Onderzoeksgroep: STATISTIEK. Identiteit van de deelnemende onderzoekers

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1 Onderzoeksgroep: STATISTIEK A Identiteit van de deelnemende onderzoekers Aerts Marc, Alonso Ariel, Beunckens Caroline, Bijnens Luc, Bollaerts Kaatje, Braekers Roel, Bruckers Liesbeth, Burzykowski Tomasz, Buyse Marc, Callaert Herman, Cortiñas Abrahantas José, Creemers An, Duchateau Luc, Faes Christel, Gaddah Auguste, Geys Helena, Gitome Arthur, Goeyvaerts Nele, Lin Dan, Haldermans Philippe, Hens Niel, Jacobs Tom, Jansen Ivy, Janssen Paul, Kadankova Tetyana, Kasim Adetayo, Laenen Annouschka, Lesaffre Emmanuel, Litière Saskia, Maringwa John, Massonnet Goele, Molenberghs Geert, Namata Harriet, Pramana Setia, Assam Nkouibert, Qi Zhu, Renard Didier, Serroyen Jan, Skhedy Ziv, Sotto Cristina, Thijs Herbert, Tibaldi Fabian, Tilahun Eshete Abel, Valkenborg Dirk, Vandersmissen Veerle, Van Effelterre Thierry, Van Rompaye Bart, Van Sanden Suzy, Veraverbeke Noël, Verbeke Geert, Weyler Joost, Winters Bart, Wouters Kristien, Wouters Luc. B Titel(s) van het (de) onderzoeksproject(en) a. Mathematische statistiek b. Biostatistiek C Beschrijving van de ontwikkelde onderzoeksactiviteit(en) per project - Research on statistical education (HC) - Resampling, goodness of fit (NV, PJ, Jan Swanepoel) - Extension of Koziol-Green model (RB, NV) - Copula process with covariates (NV) - Empirical likelihood for non smooth criterion function (NV, Ingrid Van Keilegom, Elisa Molanes) - Weak convergence for copula estimator (NV, Irène Gijbels, Marek Omelka) - Wide class of Lévy processes: semi-markov and semi-markov walks with drift (TK, NV) - Copula model for association between error and covariate in homoscedastic regression (RB, Ingrid Van Keilegom) - Weak convergence of conditional distribution function in Koziol-Green model with dependent censoring (RB, AG) - Extension of Koziol-Green model with parameter of the copula estimated by a likelihood method (RB, AG) - A zero-inflated Cox regression model under a fixed detection limit. Extension using copulas (RB, Paul Markel) - Fitting conditional survival models using transformation to mixed-effects model (GMa, PJ, TB) - Two-stage estimation in copula models: methodology, simulations and example (GMa, PJ, Luc Duchateau) - Frailty models book (PJ and Luc Duchateau) - Frailty versus copula models (PJ, Luc Duchateau, Klaartje Goethals) - Fitting frailty models via transformation: the continuous case (PJ, GMa, Ricardo Cao) - The choice of the copula using pseudo-likelihood ratio tests (PJ, GMa, Luc Duchateau) - Asymptotic theory for the estimated heterogeneity parameter in frailty models (PJ, GMa)

2 2. - Goodness-of-fit for survival data (PJ, NV, Jan Swanepoel, GMa, Luc Duchateau,) - Validation of prognostic indices using the frailty model (PJ, Catherine Legrand, Richard Sylvester, Luc Duchateau) - Competing risks (IAP working group) - Missing data and sensitivity analysis (GM, MA, HT, IJ, CB, CS, AC, Geert Verbeke, Dimitris Rizopoulos, Sypridoula Tsonaka, Kristel Van Steen, Els Goetghebeur, Michael G. Kenward, Stijn Vansteelandt) - Missing data in clinical trials (GM, Michael G. Kenward, Raymond J. Carroll, Craig Mallinckrodt, CB, IJ, CS) - Pattern-mixture models (GM, HT, Michael G. Kenward, CB, IJ) - Surrogate markers (GM, TB, HG, Fabian Tibaldi, JC, AA, ZS, Tony Vangeneugden, Didier Renard, AT, PA) - Neuron synchronization (Carmen Cadarso, HG, GM, AA, CF) - Logistic mixed models in item response theory (GM, Geert Verbeke, Paul De Boeck, Dirk Smits, Edward Ip, Yuri Goegebeur) - Models for discrete repeated measures (GM, Geert Verbeke) - Small-sample degrees of freedom (GM, CF, MA, Geert Verbeke, Michael G. Kenward) - Methods for clustered data (MA, HG, CF, GM) - Models for infectious diseases (MA, ZS, GM, NH) - Methods for optimization in statistics (GM, Geert Verbeke, Iven Van Mechelen, Francis Tuerlinckx) - Psychometric methods in clinical studies (GM, AL, AA, Tony Vangeneugden) - Combined longitudinal-overdispersed models (GM, Geert Verbeke, Clarice Demétrio, Tony Vangeneugden) - Survival data and measures of association (AA, GM, PA, AT) - Misspecified random effects distribution (AA, GM, SL) - Generalized linear mixed models (GLMM) (GM, SL, AA) - Diagnostic tools for GLMM (GM, SL, AA) - Biomarkers (AA, GM, Didier Renard, Christelle Darstein) - Reliability of rating scales (GM, AA, AL) - Reliability estimation in clinical trial data with repeated measurements (AL, AA, GM, Tony Vangeneugden) - Topics in modeling infectious diseases (MA, ZS, GM, CF, NH, JC, KB, HN, Pierre Van Damme, Philippe Beutels, Heidi Theeten, Koen Van Herck, Elke Leuridan, Gaelle Boulet, John-Paul Bogers, Kris Verstreken (Universiteit Antwerpen), Frank Boelaert (European Food Safety Agency), Koen Mintiens, Stefan Roels (Centrum voor Onderzoek in de Dierengeneeskunde en Agrochemie), Dirk Berkvens, Nico Speybroeck (Instituut voor Tropische Geneeskunde), Patrick Cras (Universiteit Antwerpen), Claude Saegerman (Universiteit Luik), Peter Teunis en Jacco Wallinga (RIVM, Bilthoven) - Topics in Microbial Risk Assessment, Zoonotic Diseases (e.g. Salmonella), Vectorborne diseases (e.g. Bluetongue) and Food Safety, (MA, ZS, CF, JC, KB, HN, Koen Mintiens, Ides Boone, Yves Van der Stede en Stefan Roels (Centrum voor Onderzoek in de Dierengeneeskunde en Agrochemie), Stefaan Ribbens en Jeroen Dewulf (Universiteit Gent), Koen Grijspeerdt (Instituut voor Landbouw- en Visserijonderzoek), Peter Teunis (RIVM, Bilthoven) - Analysis of bluetongue infection in Belgium, the Netherlands and Germany (MA, CF, JC) - Topics in model selection (MA, NH, Jeffrey Simonoff (New York University)) - Topics in missing data (MA, GM, HT, NH, IJ, AC, Geert Verbeke (K.U.Leuven), Mike Kenward (London School of Hygiene and Tropical Medicine)) - Topics in mixed models (MA, GM, JS, Geert Verbeke (K.U.Leuven))

3 3. - Topics in medical diagnostic testing (MA, NH, Kostas Fokianos (University Cyprus), Frank Buntinx (K.U.Leuven)) - Degrees of freedom approximation and effective sample size for correlated data such as repeated measures and meta-analysis (MA, CF, GM) - Topics in modelling of longitudinal outcomes of different nature (with extension of a highdimensional joint model for modeling many longitudinal endpoints) (MA, CF, HG, GM) - Topics in the analysis of juvenile toxicity studies (MA, CF, HG) - Topics in p-spline regression with shape restrictions (MA, KB, Paul Eilers (Universiteit Utrecht)) - Spatial epidemiology (CF) - Semiparametric mixed models (CF, JM, HG, ZS) - Analysis of infectious disease data; Analysis of microarray data; Bioinformatics (ZS) - Methods of the analysis of microarray data (TB, DL, ZS, IJ) - Methods of the analysis of mass-spectrometry data (TB, DV, QZ, IJ) - Validation of surrogate endpoints in multiple randomized clinical trials (TB, Marc Buyse) - Dealing with various issues when modelling infectious diseases (NH, MA, KB, AC, CF, NG, HN, ZS, Philippe Beutels, Joke Bilcke, Olivier Lejeune, Benson Ongunjimi, Pierre Van Damme (Antwerpen)) - Modelling the force of infection from seroprevalence data: to monotonize or not to monotonize? (NH, MA, Andrea Kvitkovicova, Daniël Hlubinka (Prague), Pierre Van Damme, Philippe Beutels (Antwerpen)) - Elucidation on country-specific differences of the sero-epidemiology of B19 and VZV in five different European countries (NH, MA, ZS, Nigel Gay, John Edmunds and Alessia Melagaro (Health Protection Agency)) - Caregiver concerns about the number of vaccine injections and willingness to pay to reduce them (NH, MA, Heidi Theeten, Pierre Van Damme, Philippe Beutels (Antwerpen), Corinne Vandermeulen, Mathieu Roelants, Karel Hoppenbrouwers (K.U.Leuven) - Who mixes with who? Analyzing contact data (NH, NG, MA, ZS and the polymod working group) - The EM-algorithm by the method of weights (NH, Kennedy Otwombe (Witwatersrand)) - The MAR-bodyguard for the shared parameter model, A non-parametric alternative to weighted estimating equations under MAR (NH, AC, MA, GM) - Modelling bivariate current status data (NH, MA, GM, Andreas Wienke (Martin-Luther Universität Halle Wittenberg)) - Model selection based on presmoothing (NH, MA, Jeff Simonoff (New York)) - Biomarker discovery from COFRADIC MALDITOF-MS data: deconvolution and feature extraction for mass spectral serum profiles (DV, TB, Janne Lehtiö (Karolinska Institutet), Koen Kas (Pronota)) - Monoisotopic peak validation using a Poisson approximation in a combined fractional diagonal chromatography and mass spectrometry setting (DV, TB, IJ) - A model based method for predicting the isotopic distribution of peptides (DV, TB, IJ) - Missing observations in mass spectrometry data (DV, TB, IJ) - Peptide-abundance non-indentifiability in proteolytic 18 O stable-isotope labeling (DV, TB, IJ, ZQ) - A model for estimating the peptide abundance in proteolytic 18 O stable-isotope labeled MALDI-TOF mass spectra (DV, TB, Koen Kas (Pronota)) - Methods to detect overlapping peptide peaks in LC-dimension (DV, TB, ZQ) - Methods to detect overlapping peptide peaks in m/z-dimension (DV, TB, AK) - Label-free quantitative proteomics (DV, TB, Jean-Paul Noben) - Simulation of microarray (ZQ, DV, TB, IJ)

4 4. - The EM-algorithm for correcting sequencing errors of serial analysis of gene expression data (DV, TB, PH) - Incomplete longitudinal data: generalized linear mixed models (GLMM); (weighted) generalized estimating equations ((W)GEE); multiple imputation; sensitivity analysis; local influence; pattern-mixture models; shared-parameter models; latent-class mixture model (CB, IJ, CS) - Classification of psychotropic drugs based on sleep-waking behaviour data. Spline models, with a mixed effects formulation. Fractional polynomial models with random effects. Supervised and unsupervised learning analysis. Linear, flexible and mixture discriminant analysis. Neural networks, support vector machine, classification and regression trees, bagging, random forest and boosting methods. Frailty models to estimate force of infection. Information theory, entropy, mutual information and entropy power (JC) - Cleaning and analyzing Belgian contact data: mining social mixing patterns and their influence on modeling infectious diseases (NG, NH, MA, Philippe Beutels) - Using empirical social contact data to model person to person infectious disease transmission: an illustration for varicella. Programming and implementing one of the transmission models based on the mass action principle (NG, Benson Ogunjimi) - Estimating transmission parameters using social contact data and serological data on VZV and B19 (NG, NH, MA, Benson Ogunjimi and Philippe Beutels) - Minimal psychiatric data: development of a new registration instrument (AL, LB, GM) - Long-stay patients in psychiatry (AL, LB) - Registration in institutions for Sheltered Living in Limburg (AL) - Attitudes towards jobs in youngsters (AL) - Linear mixed model with multivariate dale model for Gaussian longitudinal data with nonmonotone missingness (CS, GM, CB) - Stochastic EM for Gaussian longitudinal data with missingness (CS, GM, CB) - Meaningful parametrizations for missing data models (CS, GM, Geert Verbeke) - Modelling prevalence and force of infection on case notification and serological data (KB, MA, ZS, NH, HN, CF, Frank Boelaert (EFSA)) - Ontwikkeling van een methodologie voor de kwantitatieve beoordeling van zoonotische risico s toegepast op het model Salmonella bij varkens (KB, MA, ZS, Georges Daube (Liège), Lieven De Zutter (Gent), Koen Grijspeerdt (ILVO), Koen Mintiens (CODA)) - P-splines regression with shape contraints (KB, MA, Paul Eilers (Leiden)) - Dose response study (DL, An de Bondt, Hinrich W. Göhlmann, Tim Perera, Ilse Van den Wyngaert, Tamara Geerts, Luc Bijnens (Janssen Pharmaceutica)) - Comparison of several treatments with one control (DL, An de Bondt, Hinrich W. Göhlmann, Roxana Ion, Ilse Van den Wyngaert, Tamara Geerts, Luc Bijnens (Janssen Pharmaceutica)) - Biomarker selection and evaluation (DL, An de Bondt, Hinrich W. Göhlmann, Willem Talloen, Luc Bijnens (Janssen Pharmaceutica)) - Flexible modeling, smoothing longitudinal data, penalized splines, adaptive penalized splines, simultaneous confidence bands, historical controls, crossover designs (JM, HG, CF) - Surrogate markers (AT, GM, TB, HG, Fabian Tibaldi, JC, AA, ZS, Tony Vangeneugden, Didier Renard, PA) - EEG data analysis (AT, NG, Abdel Ahanun, Pim Drinkenbrug) - Flexible modeling of serial correlation (JS, GM) - Modeling of HIV-1 viral dynamics (JC, GM) - Taxonomy of non-linear models for longitudinal data (JS, Geert Verbeke, Marie Davidian) - Normalization of microarrays (PH, ZS, SVS, DL, SP) - Connection dose-response data + microarrays (PH, ZS, SVS, DL, SP)

5 5. - Nonlinear mixed effects modeling (TJ, GM, Dunne (Dublin), R. Straetemans (Janssen Pharmaceutica)) - IVIVC modeling (TJ, GM, Dunne (Dublin), R. Straetemans (Janssen Pharmaceutica)) - Dose reponse for drug development within microarray setting (SP) - Peptide microarray using Pamgene technology (AG, DL, SVS, ZS, Wim Talloen), Hinrich Goehlmann, Luc Bijnens (Janssen Pharmaceutica)) - Analysis of microarray data. Biomarkers. Analysis based on Laplace transforms (SVS, DL) - Fractional polynomial mixed models, linear discriminant analysis, flexible discriminant analysis, mixture discriminant analysis, model average, mutual information (KW, JC, GM) - Prevalence and persistence of Salmonella in Belgian broiler chicken flocks: an identification of risk factors (HN, MA, ZS, CF, NH) - Estimation of the prevalence and force of infection of Hepatitis C among injecting drug users in four European countries (HN, MA, ZS, CF, NH) - Hierarchical semi-parametric Bayesian models for the force of infection for parvovirus B19 (HN, MA, ZS, CF, NH) - Methods to detect overlapping peptide peaks in m/z-dimension (AT, DV, TB, ZS) - A cross-validation study to select a classification procedure for clinical diagnosis based on proteomic mass spectrometry data (AT, DV, SVS, DL, ZQ, PH, IJ, ZS, TB) - A latent response approach to multi-compound screening using baseline gene expression profile (AT, DL, ZS, Willem Talloen, Hinrich Goehlmann, Luc Bijnens (Janssen Pharmaceutica)) - Gene signatures based on microarray experiments from two neighbouring tissues (AT, AG, DL, SVS, ZS, Willem Talloen, Hinrich Goehlmann, Luc Bijnens (Janssen Pharmaceutica)) - An evidence for co-infection of HCV and HIV in Europe: individual and European levels (AT, ZS, HN, JM, MA, Lucas Wiessing, Mirjam Kretzschmar) - Information-theory based surrogate marker evaluation from several randomized clinical trials with continuous true and binary surrogate endpoints (PA, AT, AA, GM) - Information-theory based surrogate marker evaluation from several randomized clinical trials with binary true and binary surrogate endpoints (PA, AT, AA, GM) - Using earlier measures in longitudinal sequence as potential surrogate for a later one (PA, AT, AA, GM) - Application of information-theoretic approach for surrogate marker evalution to survival endpoints based on R-square measures for censored data (PA, AT, AA, GM) - Altered circadian locomotor activity in APP23 mice: a model for eating and drinking behaviour (PA, Universiteit Antwerpen, Born-Bunge Instituut) - Analysis in clinical pharmacology model for pain: multi-modal and tissue-differentiated experimental pain assessment (PA, Eli Lilly) - Post-operative nomogram predicting biochemical progression free survival at 12 and 60 months after prostatectomy for T3a prostate cancer patients (PA, UZGasthuisberg) - Determination of optimal cutoff values for survival of T3a cancer patients (PA, UZGasthuisberg) - Cancer related and non-cancer related pre-operative nomogram predicting biochemical and clinical progression free survival after prostatectomy for T3 prostate cancer patients (PA, UZGasthuisberg) - Study of the effect bifidogenic effect of periobiotics on the intestinal flora of the neonate (PA) - Psychiatric epidemiology, mixture models, latent variable modeling (LB, GM, JS, AL) - Health and environment (LB) - Missing data: a MAR bodyguard for the SPM (AC, MA, NH, GM) - Missing data: a new method to handle missing covariates (AC, MA, NH)

6 6. - Infectious diseases: an analysis of costs of pneumococcal disease (AC, MA, NH, ZS, Philippe Beutels (Antwerpen)) D Mededelingen van resultaten van het onderzoekswerk 1 Doctoraats- en aggregaatsthesissen 11 In de onderzoeksgroep behaalde doctoraten Saskia Litière: The impact of a misspecified random-effects distribution on estimation in generalized linear mixed models. 20 december Supervisor: Geert Molenberghs. Co-supervisor: Ariel Alonso Caroline Beunckens: Analysis and sensitivity analysis for incomplete longitudinal data. 7 september Supervisor: Geert Molenberghs Jan Serroyen: Flexible modeling tools for continuous longitudinal data. 19 december Supervisor: Geert Molenberghs 12 (Co)promoties van doctoraten, niet behaald aan de UHasselt Sabine Tremmery: The clinical symptomatology and comorbidity of attentiondeficit/hyperactive disorder in a healthy school population. 17 december Supervisors: Jelle Jolles en Jan K. Buitelaar. Co-supervisor: Geert Molenberghs 13 Lidmaatschappen van jury's van buitenlandse doctoraten Noël Veraverbeke 30 maart University of La Coruña, Spain. Jurylid voor doctoraat van Elisa Maria Molanes López. Nonparametric statistical inference for relative curves in two-sample problems (promotor: Ricardo Cao) Geert Molenberghs 8 februari University of Southern Denmark, Odense, Denmark. Jurylid voor doctoraat van Maria Iachina. Statistical analysis of incomplete longitudinal twin data, with an application to the study of the effect of stress on depression symptomatology (promotoren: Kaare Christensen en Bent Jorgensen) Paul Janssen januari North-West University, Potchefstroom, Zuid Afrika. Jurylid voor H.M. Weideman. Goodness-of-fit tests based on new characterizations of the exponential distribution (promotor: Jan Swanepoel) 30 maart University of La Coruña, Spain. Jurylid voor doctoraat van Elisa Maria Molanes López. Nonparametric statistical inference for relative curves in two-sample problems (promotor: Ricardo Cao) 14 Lidmaatschappen van jury's van binnenlandse doctoraten Marc Aerts

7 7. 5 april Université de Liège. Jurylid voor doctoraat van David Magis Influence, information and item response theory in discrete data analysis. (promotor: G. Haesbroeck) Paul Janssen 15 juni K.U.Leuven. Jurylid voor doctoraat van Kris Bogaerts Statistical modelling of tooth emergence based on multivariate interval-censored data. (promotor: E. Lesaffre) 2 Wetenschappelijke publicaties Internationale wetenschappelijke publicaties 20 Gepubliceerde artikels in internationale tijdschriften (opgenomen in de JCR 1 of in een door de Onderzoeksraad erkende alternatieve tijdschriftenlijst) Janssen, P., Swanepoel, J. and Veraverbeke, N. (2007). Modifying the kernel distribution function estimator towards reduced bias. Statistics, 41, Kadankova, T. and Veraverbeke, N. (2007). On several two-boundary problems for a particular class of Lévy processes. Journal of Theoretical Probability, 20, Braekers, R. and Veraverbeke, N. (2007). A conditional Koziol-Green model under dependent censoring. Statistics and Probability Letters (to appear) (doi: /j.spl ) Wang, L. and Veraverbeke, N. (2007). Bayes prediction based on right censored data. Statistical Papers, 48 (to appear) (doi: /s ) Wang, L. and Veraverbeke, N. (2007). MSE superiority of Bayes and empirical Bayes estimators in two seemingly unrelated regressions. Statistics and Probability Letters (to appear) (doi: /j.spl ) Claeskens, G., Nguti, R. and Janssen, P. (2007). Likelihood ratio and score tests for a shared frailty model: a non-standard problem. Test. (to appear) Alonso, A. and Molenberghs, G. (2007). Evaluating time to cancer recurrence as a surrogate marker for survival from an information theory perspective. Statistical Methods in Medical Research, 63, Tibaldi, F., Verbeke, G., Molenberghs, G., Renard, D., Van den Noortgate, W., and De Boeck, P. (2007). Conditional mixed models with crossed-random effects. British Journal of Mathematical and Statistical Psychology, 60, Molenberghs, G., Vangeneugden, T., and Laenen, A. (2007). Estimating reliability and generalizability from hierarchical biomedical data. Journal of Biopharmaceutical Statistics, 17, JCR : Journal Citation Reports (als afzonderlijke publicatie van de Science Citation Index en van de Social Sciences Citation Index, opgemaakt door het Institute for Scientific Information).

8 8. Alonso, A. and Molenberghs, G. (2007). Surrogate marker evaluation from an information theory perspective. Biometrics, 63, Speybroeck, N., Marcotty, T., Aerts, M., Dolan, T., Williams, B., Lauer, J., Molenberghs, G., Burzykowski, T., Mulumba, M., and Berkvens, D. (2007). Titrating Theileria parva: single stocks against combination of stocks. International Journal for Parasitology, 00, Beunckens, C., Molenberghs, G., Thijs, H., and Verbeke, G. (2007). Incomplete hierarchical data. Statistical Methods in Medical Research, 16, Fieuws, S., Verbeke, G., and Molenberghs, G. (2007). Random-effects models for multivariate repeated measures. Statistical Methods in Medical Research, 16, Molenberghs, G. and Verbeke, G. (2007). Likelihood ratio, score, and Wald tests in a constrained parameter space. The American Statistician, 61, 1-6. Wouters, K., Ahnaou, A., Cortiñas, J., and Molenberghs, G., Geys, H., Bijnens, L., and Drinkenbrug, H.I.M. (2007). Psychotropic drug classification based on sleep-wake behavior of rats. Applied Statistics, 56, Litière, S., Alonso, A., and Molenberghs, G. (2007). Type I and type II error random-effects misspecification in generalized linear mixed models. Biometrics, 63, Faes, C., Geys, H., Molenberghs, G., Aerts, M., Cadarso-Suarez, C., Acuña, C., and Cano, M. (2008). A flexible method to measure synchrony in neuronal firing. Journal of the American Statistical Association, Case Studies, 101, Laenen, A., Alonso, A., and Molenberghs, G. (2007) A measure for the reliability of a rating scale based on longitudinal clinical trial data. Psychometrika, 00, (doi: /S ). Tremmery, S., Buitelaar, J.K., Steyaert, J., Molenberghs, G., Feron, F.J.M., Kalff, A.C., Hurks, P.P.M., Hendriksen, J.G.M., Van Zeben, T.M.C.B., Vles, J.S.H., and Jolles, J. (2007). The use of health care services and psychotropic medication in a community sample of 9 year old school ADHD children. European Child and Adolescent Psychiatry, 00, Shkedy, Z., Decin, L., Molenberghs, G., and Aerts, C. (2007). Estimating stellar parameters from spectra using a hierarchical Bayesian approach. Monthly Notices to the Royal Astronomical Society, 377, Tilahun, A., Assam, P., Alonso, A., and Molenberghs, G. (2007). Flexible surrogate marker evaluation from several randomized clinical trials with continuous endpoints, using R and SAS. Computational Statistics and Data Analysis, 51, Verbeke, G., Molenberghs, G., and Beunckens, C. (2007). Formal and informal model selection with incomplete data. Statistical Science (accepted for publication). Gyselaers, W., Molenberghs, G., and Ombelet, W. (2007). Interlobar venous flow is different between left and right kidney in uncomplicated third trimester pregnancy. Gynecologic and Obstetric Investigation, 00,

9 9. Beunckens, C., Molenberghs, G., Verbeke, G., and Mallinckrodt, C. (2007). A latent-class mixture model for incomplete longitudinal Gaussian data. Biometrics, 00, Parzen, M., Lipsitz, R., Fitzmaurice, G., Ibrahim, J.G., Troxel, A., and Molenberghs, G. (2007). Pseudo-likelihood methods for the analysis of longitudinal binary data subject to nonignorable non-monotone missingness. Journal of Data Science, 5, Beunckens, C., Sotto, C., and Molenberghs, G. (2007). A simulation study comparing weighted estimating equations with multiple imputation based estimating equations for longitudinal binary data. Computational Statistics and Data Analysis, 00, (doi: /j.csda ) Kellen, E., Zeegers, M.P., Dirx, M., Houterman, S., Droste, J., Lawrence, G., Truyers, C., Bruckers, L., Molenberghs, G., and Buntinx, F. (2007). Occurrence of both bladder and prostate cancer in five cancer registries in Belgium, the Netherlands and the United Kingdom. European Journal of Cancer, 00, Faes, C., Aerts, M., Geys, H., and Molenberghs, G. (2007). Model averaging using fractional polynomials to estimate a safe level of exposure. Risk Analysis, 27, Molenberghs, G. (2007). Editorial: What to do with missing data? Journal of the Royal Statistical Society, Series A, 170, Verbeke, G. and Molenberghs, G. (2007). What can go wrong with the score test. The American Statistician, 61, de Jonge, E., Yigit, R., Molenberghs, G., Straetmans, D., and Ombelet, W. (2007). Predictors of oligoamenorrhea at 1-year follow-up in premenopausal women using a levonorgestrelreleasing intrauterine system. Contraception, 76, Rizopoulos, D., Verbeke, G., and Molenberghs, G. (2007). Shared parameter models under random-effects misspecification. Biometrika, 00, Tilahun, A., Assam, P., Alonso, A., and Molenberghs, G. (2007). Information-theory based surrogate marker evaluation from several randomized clinical trials with binary endpoints, Using SAS. Journal of Biopharmaceutical Statistics, 18, Jansen, I. and Molenberghs, G. (2007). A flexible marginal modeling strategy for nonmonotone missing data. Journal of the Royal Statistical Society, Series A, 171, Toussaint, J.F., Assam, P., Caij, B., Dekeyser, F., Knapen, K., Imberechts, H., Goris, N., Molenberghs, G., Mintiens, K., and De Clercq, K. (2007). Uncertainty of measurement for competitive and indirect ELISAs. Scientific and Technical Review of the OIE, 26, Molenberghs, G., Verbeke, G., and Demétrio, C. (2007). An extended random-effects approach to modeling repeated, overdispersed count data. Lifetime Data Analysis, 00,

10 10. Molenberghs, G. (2007). Norman Breslow's leadership for the International Biometric Society. Lifetime Data Analysis, 00, Molenberghs, G., Beunckens, C., Sotto, C., and Kenward, M.G. (2007). Every missing not at random model has got a missing at random counterpart with equal fit. Journal of the Royal Statistical Society, Series B, 70, Tibaldi, F., Renard, D., and Molenberghs, G. (2007). Accounting for variability in individual hierarchical clinical trial data. Pharmaceutical Statistics, 00, Molenberghs, G. and Lesaffre, E. (2007). Missing data. Wiley Encyclopedia of Clinical Trials. Vangeneugden, T., Molenberghs, G., Laenen, A., Alonso, A., and Geys, H. (2007). Generalizability in non-gaussian longitudinal clinical trial data based on generalized linear mixed models. Journal of Biopharmaceutical Statistics, 00, Assam, P., Tilahun, A., Alonso, A., and Molenberghs, G. (2007). Information-theory based surrogate marker evaluation from several randomized clinical trials with continuous true and binary surrogate endpoints. Clinical Trials, 00, Molenberghs, G., Burzykowski, T., Alonso, A., Assam, P., Tilahun, A., and Buyse, M. (2008). The meta-analytic framework for the evalution of surrogate endpoints in clinical trials. Journal of Statistical Planning and Inference, 138, Litière, S., Alonso, A., Molenberghs, G., and Geys, H. (2007). The impact of a misspecified random-effects distribution on the estimation and performance of inferential procedures in generalized linear mixed models. Statistics in Medicine, 00, Decin, L., Hony, S., de Koter, A., Molenberghs, G., Dehaes, S., and Markwick-Kemper, F. (2007). The variable mass loss of the AGB star WX Psc as traced by the CO J = 1-0 through 7-6 lines and the dust emission. Astronomy & Astrophysics, 475, Namata, H., Shkedy, Z., Faes, C, Aerts, M., Molenberghs G., Theeten, H., Van Damme, P. and Beutels, P. (2007). Estimation of the force of infection from current status data using generalized linear mixed models. Journal of Applied Statistics, 34, Maringwa, J., Geys, H., Shkedy, Z., Faes, C., Molenberghs, G., Aerts, M., Van Ammel, K., Teisman, A., and Bijnens, L. (2007). Application of semiparametric mixed models and simultaneous cofidence bands in a cardiovascular safety experiment with longitudinal data. Journal of Biopharmaceutical Statistics, 00, Molenberghs, G. and Verbeke, G. (2007). Discussion of Diggle, P., Farewell, D., and Henderson, R.: ``Analysis of longitudinal data with drop-out: objectives, assumptions, and a proposal," Journal of the Royal Statistical Society, Series B, 56, 542. Alonso, A., Molenberghs, G. Burzykowski, T., Renard, D., Geys, H., Shkedy, Z., Tibaldi, F., Cortiñas Abrahantes, J. and Buyse, M. (2007). Response to Qu and Case s letter about Prentice s approach and the meta-analytic paradigm: a reflection on the role of statistics in the evaluation of surrogate endpoints (Biometrics, 60, ), Biometrics, 63, 1-2.

11 11. Pryseley, A., Tilahun, A., Alonso, A., and Molenberghs, G. (2007). Information-theory based surrogate marker evaluation from several randomized clinical trials with continuous true and binary surrogate endpoints, using R. Clinical Trials 00, (doi / ). Aelvoet, W., Windey, F., Molenberghs, G., Temmerman, M., Van Reepts, P., and Foidart, J.M. (2007). Screening for inter-hospital differences in cesarean section rates in low-risk deliveries using administrative data. Can it contribute to quality of care initiatives? BioMed Central Health Services Research, 00, Faes, C., Geys, H., Aerts, M., Molenberghs, G. (2007). A flexible method to measure synchrony in neuronal firing. Journal of the American Statistical Society, 00, Cortiñas Abrahantes, J., Aerts, M., van Everbroeck, B., Saegerlan, C., Berkvens, D., Geys, H., Mintiens, K., Roels, S., and Cras, P. (2007). Classification of sporadic Creutzfeldt-Jacob disease based on clinical and neuropathological characteristics. European Journal of Epidemiology, 22, Maringwa, J.T., Faes, C., Geys, H., Aerts, M., Teuns, G., Van Den Poel, B., and Bijnens, L. (2007). On the use of historical control data in pre-clinical safety studies. Journal of Biopharmaceutical Statistics, 17, Van den Bruel, A., Aertgeerts, B., Bruyninckx, R., Aerts, M., and Buntinx, F. (2007). Sings and symptoms for the diagnosis of serious infections in children: a prospective study in primary care. British Journal of General Practics, 57, Mossong, J., Hens, N., Friederichs, V., Davidkin, I., Broman, M., Litwinska, B., Siennicka, J. Trzcinska, A., Van Damme, P., Beutels, P., Vyse, A., Shkedy, Z., Aerts, M., Gabutti, G., Salmaso, S. (2007). Parvovirus B19 infection in 5 European countries: seroepidemiology, force of infection and maternal risk of infection. Epidemiology and Infection, 0, Bollaerts, K., Aerts, M., Ribbens, S., Van der Stede, Y., Boone, I. and Mintiens, K. (2008). Identification of salmonella high risk pig-herds in Belgium using semi-parametric quantile regression. Journal of Royal Statistical Society, Series A, 171, Bollaerts, K., Aerts, M., Faes, C., Grijspreedt, K., Dewulf, J., Mintiens, K. (2008). Human Salmonellosis: estimation of dose-illness from outbreak data. Risk Analysis, 0, Maringwa, J.T., Geys, H., Shkedy, Z., Faes, C., Molenberghs, G., Aerts, M., Van Ammel, K., Teisman, A., and Bijnens, L. (2008). Application of semiparametric mixed models and simultaneous confidence bands in a cardiovascular safety experiment with longitudinal data. Pharmaceutical Statistics, 0, Hens, N., Aerts, M., Shkedy, Z., Kimani, P.K., Kojouharova, M., Van Damme, P., and Beutels, P. (2007). Modeling age-time dependent incidence rates of hepatitis B and estimating the prevalence and force of infection using generalized additive models. To appear in Epidemiology and Infection (doi: /s ) Theeten, H., Hens, N., Vandermeulen, C., Depoorter, A.M., Roelants, M., Aerts, M., Hoppenbrouwers, K. and Van Damme, P. (2007). Infant vaccination coverage in 2005 and

12 12. predictive factors for incomplete or invalid vaccination in Flanders, Belgium: an EPI survey. Vaccine, 25, Hens, N., Faes, C., Aerts, M., Shkedy, Z., Mintiens, K., Laevens, H. and Boelaert, F. (2007). Handling missing data when modeling the force of infection: a population averaged approach. Journal of Agricultural, Biological, Environmental Statistics, 12, Hens, N., Aerts, M., Shkedy, Z., Theeten, H., Van Damme, P., Beutels, Ph. (2007). Modelling multi-sera data: the estimation of new joint and conditional epidemiological parameters. To appear in Statistics in Medicine ( /sim.3089). Hens, N., Gay, N., Shkedy, Z., Aerts, M. and Edmunds, J. (2007). A comparison of heterogeneity in the acquisition of varicella zoster virus and parvovirus B19 for five different European countries. European Journal of Public Health, 17, Maringwa, J.T., Geys, H., Shkedy, Z., Faes, C., Molenberghs, G., Aerts, M., Van Ammel, K., Teisman, A., and Bijnens, L. (2006). Analysis of cardiovascaular safety experiment with longitudinal data using penalized smoothing splines. Statistical Modelling (in print). Thijssen, S., Cuypers, A., Maringwa, J.T., Smeets, K., Horemans, N., Lambrichts, I., Van Kerkhove E. (2007). Low cadmium exposure triggers a biphasic oxidative stress response in mice kidneys. Toxicology, 236, Thijssen, S., Lambrichts, I., Maringwa, J.T., Van Kerkhove, E (2007). Changes in expression of fibrotic markers and histopathological alterations in kidneys of mice chronically exposed to low and high Cd doses. Toxicology, 238, Valkenborg, D., Assam, P., Krols, L., Thomas, G., Kas, K., and Burzykowski, T. (2007). Using a Poisson approximation to predict the isotopic distribution of sulphur-containing peptides in a peptide-centric proteomic approach. Rapid Communications in Mass Spectrometry, 21, Haldermans, P., Shkedy, Z., Van Sanden, S., Burzykowski, T., and Aerts, M. (2007). Using linear mixed models for normalization of cdna microarrays. Statistical Applications in Genetics and Molecular Biology, 6, 1, 19. Van Sanden S., Lin, D., Burzykowski, T. (2007). Performance of gene selection and classication methods in a microarray setting: a simulation study. Simulation and Computation, 37(2), (SCI ). Lin, D., Shkedy, Z., Burzykowski, T., Aerts, M., Göhlmann, H.W.H., De Bondt, A., Perera, T., Geerts, T., and Bijnens, L. (2007). Classification of trends in dose-response microarray experiments using information theory selection methods. Journal of the American Statistical Society, Proceedings of Joint Statistical Meeting, Special Issue. Smeets, K., Ruytinx, J., Van Belleghem, F., Semane, B., Lin, D., Vangronsveld, J. and Cuypers, A. (2007). Critical evaluation and statistical validation of a hydroponic culture system for aarabidopsis thaliana. Accepted in Plant Physiology and Biochemistry.

13 13. Keune, H., Loots, I., Bruckers, L., Bilau, M., Koppen, G., van Larebeke N., Schoeters, G., Nelen, V. (2007). Monitoring environment, health and perception: an experimental survey on health and environment in Flanders, Belgium. IJENVI special issue on Risk perception and social trust. Bilau, M., Matthys, C. Baeyens, W., Bruckers, L., De Backer, G., Den Hond, E., Keune, H., Koppen G., Nelen, V., Schoeters, G., Van Larebeke, N., Willems, J.L., and De Henauw S. (2008). Dietary exposure to dioxin-like compounds in three age groups: results from the Flemish environment and health study. Chemosphere, 70, Robaeys, G., De Bie, J., Wichers, M.C., Bruckers, L., Nevens, F., Michielsen, P., Van Ranst, M., Buntinx, F. (2007). Early prediction of major depression in chronic hepatitis C patients during peg-interferon alpha-2b treatment by assessment of vegetative-depressive symptoms after four weeks. World Journal Gastroenterology, 13, Kellen, E., Zeegers, M.P., Dirx, M., Houterman, S., Droste, J., Lawrence, G., Truyers, C., Bruckers, L., Molenberghs, G., Joniau, S., and Buntinx, F. (2007). Occurrence of both bladder and prostate cancer in five cancer registries in Belgium, The Netherlands and the United Kingdom. European Journal Cancer, Vandeloo, M., Bruckers, L., and Janssens, J. (2007). Effects of lifestyle in the onset of puberty as determinant for breast cancer. European Journal of Cancer Prevention, 16, Rafter, J., Bennett, M., Caderni, G., Clune, Y., Hughes, R., Karlsson, P.C., Klinder, A., O Riordan, M., O Sullivan, G.C., Pool-Zobel, B., Rechkemmer, G., Roller, M., Rowland, I., Salvadori, M., Thijs H., Van Loo, J., Watzl, B. and Collins, J.K. (2007). Dietary synbiotic reduces cancer risk factors in polypectomised and colon cancer patients. The American Journal of Clinical Nutrition, 85, Huan-I. Chan, WU, A.W., Finnern, H.W., Thijs, H., Gath, J.C., and Fairclough, D.L. (2007). Handling missing quality of life data in HIV clinical trials what is practical? Quality of Life Research, Accepted. De Gramont, A., Buyse, M., Cortiñas Abrahantes, J., Burzykowski, T., Quinaux, E., Cervantes, A., Figere, A., Lledo, G., Flesh, M., Mineur, L., Carola, E., Etienne, P.L., Rivera, F., Chirivella, I., Perez-Staub, N., Louvet, C., Andr., T., Tabah-Fisch,n I., Tournigand, C. (2007). Reintroduction of oxaliplatin improves survival in advanced colorectal cancer. Journal of Clinical Oncology 25, Namata, H., Shkedy, Z., Faes, C., Aerts, M., Molenberghs, G., Theeten, H. Van Damme, P. and Beutels, P. (2007). Estimation of the force of infection from current status data using generalized linear mixed models. Journal of Applied Statistics, 34, Namata, H., Méroc, R., Aerts, M., Faes, C., Cortiñas Abrahantes, J., Imbrechts, H., and Mintiens, K. (2007). Salmonella in Belgian laying hens : an identification of risk factors. Preventive Veterinary Medicine, doi ( /j.prevetmed; ) (in press). Van Sanden, S., Lin, D., and Burzykowski, T. (2007). Performance of classification methods in a microarray setting: a simulation study. Biocybernetics and biomedical engineering, 27,

14 14. Cortiñas Abrahantes, J., Burzykowski, T., Legrand, C., Janssen, P. Ducrocq, V., Duchateau, L. (2007). Comparison of different estimation procedures for proportional hazards model with random effects. Computational Statistics and Data Analysis, 51, Lin, D., Shkedy, Z., Yekutieli, D., Burzykowski, T., Gohlmann H.W.H., De Bondt, A., Perera, T., Geerts, T., Bijnens, L. (2007). Testing for trend in dose-response microarray experiments: comparison of several testing procedures, multiplicity and resampling-based inference. Statistical Applications in Genetics and Molecular Biology, 6, Article 26. Buyse, M., Burzykowski, T., Carroll, K., Michiels, S., Sargent, D., Miller, L.L., Elfring, G.L., Pignon J-P., Piedbois, P. (2007). Progression-free survival is a surrogate for survival in advanced colorectal cancer. Journal of Clinical Oncology 25, Collette, L. Buyse, M., Burzykowski, T. (2007). Are prostate-specific antigen changes valid surrogates for survival in hormone refractory prostate cancer? A meta-analysis is needed! Journal of Clinical Oncology, 25, Sterne, J., Burzykowski, T. (2007). The assessment of the usefulness of hemilaminecdtomy without fenestration in the treatment of thoracolumbar disc disease in chrondrodystophic dogs. Polish Journal of Veterinary Sciences, 10, Lassere, M., Johnson, K., Boers, M., Tugwell, P., Brooks, P., Simon, L. Strand, V., Conaghan, P. Ostergaard, M., Maksymowych, W.P., Landewé, R., Bresnihan, B., Tak, P.P., Wakefield, R., Mease, P., Bingham, C.O. III, Hughes, M., Altman, D., Buyse, M., Galbraith, S., Wells, G. (2007). Definitions and validation criteria for biomarkers and surrogate endpoints: development and testing of a quantitatieve hierarchical levels of evidence schema. Journal of Rheumatology 34, Lassere, M., Johnson, K., Hughes, M., Altman, D., Buyse, M., Galbraith, S., Wells, G. (2007). Simulation studies of surrogate endpoint validation using single trial and multitrial statistical approaches. Journal of Rheumatology 34, Zelefsky, J.R., Srinivasan, M., Kundu, A., Lietman, T., Whitcher, J.P., Wang, K., Buyse, M. Cunningham, E.T. (2007). Hookworm infestation as a risk factor for Mooren s ulcer in South India. Ophtalmology, 144, Mehrzad, J., Dosogne, H., De Spiegeleer, B., Duchateau, L., and Burvenich, C. (2007). Bovine blood neutrophil acyloxyacyl hydrolase (AOAH) activity during endotoxin and coliform mastitis. Veterinary Research 38, van Hoek, I., Vandermeulen, E., Duchateau, L., Lefebre, H.P., Croubles, S., Peremans, K., Polis, I. and Daminet, S. (2007). Comparison and reproducibility of plasma clearance of exogenous creatinine, exo-iohexol, endo-iohexol, and Cr-51-EDTA in young adult and aged healthy cats. Journal of Veterinary Internal Medicine, 21, Rasschaert, K., Verdonck, F., Goddeeris, B.M., Duchateau, L., and Cox, E. (2007). Screening of pigs resistant to F4 enterotoxigenic Escherichia coli (ETEC) infection. Veterinary Microbiology 123,

15 15. Todem, D., Kim, K.M., Lesaffre, E. (2007). Latent-variable models for longitudinal data with bivariate ordinal outcomes. Statistics in Medicine 26, Küchenhoff, L.H., Lederer, W., Lesaffre, E. (2007). Asymptotic variance estimation for the misclassification SIMEX. Computational Statistics and Data Analysis 51, Komárek, A. and Lesaffre, E. (2007). Bayesian accelerated failure time model for correlated interval-censored data with a normal mixture as error distribution. Statistics Sinica 17, Sariachvili, M., Droste, J., Dom, S., Wieringa, M., Vellinga A., Hagendorens, M. Bridts, C., Stevens W., Sprundel, M.V., Desager, K., Weyler, J. (2007). Is breast feeding a risk factor for eczema during the first year of life? Pediatric Allergy Immunology, 18, Van Goethem, M., Schelfout, K., Kersschot, E., Colpaert, C., Verslegers, I., Biltjes, I., Tjalma, W.A., De Schepper, A., Weyler, J., Parizel P.M. (2007). MR mammography is useful in the preoperative locoregional staging of breast carcinomas with extensive intraductal component. European Journal Radiology 62, Specenier, P.M., Van den Weyngaert, D., Van Laer, C., Weyler, J., Van den Brande, J., Huizing, M.T., Dyck, J., Schrijvers, D., Vermorken, J.B. (2007). Phase II feasibility study of concrurrent radiotherapy and gemcitabine in chemonaive patients with squamous cell carcinoma of the head and neck: long-term follow up data. Annals of Oncology, 18, Fieuws, S., Verbeke, G., Maes, B., Van Renterghem, Y. (2007). Predicting renal graft failure using multivariate longitudinal profiles. Biostatistics, accepted. Verbeke, G. and Fieuws, S. (2007). The effect of miss-specified baseline characteristics on inference for longitudinal trends in linear models. Biostatistics, 0, 0, Rizopoulos, D., Verbeke, G., Lesaffre, E. (2007). A two-part joint model for the analysis of survival and longitudinal binary data with excess zeros. Biostatistics, accepted. Moons, E., Wets, G., and Aerts, M. (2007). Nonlinear models for determining mode choice. Lecture Notes in Computer Science. Springer, Berlin/Heidelberg, Overige wetenschappelijke publicaties 25 Overige artikels Callaert, H. (2007). Statistiekonderwijs: ontwkkelingen in Vlaanderen en wereldwijd. In: Wiskunde onderwijs in Vlaanderen en Europa: een stand van zaken en perspectieven voor de toekomst. D. De Bock, J. Deprez, D. Janssens, W. Van Dooren (Eds.). ISBN Molenberghs, G., Beunckens, C., Thijs, H., Jansen, I., Verbeke, G., Kenward, M.G., and Van Steen, K. (2007). Analysis of Incomplete Data. In: SAS System for Clinical Trials II.

16 16. Dmitrienko, A., Chuang-Stein, C., and D'Agostino, R. (Eds.) Cary: SAS Press, pp Fitzmaurice, G. and Molenberghs, G. (2007). Historical Perspective. In: Advances in Longitudinal Data Analysis: A Handbook. Fitzmaurice, G., Davidian, M., Molenberghs, G., and Verbeke, G. (Eds.) London: Chapman Hall/CRC, pp ISBN 10: Molenberghs, G. and Fitzmaurice, G. (2007). Incomplete Data: Introduction and Overview. In: Advances in Longitudinal Data Analysis: A Handbook. Fitzmaurice, G., Davidian, M., Molenberghs, G., and Verbeke, G. (Eds.) London: Chapman Hall/CRC, pp ISBN10: Molenberghs, G., Verbeke, G., and Kenward, M.G. (2007). Sensitivity Analysis. In: Advances in Longitudinal Data Analysis: A Handbook. Fitzmaurice, G., Davidian, M., Molenberghs, G., and Verbeke, G. (Eds.) London: Chapman Hall/CRC, pp ISBN 10: Laenen, A., Bruckers, L., Goossens, M., Houben, L. and Molenberghs, G. (2007). Wachttijden in de centra geestelijke gezondheidszorg onderzocht. Acta Hospitalia, 46, Méroc, E., De Clercq, K., Mintiens, K., Faes, C., Cortinas, J., Aerts, M., Ducheyne, E., Hendrickx, G. and Mellor, Ph. (2007). Role of human interventions. In: EFSA Report on Epidemiology analysis of the 2006 bluetongue virus serotype 8 epidemic in north-western Europe. ( gue.htm) Cuypers, W., Gemis, M., Stulens, K., Vanelven, L., Plessers, B., Bruckers, L. (2007). Gevraagd in Limburg: GPS voor het zorgcircuit psychotische stoornissen. Acta Hospitalia. Themanummer 1, Geys, H., Faes, C., and Catalano, P. (2007). Joint models for continuous and discrete longitudinal data. In: Longitudinal Data Analysis: A Handbook. Fitzmaurice, G., Davidian, M., Verbeke, G., Molenberghs, G. (Eds.) Chapman and Hall. ISBN 10: Artikels in proceedings Molenberghs, G., Burzykowski, T., Alonso, A., Assam, P., Tilahun, A., and Buyse, M. (2007). The meta-analytic framework for the evalution of surrogate endpoints in clinical trials. In: Proceedings of the 18th International Workshop on Statistical Modelling, Barcelona, Spain, Puig, P. (Ed), pp ISBN Faes, C., Aerts, M., Geys, H., Molenberghs, G., and Teuns, G. (2007). A high-dimensional joint model for longitudinal endpoints of different type. In: Proceedings of the 18th International Workshop on Statistical Modelling, Barcelona, Spain, Puig, P. (ed), pp ISBN

17 17. Jacobs, T., Straetemans, R., Rossenu, S., Dunne, A., Molenberghs, G., and Bijnens, L. (2007). A new, convolution-based, approach to develop a level A in vitro in vivo correlation (IVIVC) for an extended-release oral dosage form. In: Proceedings of the Joint Statistical Meetings 2007, Salt Lake City, Utah. Laenen, A., Alonso, A., and Molenberghs, G. (2007). A family of measures to evaluate scale reliability based on longitudinal clinical trial data. In: Proceedings of the 15 th Annual Meeting of the Belgian Statistical Society. Antwerpen, Belgium. ISBN Braekers, R. and Gaddah, A. (2007). A Koziol-Green estimator for the conditional distribution function under dependent censoring. In: Bulletin of the International Statistical Institute, 56 th Session, Lisboa, Portugal. ISBN Massonnet, G., Janssen, P., Duchateau, L. (2007). Modeling udder data using copula models for quadruples. In: VIII Tartu Conference of Multivariate Statistics & the VI Conference on Multivariate Distributions with Fixed Marginals, Tartu, Estonia. Tõnu Kollo and Ants Kassik (Eds.). ISBN Buntinx, F., Aertgeerts, B., Aerts, M., Bruyninckx, R., Knottnerus, J.A., Van den Bruel, A., Van den Ende, J. (2007). Multivariable analysis in diagnostic accuracy studies. What are the possibilities? In: The evidence base of clinical diagnosis. Boone, I., Van der Stede, Y., Bollaerts, K. Vose, D., Daube, G., Aerts, M. and Mintiens, K. (2007). Belgian farm-to-consumption risk assessment-model for Salmonella in pigs: methodology for assessing the quality of data and information sources. In: Proceedings of the 7 th International Symposium on the Epidemiology and Control of Foodborne Pathogens in Pork. Verona, Spain. ISBN Bollaerts, K., Aerts, M., Ribbens, S., Van der Stede, Y., Boone, I., and Mintiens, K. (2007). Identification of Salmonella high risk pig farms in Belgium using semi-parametric quantiles regression. In: Proceedings of the 7 th International Symposium on the Epidemiology and Control of Foodborne Pathogens in Pork. Verona, Spain. ISBN Aerts, M., Bollaerts, K., Hens, N., Shkedy, Z., Faes, C., Van Damme, P., and Beutels, P. (2007). Direct models for multiple infection measurements of antibody levels. In: Proceedings of the 22 nd International Workshop on Statistical Modelling, del Castillo, J., Espinal, A., and Puig, P. (Eds.) Barcelona: Universitat Autònoma de Barcelona, ISBN Bollaerts, K., Aerts, M., Hens, N., Faes, C., Shkedy, Z., Beutels, P., and Van Damme, P. (2007). Estimation of true prevalence and force of infection directly from antibody levels. In: Bulletin of the International Statistical Institute, 56 th Session. Lisboa, Portugal. ISBN Hens, N., Aerts, M., Eilers, P., Beutels, P. (2007). A symmetric two-dimensional B-spline appraoch to model social contacts and mixing patterns relevant to the spread of infectious

18 18. disceases. In: Bulletin of the International Statistical Institute, 56 th Portugal. ISBN Session. Lisboa, Creemers, A., Aerts, M., Hens, N., Shkedy, Z., Beutels, P. and de Smet, F. (2007). Flexible estimating equations as a new technique to perform a cost-effectiveness analysis for pneumococcal infections. In: Bulletin of the International Statistical Institute, 56 th Session, Lisboa, Portugal. ISBN: Bollaerts, K., Aerts, M., Hens, N., Faes, C., Van der Stede, Y., and Mintiens, K. (2007). Estimating Salmonella prevalence in pigs: a new method to estimate the true prevalence directly from antibody levels. In: Proceedings of the Fourth Lustrum of the Dutch and Flemish Society for Veterinary Epidemiology and Economics, Wageningen, Van der Stede, Y., Bollaerts, K., Cortiñas Abrahantes, J., Aerts, M., Imberechts, H., and Mintiens, K. (2007). Identification of Salmonella risk farms by serological surveillance at pre-harvest level: mission impossible? In: Proceedings of the Fourth Lustrum of the Dutch and Flemish Society for Veterinary Epidemiology and Economics, Wageningen, Bilcke, J., Aerts, M., and Beutels, P. (2007). Statistical issues in cost-effectiveness analysis. In: Proceedings of the 15 th Annual Meeting in the Belgian Statistical Society, Antwerpen, Belgium, page 23. ISBN Boulet, G., Depuydt, C., Horvath, C., Aerts, M., Hens, N., Bogers, J. (2007). HPV 16 integration status as a biomarker for CIN2+. In: proceedings of the 15 th Annual Meeting of the Belgian Statistical Society, Antwerpen, Belgium, page 54. ISBN Mossong, J., Hens, N., Jit, M., Beutels, P., Auranen, K., Mikolajczyck, R., Massari, M., Salmaso, S., Scalia Tomba, G., Wallinga, J., Heijne, J., Sadkowska-Todys, M., Rosinska, M., Edmunds, J. (2007). Estimating social mixing patterns relevant to the spread of infectious diseases. In: Proceedings of the symposium on Advances in Infectious Diseases Modelling Les Pensires Conference Center Veyrier du Lac France, December. Grijspeerdt, K., Messens, W., Bollaerts, K., Van Dessel, P., Delhalle, L., Maes, D., Boone, I., Mintiens, K. (2007). Quantitative risk assessment of human salmonellosis through consumption of pork in Belgium: a modular risk model. In: Proceedings of the 7 th International Symposium on the Epidemiology and Control of Foodborne Pathogens in Pork. Verona, Spain. ISBN Koch, K., Schönauer, S., Jansen, I., Van den Bussche, J. Burzykowski, T. (2007). Finding clusters of positive and negative coregulated genes in geneexpression data. In: Proceedings of the 74 th IEEE International Conference on Bioinformatics and Biooengineering vol. I, Yang, J.Y., Tang, M.Q., Zhu, M.M., Zhang, Y., Arebnia, H.R., Deng, Y., Bourkakis, N.G. (Eds.), IEE Press, pp ISBN: Uitgaven van publicaties of proceedings als editor

19 19. Auget, J.-L., Balakrishnan, N., Mesbah, M., and Molenberghs, G. (2007). Advances in Statistical Methods for the Health Sciences: Applications to Cancer and AIDS Studies, Genome Sequence Analysis, and Survival Analysis. New York: Birkhäuser. ISBN-10: , e-isbn-10: X Fitzmaurice, G., Davidian, M., Molenberghs, G., and Verbeke, G. (2007). Advances in Longitudinal Data Analysis: A Handbook. London: Chapman Hall/CRC. ISBN-10: , ISBN-13: Uitgaven van wetenschappelijke boeken Molenberghs, G., and Kenward, M.G. (2007). Missing data in clinical studies. New York: John Wiley. ISBN Lousbergh, D., Claes, E., Op De Beeck, L., Rummens, J.L., Vanden Brande, J., Faes, C., Bruckers, L., Molenberghs, G., Dhollander., Kellen, E., Hensen, K., Lathouwers, D., Meekers, E., Buntinx, F. (2007). Ten years of cancer in the Belgian province of Limburg: Hasselt, LIKAS. ( ISBN Euroregionaal jongerenonderzoek: bijkomende verwerkingen van de Limburgse resultaten: juli 2005 / onderzoeksuitvoering : Liesbeth Bruckers; voorwoord: Sonja Claes Hasselt: provincie Limburg, p. BBB Congressen en voordrachten 31 Organisatie van internationale wetenschappelijke congressen of zomerschool Workshop on Statistical Inference for Dependent Data. Universiteit Hasselt april 2007 Organisatie: Noël Veraverbeke en Paul Janssen, 60 deelnemers. 32 Voordrachten op internationale wetenschappelijke congressen Herman Callaert februari Conference of the European Society for Research in Mathematics Education CERME-5, Larnaca, Cyprus. Understanding confidence intervals augustus Internationaal Symposium Wiskundeonderwijs in Vlaanderen en Europa: een stand van zaken en perspectieven voor de toekomst, Leuven. Statistiekonderwijs: ontwikkelingen in Vlaanderen en wereldwijd. (uitgenodigd plenaire spreker). Op exploratie in de statistiek (workshop). Noël Veraverbeke 31 augustus - 3 september Workshop Robust and Nonparametric Inference, Hejnice, Czech Republic. Distribution function estimation (2 september 2007). Geert Molenberghs

20 januari Fourth Meeting of the Eastern Mediterranean Region of the International Biometric Society, EMR2007, Eilat, Israel. A latent-variable model as a basis for sensitivity analysis in incomplete longitudinal data (25 januari 2007) maart International Biometric Society Eastern North American Region, Atlanta, USA. Round table discussion leader on Is there a future for surrogate marker evaluation in randomized clinical studies? (12 maart 2007) maart Spring meeting of the Eastern North American Region, Atlanta, USA. Formal and informal model selection and assessment when data are incomplete. (13 maart 2007). 3-4 mei INSERM Workshop #176, Toulon, France. Model assessment and sensitivity analysis when data are incomplete, with emphasis on the Slovenian Public Opinion Survey (3 mei 2007). 6-8 juni First Nordic-Baltic Biometric Conference, Research Center Foulum, Denmark. Model assessment and sensitivity analysis when data are incomplete (7 juni 2007) juni XI Conferencia española de biometría y I encuentro ibericoamericana de biometría, Salamanca, Spain. Model assessment and sensitivity analysis when data are incomplete (21 juni 2007). 1-6 juli International Workshop on Statistical Modeling, Barcelona, Spain. The meta-analytic framework for the evaluation of surrogate endpoints in clinical trials (6 juli 2007) juli Tenth meeting of new researchers in statistics and probability. IMS, Salt Lake City, Utah, USA. Publishing in Biometrics: a journal of the International Biometric Society (26 juli 2007). 29 juli 2 augustus Joint Statistical Meetings, Salt Lake City, Utah, USA. A sensible way to design a longitudinal study (discussant) (31 juli 2007). 29 juli 2 augustus Joint Statistical Meetings, Salt Lake City, Utah, USA. Round table discussion leader on Incomplete Data in Longitudinal Studies (1 augustus 2007). 29 juli 2 augustus Joint Statistical Meetings, Salt Lake City, Utah, USA. Approaches for surrogate marker evaluation from multiple randomized clinical trials (2 augustus 2007). 26 september Pharma Statistics Conference, Johnson & Johnson Pharmaceutical Research and Development, Titusville, New Jersey, USA. The meta-analytic framework for the evaluation of surrogate endpoints in clinical trials. Keynote speaker (26 september 2007). 5 oktober IV Meeting of the Central American and Crabibbean Region of the International Society and IV Columbian-Venezuelan Statistical Meeting, Margarita Island,