Studie Geneeskunde, Universiteit Leiden Co-schappen, Leids Universitair Medisch Centrum (cum laude)
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1 Curriculum Vitae Curriculum Vitae Lara Maria Leijser Geboren op 17 oktober 1978 te Goirle, Nederland V.W.O., Koning Willem II College, Tilburg Studie Biomedische Wetenschappen, Universiteit Leiden Stage afdeling Radiologie, Leids Universitair Medisch Centrum (Dr. L. Liauw, Prof. Dr. M.A. van Buchem) Stage en scriptie afdeling Kindergeneeskunde, divisie Neonatologie, Leids Universitair Medisch Centrum (Dr. Ir. G.T.M. Wagenaar, Prof. Dr. F.J. Walther) Studie Geneeskunde, Universiteit Leiden Co-schappen, Leids Universitair Medisch Centrum (cum laude) Wetenschappelijk onderzoek (extra-curriculair) 2001 Afdeling Neurologie, Leids Universitair Medisch Centrum (Dr. L.A.E.M. Laan) Afdeling Kindergeneeskunde, divisie Neonatologie, Leids Universitair Medisch Centrum (Dr. G. van Wezel-Meijler) 327
2 Curriculum Vitae Clinical Research Fellow, Department of Paediatrics and Neonatal Medicine, Hammersmith Hospital, Londen, Engeland (Dr. F.M. Cowan, Prof. Dr. M.A. Rutherford) Sinds 2006 Promotie-onderzoek (ZonMw-Agiko), afdeling Kindergeneeskunde, divisie Neonatologie, Leids Universitair Medisch Centrum. Titel: Imaging the preterm infant s brain (Prof. Dr. F.J. Walther, Dr. G. van Wezel-Meijler) Sinds 2009 Opleiding Kindergeneeskunde Juliana Kinderziekenhuis, HagaZiekenhuis, Den Haag (Dr. F. Brus) Leids Universitair Medisch Centrum, Leiden (Drs. R.N. Sukhai) 328
3 List of publications List of publications van Wezel-Meijler G, Steggerda SJ, Leijser LM. Cranial ultrasonography in neonates: its role and limitations. Semin Perinatol 2010, in press. Review Leijser LM, Steggerda SJ, de Bruïne FT, van Zuijlen A, van Steenis A, Walther FJ, van Wezel-Meijler G. Lenticulostriate vasculopathy in very preterm infants. Arch Dis Child Fetal Neonatal Ed 2009 May 19 [Epub ahead of print] van Wezel-Meijler G, Leijser LM, de Bruïne FT, Steggerda SJ, van der Grond J, Walther FJ. Magnetic resonance imaging of the brain in newborn infants: practical aspects. Early Hum Dev 2009; 85(2): Review Steggerda SJ, Leijser LM, Walther FJ, van Wezel-Meijler G. Neonatal cranial ultrasonography: how to optimize its performance. Early Hum Dev 2009; 85(2): Review Leijser LM, de Bruïne FT, Steggerda SJ, van der Grond J, Walther FJ, van Wezel-Meijler G. Brain imaging findings in very preterm infants throughout the neonatal period: Part I. Incidences and evolution of lesions, comparison between ultrasound and MRI. Early Hum Dev 2009; 85(2): Leijser LM, Steggerda SJ, de Bruïne FT, van der Grond J, Walther FJ, van Wezel-Meijler G. Brain imaging findings in very preterm infants throughout the neonatal period: Part II. Relation with perinatal clinical data. Early Hum Dev 2009; 85(2): Steggerda SJ, Leijser LM, Wiggers-de Bruïne FT, van der Grond J, Walther FJ, van Wezel- Meijler G. Cerebellar injury in preterm infants: incidence and findings on US and MRI. Radiology 2009; 252(1): Leijser LM, Srinivasan L, Rutherford MA, van Wezel-Meijler G, Counsell SJ, Allsop JM, Cowan FM. Frequently encountered cranial ultrasound features in the white matter of preterm infants: correlation with MRI. Eur J Paediatr Neurol 2009; 13(4):
![Arch Dis Child Fetal Neonatal Ed 2009 May 19 [Epub ahead of print] van Wezel-Meijler G, Leijser LM, de Bruïne FT, Steggerda SJ, van der Grond J, Walther FJ.](/docs-images/45/11525736/images/page_3.jpg "Magnetic resonance imaging of the brain in newborn infants: practical aspects. Early Hum Dev 2009; 85(2): 85-92. Review Steggerda SJ, Leijser LM, Walther FJ, van Wezel-Meijler G.")
4 List of publications Leijser LM, Liauw L, Veen S, de Boer IP, Walther FJ, van Wezel-Meijler G. Comparing brain white matter on sequential cranial ultrasound and MRI in very preterm infants. Neuroradiology 2008; 50(9): Leijser LM, Vein AA, Liauw L, Strauss T, Veen S, Wezel-Meijler G. Prediction of short-term neurological outcome in full-term neonates with hypoxic-ischaemic encephalopathy based on combined use of electroencephalogram and neuro-imaging. Neuropediatrics 2007; 38(5): Soares-Fernandes JP, Teixeira-Gomes R, Cruz R, Ribeiro M, Magalhães Z, Rocha JF, Leijser LM. Neonatal pyruvate dehydrogenase deficiency due to a R302H mutation in the PDHA1 gene: MRI findings. Pediatr Radiol 2008; 38(5): Leijser LM, de Vries LS, Rutherford MA, Manzur AY, Groenendaal F, de Koning TJ, van der Heide-Jalving M, Cowan FM. Cranial ultrasound in metabolic disorders presenting in the neonatal period: characteristic features and comparison with MR imaging. AJNR Am J Neuroradiol 2007; 28(7): Leijser LM, Srinivasan L, Rutherford MA, Counsell SJ, Allsop JM, Cowan FM. Structural linear measurements in the newborn brain: accuracy of cranial ultrasound compared to MRI. Pediatr Radiol 2007; 37(7): Leijser LM, Cowan FM. State-of-the-Art Neonatal cranial ultrasound. Ultrasound 2007; 15(1): Review Liauw L, Palm-Meinders IH, van der Grond J, Leijser LM, le Cessie S, Laan LA, Heeres BC, van Buchem MA, van Wezel-Meijler G. Differentiating normal myelination from hypoxicischemic encephalopathy on T1-weighted MR images: a new approach. AJNR Am J Neuroradiol 2007; 28(4): Leijser LM, de Vries LS, Cowan FM. Using cerebral ultrasound effectively in the newborn infant. Early Hum Dev 2006; 82(12): Review 330
5 List of publications Leijser LM, Klein RH, Veen S, Liauw L, van Wezel-Meijler G. Hyperechogenicity of the thalamus and basal ganglia in very preterm infants: radiological findings and shortterm neurological outcome. Neuropediatrics 2004; 35(5): Wagenaar GT, ter Horst SA, van Gastelen MA, Leijser LM, Mauad T, van der Velden PA, de Heer E, Hiemstra PS, Poorthuis BJ, Walther FJ. Gene expression profile and histopathology of experimental bronchopulmonary dysplasia induced by prolonged oxidative stress. Free Radic Biol Med 2004; 36(6):
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7 List of abbreviations List of abbreviations ADC Apparent diffusion coefficient AF Anterior fontanel BG Basal ganglia BGT Basal ganglia and/or thalamus BPD Bronchopulmonary dysplasia CBFV Cerebral blood flow velocity CI Confidence interval CP Cerebral palsy CT Computed tomography cus Cranial ultrasonography / ultrasound CV Convex DEHSI Diffuse and excessive high signal intensity (in the periventricular and/or subcortical white matter) DTI Diffusion-tensor imaging DWI Diffusion-weighted imaging ECS Extracerebral spaces EG-BGT Echogenicity of the basal ganglia and/or thalami region FA Fractional anisotropy FLAIR Fluid-attenuated inversion recovery GA Gestational age GM Grey matter HC Head circumference HIE Hypoxic-ischaemic encephalopathy HPI Parenchymal haemorrhage IHF Interhemispheric fissure IPE Intraparenchymal echodensity iv Intravenous IVH Intraventricular haemorrhage LA Linear array LSV Lenticulostriate vasculopathy LV Lateral ventricles 333
8 List of abbreviations MCA Middle cerebral artery MDI Mental developmental index MF Mastoid fontanels MR Magnetic resonance MRI Magnetic resonance imaging NEC Necrotizing enterocolitis NPV Negative predictive value OR Odds ratio PA Phased array PDA Patent ductus arteriosus PDI Psychomotor developmental index PF Posterior fontanel PHVD Post-haemorrhagic ventricular dilatation PI Pulsatility index P/IVH Peri- and intraventricular haemorrhages PLIC Posterior limb of the internal capsule PMA Postmenstrual age PPV Positive predictive value PVE Periventricular echodensities / echogenicity PVHI Periventricular haemorrhagic infarction PVL Periventricular leukomalacia PWML Punctate white matter lesions RDS Respiratory distress syndrome RI Resistance index ROI Region of interest SI Signal intensity SNR Signal-to-noise ratio TE Echo time TEA Term equivalent age TORCH Toxoplasmosis, Other, Rubella, Cytomegalovirus, Herpes (includingparvo B19) TR Repetition time TW Temporal windows WM White matter 334
9 Authors and affiliations Authors and affiliations From the department of Paediatrics, division of Neonatology, Leiden University Medical Center, Leiden, the Netherlands: Lara Leijser, Gerda van Wezel-Meijler, Sylke Steggerda, Frans Walther, Sylvia Veen, Inge de Boer, Richard Klein, Ankie van Zuijlen, Andrea van Steenis From the department of Radiology, division of Neuroradiology, Leiden University Medical Center, Leiden, the Netherlands: Francisca de Bruïne, Jeroen van der Grond, Lishya Liauw From the departments of Paediatrics and Neonatal Medicine, Hammersmith Hospital, Imperial College London, London, United Kingdom: Frances Cowan From the department of Imaging Sciences, Robert Steiner MR Unit, MRC Clinical Sciences Center, Hammersmith Hospital, Imperial College London, London, United Kingdom: Mary Rutherford, Latha Srinivasan, Serena Counsell, Joanna Allsop From the department of Neonatology, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, the Netherlands: Linda de Vries 335
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