Early mortality rate (EMR) in Acute Myeloid Leukemia (AML)

Save this PDF as:
 WORD  PNG  TXT  JPG

Size: px
Start display at page:

Download "Early mortality rate (EMR) in Acute Myeloid Leukemia (AML)"

Transcription

1 Early mortality rate (EMR) in Acute Myeloid Leukemia (AML) George Yaghmour, MD Hematology Oncology Fellow PGY5 UTHSC/West cancer Center, Memphis, TN May,1st,2015

2 Off-Label Use Disclosure(s) I do not intend to discuss an off-label use of a product during this activity

3 Financial Disclosure(s) I have not had any relevant financial relations during the past 12 months to disclose

4 Our Question: SWOG described the expected EMR for patients with Non-M3 AML by age enrolled in clinical trials. However, the real world data from experience outside of clinical trials is unknown? Aim of study To fill this knowledge gap, we aimed to use a large national cancer registry database to estimate the frequency of early mortality in patients with newly diagnosed AML in the United States And compare these findings with the SWOG cohort.

5 INTRODUCTION AML is the most common type of leukemia in adults with an estimated incidence of 3.7 per 100,000 persons Estimated 14,000 new cases of AML were diagnosed and 10,000 deaths were reported in the year The overall prognosis of AML is poor with 5-year relative survival rate of 17 19%. AML is an oncologic emergency due to the potential for early mortality from infection, hemorrhage, or sequelae of hyperleukocytosis.

6 INTRODUCTION There is limited data regarding the incidence of early death in these patients. A significant proportion of deaths related to AML occur within the first month of diagnosis. A previously published study based on SWOG cohort showed an estimated EMR of 12%. We sought to compare SWOG s reported EMR in AML to those of the general population.

7 Methods AND MATERIALS Our study utilized case listings from 18 population-based regional cancer registries in the National Cancer Institute s Surveillance, Epidemiology, and End Results (SEER) program from 1973 to 2010 SEER 18 covers approximately 28% of the US population. SEER registries maintain data including patient demographics, incidence, mortality, primary site, tumor structure, and follow-up information. The SEER database classifies cancer histology and topography information on the basis of the third edition of the International Classifications of Diseases for Oncology (ICD-O-3).

8 Methods AND MATERIALS we identified patients > 18 years of age diagnosed with non- M3 AML between 1990 and 2005 from SEER 18. We examined EMR of these patients overall and by age group then compared them with those reported by SWOG. EMR in SWOG studies was defined as death within 30 days of initiation of induction chemotherapy.

9 Methods AND MATERIALS We used two definitions of EMR to include deaths within 1 month (EMR1) and deaths within 2 months of diagnosis (EMR2). We calculated survival rates at 1 month and 2 months overall and for levels of each covariate using the actuarial method. The difference between the EMR in the two groups was analyzed using Fisher s Exact test. We also performed stepwise logistic regression analysis to identify the predictors of early mortality in the SEER study cohort.

10 Analysis SEER*Stat Microsoft Excel 2007, Statistical Package for Social Sciences (SPSS) 21.0 (IBM Corporation, Armonk, NY) and GraphPad Prism 6 Comparisons made using Fishers Exact test Log Rank test(mantel-cox) 2 sided p-values

11 Results In the SEER studies: Total of 26,272 patients with AML were identified 54% males and 85% were whites. The SEER EMR rate was 27% (n = 7022) within one month and was 38% (n = 10,068) within two months of diagnosis The SWOG cohort : Total 968 patients from 5 different clinical trials. 55% Male, 89% white. The SWOG cohort had an EMR of 12.2% (n=116) with the difference being statistically significant (p value <0.001).

12

13 Results

14

15

16 Conclusions Our population-based study shows that EMR in AML is much higher than suspected across all age groups Both the SEER and SWOG cohorts demonstrated a strong correlation between age and higher EMR. It also identifies patients with monocytic differentiation and black patients as being at higher risk for early mortality. This study reinforces the thought that AML should be treated in highly specialized referral centers.

17 Conclusions Limitations The SEER registry does not include information about chemotherapy use. A significant proportion of EMR in AML patient is related to chemotherapy related toxicity. We could not analyze performance status, cytogenetic profile and cause of death among the patients studied. Strengths large sample size in a population-based setting, which provides clinicians with real world data of EMR in an unselected AML population highly representative to what most US clinicians will encounter. Future studies could further investigate the causes of EMR as well as response to induction chemotherapy in SEER.

18 Questions? THANK YOU

Treatment of Low Risk MDS. Overview. Myelodysplastic Syndromes (MDS)

Treatment of Low Risk MDS. Overview. Myelodysplastic Syndromes (MDS) Overview Amy Davidoff, Ph.D., M.S. Associate Professor Pharmaceutical Health Services Research Department, Peter Lamy Center on Drug Therapy and Aging University of Maryland School of Pharmacy Clinical

More information

Big Data and Oncology Care Quality Improvement in the United States

Big Data and Oncology Care Quality Improvement in the United States Big Data and Oncology Care Quality Improvement in the United States Peter P. Yu, MD, FACP, FASCO President, American Society of Clinical Oncology Director of Cancer Research, Palo Alto Medical Foundation

More information

Six Degrees of Separation No More: Using Data Linkages to Improve the Quality of Cancer Registry and Study Data

Six Degrees of Separation No More: Using Data Linkages to Improve the Quality of Cancer Registry and Study Data Six Degrees of Separation No More: Using Data Linkages to Improve the Quality of Cancer Registry and Study Data Prepared for the 138th Annual Meeting of the American Public Health Association Denver, CO

More information

Komorbide brystkræftpatienter kan de tåle behandling? Et registerstudie baseret på Danish Breast Cancer Cooperative Group

Komorbide brystkræftpatienter kan de tåle behandling? Et registerstudie baseret på Danish Breast Cancer Cooperative Group Komorbide brystkræftpatienter kan de tåle behandling? Et registerstudie baseret på Danish Breast Cancer Cooperative Group Lotte Holm Land MD, ph.d. Onkologisk Afd. R. OUH Kræft og komorbiditet - alle skal

More information

Tips for surviving the analysis of survival data. Philip Twumasi-Ankrah, PhD

Tips for surviving the analysis of survival data. Philip Twumasi-Ankrah, PhD Tips for surviving the analysis of survival data Philip Twumasi-Ankrah, PhD Big picture In medical research and many other areas of research, we often confront continuous, ordinal or dichotomous outcomes

More information

The Georgia Cancer Registry A State s Perspective

The Georgia Cancer Registry A State s Perspective The Georgia Cancer Registry A State s Perspective Kevin C. Ward, PhD, MPH, CTR Director Georgia Center for Cancer Statistics Emory University kward@emory.edu Georgia Center for Cancer Statistics Located

More information

Travel Distance to Healthcare Centers is Associated with Advanced Colon Cancer at Presentation

Travel Distance to Healthcare Centers is Associated with Advanced Colon Cancer at Presentation Travel Distance to Healthcare Centers is Associated with Advanced Colon Cancer at Presentation Yan Xing, MD, PhD, Ryaz B. Chagpar, MD, MS, Y Nancy You MD, MHSc, Yi Ju Chiang, MSPH, Barry W. Feig, MD, George

More information

State of the Nation: An overview of the impact and priorities for lung cancer in Northern Ireland

State of the Nation: An overview of the impact and priorities for lung cancer in Northern Ireland State of the Nation: An overview of the impact and priorities for lung cancer in Northern Ireland Introduction Lung cancer is Northern Ireland s biggest cancer killer. It causes more than one in five of

More information

Table 16a Multiple Myeloma Average Annual Number of Cancer Cases and Age-Adjusted Incidence Rates* for 2002-2006

Table 16a Multiple Myeloma Average Annual Number of Cancer Cases and Age-Adjusted Incidence Rates* for 2002-2006 Multiple Myeloma Figure 16 Definition: Multiple myeloma forms in plasma cells that are normally found in the bone marrow. 1 The plasma cells grow out of control and form tumors (plasmacytoma) or crowd

More information

Prognosis of Patients With Breast Cancer: Causes of Death and Effects of Time Since Diagnosis, Age, and Tumor Characteristics

Prognosis of Patients With Breast Cancer: Causes of Death and Effects of Time Since Diagnosis, Age, and Tumor Characteristics Prognosis of Patients With Breast Cancer: Causes of Death and Effects of Time Since Diagnosis, Age, and Tumor Characteristics Edoardo Colzani, M.D., M.P.H. Department of Medical Epidemiology and Biostatistics

More information

Table 23a Testicular Cancer Average Annual Number of Cancer Cases and Age-Adjusted Incidence Rates* for

Table 23a Testicular Cancer Average Annual Number of Cancer Cases and Age-Adjusted Incidence Rates* for Testicular Cancer Figure 23 Definition: Testicular cancer usually develops in one or both testicles in young men. This cancer is highly treatable and usually curable. 1 Background: From 2002 to 2006, there

More information

Temporal Trends in Demographics and Overall Survival of Non Small-Cell Lung Cancer Patients at Moffitt Cancer Center From 1986 to 2008

Temporal Trends in Demographics and Overall Survival of Non Small-Cell Lung Cancer Patients at Moffitt Cancer Center From 1986 to 2008 Special Report Temporal Trends in Demographics and Overall Survival of Non Small-Cell Lung Cancer Patients at Moffitt Cancer Center From 1986 to 2008 Matthew B. Schabath, PhD, Zachary J. Thompson, PhD,

More information

Survival Rate of Childhood Leukemia in Shiraz, Southern Iran

Survival Rate of Childhood Leukemia in Shiraz, Southern Iran Original Article Iran J Pediatr Feb 23; Vol 23 (No ), Pp: 5358 Survival Rate of Childhood Leukemia in Shiraz, Southern Iran AlmasiHashiani, Amir, MSc; Zareifar, Soheil 2, MD; Karimi, Mehran 2, MD; Khedmati,

More information

Seton Medical Center Hepatocellular Carcinoma Patterns of Care Study Rate of Treatment with Chemoembolization 2007 2012 N = 50

Seton Medical Center Hepatocellular Carcinoma Patterns of Care Study Rate of Treatment with Chemoembolization 2007 2012 N = 50 General Data Seton Medical Center Hepatocellular Carcinoma Patterns of Care Study Rate of Treatment with Chemoembolization 2007 2012 N = 50 The vast majority of the patients in this study were diagnosed

More information

National Cancer Institute Research on Childhood Cancers. In the United States in 2005, approximately 9,510 children under age 15 will be

National Cancer Institute Research on Childhood Cancers. In the United States in 2005, approximately 9,510 children under age 15 will be CANCER FACTS N a t i o n a l C a n c e r I n s t i t u t e N a t i o n a l I n s t i t u t e s o f H e a l t h D e p a r t m e n t o f H e a l t h a n d H u m a n S e r v i c e s National Cancer Institute

More information

Munich Cancer Registry

Munich Cancer Registry Munich Cancer Registry Incidence and Mortality Selection Matrix Homepage Deutsch GIST: Gastroint. stromal tumor Survival Year of diagnosis 1998-14 Patients 837 Diseases 838 Cases evaluated 6 Creation date

More information

chapter 5. Quality control at the population-based cancer registry

chapter 5. Quality control at the population-based cancer registry chapter 5. Quality control at the population-based cancer registry All cancer registries should be able to give some objective indication of the quality of the data that they have collected. The methods

More information

Lung Cancer. Public Outcomes Report. Submitted by Omar A. Majid, MD

Lung Cancer. Public Outcomes Report. Submitted by Omar A. Majid, MD Public Outcomes Report Lung Cancer Submitted by Omar A. Majid, MD Lung cancer is the most common cancer-related cause of death among men and women. It has been estimated that there will be 226,1 new cases

More information

A Study To Evaluate PF With Chemotherapy In Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome

A Study To Evaluate PF With Chemotherapy In Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome A service of the U.S. National Institutes of Health Trial record 1 of 5 for: efficacy of PF-04449913 Previous Study Return to List Next Study A Study To Evaluate PF-04449913 With Chemotherapy In Patients

More information

Impact of Diabetes on Treatment Outcomes among Maryland Tuberculosis Cases, 2004-2005. Tania Tang PHASE Symposium May 12, 2007

Impact of Diabetes on Treatment Outcomes among Maryland Tuberculosis Cases, 2004-2005. Tania Tang PHASE Symposium May 12, 2007 Impact of Diabetes on Treatment Outcomes among Maryland Tuberculosis Cases, 2004-2005 Tania Tang PHASE Symposium May 12, 2007 Presentation Outline Background Research Questions Methods Results Discussion

More information

The Blood Cancer Twice As Likely To Affect African Americans: Multiple Myeloma

The Blood Cancer Twice As Likely To Affect African Americans: Multiple Myeloma The Blood Cancer Twice As Likely To Affect African Americans: Multiple Myeloma 11 th Annual National Leadership Summit on Health Disparities Innovation Towards Reducing Disparities Congressional Black

More information

Singapore Cancer Registry Annual Registry Report Trends in Cancer Incidence in Singapore 2009 2013. National Registry of Diseases Office (NRDO)

Singapore Cancer Registry Annual Registry Report Trends in Cancer Incidence in Singapore 2009 2013. National Registry of Diseases Office (NRDO) Singapore Cancer Registry Annual Registry Report Trends in Cancer Incidence in Singapore 2009 2013 National Registry of Diseases Office (NRDO) Released November 3, 2014 Acknowledgement This report was

More information

Non-Hodgkin s Lymphoma

Non-Hodgkin s Lymphoma Non-Hodgkin s Lymphoma Figure 17 Definition: Non-Hodgkin s Lymphoma (NHL) starts in cells called lymphocytes. 1 These cells reside in lymph nodes and lymphoid tissues that are part of the immune system.

More information

Adjuvant Therapy Non Small Cell Lung Cancer. Sunil Nagpal MD Director, Thoracic Oncology Jan 30, 2015

Adjuvant Therapy Non Small Cell Lung Cancer. Sunil Nagpal MD Director, Thoracic Oncology Jan 30, 2015 Adjuvant Therapy Non Small Cell Lung Cancer Sunil Nagpal MD Director, Thoracic Oncology Jan 30, 2015 No Disclosures Number of studies Studies Per Month 12 10 8 6 4 2 0 1 2 3 4 5 6 7 8 9 10 11 12 1 2 3

More information

Blood Cancers Data Quality Report

Blood Cancers Data Quality Report Blood Cancers Data Quality Report National Cancer Data Repository (NCDR) - 21 Haematological Malignancies Site-Specific Clinical Reference Group Knowledge and Intelligence Team (Northern and Yorkshire)

More information

National Cancer Institute

National Cancer Institute National Cancer Institute Information Systems, Technology, and Dissemination in the SEER Program U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Information Systems, Technology,

More information

SECOND PRIMARY BREAST CANCERS FOLLOWING HAEMATOLOGIC MALIGNANCIES A CASE SERIES STUDY FARAH TANVEER PGY 3 DR.MEIR WETZLER DR.

SECOND PRIMARY BREAST CANCERS FOLLOWING HAEMATOLOGIC MALIGNANCIES A CASE SERIES STUDY FARAH TANVEER PGY 3 DR.MEIR WETZLER DR. SECOND PRIMARY BREAST CANCERS FOLLOWING HAEMATOLOGIC MALIGNANCIES A CASE SERIES STUDY FARAH TANVEER PGY 3 DR.MEIR WETZLER DR. TRACEY O CONNOR RESEARCH QUESTON Patients with previously diagnosed hematologic

More information

NEOPLASMS OF KIDNEY (RENAL CELL CARCINOMA) And RENAL PELVIS (TRANSITIONAL CELL CARCINOMA)

NEOPLASMS OF KIDNEY (RENAL CELL CARCINOMA) And RENAL PELVIS (TRANSITIONAL CELL CARCINOMA) NEOPLASMS OF KIDNEY (RENAL CELL CARCINOMA) And RENAL PELVIS (TRANSITIONAL CELL CARCINOMA) Merat Esfahani, MD Medical Oncologist, Hematologist Cancer Liaison Physician SwedishAmerican Regional Cancer Center

More information

Cancer Survival Analysis

Cancer Survival Analysis Cancer Survival Analysis 2 Analysis of cancer survival data and related outcomes is necessary to assess cancer treatment programs and to monitor the progress of regional and national cancer control programs.

More information

Examination of Racial Disparities in Epithelial Ovarian Cancer Survival

Examination of Racial Disparities in Epithelial Ovarian Cancer Survival Examination of Racial Disparities in Epithelial Ovarian Cancer Survival Jennifer Todd A, Martin Whiteside B, Paul Terry C A Meharry Medical College, School of Graduate Studies and Research B Tennessee

More information

Relapsed or Refractory Adult Acute Lymphoblastic Leukemia (ALL): Distinct Patient Populations With Significant Unmet Medical Need

Relapsed or Refractory Adult Acute Lymphoblastic Leukemia (ALL): Distinct Patient Populations With Significant Unmet Medical Need Relapsed or Refractory Adult Acute Lymphoblastic Leukemia (ALL): Distinct Patient Populations With Significant Unmet Medical Need Hagop M. Kantarjian, MD Chairman, Leukemia Department Department of Hematology

More information

Measures of Prognosis. Sukon Kanchanaraksa, PhD Johns Hopkins University

Measures of Prognosis. Sukon Kanchanaraksa, PhD Johns Hopkins University This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike License. Your use of this material constitutes acceptance of that license and the conditions of use of materials on this

More information

Monitoring Clinical Stage to Improve Care

Monitoring Clinical Stage to Improve Care Monitoring Clinical Stage to Improve Care Stephen Dreyer, MD, FACS Cancer Liaison State Chair Nebraska Fremont, NE M. Asa Carter, CTR Manager, Accreditation and Standards American College of Surgeons Chicago,

More information

EXPANDING THE EVIDENCE BASE IN OUTCOMES RESEARCH: USING LINKED ELECTRONIC MEDICAL RECORDS (EMR) AND CLAIMS DATA

EXPANDING THE EVIDENCE BASE IN OUTCOMES RESEARCH: USING LINKED ELECTRONIC MEDICAL RECORDS (EMR) AND CLAIMS DATA EXPANDING THE EVIDENCE BASE IN OUTCOMES RESEARCH: USING LINKED ELECTRONIC MEDICAL RECORDS (EMR) AND CLAIMS DATA A CASE STUDY EXAMINING RISK FACTORS AND COSTS OF UNCONTROLLED HYPERTENSION ISPOR 2013 WORKSHOP

More information

Analysis of Population Cancer Risk Factors in National Information System SVOD

Analysis of Population Cancer Risk Factors in National Information System SVOD Analysis of Population Cancer Risk Factors in National Information System SVOD Mužík J. 1, Dušek L. 1,2, Pavliš P. 1, Koptíková J. 1, Žaloudík J. 3, Vyzula R. 3 Abstract Human risk assessment requires

More information

Stem Cell Transplantation in Leukemia. D. Niederwieser University of Leipzig Germany

Stem Cell Transplantation in Leukemia. D. Niederwieser University of Leipzig Germany Stem Cell Transplantation in Leukemia D. Niederwieser University of Leipzig Germany probability Stem Cell Transplantation in Acute Myeloid Leukemia Outcome according to cytogenetics AML 96 n = 35, 163,

More information

The Ontario Cancer Registry moves to the 21 st Century

The Ontario Cancer Registry moves to the 21 st Century The Ontario Cancer Registry moves to the 21 st Century Rebuilding the OCR Public Health Ontario Grand Rounds Oct. 14, 2014 Diane Nishri, MSc Mary Jane King, MPH, CTR Outline 1. What is the Ontario Cancer

More information

Supplementary Online Content

Supplementary Online Content Supplementary Online Content Bleicher RJ, Ruth K, Sigurdson ER, et al. Time to Surgery and Breast Cancer Survival in the United States. JAMA Oncology. Published online December 10, 2015. doi:10.1001/jamaoncol.2015.4508.

More information

Clinical trial enrollment among older cancer patients

Clinical trial enrollment among older cancer patients Clinical trial enrollment among older cancer patients Sharon H. Giordano MD, MPH Professor, Health Services Research Mariana Chavez Mac Gregor MD, MSc Assistant Professor, Breast Medical Oncology Department

More information

The incidence of leukemia in Saudi Arabia

The incidence of leukemia in Saudi Arabia The incidence of leukemia in Saudi Arabia Descriptive epidemiological analysis of data from the Saudi Cancer Registry (2001-2008) Ibrahim G. Alghamdi, MPhil, PhD, Issam I. Hussain, MPhil, PhD, Mohamed

More information

DNA Methylation in MDS/MPD/AML: Implications for application

DNA Methylation in MDS/MPD/AML: Implications for application DNA Methylation in MDS/MPD/AML: Implications for application James G. Herman, M.D. Professor of Oncology Evelyn Grollman Glick Scholar The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Disclosures

More information

Effect of Risk and Prognosis Factors on Breast Cancer Survival: Study of a Large Dataset with a Long Term Follow-up

Effect of Risk and Prognosis Factors on Breast Cancer Survival: Study of a Large Dataset with a Long Term Follow-up Georgia State University ScholarWorks @ Georgia State University Mathematics Theses Department of Mathematics and Statistics 7-28-2012 Effect of Risk and Prognosis Factors on Breast Cancer Survival: Study

More information

Basics and limitations of adjuvant online an internet based decision tool

Basics and limitations of adjuvant online an internet based decision tool Basics and limitations of adjuvant online an internet based decision tool J. Huober SAKK, Bern 31.10.2013 Univ.-Frauenklinik Ulm Integratives Tumorzentrum des Universitätsklinikums und der Medizinischen

More information

Secondary Cancer Rates Following Breast Cancer Diagnosis

Secondary Cancer Rates Following Breast Cancer Diagnosis Copyright E 2007 Journal of Insurance Medicine J Insur Med 2007;39:98 106 ORIGINAL RESEARCH Secondary Cancer Rates Following Breast Cancer Diagnosis David Wesley, MD Life table analysis and other mortality

More information

Prevalence of HPV Infection in Head and Neck Cancers by Anatomic Subsite

Prevalence of HPV Infection in Head and Neck Cancers by Anatomic Subsite Prevalence of HPV Infection in Head and Neck Cancers by Anatomic Subsite Lihua Liu, PhD Los Angeles Cancer Surveillance Program University of Southern California Head and Neck Cancers A variety of sites

More information

Chapter 13. The hospital-based cancer registry

Chapter 13. The hospital-based cancer registry Chapter 13. The hospital-based cancer registry J.L. Young California Tumor Registry, 1812 14th Street, Suite 200, Sacramento, CA 95814, USA Introduction The purposes of a hospital-based cancer registry

More information

Table 24a Thyroid Cancer Average Annual Number of Cancer Cases and Age-Adjusted Incidence Rates* for

Table 24a Thyroid Cancer Average Annual Number of Cancer Cases and Age-Adjusted Incidence Rates* for Thyroid Cancer Figure 24 Definition: Thyroid cancer starts in the thyroid gland. 1 The thyroid is made up of two main types of cells, thyroid follicular cells and parafollicular cells. 1 Different types

More information

Alaska Comprehensive Cancer Control Plan 2011-15

Alaska Comprehensive Cancer Control Plan 2011-15 Alaska Comprehensive Cancer Control Plan 2011-15 Alaska Comprehensive Cancer Plan 2011-2015 STATE of ALASKA Department of Health and Social Services ALASKA Comprehensive Cancer Partnership Prevention Promotion

More information

Ellis Fischel Cancer Center Registry Data Public Reporting of Outcomes: Breast Cancer

Ellis Fischel Cancer Center Registry Data Public Reporting of Outcomes: Breast Cancer Ellis Fischel Cancer Center Registry Data 13 Public Reporting of Outcomes: Breast Cancer To satisfy Standard 1.12 of the American College of Surgeons Commission on Cancer, a review of outcomes related

More information

Advances In Chemotherapy For Hormone Refractory Prostate Cancer. TAX 327 study results & SWOG 99-16 study results presented at ASCO 2004

Advances In Chemotherapy For Hormone Refractory Prostate Cancer. TAX 327 study results & SWOG 99-16 study results presented at ASCO 2004 Ronald de Wit Rotterdam Cancer Institute The Netherlands Advances In Chemotherapy For Hormone Refractory Prostate Cancer TAX 327 study results & SWOG 99-16 study results presented at Slide 1 Prostate Cancer

More information

Organizing a breast cancer database: data management

Organizing a breast cancer database: data management Review Article Page 1 of 5 Organizing a breast cancer database: data management Min Yi, Kelly K. Hunt Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston,

More information

Cancer research in the Midland Region the prostate and bowel cancer projects

Cancer research in the Midland Region the prostate and bowel cancer projects Cancer research in the Midland Region the prostate and bowel cancer projects Ross Lawrenson Waikato Clinical School University of Auckland MoH/HRC Cancer Research agenda Lung cancer Palliative care Prostate

More information

Stage IV Renal Cell Carcinoma. Changing Management in A Comprehensive Community Cancer Center. Susquehanna Health Cancer Center

Stage IV Renal Cell Carcinoma. Changing Management in A Comprehensive Community Cancer Center. Susquehanna Health Cancer Center Stage IV Renal Cell Carcinoma Changing Management in A Comprehensive Community Cancer Center Susquehanna Health Cancer Center 2000 2009 Warren L. Robinson, MD, FACP January 27, 2014 Introduction 65,150

More information

2010 SITE REPORT St. Joseph Hospital PROSTATE CANCER

2010 SITE REPORT St. Joseph Hospital PROSTATE CANCER 2010 SITE REPORT St. Joseph Hospital PROSTATE CANCER Humboldt County is located on the Redwood Coast of Northern California. U.S census data for 2010 reports county population at 134,623, an increase of

More information

Table 8a Esophageal Cancers Average Annual Number of Cancer Cases and Age-Adjusted Incidence Rates* for

Table 8a Esophageal Cancers Average Annual Number of Cancer Cases and Age-Adjusted Incidence Rates* for Esophageal Cancers Figure 8 Definition: The esophagus connects the throat to the stomach by way of a hollow, muscular tube. 1 Cancers of the esophagus start in the inner mucosa layer and spread outward

More information

AML: How to characterize and treat elderly patients non fit for standard chemotherapy

AML: How to characterize and treat elderly patients non fit for standard chemotherapy m1 AML: How to characterize and treat elderly patients non fit for standard chemotherapy Clinic for Medicine III University Hospital Munich Campus Grosshadern AMLCG study group Karsten Spiekermann, MD

More information

Munich Cancer Registry

Munich Cancer Registry Munich Cancer Registry Baseline statistics Selection Matrix Homepage Deutsch Munich Cancer Registry at Munich Cancer Center Marchioninistr. 15 Munich, 81377 Germany http://www.tumorregister-muenchen.de/en

More information

No. prev. doc.: 8770/08 SAN 64 Subject: EMPLOYMENT, SOCIAL POLICY, HEALTH AND CONSUMER AFFAIRS COUNCIL MEETING ON 9 AND 10 JUNE 2008

No. prev. doc.: 8770/08 SAN 64 Subject: EMPLOYMENT, SOCIAL POLICY, HEALTH AND CONSUMER AFFAIRS COUNCIL MEETING ON 9 AND 10 JUNE 2008 COUNCIL OF THE EUROPEAN UNION Brussels, 22 May 2008 9636/08 SAN 87 NOTE from: Committee of Permanent Representatives (Part 1) to: Council No. prev. doc.: 8770/08 SAN 64 Subject: EMPLOYMENT, SOCIAL POLICY,

More information

Table 7a Corpus Uterus Cancer Average Annual Number of Cancer Cases and Age-Adjusted Incidence Rates* for

Table 7a Corpus Uterus Cancer Average Annual Number of Cancer Cases and Age-Adjusted Incidence Rates* for Corpus Uterus Cancer Figure 7 Definition: The uterus is a hollow organ in the pelvis of females. 1 There are three parts: the top is called the fundus, the middle is called the corpus, and the bottom part

More information

An Introduction to the. cancer registry. instructor s guide

An Introduction to the. cancer registry. instructor s guide An Introduction to the cancer registry instructor s guide National Cancer Registrars Association Education Foundation 1340 Braddock Place, Suite 203 Alexandria, Virginia 22314 (703) 299-6640 www.ncraeducationfoundation.org

More information

Costs Associated with Neutropenia in Elderly Patients Treated First-Line for Advanced Non-Small Cell Lung Cancer

Costs Associated with Neutropenia in Elderly Patients Treated First-Line for Advanced Non-Small Cell Lung Cancer Costs Associated with Neutropenia in Elderly Patients Treated First-Line for Advanced Non-Small Cell Lung Cancer Michael Stokes United BioSource Corporation ISPOR 13 th Annual International Meeting Toronto,

More information

Munich Cancer Registry

Munich Cancer Registry Munich Cancer Registry Baseline statistics Selection Matrix Homepage Deutsch Munich Cancer Registry at Munich Cancer Center Marchioninistr. 15 Munich, 81377 Germany http://www.tumorregister-muenchen.de/en

More information

CHILDHOOD CANCER INCIDENCE UPDATE:

CHILDHOOD CANCER INCIDENCE UPDATE: CHILDHOOD CANCER INCIDENCE UPDATE: A REVIEW AND ANALYSIS of CANCER REGISTRY DATA, 979, FOR DOVER TOWNSHIP (OCEAN COUNTY), NEW JERSEY Technical Report January Division of Epidemiology, Environmental and

More information

Number. Source: Vital Records, M CDPH

Number. Source: Vital Records, M CDPH Epidemiology of Cancer in Department of Public Health Revised April 212 Introduction The general public is very concerned about cancer in the community. Many residents believe that cancer rates are high

More information

A Population Based Risk Algorithm for the Development of Type 2 Diabetes: in the United States

A Population Based Risk Algorithm for the Development of Type 2 Diabetes: in the United States A Population Based Risk Algorithm for the Development of Type 2 Diabetes: Validation of the Diabetes Population Risk Tool (DPoRT) in the United States Christopher Tait PhD Student Canadian Society for

More information

Long Term Low Dose Maintenance Chemotherapy in the Treatment of Acute Myeloid Leukemia

Long Term Low Dose Maintenance Chemotherapy in the Treatment of Acute Myeloid Leukemia Long Term Low Dose Chemotherapy in the Treatment of Acute Myeloid Leukemia Murat TOMBULO LU*, Seçkin ÇA IRGAN* * Department of Hematology, Faculty of Medicine, Ege University, zmir, TURKEY ABSTRACT In

More information

Social inequalities impacts of care management and survival in patients with non-hodgkin lymphomas (ISO-LYMPH)

Social inequalities impacts of care management and survival in patients with non-hodgkin lymphomas (ISO-LYMPH) Session 3 : Epidemiology and public health Social inequalities impacts of care management and survival in patients with non-hodgkin lymphomas (ISO-LYMPH) Le Guyader-Peyrou Sandra Bergonie Institut Context:

More information

Completeness of Physician Billing Claims for Diabetes Prevalence Estimation

Completeness of Physician Billing Claims for Diabetes Prevalence Estimation Completeness of Physician Billing Claims for Diabetes Prevalence Estimation Lisa M. Lix 1, John Paul Kuwornu 1, George Kephart 2, Khokan Sikdar 3, Hude Quan 4 1 University of Manitoba; 2 Dalhousie University;

More information

Munich Cancer Registry

Munich Cancer Registry Munich Cancer Registry Incidence and Mortality Selection Matrix Homepage Deutsch ICD-1 C25: Pancreas cancer Survival Year of diagnosis 1988-1997 1998-214 Patients 867 11,778 Diseases 867 11,779 Cases evaluated

More information

Can I have FAITH in this Review?

Can I have FAITH in this Review? Can I have FAITH in this Review? Find Appraise Include Total Heterogeneity Paul Glasziou Centre for Research in Evidence Based Practice Bond University What do you do? For an acutely ill patient, you do

More information

Introduction Objective Methods Results Conclusion

Introduction Objective Methods Results Conclusion Introduction Objective Methods Results Conclusion 2 Malignant pleural mesothelioma (MPM) is the most common form of mesothelioma a rare cancer associated with long latency period (i.e. 20 to 40 years),

More information

Always Start with PECO

Always Start with PECO Goals of This Course Be able to understand a study design (very basic concept) Be able to understand statistical concepts in a medical paper Be able to perform a data analysis Understanding: PECO study

More information

Research Article Frequency of Surgery in Black Patients with Malignant Pleural Mesothelioma

Research Article Frequency of Surgery in Black Patients with Malignant Pleural Mesothelioma Disease Markers Volume 2015, Article ID 282145, 5 pages http://dx.doi.org/10.1155/2015/282145 Research Article Frequency of Surgery in Black Patients with Malignant Pleural Mesothelioma Emanuela Taioli,

More information

A Career in Pediatric Hematology-Oncology? Think About It...

A Career in Pediatric Hematology-Oncology? Think About It... A Career in Pediatric Hematology-Oncology? Think About It... What does a pediatric hematologist-oncologist do? What kind of training is necessary? Is there a future need for specialists in this area? T

More information

WHI - Volume 8, Section 4 - Outcome Classifications: Cancer Outcomes Page 4-1 SECTION 4 OUTCOME CLASSIFICATIONS: CANCER OUTCOMES

WHI - Volume 8, Section 4 - Outcome Classifications: Cancer Outcomes Page 4-1 SECTION 4 OUTCOME CLASSIFICATIONS: CANCER OUTCOMES WHI - Volume 8, Section 4 - Outcome Classifications: Cancer Outcomes Page 4-1 SECTION 4 OUTCOME CLASSIFICATIONS: CANCER OUTCOMES INTRODUCTION Breast and colorectal cancers are primary outcomes of the Dietary

More information

Become a Cancer Registrar

Become a Cancer Registrar PAGE 1 OF 5 Cancer registrars ensure that timely, accurate, and complete data are maintained on all types of cancer diagnosed and/or treated within a health care institution or within a defined population.

More information

Appendix G STATISTICAL METHODS INFECTIOUS METHODS STATISTICAL ROADMAP. Prepared in Support of: CDC/NCEH Cross Sectional Assessment Study.

Appendix G STATISTICAL METHODS INFECTIOUS METHODS STATISTICAL ROADMAP. Prepared in Support of: CDC/NCEH Cross Sectional Assessment Study. Appendix G STATISTICAL METHODS INFECTIOUS METHODS STATISTICAL ROADMAP Prepared in Support of: CDC/NCEH Cross Sectional Assessment Study Prepared by: Centers for Disease Control and Prevention National

More information

Childhood cancer incidence and mortality in Canada

Childhood cancer incidence and mortality in Canada Catalogue no.82-624 X ISSN 1925-6493 Health at a Glance Childhood cancer incidence and mortality in Canada by Lawrence Ellison and Teresa Janz Release date: September 22, 215 How to obtain more information

More information

David Feltl, M.D., Ph.D., MBA. Structure and organization of cancer care in the Czech Republic. Assessment of outputs and outcomes.

David Feltl, M.D., Ph.D., MBA. Structure and organization of cancer care in the Czech Republic. Assessment of outputs and outcomes. David Feltl, M.D., Ph.D., MBA Structure and organization of cancer care in the Czech Republic. Assessment of outputs and outcomes. Contents Cancer epidemiology in the Czech Republic National oncology program

More information

PROTOCOL OF THE RITA DATA QUALITY STUDY

PROTOCOL OF THE RITA DATA QUALITY STUDY PROTOCOL OF THE RITA DATA QUALITY STUDY INTRODUCTION The RITA project is aimed at estimating the burden of rare malignant tumours in Italy using the population based cancer registries (CRs) data. One of

More information

BC Cancer Agency Mandate

BC Cancer Agency Mandate BC Cancer Agency s approach to improving the quality of care in oncology Dr David idlevy President BC Cancer Agency Mandate To provide a province wide, population based cancer control program for BC &

More information

2012 Report on Cancer Statistics in Alberta

2012 Report on Cancer Statistics in Alberta 2012 Report on Cancer Statistics in Alberta Childhood Cancer Surveillance & Reporting CancerControl AB February 2015 Acknowledgements This report was made possible through Surveillance & Reporting, Cancer

More information

EDUCATING, SUPPORTING & COORDINATING CARE: ONCOLOGY NURSE NAVIGATORS

EDUCATING, SUPPORTING & COORDINATING CARE: ONCOLOGY NURSE NAVIGATORS EDUCATING, SUPPORTING & COORDINATING CARE: ONCOLOGY NURSE NAVIGATORS Nancy Foreman, RN, BSN Oncology Nurse Navigator Cancer Centers of Northern Arizona Healthcare Learning Objectives: Identify five services

More information

Research funding was provided by TAP Pharmaceutical Products, Inc.

Research funding was provided by TAP Pharmaceutical Products, Inc. DOES THE DOSING FREQUENCY OF PROTON PUMP INHIBITORS (PPIs) AFFECT SUBSEQUENT RESOURCE UTILIZATION AND COSTS AMONG PATIENTS DIAGNOSED WITH GASTROESOPHAGEAL REFLUX DISEASE (GERD)? Boulanger L 1, Mody R 2,

More information

Hepatitis C Virus Infection: Prevalence Report, 2003 Data Source: Minnesota Department of Health HCV Surveillance System

Hepatitis C Virus Infection: Prevalence Report, 2003 Data Source: Minnesota Department of Health HCV Surveillance System Hepatitis C Virus Infection: Prevalence Report, 2003 Data Source: Minnesota Department of Health HCV Surveillance System P.O. Box 9441 Minneapolis, MN 55440-9441 612-676-5414, 1-877-676-5414 www.health.state.mn.us/immunize

More information

Evaluation of Treatment Pathways in Oncology: Modeling Approaches. Feng Pan, PhD United BioSource Corporation Bethesda, MD

Evaluation of Treatment Pathways in Oncology: Modeling Approaches. Feng Pan, PhD United BioSource Corporation Bethesda, MD Evaluation of Treatment Pathways in Oncology: Modeling Approaches Feng Pan, PhD United BioSource Corporation Bethesda, MD 1 Objectives Rationale for modeling treatment pathways Treatment pathway simulation

More information

Electronic health records to study population health: opportunities and challenges

Electronic health records to study population health: opportunities and challenges Electronic health records to study population health: opportunities and challenges Caroline A. Thompson, PhD, MPH Assistant Professor of Epidemiology San Diego State University Caroline.Thompson@mail.sdsu.edu

More information

Munich Cancer Registry

Munich Cancer Registry Munich Cancer Registry Baseline statistics Selection Matrix Homepage Deutsch Munich Cancer Registry at Munich Cancer Center Marchioninistr. 15 Munich, 81377 Germany http://www.tumorregister-muenchen.de/en

More information

NIH/NCI Funding Opportunities for Cardio-Oncology Clinical Trials and Research Projects

NIH/NCI Funding Opportunities for Cardio-Oncology Clinical Trials and Research Projects NIH/NCI Funding Opportunities for Cardio-Oncology Clinical Trials and Research Projects Lori Minasian, M.D., FACP Deputy Director NCI Division of Cancer Prevention September 30, 2016 Outline Perspective

More information

C a nc e r C e nter. Annual Registry Report

C a nc e r C e nter. Annual Registry Report C a nc e r C e nter Annual Registry Report 214 214 Cancer Registry Report Larraine A. Tooker, CTR Please note that the 214 Cancer Registry Annual Report is created in 214, but it reflects data on cases

More information

UMHS-PUHSC JOINT INSTITUTE

UMHS-PUHSC JOINT INSTITUTE Imaging Biomarkers for Staging and Assessing Response to Therapy in Multiple Myeloma Qian Dong, MD. Radiology University of Michigan Wei Guo, MD. Orthopedic Oncology Peking University Second Hospital Team

More information

PROGNOSIS IN ACUTE LYMPHOBLASTIC LEUKEMIA PROGNOSIS IN ACUTE MYELOID LEUKEMIA

PROGNOSIS IN ACUTE LYMPHOBLASTIC LEUKEMIA PROGNOSIS IN ACUTE MYELOID LEUKEMIA PROGNOSIS IN ACUTE LYMPHOBLASTIC LEUKEMIA UNFAVORABLE Advanced age High leukocyte count at diagnosis Presence of myeloid antigens Late achievement of CR Chromosomal abnormalities: t(9:22)(q34:q11) t(4;11)(q21;q23)

More information

Munich Cancer Registry

Munich Cancer Registry Munich Cancer Registry Survival Selection Matrix Homepage Deutsch Munich Cancer Registry at Munich Cancer Center Marchioninistr. 15 Munich, 81377 Germany http://www.tumorregister-muenchen.de/en Cancer

More information

Finnish Cancer Registry Institute for Statistical and Epidemiological Cancer Research. Survival ratios of cancer patients by area in Finland

Finnish Cancer Registry Institute for Statistical and Epidemiological Cancer Research. Survival ratios of cancer patients by area in Finland Survival ratios of cancer patients by area in Finland Pages 2 14 present the relative survival ratios for patients diagnosed in 2005 2012 and followed-up in 2010 2012 (see Methods p. 15) on different university

More information

Lung Cancer in the West Midlands

Lung Cancer in the West Midlands West Midlands Cancer Intelligence Unit Lung Cancer in the West Midlands Supporting the fight against cancer through timely, high quality information provision R11/05 November 2011 0 Author: TE Last updated:

More information

Chapter 2 History of MD Anderson s Tumor Registry

Chapter 2 History of MD Anderson s Tumor Registry Chapter 2 History of MD Anderson s Tumor Registry Sarah H. Taylor The Tumor Registry Department at The University of Texas MD Anderson Cancer Center is responsible for a database that contains demographic

More information

Munich Cancer Registry

Munich Cancer Registry Munich Cancer Registry Survival Selection Matrix Homepage Deutsch Munich Cancer Registry at Munich Cancer Center Marchioninistr. 15 Munich, 81377 Germany http://www.tumorregister-muenchen.de/en Cancer

More information

HIV/AIDS in the Binghamton Tri-County Region Revised June 2007

HIV/AIDS in the Binghamton Tri-County Region Revised June 2007 HIV/AIDS in the Binghamton Tri-County Revised June 2007 HIV is the virus that causes AIDS. You can be infected with HIV but not diagnosed with AIDS. The Centers for Disease Control (CDC) estimated that

More information

La personalizzazione terapeutica: quanto influisce l età

La personalizzazione terapeutica: quanto influisce l età La personalizzazione terapeutica: quanto influisce l età PierFranco Conte University of Padova Department of Surgery, Oncology and Gastroenterology IOV Istituto Oncologico Veneto I.R.C.C.S. Breast Cancer

More information

Simplifying the measurement of co-morbidities and their influence on chemotherapy toxicity

Simplifying the measurement of co-morbidities and their influence on chemotherapy toxicity Simplifying the measurement of co-morbidities and their influence on chemotherapy toxicity Dr Rajesh Sinha BSc MBBS MRCP, Clinical Research Fellow in Medical Oncology Brighton and Sussex University Hospitals

More information