I. REPORT FOCUS A. INTRODUCTION FUNCTIONS OF STEM CELLS STEM CELL APPLICATIONS STEM CELL MILESTONES DEFINITION AND IMPORTANCE STEM CELL DEBATE

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1 I. REPORT FOCUS A. INTRODUCTION FUNCTIONS OF STEM CELLS STEM CELL APPLICATIONS STEM CELL MILESTONES DEFINITION AND IMPORTANCE STEM CELL DEBATE CONCLUSION B. STEM CELLS - THE BEGINNING OF ALL BLOOD CELLS ADULT STEM CELLS EMBRYONIC STEM CELLS UMBILICAL CORD BLOOD STEM CELLS TOTIPOTENT STEM CELLS PLURIPOTENT STEM CELLS MULTIPOTENT STEM CELLS OLIGOPOTENT STEM CELLS UNIPOTENT STEM CELLS INDUCED PLURIPOTENT STEM CELLS (IPSCS) DISEASE DETECTION CHALLENGES TO CULTURE STANDARD GUIDELINE FOR IPS TECHNOLOGY C. ADVANCES IN STEM CELL RESEARCH D. SIMILARITIES AND DIFFERENCES BETWEEN EMBRYONIC AND ADULT STEM CELLS E. THE CONTROVERSY ON STEM CELL STEM CELLS BACKGROUND OUTLOOK ARGUMENT PROPER USE TRANSCENDENCE THE BEGINNING LIFE IMPORTANCE F. A REVIEW ON ADULT STEM CELLS THE ROLE OF ADULT STEM CELLS IN TISSUE REPAIR ADULT STEM CELLS AND CANCER FIRST TRANSPLANTATION OF HUMAN ORGAN GROWN FROM ADULT STEM CELLS ADVANTAGES OF ADULT BM CELLS TRANSPLANTATION IN CARDIOLOGY CONCLUSION G. A REVIEW ON EMBRYONIC STEM CELLS HISTORY MAJOR SUPPORT TO EMBRYONIC STEM CELL RESEARCH A COMBINED EFFORT CONFUSING LEGISLATION REWARDING THE DESERVING GOVERNMENTAL POLICY IN DIFFERENT REGIONS

2 AMERICANS UNITED STATES AFRICA EMBRYONIC STEM CELL RESEARCH CONTROVERSY CREATION OF EMBRYONIC CHARACTERISTICS FROM HUMAN UMBILICAL CORD BLOOD HUMAN EMBRYONIC STEM CELLS (HES) CLASSIFICATION AND DIFFERENTIATION ORIGIN, EXPANSION AND APPLICATIONS OF HUMAN EMBRYONIC STEM CELLS ADVANTAGES OF ES CELL TRANSPLANTATION IN CARDIOLOGY H. A REVIEW ON CORD BLOOD STEM CELLS ENHANCEMENTS USES OF CORD BLOOD BANKING FOCUS AND SCOPE OF COMPANIES INTO CORD BLOOD STEM CELLS BMSN (BIO-MATRIX SCIENTIFIC GROUP, INC.) MEDISTEM INC. CRYO-CELL INTERNATIONAL, INC. GLANCE AT U.S PRIVATE FAMILY BANKS CORD BLOOD AMERICA, INC. VIACELL, INC. OTHER COMPANIES PROGRESS IN CORD BLOOD COLLECTION, PROCESSING AND TRANSPLANTATION TIGHT MEASURES AND CERTIFICATIONS TEST ON STEM CELLS FROM BLOOD CORD I. ROLE OF STEM CELLS IN VARIOUS APPLICATIONS ROLE OF STEM CELLS IN BONE & CARTILAGE CURRENT DEVELOPMENTS REPAIR OF CARTILAGE AND BONE WITH STEM CELLS ROLE OF ADULT STEM CELLS IN BONE AND CARTILAGE TISSUE ENGINEERING CARTILAGE AND BONE REBUILDING ROLE OF STEM CELLS IN CARDIAC BACKGROUND INTRODUCTION ADULT CARDIAC STEM (ACS) CELLS MARKERS OF STEM CELL-DERIVED CARDIOMYOCYTE DIFFERENTIATION MYOCARDIAL TRANSPLANTS: ADVANTAGES AND LIMITATIONS ASSOCIATED WITH DIFFERENT CELL-TYPES ROLE OF STEM CELLS IN SKIN UNDERSTANDING CELL TYPES SOMATIC STEM CELLS IN DERMATOLOGY

3 STEM CELLS AND THEIR OFFSPRING ARRANGEMENT IN HUMAN EPIDERMIS SCLERODERMA PATIENTS GAIN FROM STEM CELL THERAPY ROLE OF STEM CELLS IN DIABETES STEM CELLS 'CURE DIABETES' DIABETES STEM-CELL TREATMENT LOOKS TO CELL CAPSULES GROWTH OF CELL-BASED THERAPIES FOR DIABETES FUTURE OF DIABETES WITH STEM CELLS THERAPY ROLE OF STEM CELLS IN BLOOD DISORDERS HEMATOPOIETIC BEGINNING OF HEPATIC STELLATE CELLS IN THE MATURE LIVER TIME FROM ANALYSIS TO CURING COMMENCEMENT FORETELL SURVIVAL IN YOUNGER AND NOT OLDER, SEVERE MYELOID LEUKEMIA PATIENTS ENDURING PRESERVATION OF HUMAN HEMATOPOIETIC STEM/PROGENITOR CELLS BY APPEARANCE OF BMI1 SIGNALING PATHWAYS GOVERNING STEM-CELL FATE HEMATOLOGICAL EFFECT OF STEM CELL FACTOR (IN-VIVO AND IN-VITRO) ON RATS IS FAT TISSUE A RESOURCE OF PRICELESS BLOOD STEM CELLS? ROLE OF STEM CELLS IN NEURO STEM CELLS PROGRESS FOR THE CURE OF NEUROLOGICAL DISORDERS USAGE OF STEM CELLS IN NEUROLOGICAL DISEASES (HOPE OR HYPE) STEM CELLS APPLIED IN NERVOUS SYSTEM REPAIR STEM CELLS ACT THROUGH VARIOUS METHODS TO BENEFIT MICE WITH NEURODEGENERATIVE ILLNESS ROLE OF STEM CELLS IN CANCER OPTION OF RESOURCE OF STEM CELLS FOR CANCER THERAPY CANCER STEM CELLS AND ONCOLOGY THERAPEUTICS CANCER STEM CELL SUGGESTION IN THYROID CANCER FUTURE POTENTIALS J. STEM CELLS TECHNOLOGY AUTOMATED STEM CELL CULTURE WITH GREATER CONSISTENCY RESTRICTIONS OBSERVED IN THE MANUAL CULTIVATION AUTOMATION SOLUTION CONSISTENCY AND REPRODUCIBILITY K. STEM CELLS IN VARIOUS TECHNOLOGIES CELL BASED TECHNOLOGIES A) HEART DISEASE OR AILMENT B) DIABETES C) STEM CELL THERAPY OR TREATMENT FOR DIABETES D) PARKINSON'S DISEASE CORD BLOOD BANKING PUBLIC BANKS PRIVATE BANKS

4 CRYOPRESERVATION STEM CELL BANKING STEM CELL CHARACTERIZATION STEM CELL DRUG DISCOVERY EMBRYONIC STEM CELLS AS A SOURCE OF MODELS FOR DRUG DISCOVERY STEM CELL PRODUCTION NEW WAY OF PRODUCING STEM CELLS FOUND STEM CELL TRANSPLANTS XENOTRANSPLANTAION BLOOD TRANSFUSION MOLECULAR BIOLOGY II. MARKET ANALYSIS STEM CELLS MARKET AND APPLICATIONS - SNAPSHOT A. STEM CELLS MARKET AND APPLICATIONS - SEGMENTATION B. STEM CELLS - BY COUNTRY C. STEM CELLS - PRODUCT SEGMENTS C1. STEM CELL PRODUCT SEGMENTS - GEOGRAPHIC REGION ADULT STEM CELLS CORD BLOOD STEM CELLS EMBRYONIC STEM CELLS OTHER STEM CELLS

5 C2. STEM CELLS - BY PRODUCT THE USA CANADA MEXICO BELGIUM DENMARK FRANCE GERMANY GREECE SPAIN SWEDEN THE UNITED KINGDOM REST OF AUSTRALIA CHINA INDIA JAPAN SOUTH KOREA REST OF ARGENTINA BRAZIL COLUMBIA MIDDLE EAST SOUTH AFRICA REST OF REST OF THE WORLD D. STEM CELLS - APPLICATIONS STEM CELL - APPLICATIONS - GEOGRAPHIC REGION BONE & CARTILAGE CARDIAC SKIN

6 DIABETES BLOOD DISORDERS NEURO CANCER OTHERS* DIGESTIVE SYSTEM DRUG DEVELOPMENT EYES INJURIES REPRODUCTIVE SYSTEM OTHERS E. STEM CELLS - TECHNOLOGIES STEM CELLS - TECHNOLOGIES - GEOGRAPHIC REGION CELL BASED TECHNOLOGIES

7 CORD BLOOD BANKING CRYOPRESERVATION STEM CELL BANKING STEM CELL CHARACTERIZATION STEM CELL DRUG DISCOVERY STEM CELL PRODUCTION STEM CELL TRANSPLANTS XENOTRANSPLANTATION

8 OTHERS F. STEM CELLS - BY APPLICATION THE USA CANADA MEXICO BELGIUM DENMARK FRANCE GERMANY GREECE SPAIN SWEDEN THE UNITED KINGDOM REST OF AUSTRALIA CHINA INDIA JAPAN SOUTH KOREA REST OF THE ARGENTINA BRAZIL COLUMBIA MIDDLE EAST SOUTH AFRICA REST OF G. STEM CELLS - BY TECHNOLOGIES THE USA CANADA MEXICO

9 BELGIUM DENMARK FRANCE GERMANY GREECE SPAIN SWEDEN THE UNITED KINGDOM REST OF AUSTRALIA CHINA INDIA JAPAN SOUTH KOREA REST OF ARGENTINA BRAZIL COLUMBIA MIDDLE EAST SOUTH AFRICA REST OF H. GROWTH RATE ANALYSIS GLOBAL STEM CELLS PRODUCTS, APPLICATIONS AND TECHNOLOGIES GROWTH RATES STEM CELLS - PRODUCT SEGMENTS GLOBAL STEM CELLS PRODUCT SEGMENTS MARKET GROWTH RATES ADULT STEM CELLS CORD BLOOD STEM CELLS EMBRYONIC STEM CELLS STEM CELLS - APPLICATIONS GLOBAL STEM CELL APPLICATIONS MARKET GROWTH RATES BONE & CARTILAGE CARDIAC SKIN DIABETES BLOOD DISORDERS NEURO CANCER DIGESTIVE SYSTEM DRUG DEVELOPMENT EYES INJURIES

10 REPRODUCTIVE SYSTEM STEM CELL - TECHNOLOGIES GLOBAL STEM CELL TECHNOLOGIES MARKET GROWTH RATES CORD BLOOD BANKING STEM CELL CHARACTERIZATION XENOTRANSPLANTATION STEM CELL DRUG DISCOVERY STEM CELL TRANSPLANTS STEM CELL PRODUCTION STEM CELL BANKING CRYOPRESERVATION CELL BASED TECHNOLOGIES F. INVESTMENT FOCUS III. INDUSTRY OVERVIEW A. INDUSTRY ACTIVITIES MERGERS/ACQUISITIONS/AGREEMENTS/PATENTS GRANTS/JOINT VENTURES/etc SPECIAL HUMAN CELLS DERIVED FROM STEM CELLS RESTORE MOVEMENT IN RATS WITH SPINAL CORD INJURY ASTROCYTES DERIVED FROM HUMAN STEM CELLS IMPROVE THE LOCOMOTOR FUNCTIONS OF RATS WITH SPINAL CORD INJURY CORD BLOOD AMERICA PURCHASE OF CORD BLOOD STEM CELLS STORED BY REPRODUCTIVE GENERATIVE INSTITUTE AN ILLINOIS FIRM LIFESPAN OF BONE MARROW STEM CELLS PREDICTED THROUGH COMPUTER MODEL, SOLVES THE REGENERATIVE PROBLEMS RECENT STUDY REVEAL A COMBINATION OF CELLASTIM AND OPTIFERRIN IS IDEAL FOR STEM CELL EXPANSION WHICH REPLACES NEED OF BLOOD PRODUCTS SINGLE BLASTOMERE TECHNOLOGY SECURES PATENT TO GENERATE EMBRYONIC STEM CELLS ENSURING EMBRYO SAFETY MESENCHYMAL STEM CELLS TO IMPROVE THE DAMAGED CELLS AFTER HEART ATTACK STEMCELLS, INC. COMPLETES SECOND TRIAL OF HUCNS-SC(R) NEURAL STEM CELLS, A POTENTIAL TREATMENT FOR MYELINATION DISORDER AMNIOTIC FLUID COLLECTED DURING THIRD TRIMESTER IS A RELIABLE SOURCE OF STEM CELLS FOR REGENERATIVE MEDICINE AND STEM CELL BANKING CORD BLOOD AMERICA, INC. ANNOUNCES PURCHASE OF MINORITY INTEREST IN VIDAPLUS EXPECTED TO GAIN REVENUE AND POPULARITY IN INDUCED PLURIPOTENT STEM CELLS ARE SAFER AND CANCEROUS GROWTH MAY BE AVOIDED MICRORNAS ENHANCES THE GENERATION OF INDUCED PLURIPOTENT STEM CELLS (IPS), THROUGH REPROGRAMMING SKIN STEM CELLS ROLE OF STEM CELLS IN REPAIRING DAMAGED HEART OF CHILDREN

11 THE FRAUNHOFER INSTITUTE IS FOCUSED TO STUDY THE CELL THERAPEUTIC PROCESSES IN ORDER TO OFFER SUITABLE SOLUTIONS MIRNA THERAPEUTICS, INC. PUBLISH NEW DATA ON MIR-34 IN INHIBITING THE GROWTH OF CANCER CELLS BIOCELLS, INC., TO STORE DENTAL PULP STEM CELLS WHICH AIDS IN STIMULATING NEURAL CELLS AND A SOURCE OF REGENERATIVE MEDICINE NEOSTEM, INC.'S RECOMMENDED FOR THE FINANCIAL AWARD OF $1,700,000 TO DEVELOP VERY SMALL EMBRYONIC-LIKE STEM CELLS WHICH IS A POTENTIAL CURE FOR OSTEOPOROSIS FROM DEPARTMENT OF DEFENSE PEER REVIEWED MEDICAL RESEARCH PROGRAM BIOHEART REPORTS THE USE OF ADIPOSE DERIVED STEM CELLS IN CURING CRITICAL LIMB ISCHEMIA POSITION OF DNA IN STEM CELL TRANSPLANT SUCCESS & FUNDING THE CHEAPEST STEM CELL TRANSPLANT FROM INDIA HUMAN STEM CELLS CALLED PARTHENOGENETIC CELLS, WHICH ARE DEVELOPED BY UNFERTILIZED HUMAN EGGS-ETHICAL CONSIDERATIONS AND MEDICAL ADVANTAGES ADVANCED CELL TECHNOLOGY AND THE ROSLIN INSTITUTE ANNOUNCE AGREEMENT FOR STORAGE AND DISTRIBUTION OF EMBRYONIC STEM CELLS USING ACT'S BLASTOMERE TECHNOLOGY STEM CELL TECHNOLOGY - A BREAKTHROUGH IN GROWING FUNCTIONAL INTESTINE TISSUE ADVANCED CELL TECHNOLOGY CLEARED BY FDA FOR THE FIRST CLINICAL TRIAL ON USING RETINAL STEM CELLS FOR CURING STARGARDT S MACULAR DYSTROPHY EHSI: STEM CELLS COULD HELP HEART ATTACK VICTIMS STEMCYTE, INC. RECEIVED TWO AWARDS TOTALING TO $488,950 FOR ADVANCED THERAPEUTIC APPLICATIONS OF UMBILICAL CORD BLOOD STEM CELLS FROM THE QUALIFYING THERAPEUTIC DISCOVERY PROJECT (QTDP) SHRINK NANOTECHNOLOGIES REVEALS VIDEOS OF STEMDISC450 PROTOTYPE, A DEVICE FOR GROWING HUMAN EMBRYONIC STEM CELLS X-BODY BIOSCIENCES AWARDED GRANT FOR THERAPEUTIC DISCOVERY PROJECT TARGETING METASTATIC TUMOR STEM CELLS STEM CELLS REPAIR DAMAGED SPINAL CORD TISSUE IN RATS ROCHE S CELLAVISTA SYSTEM ENHANCES THE STUDY OF SELF RENEWAL OF EMBRYONIC STEM CELLS GERON ENTERS INTO A LICENSE AGREEMENT FOR PRODUCTION OF CHONDOCYTES FROM IPS GUIDED ADULT STEM CELLS CAN EFFECTIVELY REPAIR HEARTS NEW CULTURE DISH OVERCOMES THE LIMITATIONS IN HUMAN EMBRYONIC STEM CELL RESEARCH STEM CELL THERAPY A MAJOR ROLE FOR ACUTE LUNG DAMAGE IN MICE NEW APPROACH IN MEDICAL APPLICATION OF RESOURCEFUL AND PROTECTED PLURIPOTENT STEM CELLS FOR ENGENDERING

12 REGENERATIVE STEM CELL TREATMENTS WITH PATIENTS HAVING CONGESTIVE HEART FAILURE BIOHEART THERAPIES STEM CELL MODULATOR PIPELINE WITH ACQUISITION OF FATE THERAPEUTICS WITH VERIO THERAPEUTICS SRU BIOSYSTEMS ANNOUNCES INTRODUCTION OF BIND(R) SCANNER FOR PRIMARY AND STEM CELL APPLICATIONS NEW PROGRESS DIRECTED TO A GET THROUGH PROCESS FOR EXTENDED MEDICAL APPLICATION OF MATURE STEM CELLS AGREEMENT FOR PATENT AND CULTIVATION OF PLURIPOTENT STEM CELLS APPLICATION ON CHEMOKINE TECHNOLOGY TO INCREASE EFFICACY OF TISSUE-SPECIFIC STEM CELL HOMING IN COPD TREATMENT TESTING OF RETINAL PIGMENT FROM HUMAN PARTHENOGENETIC STEM CELLS AUGMENTATION FEATURE HELP STEM CELL GROWTH: REGENERATION ADULT ALLOGENEIC MESENCHYMAL STEM CELLS TREATMENT FOR STROKE FROM STEMEDICA CELL TECHNOLOGIES, INC STEM CELL MANUFACTURING FOR STROKE AND CLINICAL TRIAL FROM RENEURON GROUP PLC PATENT GRAND FOR PLURIPOTENT RAT STEM CELLS AND GENETICALLY ENGINEERED RATS FOR STEMCELLS, INC. STEM CELLS BUILD NEW BLOOD VESSELS FOR THE TREATMENT PERIPHERAL ARTERIAL DISEASE PROPRIETARY ADULT STEM CELL LINES FORMATION THE SYNTHEMAX(TM) SURFACE FOR SCALABLE GROWTH OF HUMAN EMBRYO DEVELOPED BY GERON CORPORATION AND CORNING INCORPORATED. STEM CELL INNOVATIONS TO OFFER AGENNIX THE RESEARCH AND ASSAY SERVICES CARDIAC STEM CELL THERAPY PRESENTATION - BMT TANDEM MEET BY OSIRIS THERAPEUTICS STEM CELL THERAPY FOR CARDIAC DISEASES EFFECTIVE USE OF PROPRIETARY STEM CELLS IN THE TREATMENT OF CIRRHOSIS OF THE LIVER REGENOCYTE EFFECTIVELY CURES CARDIOMYOPATHY PATIENT USING INDIVIDUAL ADULT STEM CELLS LIMBS WITH PERIPHERAL ARTERIAL DISEASE CAN BE SAVED BY USING ADULT STEM CELLS GAMIDA CELL LTD. CONTINUATION OF RESEARCH ON STEMEX(R), A CORD BLOOD STEM CELL PRODUCT, FOR LEUKEMIA AND LYMPHOMA BIOHEART S INNOVATION OF FIRST FDA GRANT CLINICAL TRIAL TO TEST CONGESTIVE HEART FAILURE FOR GENE-MODIFIED STEM CELL THERAPY FATE THERAPEUTICS GETS GRANT OF FIRST U.S. COPYRIGHT FOR INDUCED PLURIPOTENT STEM CELL EXPERTISE STEM CELL THERAPY INTERNATIONAL CORP. COMPLETELY AMALGAMATED WITH HISTOSTEM, CO., LTD.

13 INDIA THE NEXT POTENTIAL STEM CELL MARKET - CORDLIFE ROMANIA STARTS ITS EARLIEST STEM CELL FRIENDLY CASE STEM CELL GROUP MAKES A SUBSTITUTE BONE PIECE NEW CORD BLOOD THERAPY! A NEW RAY OF HOPE FOR MANY THALASSEMIA AFFECTED PATIENTS. FLORIDA UNIVERSITY SCIENTISTS DISCOVER THAT BLOOD STEM CELLS CAN BE CHANGED TO VISUALIZATION CELLS DISSIMILARITY ESTABLISHED BETWEEN EMBRYONIC STEM CELLS AND REPROGRAMMED SKIN CELLS BUSH S STEM CELL RESTRICTIONS TO GO SAYS PRESIDENT OBAMA OBAMA TO LIFT THE BAN IMPOSED BY BUSH ON EMBRYONIC STEM CELL RESEARCH INITIAL STEM CELL TEST GRANTED BY FDA A STEP FORWARD IN DIABETES TREATMENT DISCOVERED BY NOVOCELL B. MARKET TRENDS STEM CELL TREATMENTS GIVE NEW EXPECTATION NEW METHOD FOUND TO OVERCOME IMMUNE SYSTEM REJECTION OF HUMAN EMBRYONIC STEM CELLS PLURIPOTENT STEM CELLS GENERATED FROM HORSES FOR THE FIRST TIME DARK CLOUDS OF UNCERTAINTIES LOOM OVER EMBRYONIC STEM CELL RESEARCH DONOR STEM CELL RESEARCH MAY REPAIR HEART DAMAGE HUMAN INDUCED PLURIPOTENT STEM CELLS SHOW MUTATION PREVALENT MUTATIONS FOUND IN REPROGRAMMED STEM CELLS ANTI-AGING INDUSTRY GOES FOR STEM CELL THERAPY STEM CELL TREATMENT TO CURE DIABETES REVOLUTIONARY STEM CELL REMEDY REINSTATES SIGHT UCLA STUDY REVEALS THE USE OF STEM CELLS TO DESTROY HIV STEM CELLS CAPABLE OF ASSISTING ANGINA PATIENTS AGREEMENT SKETCHING OUT MORAL APPROACH TO STEM CELL PLANNED HOTTEST DEVELOPMENTS IN STEM CELLS TREATMENTS EMBRYONIC STEM CELLS STUDY BEING TURNED INTO A CONTENTIOUS DISCUSSION ADULT STEM CELLS GROWING TO BE A HOPEFUL MARKET UNITED STATES ORTHOPEDIC STEM CELL FORECASTED TO GENERATE REVENUES WORTH $1.1 BILLION BY 2015 HUMAN EXPERIMENTAL TEST OF STEM CELL BASED MEDICINE STEM CELLS CAPABLE OF REINSTATING MISPLACED BRAIN TASKS GROWING HEART VALVES FROM STEM CELLS STEM CELL TREATMENT COULD POSSIBLY WORK IN OPPOSITION TO BRAIN INFLAMMATION RESOURCEFUL STEM CELLS DISCOVERED IN AMNIOTIC FLUID STEM CELL PROGRESS BEING HIT BY TRADITIONALIST C. INDUSTRY LEADERS AASTROM BIOSCIENCES, INC.

14 BIOHEART, INC. CORD BLOOD REGISTRY CRYOLIFE, INC. OSIRIS THERAPEUTICS, INC. SIGMA-ALDRICH, CO. STEM CELL INNOVATIONS, INC. THERMO FISHER SCIENTIFIC, INC VIACORD RENEURON GROUP PLC CRYOCORD SDN. BHD D. STEM CELLS MARKET - A LOOK A HEAD..!! E. KEY COMPANY PROFILES V. APPENDIX RESEARCH FOCUS ABOUT AXIS RESEARCH MIND DISCLAIMER FEEDBACK