol CAS: , EIECS: C 3 REAC: preregistered, reference nr C 3 4,6-Dimethyl-2-hydroxypyrimidine ydrochloride C 3 CAS: , EIECS: REAC: preregistered, reference nr CL 3 C 2-ydroxy-4-methylpyrimidine ydrochloride 4-Methyl-2-pyrimidinol C 3 CAS: , EIECS: Cl REAC: preregistered, reference nr Minimum purity 98.0 %

14 Fine Chemicals 2-ydroxypyrimidine Sulphate 2-Pyrimidinol Sulphate CAS: , EIECS: not registered. 2 S 4 REAC: preregistered, reference nr Minimum purity 98.0 % ther Fine Chemicals - Pyridines 3-Carboxy-2-hydroxy-6-methylpyridine 2-hydroxy-6-methylnicotinic acid C CAS: , EIECS: REAC: preregistered, reference nr C 3 Minimum purity 98.0 % 3-Cyano-2-hydroxy-6-methylpyridine 3-Cyano-6-methyl-2(1)-pyridinone C CAS: , EIECS: REAC: preregistered, reference nr C 3 Minimum purity 98.0 % 2-ydroxy-6-methylpyridine CAS: , EIECS: REAC: preregistered, reference nr C 3 Minimum purity 97.0 % 2,5-Pyridinedicarboxylic Acid Isocinchomeronic Acid C CAS: , EIECS: REAC: preregistered, reference nr C

15 Fine Chemicals 3,4-Pyridinedicarboxylic Acid Cinchomeronic Acid CAS: , EIECS: REAC: preregistered, reference nr C C 3,5-Pyridinedicarboxylic Acid Dinicotinic Acid CAS: , EIECS: C C REAC: preregistered, reference nr ,4-Pyridinedicarboxylic Acid Monohydrate Lutidinic Acid C CAS: , EIECS: REAC: preregistered, reference nr Minimum purity 98.0 % C ther Fine Chemicals Pyrazoles 3-Amino-4-carbethoxypyrazole CC 2 5 Ethyl 3-amino-4-pyrazolecarboxylate CAS: , EIECS: REAC: preregistered, reference nr Amino-5-hydroxypyrazole CAS: , EIECS REAC: preregistered, reference nr Minimum purity 98.3 %

16 Fine Chemicals 3,5-Dimethylpyrazole CAS: , EIECS: REAC: preregistered, reference nr Pyrazole-1-carboxamidine hydrochloride 1-Amidinopyrazole hydrochloride CAS: , EIECS: Cl REAC: preregistered, reference nr Pyrazole-1-carboxamidine sulfate CAS: not registered REAC: preregistered, reference nr S 4 3,5-Pyrazoledicarboxylic Acid Diethyl Ester CAS: , EIECS: not registered EtC CEt REAC: preregistered, reference nr ,5-Pyrazoledicarboxylic Acid Monohydrate CAS: , EIECS: C C REAC: preregistered, reference nr

17 Fine Chemicals ther Fine Chemicals -Acetyl glycine CAS: , EIECS: C 3 C()C 2 C REAC: preregistered, reference nr Amino-4,6-dihydroxypteridine Monohydrate Xanthopterin CAS: , EIECS: not registered REAC: preregistered, reference nr Minimum purity 97.0 % 5-Benzimidazolecarboxylic Acid CAS: , EIECS: not registered REAC: preregistered, reference nr C Minimum purity 92.0 % -Benzylideneaniline CAS: , EIECS: REAC: preregistered, reference nr (S)--(1-Bromo-2-propyl)-phthalimide CAS: not available, EIECS: not available REAC: preregistered, reference nr C 3 Br Minimum purity 98.0 %; optical purity 95 %

18 Fine Chemicals 5-n-Butyl barbituric acid CAS: , EIECS: Bu REAC: preregistered, reference nr Butylphthalimide CAS: , EIECS: REAC: ot preregistered Chalcone Benzalacetophenone, 1,3-Diphenyl-3-propen-1-one CAS: , EIECS: REAC: preregistered, reference nr Minimum purity 97.0 % (+)-4-Cholesten-3-one CAS: , EIECS: REAC: preregistered, reference nr Minimum purity 98.0 % Cyanoacetyl urea CAS: , EIECS: CC 2 C()C() 2 REAC: preregistered, reference nr Cyclohexyl-5-ethyl barbituric acid CAS: , EIECS: Et REAC: preregistered, reference nr Minimum purity 99.6 %

19 Fine Chemicals 2,5-Dihydroxy-1,4-benzoquinone CAS: , EIECS: REAC: preregistered, reference nr Minimum purity 98.0 % 4,4 -Dimethylbenzil Di-p-Tolylethanedione CAS: , EIECS: REAC: preregistered, reference nr Minimum purity 99.8 % 2,5-Dimethyl benzoxazole CAS: , EIECS: REAC: preregistered, reference nr ,2-Diphenyl acetic acid α-phenylbenzene acetic acid CAS: , EIECS: (C 6 5 ) 2 CC REAC: preregistered, reference nr Minimum purity 98.0 % 2,2-Diphenyl glycine α,α-diphenylglycine CAS: , EIECS: (C 6 5 ) 2 C( 2 )C REAC: preregistered, reference nr Minimum purity 98.0 %

20 Fine Chemicals 4,5-Diphenyl imidazole CAS: , EIECS: REAC: preregistered, reference nr Glycofurol CAS: CAS: , EIECS: CAS: , EIECS: REAC : exempted (n=1+2) n = 1,2 n Excipient (solvent for Injectables) -(3-ydroxypropyl)-phthalimide 3-Phthalimido-1-propanol CAS: , EIECS: REAC: preregistered, reference nr Minimum purity 99.0% 1-Indazole CAS: , EIECS: REAC: ot preregistered Melatonin -(2-(5-methoxyindol-3-yl)ethyl)acetamide CAS: , EIECS: REAC: exempted API used with sleep disorders and jet lag (no DMF available)

21 Fine Chemicals D,L-2-Phenylsuccinic Acid D,L-2-Phenylbutanedioic Acid CAS: , EIECS: REAC: preregistered, reference nr Minimum purity 98.0 % C C Application chemical in the electronic industry Phthalhydrazide 2,3-Dihydro-1,4-phthalazinedione CAS: , EIECS: REAC: preregistered, reference nr m-tolyl Acetic acid CAS , EIECS: REAC: preregistered, reference nr C

22 Product index Product index -Acetyl glycine 17 3-Amino-4-carbethoxypyrazole 15 5-Amino-4,6-dihydroxy-2-methylpyrimidine 12 2-Amino-4,6-dihydroxypteridine Monohydrate 17 5-Amino-4,6-dihydroxypyrimidine 12 2-Amino-4,6-dimethylpyrimidine 12 2-Amino-4-hydroxy-6-isopropylpyrimidine 12 2-Amino-4-hydroxy-6-methylpyrimidine 12 4-Amino-6-hydroxy-2-methylpyrimidine Dihydrate 13 3-Amino-5-hydroxypyrazole 15 Benzil 9 Benzilic Acid 9 5-Benzimidazolecarboxylic Acid 17 Benzoin 9 -Benzylideneaniline 17 2-Bromoethanesulfonic Acid Sodium Salt (BES a) 10 -(2-Bromoethyl)-phtalimide (BREPI) 10 -(3-Bromopropyl)-phthalimide (BRPPI) 10 (S)--(1-Bromo-2-propyl)phthalimide 17 5-n-Butyl barbituric acid (BUBA) 18 -Butylphthalimide 18 Calcium Valproate 4 3-Carboxy-2-hydroxy-6-methylpyridine 14 Chalcone 18 (+)-4-Cholesten-3-one 18 Cyanoacetyl urea 18 3-Cyano-2-hydroxy-6-methylpyridine 14 1-Cyclohexyl-5-ethyl barbituric acid (CEBA) 18 Deferiprone (DMP) 6 2,5-Dihydroxy-1,4-benzoquinone 19 4,6-Dihydroxy-2-methylpyrimidine 13 4,4 -Dimethylbenzil 19 2,5-Dimethyl benzoxazole 19 2,4-Dimethyl-6-hydroxypyrimidine 13 4,6-Dimethyl-2-hydroxypyrimidine 13 4,6-Dimethyl-2-hydroxypyrimidine ydrochloride 13 3,5-Dimethylpyrazole 16 2,2-Diphenyl acetic acid 19 2,2-Diphenyl glycine 19 4,5-Diphenyl imidazole 19 Divalproex Sodium 4 Ethosuximide 4 Ethyl benzilate 10 Glycofurol 20 -(2-ydroxyethyl)-phthalimide (EPI) 10 2-ydroxy-6-methylpyridine 14 2-ydroxy-4-methylpyrimidine ydrochloride 13 -(3-ydroxypropyl)-phthalimide (YPPI) 20 2-ydroxypyrimidine Sulphate 14 1-Indazole

23 Product index Magnesium Pemoline 7 Magnesium Valproate 4 Melatonin 20 Methyl benzilate 11 xaprozin 7 Pemoline 7 Phenylethylacetylurea (PEAU) 5 D,L-2-Phenylsuccinic Acid 21 Phenytoin 5 Phenytoin Calcium 5 Phenytoin Sodium 5 Phthalhydrazide 21 -Phthaloylglycine (GLYPI) 11 Phthalylsulfacetamide 7 1-Pyrazole-1-carboxamidine hydrochloride 16 1-Pyrazole-1-carboxamidine sulfate 16 2,4-Pyridinedicarboxylic Acid Monohydrate 15 2,5-Pyridinedicarboxylic Acid 14 3,4-Pyridinedicarboxylic Acid 15 3,5-Pyridinedicarboxylic Acid 15 3,5-Pyrazoledicarboxylic Acid Monohydrate 16 3,5-Pyrazoledicarboxylic Acid Diethyl Ester 16 Sodium Valproate 5 Sulfacetamide 7 Sulfacetamide Sodium 8 Sulfanilamide 11 m-tolyl Acetic acid 21 Valdisoval 6 Valproic Acid 6 Valpromide 6 Xantopterin

24 Product index CAS numbers cross reference table CAS number Product name Phenytoin Sulfanilamide ,5-Dimethylpyrazole Melatonin Methyl benzilate Benzilic Acid Ethosuximide Phenylethylacetylurea Chalcone Valproic Acid ,5-Pyridinedicarboxylic Acid ,6-Dimethyl-2-hydroxypyrimidine ,2-Diphenyl acetic acid Benzoin Phthalylsulfacetamide Benzil Sulfacetamide Indazole ,4-Pyridinedicarboxylic Acid ,4-Pyridinedicarboxylic Acid Monohydrate ,5-Pyridinedicarboxylic Acid Benzylideneaniline Acetyl glycine (2-Bromoethyl)phthalimide Benzoin (+)-4-Cholesten-3-one ,5-Dihydroxy-1,4-benzoquinone m-tolyl Acetic acid Phenytoin Sodium D,L-2-Phenylsuccinic Acid ,5-Diphenyl imidazole Amino-4,6-dimethylpyrimidine Amino-6-hydroxy-2-methylpyrimidine Dihydrate Cyclohexyl-5-ethyl barbituric acid (3-ydroxypropyl)phthalimide Sodium Valproate Phthalhydrazide Butylphthalimide n-Butyl barbituric acid Pemoline Valpromide ,2-Diphenyl glycine ,5-Pyrazoledicarboxylic Acid Monohydrate ydroxy-6-methylpyridine ,4 -Dimethylbenzil (2-ydroxyethyl)phthalimide Amino-4-hydroxy-6-methylpyrimidine

25 Product index Pyrazole-1-carboxamidine hydrochloride Cyano-2-hydroxy-6-methylpyridine Bromoethanesulfonic Acid Sodium Salt Phthaloylglycine ydroxy-4-methylpyrimidine ydrochloride ,1-Cyclobutane dicarboxylic acid (3-Bromopropyl)phthalimide ,5-Dimethyl benzoxazole Xanthopterin Amino-5-hydroxypyrazole Sulfacetamide Sodium ,4-Dimethyl-6-hydroxypyrimidine Amino-4-carbethoxypyrazole ydroxy-6-methylpyridine Benzimidazolecarboxylic Acid Phenytoin Calcium Magnesium Pemoline xaprozin Deferiprone Glycofurol Calcium Valproate ,6-Dimethyl-2-hydroxypyrimidine ydrochloride ,5-Pyrazoledicarboxylic Acid Diethyl Ester Carboxy-2-hydroxy-6-methylpyridine ,6-Dihydroxy-2-methylpyrimidine Ethyl benzilate Magnesium Valproate Amino-4,6-dihydroxypyrimidine Divalproex Sodium ydroxypyrimidine Sulphate Amino-4,6-dihydroxy-2-methylpyrimidine ,4-Pyridinedicarboxylic Acid Monohydrate Amino-4-carbethoxypyrazole Amino-4-hydroxy-6-isopropylpyrimidine

26 Product index Katwijk Chemie Mailing address: P.. Box CA Katwijk Z The etherlands Visitor s address: Snijderstraat BA Katwijk Z The etherlands Telephone +31 (0) Fax +31 (0) [email protected] Website