Research Article Frequency of Surgery in Black Patients with Malignant Pleural Mesothelioma

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1 Disease Markers Volume 2015, Article ID , 5 pages Research Article Frequency of Surgery in Black Patients with Malignant Pleural Mesothelioma Emanuela Taioli, 1 Andrea S. Wolf, 2 Jacqueline M. Moline, 1 Marlene Camacho-Rivera, 1 and Raja M. Flores 2 1 Department of Population Health, Hofstra North Shore-LIJ School of Medicine, Great Neck, NY 11021, USA 2 Department of Thoracic Surgery, Mount Sinai Medical Center, New York City, NY 10029, USA Correspondence should be addressed to Raja M. Flores; Received 9 February 2015; Accepted 7 April 2015 Academic Editor: Fabrizia Bamonti Copyright 2015 Emanuela Taioli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Introduction. Malignant Pleural Mesothelioma (MPM) is a rare disease, even less frequently described in minority patients. We used a large population-based dataset to study the role of race in MPM presentation, treatment, and survival. Methods.Allcasesof pathologicallyproven MPMwereidentified in thesurveillance, Epidemiology, and End Results (SEER) database. Age, sex, diagnosis year, stage, cancer-directed surgery, radiation, and vital status were analyzed according to self-reported race (black or white). Results. There were 13,046 white and 688 black MPM patients (incidence: 1.1 per 100,000 whites; 0.5 per 100,000 blacks; age-adjusted, p = 0.01). Black patients were more likely to be female, younger, and with advanced stage and less likely to undergo cancerdirected surgery than whites, after adjustment by stage. On multivariable analysis, younger age and having surgery were associated with longer survival for both cohorts; female gender (HR 0.82 ( )) and early stage at diagnosis (HR 0.83 ( )) were predictive of longer survival in white, but not in black, patients. Conclusions. Surgery was associated with improved survival for both black and white MPM patients. However, black patients were less likely to undergo cancer-directed surgery. Increased surgical intervention in MPM black patients with early stage disease may improve their survival. 1. Introduction Malignant Pleural Mesothelioma (MPM) is an aggressive form of asbestos-related cancer with poor prognosis [1]. Possible treatments include surgery, chemotherapy, and radiation or a combination of them, but the effectiveness of these approaches is still debated. A randomized controlled trial conducted in the UK to assess the effectiveness of extra pleural pneumonectomy in terms of survival, complications, and quality of life [2] suggested that surgery did not offer any survival advantage in comparison to chemotherapy alone. To date, however, no US study has evaluated MPM incidence, treatment, and outcomes in African American patients. There are two recently published studies on MPM outcome based on SEER data. One series [3] reportedsurvivalinrelation to histology and treatment but did not stratify or otherwise evaluate the data by race; the other analysis [4], conducted on a small sample of 294 black MPM patients, suggested that a smaller proportion of black patients received cancerdirected surgery, while the overall survival was comparable to that of white patients. This finding suggests that predictors of survival differ for black and white patients [4] and that the ethnic discrepancy in surgery rates may reflect a complex interaction between patients and/or surgeon choices, as well as clinical factors at diagnosis. The present analysis of the SEER database was conducted to assess the incidence and temporal trends of MPM in a large population-based sample of black patients, to determine theratesofcancer-directedsurgeryandradiotherapyandif choice of treatment influenced survival in this population. 2. Material and Methods TheSEERdatabasewasexploredfrom1973to2009toidentify all cases of pathologically proven MPM within the site recode ICD-O-3 variable by ICD-O-3 morphology.

2 2 Disease Markers Cases who were diagnosed at age below 18 years, postmortem cases, nonmicroscopically confirmed cases, any living case without survival time in the database, and cases of malignant mesothelioma of other sites (retroperitoneal, peritoneal, genital, heart, mediastinum, soft tissue, digestive, other, and unknown primary site) were excluded. The SEER 09 registry includes data from 9 US registries, from 1973 to 2004; the SEER 17 registry includes cases from 17 registries, from 2000 to 2004; the SEER 18 registry includes cases from greater Georgia from 2000 onward, with the exception of adjustments for the areas impacted by Hurricanes Katrina and Rita Definition of Staging. Definition of staging is as follows: localized: invasive tumor confined to pleura; ipsilateral parietal and/or visceral pleura; mesothelioma with nodules beneath the visceral pleural surface; and localized, not otherwise specified; regional: extension to adjacent organs/structure: adjacent connective tissue, pericardium, endothoracic fascia, and diaphragm; visceral pleural invasion into lung parenchyma, lung involvement not otherwise specified; extension to adjacent organs such as the chest wall, ribs, myocardium, mediastinal organs, and tissues; mesothelioma with malignant pleural fluid/effusion; regional ipsilateral lymph nodes; and regional not otherwise specified; distant: contralateral pleura and lung, extension to intra-abdominal organs, cervical tissues, peritoneum, and metastasis; further contiguous extension; unknown if extension or metastasis; and distant lymph nodes Definition of Cancer-Directed Surgery. For cases diagnosed after 1998, patients were identified as having received cancer-directed surgery if any of the following codes were present for the Rx Summ-Surg Prim Site variable: 30 = simple/partial surgical removal of primary site; 40 = total surgical removal of primary site, enucleation; 50 = debulking ; 60 = radical surgery which included partial or total removal of the primarysiteincontinuity(partialortotalremoval)withother organs. For cases prior to 1998, patients were identified as having received cancer-directed surgery if any of the following codes were present for the Site Specific Surgery variable: 10 = local surgical excision or destruction of lesion; 20 = partial/wedge/segmental resection; 30, 40 = lobectomy/bilobectomy with/without dissection of lymph nodes; 50 = complete/total/standard pneumonectomy, pneumonectomy, NOS; 60 = radical pneumonectomy plus dissection of mediastinal lymph nodes; 70 = extended radical pneumonectomy with diaphragm plus lymph nodes; 80 = surgery of regional and/or distant site(s)/node(s) only (includes removal of mediastinal mass only); 90 = resection of lung, not otherwise specified; surgery, not otherwise specified. For all cases, code 00 (which indicated no surgical procedure had been performed ) and the codes for other types of surgery (codes 01, 02, 03, 04, and 05) were used to categorize patients who did not undergo cancer-directed surgery. Number of new cases per 100, White Black Year of diagnosis Figure 1: Age-adjusted incidence rates for blacks and whites, (note: cases from SEER 9 database are included) Statistical Analysis. Age, sex, diagnosis year, stage, cancer-directed surgery, radiation, and vital status were analyzed (chemotherapy data not available) according to self-reported race (black and white). Comparisons between black and white patients were performed using the t-test for continuous variables and chi-square for categorical variables. Overall survival was defined as the time between initial date of diagnosis and either date of death or date of last follow up, whichever came first. Comparison of survival between blacks and whites was performed using multivariable regression methods based on a Cox proportional hazards model. All analyses were performed using SAS version 9.2 (Cary, NC, USA). 3. Results MPM age-adjusted incidence rates were 1.1 per 100,000 in whites and 0.5 per 100,000 in blacks (p = 0.01). The significant difference in rates has been present since 1973, when the data recording started (Figure 1). There were 13,046 white and 688 black patients with pathologic diagnosis of MPM (Table 1). Black patients were more likely to be female (26% versus 22%, p = 0.01) and younger (67 versus 70, p < ) and to present with more advanced stage of disease (65% versus 59%, p = 0.002) Therapy. Black patients were less likely to receive cancerdirected surgery than white patients (18% versus 24%, p = 0.001). Black patients were more likely than whites to undergo no surgery or radiation (73% versus 68% received no treatment; p = 0.005). There was an inverse trend in undergoing surgery with more advanced stage in both ethnicities: among whites, 31.5% of localized cases received surgery, versus 21.4% of the advanced stage white patients. Among black patients, the corresponding proportions were 29.3% for localized disease and 15.1% for advanced stages (Table 3)

3 Disease Markers 3 Table 1: Patient, disease, and treatment characteristics among whites and blacks (n = 13734). Variable Categories Whites (n =13046) Blacks(n = 688) p value Sex Male (78%) 507 (74%) Female 2887 (22%) 181 (26%) Mean age in year (95% CI) 70.2 ( ) 66.6 ( ) < Localized 1449 (11%) 75 (11%) Overall stage Regional 2155 (16%) 91 (13%) Distant 7639 (59%) 450 (65%) Unknown 1803 (14%) 72 (11%) Cancer-directed surgery No 9959 (76%) 563 (82%) Yes 3087 (24%) 125 (18%) Radiation No (87%) 611 (89%) Yes 1659 (13%) 77 (11%) No 8933 (68%) 505 (73%) Therapy Surgery only 2454 (19%) 106 (15%) Radiation only 1026 (8%) 58 (9%) Both surgery and radiation 633 (5%) 19 (3%) Mean survival in months (95% CI) 15.5 ( ) 16.7 ( ) SEER, Surveillance, Epidemiology, and End Results. Variable Table 2: Effect of patient, disease, and treatment characteristics on 5-year survival (n = 13734). Categories Whites adjusted HR (95% CI) Blacks adjusted HR (95% CI) Sex Male/female 0.82 ( ) 1.10 ( ) Age Per year decrease 0.81 ( ) 0.76 ( ) Stage Localized 1.0 (ref.) 1.0 (ref.) Regional 1.26 ( ) 0.98 ( ) Distant 1.21 ( ) 1.14 ( ) Unknown 1.11 ( ) 0.80 ( ) Cancer-directed surgery No/yes 0.65 ( ) 0.53 ( ) Radiation No/yes 1.10 ( ) 1.24 ( ) Therapy Adjusted for the other variables in the table. None 1.0 (ref.) 1.0 (ref.) Surgery only 0.68 ( ) 0.53 ( ) Radiation only 1.27 ( ) 1.24 ( ) Both surgery and radiation 0.63 ( ) 0.65 ( ) 3.2. Survival. Overallsurvivalwassimilarforblackandwhite patients (Figure 2). On multivariable analysis, female gender, younger age, early stage, and cancer-directed surgery were independent predictors of longer survival in white patients; younger age and surgery were associated with longer survival in black patients (Table 2). Three- and 5-year survival for patients who did not receive treatment was 7.9% and 3.5%, respectively, in whites and 10.6% and 6.7% in blacks. 4. Discussion This SEER analysis includes the largest sample of black patients with MPM to date and demonstrates that MPM incidence is significantly lower in blacks compared to whites. Reasons for this large difference may reside in the lower opportunity for occupational asbestos exposure among blacks. The U.S. Department of Labor periodically publishes summary statistics on the US workforce [5]andreportsthat black workers are highly represented in the health and education services, public administration, and transportation, while they are less likely to be employed in those occupations where asbestos has been used in the past, such as building and ship construction, insulation, and mining. In addition, fewer blacks served in the U.S. Navy, which was historically a source of asbestos exposure for many men [6, 7]. The observation that there is a higher proportion of women among black (compared to white) MPM patients is a new finding and warrants further investigation. Blacks are also diagnosed with

4 4 Disease Markers Summary stage Table 3: Receipt of surgery by stage among blacks and whites (n = 13734). No Whites Surgery performed Yes No Blacks Surgery performed Yes Localized 992 (68.5) 457 (31.5) 53 (70.7) 22 (29.3) Regional 1346 (62.4) 809 (37.5) 61 (67.0) 30 (33.0) Distant 6002 (78.6) 1637 (21.4) 382 (84.9) 68 (15.1) Unknown 1619 (89.8) 184 (10.2) 67 (93.0) 5 (7.0) Months Whites Blacks Kaplan-Meier survival estimates Figure 2: MPM survival according to ethnicity, Logrank chi-square: 0.45; p value ; Wilcoxon test: 4.13; p value MPM at an earlier age than whites, which could reflect earlier exposure to asbestos than whites or alternatively may reflect more aggressive disease with earlier clinical symptoms. Black MPM patients are diagnosed at a later stage than white patients; this may be due to general delays in seeking care for medical symptoms, lack of access to diagnostic procedures, lack of timely diagnosis when symptoms occur, lack of access to appropriate medical care, and/or lack of availability of insurance coverage. Another possible factor could be that symptoms at MPM onset are different in black compared to white patients, as previously reported in lung cancer [8], and this could cause delay in diagnosis. The role of each of these factors cannot be elucidated in this study, as the information is not available in the SEER database. When the therapeutic approach is analyzed according to ethnicity, black patients underwent less cancer-directed surgery than white patients, as suggested by previous analysis of a smaller SEER dataset [4]. Similar to the observed lower rates of cancer-directed surgery in black MPM patients, a studyconductedinearlystagenon-smallcelllungcancer [9] demonstrated a low rate of surgical treatment among blacks. Black MPM patients were less likely to undergo either surgery or radiation in comparison to white patients. Although late stage at diagnosis was thought to be the main reason for this difference in treatment with regard to race, the stratified analysis by stage does not support that hypothesis, as blacks underwent less cancer-directed surgery than whites at every stage of MPM. Reasons for less surgical treatment could be the presence of comorbidities in black patients at the time of MPM diagnosis or the fact that patients were diagnosed in community-based hospitals lacking adequate surgical expertise or that surgery was not considered to be a treatment option. A recently published paper [10] indicates that race disparities exist in access to high-volume hospitals, a proxy for better quality of care in complex cases [11], even after adjustment for socioeconomic and insurance status. When performed, cancer-directed surgery was associated with higher survival in both ethnic groups. Unfortunately, we were not able to analyze what type of surgical approach was performed (extrapleural pneumonectomy or radical pleurectomy/decortication) or if the approach differed according to ethnicity. Another limitation of the SEER dataset is that it does not contain information on any chemotherapy regimen administered to the patients. Other limitations include the broad definition of stage and the limited quality of the histology classification. Differences in these variables may have contributed to the observed health care disparities in rates of cancer-directed surgery, for example, if a higher proportion of blacks had nonepithelial (less favorable celltype) disease compared to whites. However, the use of the SEER database allowed us to conduct the largest study, to our knowledge, of MPM black patients. This analysis indicates that black patients with MPM are treated less frequently with surgery than their white counterparts, at every stage of their disease, but they experience similar survival as white MPM patients. This suggests that further attention to the treatment of black patients with MPM is needed to determine if black MPM patient survival would be improved with better access to the same treatments as whites. Further studies on exposure history, access to care, type of medical and surgical treatment, and hospital characteristics in black patients with MPM are needed. Conflict of Interests The authors declare that there is no conflict of interests regarding the publication of this paper. Funding The work was partly supported by CDC Grant 5R01TS and the Norman Mass Foundation.

5 Disease Markers 5 References [1] B. Price and A. Ware, Time trend of mesothelioma incidence in the United States and projection of future cases: an update based on SEER data for 1973 through 2005, Critical Reviews in Toxicology, vol. 39, no. 7, pp , [2] T. Treasure, L. Lang-Lazdunski, D. Waller et al., Extra-pleural pneumonectomy versus no extra-pleural pneumonectomy for patients with malignant pleural mesothelioma: clinical outcomes of the Mesothelioma and Radical Surgery (MARS) randomised feasibility study, The Lancet Oncology, vol. 12, no. 8, pp , [3] M.T.MilanoandH.Zhang, Malignantpleuralmesothelioma: a population-based study of survival, Thoracic Oncology,vol.5,no.11,pp ,2010. [4]R.M.Flores,E.Riedel,J.S.Doningtonetal., Frequency of use and predictors of cancer-directed surgery in the management of malignant pleural mesothelioma in a communitybased (Surveillance, Epidemiology, and End Results [SEER]) population, Thoracic Oncology, vol. 5, no. 10, pp , [5] US Department of Labor and US Bureau of Labor Statistics, Labor Force Characteristics by Race and Ethnicity, , US Bureau of Labor Statistics, Washington, DC, USA, 2013, [6] M. Binkin, M. M. Smith, A. J. Schexnider, and M. J. Eitelberg, Blacks and the Military, Brookings Institution Press, Washington, DC, USA, [7] B.C.Nalty,Strength for the Fight: A History of Black Americans in the Military,FreePress,NewYork,NY,USA,1986. [8] R. Said, T. Terjanian, and E. Taioli, Clinical characteristics and presentation of lung cancer according to race and place of birth, Future Oncology,vol.6,no.8,pp ,2010. [9] P.B.Bach,L.D.Cramer,J.L.Warren,andC.B.Begg, Racial differences in the treatment of early-stage lung cancer, The New England Medicine, vol. 341, no. 16, pp , [10] M. Sun, P. I. Karakiewicz, J. D. Sammon et al., Disparities in selective referral for cancer surgeries: implications for the current healthcare delivery system, BMJ Open, vol. 4, no. 3, Article ID e003921, [11] E. V. A. Finlayson, P. P. Goodney, J. D. Birkmeyer, and R. J. Davies, Hospital volume and operative mortality in cancer surgery: a national study, Archives of Surgery, vol. 138, no. 7, pp , 2003.

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