Curriculum Vitae. Christopher R. Martens, Ph.D.

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1 Address 354 UCB Department of Integrative Physiology University of Colorado Boulder Boulder, CO Contact spot.colorado.edu/~chma3573 Phone: EDUCATION & TRAINING Postdoctoral Integrative Physiology of Aging Laboratory, 2014-Present University of Colorado Boulder, Boulder CO Department of Integrative Physiology Mentor: Douglas R. Seals, Ph.D. Ph.D. Applied Physiology, University of Delaware, Newark DE Dissertation: Exercise and Vascular Function in Chronic Kidney Disease Mentor: David G. Edwards, Ph.D. B.S. Exercise Science, Concentration: Exercise Physiology, Minor: Biological Sciences POSITIONS 2014-present Postdoctoral Fellow, University of Colorado Boulder Department of Integrative Physiology Research Assistant, University of Delaware Department of Kinesiology & Applied Physiology Teaching Assistant, University of Delaware Department of Kinesiology & Applied Physiology Research Contractor, US Army Research Institute of Environmental Medicine, Thermal and Mountain Medicine Division, Natick MA Undergraduate Research Volunteer, University of Delaware Department of Kinesiology & Applied Physiology Page 1

2 HONORS & AWARDS 2013 Caroline tum Suden/ Frances Hellbrandt Professional Opportunity Award The American Physiological Society 2013 Dissertation Fellowship, University of Delaware 2012 University Graduate Fellowship, University of Delaware 2012 Professional Development Award Office of Graduate and Professional Education, University of Delaware 2010 Doctoral Student Investigator Award American College of Sports Medicine (Mid-Atlantic Regional Chapter) GRANT SUPPORT Current Industry Contract, ChromaDex Inc. NIAGEN Supplementation for Improving Physical and Metabolic Function in Midlife and Older Adult Humans Direct Costs: $65, UL1 TR (Pilot & Feasibility Grant) Nicotinamide-Riboside Supplementation for Improving Physiological Function in Middle-Aged and Older Adults Direct Costs: $30, Glenn/AFAR Postdoctoral Fellowship Program for Translational Research on Aging Nicotinamide Riboside Supplementation for Improving Physiological Function in Older Adults Direct Costs: $49,980 Completed 2014 T32 AG Integrative Physiology of Aging Institutional Training Grant University of Colorado School of Medicine, Division of Geriatric Medicine Direct Costs: $42,000 Role: Fellow (PI: Schwartz, R) American College of Sports Medicine Doctoral Student Research Grant Exercise and Vascular Function in Chronic Kidney Disease Direct Costs: $5,000 Page 2

3 PUBLICATIONS 1. Martens CR, Edwards DG. Peripheral vascular dysfunction in chronic kidney disease. Cardiology Research & Practice Doi /2011/ Martens CR, Kuczmarski JM, Lennon-Edwards S, Edwards DG. Impaired L-arginine uptake but not arginase contributes to endothelial dysfunction in rats with chronic kidney disease. J. Cardiovasc. Pharmacol (1): Kuczmarski JM, Martens CR, Lennon-Edwards S, Edwards DG. Cardiac function and tolerance to ischemia-reperfusion injury in chronic kidney disease. Nephrol. Dial. Transplant (8): Martens CR, Kuczmarski JM, Kim J, Guers JJ, Harris MB, Lennon-Edwards S, Edwards DG. Voluntary wheel running augments aortic L-arginine transport and endothelial function in rats with chronic kidney disease. Am. J. Physiol. Renal Physiol (4):F Kuczmarski JM, Martens CR, Kim J, Lennon-Edwards S, Edwards DG. Cardiac function is preserved following 4 weeks of voluntary wheel running in a rodent model of chronic kidney disease. J. Appl. Physiol (5): Martens CR. Taking steps in the workplace to improve vascular function. Exp. Physiol In press. 7. de Picciotto NE, Gano LB, Sindler AL, Johnson LC, Martens CR, Imai S, Seals DR. Nicotinamide mononucleotide supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness in old mice. In Revision: Aging Cell. 8. Martens CR, Kirkman D, Edwards DG. The Vascular Endothelium in Chronic Kidney Disease: A Novel Target for Exercise. In Review: Exercise Sport Sci R. 9. Martens CR, Seals DR. Practical alternatives to chronic caloric restriction for optimizing vascular function with aging. In preparation: J. Physiol. PUBLISHED ABSTRACTS 1. Martens C, Poojari D, Bellumori M, and Knight CA. Motor unit recruitment and de-recruitment asymmetry increases with increased frequency of sinusoidal force modulation Med Sci Sports Exerc. 39(5 Suppl):S Poster, National ACSM New Orleans, LA. 2. Poojari D, Bellumori M, Martens C, and Knight CA. A comparison of frequency and time domain analyses of motor unit rate coding Med Sci Sports Exerc. 39(5 Suppl):S266. Poster, National ACSM New Orleans, LA. 3. Bellumori M, Poojari D, Martens C, and Knight CA. Motor unit discharge behavior within phasic bursts from higher threshold motor units Med Sci Sports Exerc. 39(5 Suppl):S267. Poster, National ACSM New Orleans, LA 4. Martens CR, Edwards DG, Kenefick RW. The effect of prolonged exercise in the heat and subsequent submaximal exercise on markers of oxidative stress Med Sci Sports Exerc. 42(5): Poster, National ACSM Baltimore, MD. Page 3

4 5. Martens, CR, Schellhardt, T, Lennon-Edwards, S, Edwards, DG. Arginase inhibition does not restore endothelial-dependent relaxation in rats with chronic kidney disease FASEB J. 25: Poster, Experimental Biology Washington, DC. 6. Martens, CR, Kuczmarski, JM, Lennon-Edwards SL, Edwards, DG. Impaired L-arginine uptake contributes to aortic endothelial dysfunction in chronic kidney disease. Poster, NISBRE, Washington, DC. 7. Kuczmarski, JM, Martens, CR, Lennon-Edwards S, Edwards, DG. Myocardial stunning in the 5/6 ablation/infarction model of chronic kidney disease FASEB J. 26:lb658. Poster, Experimental Biology San Diego, CA. 8. Martens, CR, Kuczmarski, JM, Lennon-Edwards S, Edwards, DG. Impaired L-arginine uptake contributes to aortic endothelial dysfunction in chronic kidney disease FASEB J. 26: Poster, Experimental Biology San Diego, CA. 9. Kuczmarski JM, Martens CR, Lennon-Edwards S, Edwards DG. Cardiac dysfunction in the 5/6 ablation-infarction model of chronic kidney disease FASEB J. 27: Poster, Experimental Biology Boston, MA. 10. Martens, CR, Kuczmarski, JM, Lennon-Edwards S, Edwards, DG. The effect of L-arginine supplementation & voluntary wheel running on vascular function in rats with chronic kidney disease FASEB J. 27: Poster, Experimental Biology Boston, MA. 11. Kuczmarski JM, Martens CR, Kim J, Lennon-Edwards S, Edwards DG. Voluntary wheel running improves cardiac function in a rodent model of chronic kidney disease FASEB J. 28(S1) Poster, Experimental Biology San Diego, CA. 12. depicciotto NE, Johnson LC, Sindler AL, Martens CR, Gano LB, Mills KF, Imai S, Seals DR. SIRT1 activation with nicotinamide mononucleotide improves vascular function in old male mice. Submitted to 2015 Keystone Symposium on the Biology of Sirtuins. ORAL PRESENTATIONS Mar 2015 Nov 2014 Aug 2014 Feb 2013 Nov 2012 Translational Strategies for Optimizing Vascular Function with Aging Southern Connecticut State University, Dept. of Exercise Science Translational Strategies for Optimizing Vascular Function with Aging University of Colorado School of Medicine, Perinatal Research Center Translational Strategies for Optimizing Vascular Function with Aging Colorado Clinical and Translational Sciences Institute (CCTSI) Summit A Tale of Two Kidneys Invited Speaker as part of series Evidence-Based Living: The Secrets to Healthy Aging Osher Lifelong Learning Center, Wilmington, DE Voluntary Wheel Running Augments Vascular Function In Rats With Chronic Kidney Disease. American College of Sports Medicine, Mid-Atlantic Regional Chapter Annual Meeting Page 4

5 Sep 2012 Nov 2010 Nov 2009 Vascular Dysfunction In Chronic Kidney Disease: The Role of L-arginine. Invited Speaker BIOMS Graduate Seminar, Arginase inhibition does not improve endothelial function in rats with chronic kidney disease. American College of Sports Medicine, Mid-Atlantic Regional Chapter Annual Meeting The Effect of Prolonged Exercise in the Heat on Markers of Oxidative Stress. American College of Sports Medicine, Mid-Atlantic Regional Chapter Annual Meeting TEACHING EXPERIENCE 2015 Graduate Student Research Forum (IPHY 5010), co-instructor 2014 Graduate Seminar: Physiology of Aging (IPHY 6010), co-instructor 2013 Clinical Exercise Testing and Prescription (KAAP 475), guest-lecturer Guidelines for Exercise Testing & Prescriptions for Patients with Kidney Disease 2012 Anatomy & Physiology (KAAP 310), guest-lecturer The Heart & Cardiovascular Function Physiology of Activity Laboratory (HESC 431), instructor TRAINEE MENTORING Lawrence Cody Johnson, Ph.D. Student Natalie depicciotto, MS Student Blair Denman, MS Student John Guers, Ph.D. Student Jahyun Kim, Ph.D. Student Zachary Mease, Undergraduate Researcher 2011 Wuroh Timbo, Undergraduate Summer Scholar 2011 Alexandra Lahurd, Undergraduate Summer Scholar PROFESSIONAL DEVELOPMENT 2011 O Brien Center Rodent Kidney Physiology/Injury Workshop University of California, San Diego, VA San Diego Healthcare System, La Jolla, CA Rat & Mouse Microsurgical Workshop Wake Forrest Medical School, Department of Orthopedic Surgery, Winston-Salem, NC PROFESSIONAL SERVICE ACTIVITIES Journals Reviewed For Hypertension American Journal of Physiology, Renal Physiology American Journal of Physiology, Regulatory Integrative and Comparative Physiology Page 5

6 American Journal of Physiology, Heart and Circulatory Physiology Physiological Genomics International Journal of Sports Medicine Experimental Physiology Professional Society Memberships American College of Sports Medicine (ACSM) American Physiological Society (APS) American Heart Association (AHA) American Society of Nephrology (ASN) Gerontological Society of America (GSA) Service 2012 Graduate Student Grade Grievance Committee Member Faculty Senate, Graduate Student Representative Graduate Student Senate Curriculum Planning Committee, Dept. of Health, Nutrition, & Exercise Sciences Page 6