International Symposium Xenotransplantation

Transcription

1 International Symposium DFG-Transregio Research Group (FOR 535) together with the Robert Koch Institute Berlin 9th Minisymposium of the German Working Group (DAX) June 2006, Robert Koch Institute, Berlin Contact: Dr. Joachim Denner Robert Koch Institute Nordufer 20 D Berlin Germany Tel Fax [email protected] Secretary [email protected] [email protected] DAX Deutsche Arbeitsgemeinschaft für

2 International Symposium DFG-Transregio Research Group (FOR 535) together with the 9th Minisymposium of the German Working Group (DAX) June 2006, Robert Koch Institute, Berlin 2

3 Program Wednesday, June 07, Speaker s dinner Thursday, June 08, Opening Prof. Dr. Reinhard Kurth, President, Robert Koch-Institute, Berlin Aims and Status of the German DFG-Transregio Research Group Prof. Dr. Bruno Reichart, Dept. of Cardiac Surgery, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany Generation and characterisation of multi-transgenic pigs Cardiac : Current Status and Road to the Clinic Prof. Christopher G. A. McGregor, M.B., F.R.C.S., M.D., Mayo Clinic, Saint Marys Hospital, Rochester, USA Transgenic Animals in Experimental Models: Orthotopic Heart Transplantations in the Pig-to-Baboon Model PD Dr. Michael Schmoeckel, Dept. of Cardiac Surgery, Klinikum Großhadern, Ludwig-Maximilians-University, Munich, Germany Coffee break Production of Multi-gene Trangenic Pigs for by Sperm Mediated Gene Transfer (SMGT) Prof. Maria Luisa Lavitrano, Ph.D, Dipartimento Medicina Sperimentale Ambientale Biotecnologie Mediche, Universita di Milano-Bicocca, Monza, Italy Advances in Somatic Cloning of Multi-transgenic Pigs for Research Prof. Dr. Heiner Niemann, Dept. Biotechnology, Institute of Animal Science, Mariensee, Neustadt, Germany 3

4 Transgenic Strategies to Overcome Cellular Rejection of Pig-to-Primate Xenografts Prof. Dr. Eckhard Wolf, Institute of Molecular Animal Breeding and Biotechnology, Gene Centre, Ludwig-Maximilians-University, Munich, Germany Lunch / Press conference Reactivation of Silenced Tetracycline-controlled hrca Constructs in Transgenic Pigs Dr. Wilfried Kues, Dept. Biotechnology, Institute of Animal Science, Mariensee, Neustadt, Germany Targeting of Alpha-Galactosyltransferase with Lentiviral shrna Vectors Prof. Dr. Alexander Pfeifer, Molecular Pharmacology, Dept. of Pharmacy, Centre for Drug Research, Ludwig-Maximilians- University, Munich, Germany Strategies for Viral Gene Delivery into the Cardiovascular System Prof. Dr. Andrew H. Baker, BHF Glasgow, Cardiovascular Research Centre, University of Glasgow, Glasgow, UK AAV a Promising Vector with Secrets Dr. Hildegard Büning, Clinic I for Internal Medicine, University Cologne, Germany AAV-Mediated Gene Transfer into Cardiac Endothelial Cells in Heterotopic Heart Transplantation Models Lars Burdorf, Dept. of Cardiac Surgery, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany Coffee break Immunological aspects HLA Expression on Porcine Endothelial Cells to Prevent Human Anti- Porcine NK Cell Reactions Prof. Dr. Jörg Seebach, Laboratory for Transplantation Immunology, Dept. of Internal Medicine, University Hospital Zurich, Switzerland Modulation of Human Anti-pig T-cell Responses by Species-Specific Antibodies Prof. Dr. Reinhard Schwinzer, Transplantationslabor, Klinik für Viszeral- und Transplantationschirurgie, Medizinische Hochschule Hannover, Germany 4

5 Analysis of Disorders of Coagulation Following Discordant Xeno-Kidney Perfusion Prof. Dr. Michael Winkler, Klinik für Viszeral- und Transplantationschirurgie, Medizinische Hochschule Hannover, Germany General Discussion Buffet/Get-Together Friday, June 09, 2006 Virological aspects PERV Evolution: Receptor and Recombination Dr. Yasuhiro Takeuchi, Wohl Viron Centre, London, UK Detection of Polytropic Replication-Competent PERV-A/-B and of Ecotropic PERV-C in Multitransgenic Pigs PD Dr. Ralf Tönjes, Paul Ehrlich Institute, Langen, Germany Expression of PERV in Multitransgenic Pigs and Inhibition of Virus Transmission by RNA Interference and Neutralising Antibodies Dr. Joachim Denner, Robert Koch Institute, Berlin, Germany General Discussion Coffee break Islet cell and hepatocyte xenotransplantation Recent progress in hepatocyte and islet xenotransplantation PD Dr. Leo H. Bühler, Surgical Research Unit, Department of Surgery, University Hospital, Geneva, Switzerland Pig-to-Human Islet : Why, Where, Who, and When? Prof. Bernhard J. Hering, M.D., Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, USA Lunch 5

6 Xenogenic Islet Transplantation: A Rocky Road to a Happy End? Prof. Dr. Karin Ulrichs, Chirurgische Klinik und Poliklinik Würzburg, Germany Immunsuppressiva New Immunosuppressiva for Allo- and Prof. Dr. Dietmar Abendroth, Dept. of Surgery, University of Ulm, Ulm, Germany Stem Cell Research Status and Development of Stem Cell Research in the Cardiovascular System Prof. Dr. Bernd Fleischmann, Institute of Physiology I, University Bonn, Bonn, Germany Strategies to Derive Patient-Specific Pluripotential Stem Cells Without Embryos Prof. Dr. Hans Schöler, Max Planck Institute of Molecular Biomedicine, Münster, Germany General Discussion Members and Projects of the German DFG-Transregio Research Group (FOR 535) Project I: Speaker: Public relations and Secretary Prof. Dr. med. Bruno Reichart Dept. of Cardiac Surgery Klinikum Grosshadern, Ludwig-Maximilians-University Marchioninistr. 15, D München, Germany [email protected] Project II: Improved transgenic pig lines for xenotransplantation Prof. Dr. med. vet. Heiner Niemann, Dr. Wilfried Kues, Joseph Carnwath, PhD Dept. Biotechnology Institute for Animal Science (FAL), Mariensee D Neustadt, Germany [email protected] Project III: Transgenic strategies to prevent complement activation and immune cell attack of pig organs in preclinical xenotransplantation models Prof. Dr. med. vet. Eckhard Wolf 1, Dr. rer. nat. Regina Klose 1, Prof. Dr. med. Alexander Pfeifer 2 1 Dept. of Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians-University, Feodor-Lynen-Str. 25, D München, Germany 2 Dept. of Pharmacy, Butenandtstr. 5C, D München [email protected] 6

7 Project IV: Analysis of xenogeneic activation of the human coagulation system in xenoperfused porcine kidneys and lungs Prof. Dr. med. Michael Winkler 1, Dr. med. Andreas Tiede 2 Dr. med. Lars Friedrich 3 Depts. of 1 Visceral- and Transplantation-Surgery, 2 Haematology and Oncology, 3 Anaesthesiology, Hannover Medical School, Carl-Neuberg- Str. 1, D Hannover [email protected] Project V: Multitransgenic animals and in vivo gene transfer in experimental xenotransplantation models Priv.-Doz. Dr. med. Michael Schmoeckel 1, Prof. Dr. med. Dr. med. vet. Claus Hammer 2, Priv.-Doz. Dr. med. Frank Christ 3 Depts. of Cardiac Surgery 1, Surgical Research 2 and Anesthesiology 3 Klinikum Grosshadern, Ludwig-Maximilians-University Marchioninistr. 15, D München, Germany [email protected] Project VI: Monoclonal antibodies to porcine cell surface molecules for the control of human anti-pig cellular immune responses Prof. Dr. rer. nat. Reinhard Schwinzer Transplantationslabor, Dept. of Visceral- and Transplantation-Surgery, Medizinische Hochschule Hannover, Carl-Neuberg- Str. 1, D Hannover [email protected] Project VII: Recombinant adeno-associated virus (raav)-mediated transgene delivery into porcine organs to allow immunological modification of xenografts Prof. Dr. med. Michael Hallek, Dr. Hildegard Büning, Dr. med. Ulrich Hacker, Dr. Susan King Internal Medicine I, University Cologne, Joseph-Stelzmann-Str. 9, D Koeln [email protected] Project VIII: Evaluation of the risk posed by porcine endogenous retroviruses (PERVs) from transgenic pigs Priv.-Doz. Dr. rer. nat. Ralf R. Tönjes 1 Dr. rer. nat. Joachim Denner 2 1 Paul Ehrlich Institut Langen, Paul-Ehrlich-Str , D Langen [email protected] 2 Robert Koch Institute, Nordufer 20, D Berlin [email protected] 7