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1 UvA-DARE (Digital Academic Repository) The Post-Intensive Care Syndrome (PICS) Dettling-Ihnenfeldt, D.S. Link to publication Citation for published version (APA): Dettling-Ihnenfeldt, D. S. (2017). The Post-Intensive Care Syndrome (PICS): Impact of ICU-stay on functioning and General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam ( Download date: 18 Feb 2017

2 The Post-Intensive Care Syndrome The Post-Intensive Care Syndrome (PICS): Impact of ICU-stay on functioning and Daniela Dettling-Ihnenfeldt Daniela Dettling-Ihnenfeldt

3 The Post-Intensive Care Syndrome (PICS): Impact of ICU-stay on functioning and Daniela Dettling-Ihnenfeldt

4 The Post Intensive Care Syndrome (PICS): Impact of ICU stay on functioning and Thesis University of Amsterdam, The Netherlands The studies presented in this thesis were financially supported by: The Academic Medical Center, Amsterdam, The Netherlands The printing of this thesis was financially supported by: The Academic Medical Center, Amsterdam, The Netherlands, and the Scientific College Physical Therapy (WCF) of the Royal Dutch Society for Physical Therapy (KNGF) ISBN: Cover and lay-out: Dieter and Daniela Dettling Drawings cover: Yvonne Feuerhahn Printed by Offpage, Copyright Daniela Dettling Ihnenfeldt, Amersfoort, The Netherlands All rights reserved. No part of this publication may be reproduced in any form or by any means without permission from the author.

5 The Post-Intensive Care Syndrome (PICS): Impact of ICU-stay on functioning and ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus prof. dr. ir. K.I.J. Maex ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel op donderdag 16 februari 2017, te uur door Daniela Susanne Dettling-Ihnenfeldt geboren te Berlijn, Duitsland

6 PROMOTIECOMMISSIE Promotor: Prof. dr. F. Nollet Universiteit van Amsterdam Co-promotor: Dr. M. van der Schaaf Universiteit van Amsterdam Overige leden: Prof. dr. M.B. Vroom Universiteit van Amsterdam Prof. dr. C.A.M. van Bennekom Prof. dr. M.A.G. Sprangers Prof. dr. R.H.H. Engelbert Prof. dr. D. van Dijk Prof. dr. H.J. Stam Universiteit van Amsterdam Universiteit van Amsterdam Universiteit van Amsterdam Universiteit Utrecht Erasmus Universiteit Rotterdam Faculteit der Geneeskunde

7 CONTENTS Chapter 1 General introduction 7 Chapter 2 Poor functional status immediately after discharge 23 from an intensive care unit Chapter 3 Impact of ICU-acquired weakness on post-icu 41 physical functioning: a follow-up study Chapter 4 Functional recovery in patients with and without 61 intensive care unit acquired weakness Chapter 5 Coping style and quality of life in 83 Dutch intensive care unit survivors Chapter 6 Feasibility of Post-Intensive Care Unit Clinics: 103 an observational cohort study of two different approaches Chapter 7 General discussion 123 Summary 149 Samenvatting 155 Curriculum vitae / Portfolio 161 Contributions of authors 168 Dankwoord 171

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