Ongoing studies Time interval:

Transcription

1 Ongoing studies Time interval: Author title Gabapentin Treatment of Dependence (NIDA) Treatment for Adolescent Abuse Combined Pharmacotherap y for Dependency Year of study (S) Year of publication (P) when available Start:2007 completion: 2009 Start:2007 completion: 2009 Start: January 2010 completion: August 2014 Country Study design Substance of dependence (D) Drugs of (T) Drugs for comparison (C) Hypothesis (H) Double-Blind, Placebo Control, Safety/Efficacy Study Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), (D) cannabis (T) gabapentin in treating persons with cannabis dependence (D) abuse (T) (MET,CBT, CM) (MET)/CBT+CM (MET)/CBT+CM (MET)/CBT (D) cannabis (T)Lofexidine in combination with Marinol Patients N and characteristics Outcomes use withdrawal Sleep Mood Craving use consequences abstinence Weekly No Days of marijuana use Monthly Reduction in self reported days of marijuana use as measured by the Time-line Followback. 12 weeks/ or study participation No Narrative results Risk of bias

2 Effect of Motivational Therapy on Schizophrenia With Misuse Start: November 2008 completion: September 2011 France Placebo Control, Safety/Efficacy Study (D) cannabis in schizophrenia patients (T) therapy Behavioral: Usual care withdrawal as measured by the MWC-10 item 12 weeks/ or study participation No consumption evaluated by the Time-Line Follow Back at 6 months inclusion, 3 month, 6 month, 12 month No PANSS, GAF, number of DSM- IV criteria of cannabis dependence, May scale for response, SF- 12, la URICA, number of hospitalisation, D9THC urinanalysis at 6M and cannabis consumption evaluated by the TLFB at 6M inclusion, 3 month, 6 month, 12 month. Only

3 The Teen Check-Up Efficacy of Contingency Management in the Treatment of Adolescents With Use Disorders Treatment Project - 3 CONTINGENCY MANAGEMENT Start: September 2004 completion: June 2008 (D) Abuse Dependence (T) enhancement therapy Behavioral: education Start: April 2009 Spain (D) Abuse (T) Behavioral: Standard Behavioral: Standard Treatment Plus Contingency Management Program Start: February 2007 completion: April (D) dependence (T)Behavioral: Reinforcement for homework completion Behavioral: Reinforcement for Abstinence 234 marijuanadependent participants inclusion and 6 month for urianalysis No Self-report of marijuana use 3 months and 12 months marijuana active users 12 weeks No negative urinescreens 12 weeks No completed intervention sessions 12 weeks No Scores in psychopathology and drug scales (T-ASI, SDQ, BDI, Problem Questionnaire) 12 weeks No abstinence Oneyear follow-up period Self-efficacy,

4 FOR MARIJUANA DEPENDENCE Specialized Addiction Treatment Versus Treatment as Usual for Young Patients With Abuse and Psychosis 2011 Start: September 2007 completion: December 2010 Behavioral: Case Management Denmark (D) Abuse and Psychosis (T)Behavioral: Cognitive behavioral therapy with motivational interviewing Behavioral: Non-manualized standard use of coping skills, and attendance During 2-month period Continuous abstinence will be predicted by (a) attendance; (b) post self-efficacy for coping; and (c) use of coping skills One-year follow-up period Number of cannabisabstinent days in past month Psychotic symptoms Cognitive functioning Social functioning

5 Sources: Quality of life Client satisfaction 6 Cost of After completed data collection No