10:20 11:30 Roundtable discussion: the role of biostatistics in advancing medicine and improving health; career as a biostatistician Monday
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1 SUMMER INSTITUTE FOR TRAINING IN BIOSTATISTICS (SIBS) Week 1: Epidemiology, Data, and Statistical Software 10:00 10:15 Welcome and Introduction 10:20 11:30 Roundtable discussion: the role of biostatistics in advancing medicine and improving health; career as a biostatistician 11:40:12:00 Overview of USF SIBS: curriculum, extracurricular activities, and overall goals 2:00 5:00 Student IDs, Campus Tour, Simulation Lab Tour, and Shimberg Library Tour, Housing Orientation 5:00 7:00 Welcome Reception (COPH Atrium) 10:00 10:55 Biostatistics, Public Health, and Epidemiology: Perspectives and history Definitions: association and causation, Infectious disease epidemiology, Chronic disease epidemiology: cardiovascular disease and cancer; Current epidemiologic issues in the news 11:00 12:00 History and basics of epidemiology (cont.) Introduction to cohort studies The Framingham Heart Study: history and basic design Framingham; early results and public health implications 2:00 3:30 Introduction to data analysis software R 3:35 5:00 R: Illustration with Framingham data; population distribution and sampling variation 7:00 Team Activity 10:00 11:00 Basic principles of epidemiology (cont.) Bias and confounding, incidence and prevalence 11:05 12:00 Other important epidemiologic studies 2:00 5:00 Field Trip Moffitt Cancer Research Center 7:30 8:30 pm SIBS Team Fitness REC Center 10:00 11:00 Case-control studies Principles and examples 11:05 12:00 Epidemiologic studies; Issues and examples; Ecological studies (units in the aggregate) What about cancer clusters? 2:00 3:30 Introduction to data analysis software SAS 3:35 5:00 SAS: Illustration with Framingham data; population distribution and sampling variation
2 7:00 Team Activity 10:00 11:00 Summary of epidemiology and the role of biostatistics Speculations on the future of epidemiology 11:05 12:00 Clinical Trials: history, scope, phases, and the U.S. regulatory process Planning and implementation of phase 3 clinical trials: formulating a research question Primary and secondary endpoints, inclusion and exclusion criteria, generalizability 2:00 5:00 Field Trip Jaeb Center for Health Research Sat 10 4 Clearwater Beach Sun Free Time Week 2: Clinical Trials 10:00 11:00 Is the Evidence for LDL <70 Really Clear? Dissecting evidence that Lead to Guidelines 11:05 12:00 Issues in Evaluating Evidenced-Based Data 2:00 5:00 Field Visit: Hillsborough County Health Department 10:00 11:00 Clinical Trials: Randomization, research ethics, informed consent, IRBs, sample size Major types of trials: therapeutic and prevention. Examples from the literature 11:05 12:00 Protocol development: blinding, recruitment. Examples The UGDP (first multi-center trial; problems at the start) The LRC-CPPT trial (the first cholesterol lowering trial) Trial monitoring, protocol deviation, compliance, statistical analyses, stopping rules List of selected classical epidemiology and clinical trials topics for student reviews provided Scheduling of presentations (Thurs. and Fri.) 2:00 3:30 SAS: Association and correlation for continuous data; group comparison and testing hypothesis 3:35 5:00 SAS: Association and correlation for discrete data, RR and OR 6:30 pm Volunteer at the Hope Lodge American Cancer Society Wednes day 10:00 11:00 Other important clinical trials; and controversies ( CAST A major clinical trial reveals an underpublicized tragedy 11:05 12:00 Ethical issues: A biostatistician s role. A scandal at Harvard, and another at Montreal
3 Separate student group meetings on presentations 2:00 5:00 Field trip to Moffitt/JAEB (shadow a work group) 7:30 8:30 pm SIBS Team Fitness REC Center 10:00 11:00 Student presentations (5): Selected classical clinical trials/epidemiologic studies Discussion Some issues resolved, others arising from them 11:05 12:00 Student presentations (cont.) Summary of clinical trials methodology and related issues Use of surrogates Equivalence trials 2:00 3:30 R: Association and correlation for continuous data; group comparison and testing hypothesis 3:40 5:00 R: Association and correlation for discrete data, RR and OR 10:00 11:00 Summary and speculation on the future of clinical trials 11:05 12:00 Regression: effect modifier and confounding 2:00 5:00 Field trip to Moffitt/JAEB (shadow a work group) Sat 10 5 Busch Garden & Adventure Island (students are on their own for these activities) Sun Free Time Week 3: AIDS Clinical Trials and Modeling : Memorial Day no class 10:00 11:00 HIV/AIDS, and HIV epidemic 11:05 12:00 Human behavior and risk factors to HIV/AIDS 2:00 5:00 Field Trip: VA Patient Safety Center 6:30 pm Volunteer at the Hope Lodge 10:00 11:00 Pathogenesis of HIV-1 infection, progression 10:30 11:20 HAART regimens 2:00 5:00 Moffitt/JAEB/Project Team Meeting
4 7:30 8:30 pm SIBS Team Fitness Student REC Center 10:00 11:00 Biostatistics in AIDS clinical trials and AIDS drug development 11:05 12:00 AIDS clinical trials and datasets & longitudinal data structure 2:00 5:00 Computer Lab and team work 10:00 11:00 Between patient variation and random effects 11:05 12:00 Linear mixed effects models Top of the Palms 2:00 5:00 Moffitt/JAEB/Project Team meeting Sat 10 4:00 pm Lido Beach/St. Armand s Circle Sun Free Time Week 4: Behavioral and Mental Health, and Evidence Based Medicine 10:00 11:00 Risk factors of mood disorders (e.g., depression and suicide): Demographic characteristics 11:05 12:00 Relative risk; attributable risk; odds ratio; and 2 by 2 tables 2:00 5:00 10:00 11:00 Pearson s Chi-square test; Fisher exact test; McNamer test 11:05 12:00 Social interaction and mood disorder 2:00 5:00 Computer Lab (analysis of couple s data) 6:30 pm - Volunteer at Hope Lodge 10:00 11:00 Study of changes in mental health at individual levels 11:05 12:00 Growth curve analysis of college student drinking in freshman year 12:00-2:00 Lunch 2:00-5:00 Moffitt/JAEB/Project Team 7:30 8:30 pm SIBS Team Fitness 10:00 11:00 Bias in therapeutic research 11:00 12:00 Principles in systematic review 2:00 3:00 Meta Analysis
5 3:00 4:00 Demonstration of software (REVMAN/STATA) 10:00 11:00 logistic regression, effect modifier and interaction 11:05 12:00 logistic regression, effect modifier and interaction 2:00-3:00 Graduate studies in public health 3:00 5:00 Moffitt/JAEB/Project Team meeting Sat 9:30 5:00 Tarpon Springs/Island Wind Tours Sun Free time Week 5: Genomics and Medical Genetics 10:00 11:00 Introduction to genomic data (biology aspect) 11:05 12:00 Introduction to genomic data (clinical aspect) 2:00 5:00 Field Trip - USF Pediatric EPI Center 7:00 - Work on project report and presentation 10:00 11:00 Management of high-dimensional data and data normalization 11:05 12:00 Gene selection and multiple testing Bulls Den 2:00 3:00 Introduction to Bioconductor (statistical tools for data management and normalization) 3:00 5:00 Introduction to Bioconductor (statistical tools for gene selection and adjustment for multiple testing) 6:30 pm Volunteer at Hope lodge 10:00 11:00 Proteomic and pathway analysis 11:05 12:00 Classification and prediction 2:00-5:00 Moffitt/JAEB/Project Team meeting 7:30 8:30 pm SIBS Team Fitness REC Center 10:00 11:00 Introduction to single nucleotide polymorphisms (SNPs) 11:00 12:00 Statistical methods for SNP data 2:00 3:30 Computer Lab: Real data analysis for SNP 3:40 5:00 Computer Lab: Introduction to Bioconductor
6 Sat 10:00 11:00 Classification and prediction (continued) 11:05-12:00 Discussion of homework project Bulls Den 2:00-5:00 Moffitt/JAEB/Project Team meeting Free time Sun 12:00 5:00 Tampa Bay Ray Game Week 6: Aging Studies and Biomarkers 10:00 12:00 Lab with R and Biostatistics 2:00 5:00 Lab with SAS 7:00 Team project 10:00 12:00 Lab with R and Biostatistics 2:00 5:00 Lab with SAS 7:30 pm SIBS Team Fitness REC Center 9: 30 am 12:00 Field Trip: FMQAI 2:00-5:00 Moffitt/JAEB/Project Team meeting 7:00 - Team project (preparation for presentation) 10:00 11:30 Round Table II (former and current graduates) 11:30 12:00 Preparation for project 2:00 5:00 Team project presentation (30 minutes each) 5:00-7:00 pm Closing Ceremony and Farewell Dinner 10:00 12:00 Information Session and Wrap-up 2:00 5:00 Room clean-up and check out Sat Room clean-up and check out
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