TILDELING AV FORSKNINGSMIDLER 2015 UNIVERSITETET I BERGEN

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1 TILDELING AV FORSKNINGSMIDLER 2015 UNIVERSITETET I BERGEN Søker Prosjekttittel Institusjon Innvilget Beløp Rein Aasland The role of histone acetylation in enhancer function Universitetet i Bergen Thomas Arnesen Mathias Ziegler Human enzymes overexpressed in cancers - novel targets for cancer therapy Metabolic hub molecules as key factors in cancer development and prevention Universitetet i Bergen Universitetet i Bergen Rolf Bjerkvig Identifying molecular targets on human glioblastoma. (GBM-TARGET) Universitetet i Bergen Frits Thorsen Finding new uses for old drugs in clinical treatment of brain metastases Universitetet i Bergen Generelle driftsmidler Forskerstipend, 1-4. år Generelle driftsmidler Generelle driftsmidler Generelle driftsmidler Generelle driftsmidler Martha Chekenya Natural Killer cellular therapy for Glioblastoma:Role of KIR2DS4+NKG2C+ NK subsets in immunosurveillance and progression Universitetet i Bergen Generelle driftsmidler Per Enger Validating xct as a therapeutic target in human cancers Universitetet i Bergen Generelle driftsmidler Øystein Bruserud NY FARMAKOLOGISK TERAPI VED AKUTT MYELOGEN LEUKEMI Universitetet i Bergen Emmet Mc Cormack Translational Development of Preclinical Models and Therapies in Myeloid Neoplasia Universitetet i Bergen Generelle driftsmidler

2 Bjørn Tore Gjertsen Xiang Wang Pre-apoptotic molecular mechanisms in acute myeloid leukemia Microfluidic device for rapid collection and phenotyping of circulating tumor cells Universitetet i Bergen Generelle driftsmidler Universitetet i Bergen Kvalifiseringsstipend (3 år) Stein Døskeland Terapi-relevant cancercelle døds-signalering Universitetet i Bergen Generelle driftsmidler Per Lønning Genforandringer som årsak til behandlingsresistens samt betydning av hormonelle faktorer for utvikling av brystkreft Universitetet i Bergen Generelle driftsmidler Stian Knappskog Genetic alterations affecting response to breast cancer therapy Universitetet i Bergen Lars A Akslen Biomarkers of Breast Cancer Heterogeneity Based on Tumor-Microenvironment Interactions Universitetet i Bergen Helga Salvesen Individualized therapy based on molecular alterations in gynecologic cancer Universitetet i Bergen Generelle driftsmidler Halfdan Sørbye Treatment and markers of elderly metastatic colorectal cancer patients Haukeland universitets sykehus HF Klinisk korttidsstipend Kari Dyregrov «The cancer changed my life»: - A mixed-method study of young adult cancer survivors challenges and psychosocial needs Senter for krisepsykologi

3 TILDELING AV FORSKNINGSMIDLER 2015 NTNU, HØGSKOLEN I SØR-TRØNDELAG OG ST. OLAVS HOSPITAL Søker Prosjekttittel Institusjon Innvilget Beløp Bjørn H. Grønberg Nordic Randomized Phase II Trial Comparing High-Dose With Standard-Dose Thoracic Radiotherapy In Limited Disease Small-Cell Lung Cancer NTNU Teknisk stilling (3 år) Generelle driftsmidler Lene Grøvdal Moving Tolls- How trafficking of TLRs regulate cancer NTNU Kvalifiseringsstipend (3 år) Bodil Merete Kavli Role of activation-induced cytidine deaminase (AID) in development of B-cell lymphomas NTNU Generelle driftsmidler Therese Standal Interleukin-32 in multiple myeloma NTNU Generelle driftsmidler Kristian Starheim Targeting the RIP1 cell death pathway in tumor-associated macrophages as cancer therapy NTNU Kvalifiseringsstipend (3 år) Anders Sundan Classification of multiple myeloma NTNU Anders Waage Clinical and Translational Research on Multiple Myeloma and Chronic myeloid leukemia NTNU

4 Geir Slupphaug Identification of novel biomarkers in B-cell lymphomas by quantitative mass spectrometry NTNU Generelle driftsmidler Xiao-Mei Mai Genetic and causal association of vitamin D with lung cancer incidence in a Norwegian population NTNU Generelle driftsmidler Lars Vatten Early life factors and breast cancer risk, by molecular subtypes NTNU Gjesteforskerstipend Guro Giskeødegård Metabolomics for improved stratification of breast cancer patients based on prognosis and treatment response NTNU Kvalifiseringsstipend (3 år) Siver Moestue USPIO MRI in prostate cancer: vascular imaging and lymph node staging NTNU Frank Skorpen Exploration of the potential utility of liquid biopsiesin improving outcomes of curative treatment of non-small-cell lung cancer (NSCLC) NTNU Generelle driftsmidler Geir Bjørkøy Targeting Autophagy to interfere with tumor growth and cachexia Høgskolen i Sør-Trøndelag Generelle driftsmidler Torgeir Wethal Acute and long-term cardiovascular toxicity after modern radiotherapy for breast cancer a prospective longitudinal study St. Olavs hospital HF Generelle driftsmidler Torgrim Tandstad The SWENOTECA ABC-study St. Olavs hospital HF Generelle driftsmidler

5 TILDELING AV FORSKNINGSMIDLER 2015 UNIVERSITETET I TROMSØ Søker Prosjekttittel Institusjon Innvilget Beløp Lorena Arranz Neuroglial Regulation of the Haematopoietic Stem Cell Niche in Acute Myeloid Leukaemia Transformation Universitetet i Tromsø Generelle driftsmidler Tom Dønnem Terje Johansen Clinical Implementation of TNM-Immunoscore in Resected Non-Small Cell Lung Cancer Roles of p62/sqstm1 and LIR-containing proteins in selective autophagy and cell signalling Universitetet i Tromsø Universitetet i Tromsø Generelle driftsmidler

6 TILDELING AV FORSKNINGSMIDLER 2015 UNIVERSITETET I OSLO Søker Prosjekttittel Institusjon Innvilget Beløp Heidi Blomhoff Erwan Delbarre Regulation of proliferation and cell death by camp and vitamin A in cells of the immune system ipscs to elucidate epigenetic processes underlying pediatric gliomas linked to mutations in a histone gene Universitetet i Oslo Universitetet i Oslo Anne Simonsen The role of selective autophagy in tumor suppression Universitetet i Oslo Anne Spurkland Evaluation of TSAd as a target for cancer therapy Universitetet i Oslo Generelle driftsmidler Kvalifiseringsstipend (3 år) Generelle driftsmidler Generelle driftsmidler Jason Matthews ADP-ribosylation regulates estrogen receptor signalling and breast cancer risk Universitetet i Oslo Generelle driftsmidler Rune Blomhoff Diet, inflammation and oxidative stress in colorectal cancer patients: Preclinical and clinical studies Universitetet i Oslo Generelle driftsmidler Marit Veierød Melanomas differ: Better understand to better prevent Universitetet i Oslo Generelle driftsmidler Thomas Küntziger AKAP95 in chromosomal instability and cancer gene bookmarking Universitetet i Oslo Generelle driftsmidler Ståle Petter Lyngstadaas Understanding the radiation biology of reconstructed bone Universitetet i Oslo Generelle driftsmidler Michael Bretthauer Colorectal cancer screening and surveillance Universitetet i Oslo Forskerstipend, 1-4. år

7 Bjørn Dalhus Development of DNA base excision repair inhibitors as cancer therapy adjuvants Universitetet i Oslo Generelle driftsmidler Ludvig A Munthe Pathogenesis and treatment of B cell Cancers Universitetet i Oslo Ragnhild Eskeland Chromatin organisation in cancer Universitetet i Oslo Generelle driftsmidler Pål Øystein Falnes Functional studies of cancer relevant methylases, demethylases, and hydroxylases Universitetet i Oslo Generelle driftsmidler Gareth Griffiths Development of nanoparticle drug and sirna therapy against cancer in cells and zebrafish Universitetet i Oslo Generelle driftsmidler Fahri Saatcioglu Androgen action and prostate cancer - Development of markers and therapeutic targets Universitetet i Oslo Generelle driftsmidler Yang Jin STAMPs as biomarkers in breast cancer Universitetet i Oslo Kvalifiseringsstipend (3 år) Cinzia Progida Novel roles of Rab proteins in cell migration Universitetet i Oslo Generelle driftsmidler Michael Leitges Analysis the relevance of the PKC/PKD signaling axis during tumorigenesis Universitetet i Oslo Generelle driftsmidler Per Ottar Seglen CYTOPHAGY Universitetet i Oslo Generelle driftsmidler Kjetil Taskén Molekylære mekanismer for camp-mediert regulering av celleproliferasjon og immunfunksjon Universitetet i Oslo Generelle driftsmidler

8 TILDELING AV FORSKNINGSMIDLER 2015 OSLO UNIVERSITETSSYKEHUS OG AKERSHUS UNIVERSITETSSYKEHUS Søker Prosjekttittel Institusjon Innvilget Beløp Magnar Bjørås Molykære mekansimer for DNA reparasjon Arne Klungland Characterization of novel and known DNA modifications in cancer initiation and progression Generelle driftsmidler Bjarne Bogen T celler i immunovervåkning og immunterapi av kreft Generelle driftsmidler Jorrit Enserink PRECISION MEDICINE FOR ACUTE MYELOID LEUKEMIA PATIENTS Alexandre Corthay Cancer immunotherapy by targeting tumor-infiltrating macrophages Generelle driftsmidler Ole Audun Werner Haabeth Stig Ove Bøe Immunotherapeutic modulation of the bone marrow microenvironment in multiple myeloma Acute promyelocytic leukemia: molecular pathogenesis and mechanism of cure Kvalifiseringsstipend (3 år) Generelle driftsmidler Ingrun Alseth RNA modifications in cancer; the role of Endonuclease V Generelle driftsmidler Kyrre Emblem TREATMENT - Improved Therapy Response Assessment in Metastatic Brain Tumors Eirik Malinen Image-based targeting of cancer

9 Cecilie Kiserud Alexander Fosså Hodgkin`s lymphoma: Risk and prevalence of long-term adverse effects and challenges for the health care service Euronet-PHL-C2 studien-en europeisk randomisert studie for optimalisert behandling av barn og unge med klassisk Hodgkin lymfom Generelle driftsmidler Odd Terje Brustugun Precision oncology in lung cancer Generelle driftsmidler Odd Terje Brustugun Novel EGFR-targeting therapy in non-small cell lung cancer. Treatment effects and resistance mechanisms. Klinisk korttidsstipend Åslaug Helland Why are some cancers more aggressive? Generelle driftsmidler Torgeir Bruun Wyller Kjersti Bruheim Treatment and survival in Norwegian cancer patients beyond 75 years of age Is the new concept of patient tailored radiotherapy safe in small cervical tumours? Klinisk korttidsstipend Stein Andersson Executive functioning in survivors of pediatric brain tumors Generelle driftsmidler Harald Stenmark Cell division and cancer Generelle driftsmidler Camilla Raiborg ER-Endosome Contact: Implications for Tumour Suppressor Pathways, Cell Migration and Invasion Kaisa Haglund Cytokinesis and carcinogenesis Forskerstipend, 1-4. år Generelle driftsmidler Kay Oliver Schink Macropinocytosis in cancer cells - Culprit or Saviour? Kvalifiseringsstipend (3 år) Sebastian Schultz Final steps of autophagosome closure - mechanistic insights and potential role in cancer Kvalifiseringsstipend (3 år) Kirsten Sandvig Endocytosis and intracellular sorting of protein toxins

10 Alicia Llorente Sascha Pust Antoni Wiedlocha Extracellular Vesicles and Prostate Cancer: In Search of Tumorigenesis Mechanisms and Biomarkers Membrane crosslinkers in carcinogenesis: New possibilities for cancer diagnosis and therapy Next generation targeted radionuclide therapy for FGF receptor expressing cancers Generelle driftsmidler Kvalifiseringsstipend (3 år) Generelle driftsmidler Jørgen Wesche Novel regulators of cancer cell migration Generelle driftsmidler Ellen Margrethe Haugsten Ragnhild Lothe Switching off Met signalling - Identification of novel regulators and their relevance in metastatic prostate cancer Kreft, et resultat av genetiske og epigenetiske endringer. Modeller og mekanismer. Kvalifiseringsstipend (3 år) Generelle driftsmidler Guro Elisabeth Lind Epigenetic biomarkers for early detection and monitoring of cancer Generelle driftsmidler Rolf Skotheim Kvalitativ transkriptvariasjon i kreft Heidi Lyng Molecular biomarkers in radiotherapy of cancer Anette Weyergang AN IMMUNE-MEDIATED GATEWAY FOR ELIMINATION OF CANCER Kvalifiseringsstipend (3 år) Generelle driftsmidler Einar Rofstad Tumor-Radiobiologi Generelle driftsmidler Kristian Berg Fotokjemisk internalisering Generelle driftsmidler Randi Syljuåsen DNA damage checkpoint signaling, hypoxia and radiation Generelle driftsmidler Kristin Taskén Targeting therapy resistance in prostate cancer Generelle driftsmidler

11 Leonardo A Meza Zepeda Genome-wide genetic and epigenetic programs in cancer Generelle driftsmidler Ola Myklebost Mesenchymal Cancer Medicine Generelle driftsmidler Gunhild Mælandsmo Kjetil Boye Therapeutic approaches and molecular understanding of metastatic cancer Circulating tumor DNA as a biomarker in gastrointestinal stromal tumor Generelle driftsmidler Kjersti Flatmark Colorectal cancer metastasis - a question of location Generelle driftsmidler Øystein Fodstad Tumor-og molekylærbiologiske studier av metastaser. Utvikling av nye diagnostiske og terapeutiske metoder Generelle driftsmidler Trevor Clancy Systems immunology to guide personalized cancer medicine Kvalifiseringsstipend (3 år) Erlend Bremertun Smeland Kanutte Huse Biology of B cell lymphoma - identification of new diagnostic markers and targets for therapeutic intervention Deep profiling of tumor-cell heterogeneity and tumor-associated T cells in follicular lymphoma Kvalifiseringsstipend (3 år) Johanna Olweus Genetically engineered T cells targeting cancer stem cells Generelle driftsmidler Arne Kolstad Development of novel immunotherapies in malignant lymphoma - discovery of targets and T cell receptors Forskerstipend, 1-4. år Karl-Johan Malmberg Development of Cell Therapies for Malignant Lymphomas Based on New Insights Into Natural Killer Cell Repertoire Diversity Generelle driftsmidler Mouldy Sioud Sébastien Wälchli Improving Dendritic Cell Cancer Vaccine and Antibody Therapy: From Bench to Bedside DEVELOPMENT OF NOVEL STRATEGIES IN CANCER IMMUNOTHERAPY Generelle driftsmidler

12 June Myklebust Deciphering impact of genetic and proteomic alternations on drug sensitivity in B-cell lymphoma Generelle driftsmidler Harald Holte Novel clinical and translational aspects of malignant B-cell lymphomas Forskerstipend, 1-4. år Anders Tveita Immunotherapeutic targeting of tumor-associated macrophages Generelle driftsmidler Hege Elisabeth Giercksky Russnes Intra tumor heterogeneity; from single cell analysis to diagnostic tools. Therese Sørlie Molecular portraits of breast cancer: Translating genomics to the clinical practice Generelle driftsmidler Bjørn Naume Targeting occult tumor cell dissemination in localized breast cancer Vessela Kristensen The genetic Make-up and metabolic profile of breast cancer patients; relation to clinical course and treatment response Generelle driftsmidler Kathrine Røe Redalen BioPicture - Biologic mapping for treatment individualisation in rectal cancer by functional magnetic resonance Akershus universitetssykehus HF Kvalifiseringsstipend (3 år) Anne Ree Efficacy and Tolerability to Targeted Combined-Modality Therapy -- Biological Mechanisms in Colorectal Cancer Akershus universitetssykehus HF Anne Eskild Are women getting older at last menstrual period, and what may be causes and consequences of high age at menopause? Akershus universitetssykehus HF Hilde Nilsen Functional implications of the RNA- and DNA-processing activity of SMUG1 in telomere maintenance, stem cells, and cancer Akershus universitetssykehus HF Generelle driftsmidler Hoa Thi Tuyet Tran Acute myeloid leukemia in the elderly Akershus universitetssykehus HF Klinisk korttidsstipend