Please refer to the application instructions in order to complete sections A, B, and C of the Biographical Sketch.

Transcription

1 NAME Bradford C. Dickerson, M.D. era COMMONS USER NAME BCDICKERSON BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES. POSITION TITLE Assistant Professor of Neurology, Harvard Medical School EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) Southern Methodist University, Dallas, TX B.S Biomedical Engineering Univ. of Illinois at Chicago College Of Medicine M.D Medicine Harvard Medical School/MIT, Boston, MA M.MSc Clinical Investigation Please refer to the application instructions in order to complete sections A, B, and C of the Biographical Sketch. A. Positions and Honors Positions and Employment: Information Prog Specialist, Med/Sci Affairs Div, Alzheimer s Assn, Chicago, IL Manager, Information Program, MSA Division, Alzheimer s Association, Chicago, IL 1995 Walter Rice Craig Research Fellow, Beckman Institute Neural Systems Group, Univ. of Illinois at Urbana-Champaign, Urbana, IL Research Fellow, Rush-Presbyterian-St. Luke s Medical Center, Chicago, IL Intern, Department of Internal Medicine, Brigham & Women s Hospital, Boston, MA Clinical Fellow in Medicine, Harvard Medical School Resident, Departments of Neurology, MGH & BWH, Boston, MA Clinical Fellow in Neurology, Harvard Medical School Chief Resident, Departments of Neurology, MGH and BWH, Boston, MA Assistant in Neurology, Massachusetts General Hospital, Boston, MA Associate Neurologist, Division of Cognitive and Behavioral Neurology, Brigham & Women s Hospital, Boston, MA Instructor in Neurology, Harvard Medical School, Boston, MA Co-Director, Neuroimaging Group, MGH Gerontology Research Unit, Charlstown, MA Director of Clinical Applications, MGH Morphometry Analysis Center, Charlestown, MA Assistant Professor of Neurology, Harvard Medical School, Boston, MA Honors and Awards: 1995 Walter Rice Craig Summer Research Fellowship, Univ. of Illinois at Urbana-Champaign James Scholar, UIC College of Medicine 1996 Honorable Mention, UIC College of Medicine Student Research Symposium 1997 Second place, Sigma Xi Session of Rush University Research Forum 1998 Alpha Omega Alpha 1999 David M. Olkon Honors Scholarship, UIC College of Medicine 2001 Outstanding Resident Teacher in Neurology, Harvard Medical School 2002 Partners in Excellence Award (Neurology Chief Residents), Partners Healthcare System 2005 Mentor of the Year Award, Partners Neurology Residents Professional Societies and Committees: American Medical Writers Association Society for Neuroscience James Scholar Program Advisory Committee

2 2001- BWH Department of Internal Medicine Resident Selection Committee American Academy of Neurology Organization for Human Brain Mapping Cognitive Neuroscience Society Alzheimer s Association Speakers Committee Alzheimer s Association Medical & Scientific Advisory Board Ad-Hoc Member, Grant review committee, Fidelity Research Foundation Ad-Hoc Member, Grant review committee, Retirement Research Foundation Member, Behavioral Neurology Section, American Academy of Neurology Member, Society for Behavioral and Cognitive Neurology Member, Med/Sci Advisory Committee, Massachusetts Alzheimer's Assn Chair, Core data committee, BWH Memory Disorders Unit Chair (invited session), Winter Conference on Neural Plasticity 2005 Ad-Hoc Member, Grant review committee, National Science Foundation Chair, Organizing committee, Charles River Association for Memory B. Selected Peer-Reviewed Publications (in chronological order): Original Articles 1. detoledo-morrell L, Dickerson B, Sullivan MP, Spanovic C, Wilson R, Bennet DA. Hemispheric differences in hippocampal volume predict verbal and spatial memory performance in patients with Alzheimer s disease. Hippocampus 2000; 10(2): detoledo-morrell L, Goncharova I, Dickerson B, Wilson RS, Bennett DA. From healthy aging to Alzheimer s disease: in vivo detection of entorhinal cortex atrophy. Ann. N. Y. Acad. Sci. 2000;911: Dickerson BC, Goncharova I, Sullivan MP, Forchetti C, Wilson RS, Bennett DA, Beckett LA, detoledo- Morrell L. MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer s disease. Neurobiol. Aging 2001;22(5): Goncharova I, Dickerson BC, Stoub TR, detoledo-morrell L. MRI of human entorhinal cortex: a reliable protocol for volumetric measurement. Neurobiol. Aging 2001;22(5): Dickerson BC, Salat DH, Bates JF, Atiya M, Killiany RJ, Greve DN, Dale AM, Stern CE, Blacker D, Albert MS, Sperling RA. MRI measures of medial temporal lobe function and structure in mild cognitive impairment. Ann Neurol 2004;56: Dickerson BC, Sperling RA. Neuroimaging biomarkers for clinical trials of disease-modifying therapies in Alzheimer s disease. NeuroRx, 2005;2: [peer-reviewed review]. 7. Dickerson BC, Salat DH, Greve DN, Chua EF, Rand-Giovanetti E, Rentz DM, Bertram L, Mullin K, Tanzi RE, Blacker D, Albert MS, Sperling RA. Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD. Neurology, : Atri A, Locascio JJ, Lin JM, Yap L, Dickerson BC, Grodstein F, Irizarry MC, Growdon JH, Greenberg SM. Prevalence and effects of lobar microhemorrhages in early-stage dementia. Neurodegenerative Diseases 2005; 2(6): Desikan RS, Segonne F, Fischl B, Quinn B, Dickerson BC, Blacker D, Buckner RL, Dale A, Hyman BT, Albert MS, Killiany RJ. A computer generated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage 2006;31(3): Han X, Jovicich J, Salat D, van der Kouwe A, Quinn B, Czanner S, Pacheco J, Albert M, Killiany R, Maguire P, Rosas HD, Makris N, Dale A, Dickerson B*, Fischl B*. Reliability of MRI-derived measurements of human cerebral cortical thickness: The effects of field strength, scanner upgrade and manufacturer. Neuroimage 2006; 32(1): (*authors contributed equally) 11. Celone KA, Calhoun VD, Dickerson BC, Atri A, Chua EF, Miller SL, DePeau K, Rentz DM, Selkoe DJ, Blacker D, Albert MS, Sperling RA. Alterations in memory networks in mild cognitive impairment and Alzheimer s disease: an independent component analysis. J Neurosci 2006; 26(40): Wright CI, Williams D, Feczko E, Barrett LF, Dickerson BC, Schwartz CE, Wedig MM. Neuroanatomical correlates of extraversion and neuroticism. Cerebral Cortex 2006; 16(12): Wright CI, Feczko E, Dickerson BC, Williams D. Neuroanatomical correlates of personality in the elderly. Cerebral Cortex Mar;35(1): Wright CI, Dickerson BC, Feczko E, Negreira A, Williams D. An fmri Study of Amygdala Responses to Human Faces in Aging and Alzheimer's Disease. Biol Psychiatry 2007; Mar 2 [Epub ahead of print]. 15. Dickerson BC, Miller SL, Greve DN, Dale AM, Albert MS, Schacter DL, Sperling RA. Prefrontal-

3 hippocampal-fusiform activity during encoding predict intra-individual differences in free recall ability: An event-related functional-anatomic MRI study. Hippocampus 2007 Jun29; [Epub ahead of print]. 16. Smith EE, Egorova S, Blacker D, Killiany RJ, Muzikansky A, Dickerson BC, Tanzi RE, Albert MS, Greenberg SM, Guttmann CRG. MRI white matter hyperintensities and brain volume in the prediction of MCI and dementia. Archives of Neurology, in press. 17. Diamond EL, Miller S, Dickerson BC, Atri A, DePeau K, Fenstermacher E, Pihlajamaki M, Celone K, Salisbury S, Gregas M, Rentz D, Sperling RA. Relationship of functional MRI activation to clinical trial memory measures in Alzheimer's disease. Neurology, in press. 18. Feczko E, Augustinack JC, Fischl B, Dickerson BC. An MRI-based method for measuring volume, thickness and surface area of entorhinal, perirhinal, and posterior parahippocampal cortex. Neurobiology of Aging. 2007;in press. 19. Dickerson BC, Feczko E, Augustinack JC, Pacheco J, Morris JC, Fischl B, Buckner RL. Differential effects of aging and Alzheimer's disease on medial temporal lobe cortical thickness and surface area. Neurobiology of Aging. 2007;in press. 20. Dickerson BC, Sperling RA. Functional abnormalities of the medial temporal lobe memory system in mild cognitive impairment and Alzheimer's disease: Insights from functional MRI studies. Neuropsychologia. 2007, in press. [peer-reviewed review] 21. Miller SL, Fenstermacher E, Bates J, Sperling RA, Dickerson BC. Hippocampal Activation in Adults with Mild Cognitive Impairment Predicts Subsequent Cognitive Decline. Journal of Neurology, Neurosurgery, and Psychiatry. 2007;in press. 22. Dickerson BC, Sperling RA, Hyman BT, Albert MS, Blacker D. Clinical prediction of AD dementia across the spectrum of mild cognitive impairment. Archives of General Psychiatry 2007;64(12): Fennema-Notestine C, Gamst AC, Quinn BT, Pacheco J, Jernigan TL, Thal L, Buckner R, Killiany R, Blacker D, Dale AM, Fischl B, Dickerson BC*, Gollub RL*. [*authors contributed equally]. Feasibility of multi-site clinical structural neuroimaging studies of aging using legacy data. Neuroinformatics. 2007;5(4): Dickerson BC, Fenstermacher E, Salat DH, Wolk DA, Maguire RP, Desikan R, Pacheco J, Quinn BT, van der Kouwe A, Greve DN, Blacker D, Albert MS, Killiany RJ, Fischl B. Detection of cortical thickness correlates of cognitive performance: Reliability across MRI scan sessions, scanners, and field strengths. Neuroimage. 2008;39(1): Dickerson BC, Bakkour A, Salat DH, Feczko E, Pacheco J, Greve DN, Grodstein F, Wright CI, Blacker D, Rosas HD, Sperling RA, Atri A, Growdon JH, Hyman BT, Morris JC, Fischl B, Buckner RL. The cortical signature of Alzheimer s disease: Regionally-specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals. Cerebral Cortex, in revision. 26. King RD, Sikkel E, George T, Hynan LS, Kennedy DN, Dickerson BC. Characterization of Atrophic Changes in the Cerebral Cortex Using 2-D Fractal Dimensional Analysis. Neuroimage, submitted. C. Research Support Ongoing K23 AG22509 (Dickerson, PI) 9/30/2003-8/31/2008 Structural-functional MRI Studies of Memory in MCI & AD The goal of this career development award project is to use functional and structural MRI (routine lower resolution) to better understand the anatomic and physiologic basis of memory function and dysfunction in mild cognitive impairment and Alzheimer s disease. Corporate Sponsored (Dickerson, PI) 9/20/2005-9/31/2008 Pfizer, Inc. Longitudinal MRI morphometric methods analysis The goal of this study is to compare different methods for the analysis of longitudinal structural imaging (routine lower resolution) data with the ultimate aim to determine whether particular methods are best suited to be used for the measurement of imaging biomarkers for clinical drug trials.

4 R01-AG (Sperling, PI) 3/1/2006-2/28/2011 Evolution of memory-related fmri activation over the course of MCI and AD This study seeks to determine the validity and reliability of fmri (routine lower resolution) as an imaging biomarker of MCI and AD. Role: Co-Investigator Foundation Sponsored (Dickerson, PI) 8/1/2007 7/31/2009 Alzheimer s Association Ultra-high resolution MRI of medial temporal lobe in MCI: A pilot study The goal of this pilot study is to further develop ultra-high resolution MRI technology at 3T and 7T with large-n array head coils to identify abnormalities of medial temporal lobe subregions in patients with very mild cognitive impairment. R01 AG (Dickerson, PI) 9/15/2007 9/14/2012 Medial temporal lobe subregions in aging, MCI and AD:Structural and functional MRI This study seeks to use high-resolution MRI methods to identify structural and functional abnormalities of medial temporal lobe subregions that can be used to better differentiate the process of AD, at a very early clinical stage (prior to typical MCI), from the process of normal aging. R21 AG (Dickerson, PI) 2/15/2008-2/14/2010 Ultrahigh-resolution MRI of medial temporal lobe anatomy in aging The goal of this study is to optimize 7T and 3T in vivo and ex vivo methods for ultrahigh-resolution study of medial temporal lobe anatomy in normal aging. Completed P01 AG04953 (D. Blacker, PI) 8/1/2002-7/31/2007 Neuroimaging And Neuropsychological Studies Of Patients With Memory Problems The goal of this study is to identify imaging (routine lower resolution MRI, fmri, and also SPECT) and neuropsychological predictors of Alzheimer s disease in individuals with mild cognitive impairment and normal cognition. Role: Co-Investigator Pilot MGH ADRC grant (Dickerson, PI) 4/1/2006-3/31/2007 High-resolution MRI of brain function & structure in aging & MCI: A pilot study The goal of this study is to collect pilot high-resolution MRI and fmri data to optimize methods for studies of aging and MCI. Corporate Sponsored (Dickerson, PI) 1/1/ /31/2005 Pfizer, Inc. Development and analysis of automated region of interest identification for MRI: An MRI reliability and validity study The goal of this study is to determine whether automated methods for anatomical labeling of structural MRI scans is reliable on data acquired from different scanners and valid as compared to manual labeling methods.

5 Pending None