CURRICULUM VITAE Paolo Arosio

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1 CURRICULUM VITAE Paolo Arosio Personal Data - Date of birth: 28 July Place of birth: Vaprio d Adda (Milan) - Nationality : Italian - Address: Via Matteotti, Lissone - Phone : Phone at office: paoloarosioncco@gmail.com or : paolo.arosio@guest.unimi.it Education - PhD in Materials Engineering at Politecnico di Milano, date: Thesis under the supervision of prof. Stefano Valdo Meille on structural and morphological studies of macromolecular systems for advanced applications. - Degree in Chemistry at Università degli Studi di Milano. Graduation date : Final mark : 104/110. Final-year thesis under the supervision of Dr Marco Scavini on EXAFS study of structure of Oxygen defects in Nd 2-x Ce x CuO δ superconductor using data obtained at ESRF of Grenoble. - High School Diploma : Maturità scientifica at Liceo Statale F. Enriques -Via Martiri della Libertà, Lissone (Milano). Final mark 44/60 (July 1993). Languages - English : good knowledge. Job - Current : Post doc position in the research group of prof. A. Lascialfari at Università degli Studi di Milano, Italy. Grant for research project on NMR/MRI and magnetometry measurements on multifunctional magnetic nanoparticles for biomedical applications funded on FIRB project Rete Integrata per la Nano Medicina (RINAME) (PI: prof. D. Gatteschi) and Cariplo Foundation project BatMan (PI: prof. E. Licandro). - 04/01/ /31/2012 Research collaborator in the research group of prof. A. Lascialfari at Università degli Studi di Milano, Italy. Grant for research project on Characterization of magneto-plasomic nano-heterostructures by synchrotron radiation, magnetic susceptibility and NMR funded by Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM). - 10/01/ /31/2011 Post doc position in the research group of prof. A. Lascialfari at Università degli Studi di Milano, Italy. Grant for research project on Nuclear magnetic resonance and MUSR on molecular nanomagnets funded by Istituto NANOSCIENZE - CNR (U.O.S. S3 di Modena). - 10/01/ /30/2010 Post doc position in the research group of prof. A. Lascialfari at Università degli Studi of Milan, Italy. Grant for research project on Characterization of magnetic nanostructures for biomedical 1

2 applications funded by Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM). - 10/01/ /30/2009 Post doc position in the research group of prof. A. Lascialfari and prof. G. Poletti at Università degli Studi di Milano, Italy. Grant for research project on Design of novel magnetic biosensors for environment and health applications funded by Cariplo Fundation. - 04/01/ /30/2007 Post doc position in the research group of prof. G. Allegra and prof. S.V.Meille at Politecnico di Milano, Italy. Grant for research project on Correlazione struttura-proprietà nella progettazione di nanocompositi a matrice elastomerica funded by Cariplo Fundation : Manual designer for technical products of Promelit S.p.A, Cinisello Balsamo, Italy. Instrumentation know-how Nuclear Magnetic Resonance, Atomic Force Microscopy and X Ray Diffraction instruments: - (a) NMR STELAR (5-70 MHz) Spectrometer equipped with electromagnet (H max = 1.5 Tesla). (b) SMARTracer Stelar Relaxometer for NMR-Fast Field Cycling (10 KHz <frequency range < 10 MHz). (c) 2 NMR Spectrometers: a TecMag Double Resonance Spectrometer MHz and a TecMag Single Resonance Spectrometer MHz with pulsed unit at gradient field, equipped with superconductor magnet at 9 Tesla Oxford or 2 Bruker electromagnets. - Multimode (N) Atomic Force Microscope equipped with Nanoscope IIId controller (Bruker, Santa Barbara, CA, USA) and with a 12 μm piezo scanner, working temperature range 0-60 C. - (a) Bruker P4 X ray Diffractometer with monochromatic radiation (K of Cu: λ = 1.542Å), equipped with a 2D HiStar detector and air gun for high temperature. (b) Bruker Nanostar system, with focusing windows, a 2D HiStar detector and a WAXS (Wide Angle X ray Scattering) unit. (c) Italstructres õ/õ X ray Diffractometer, with K of Cu radiation Ni filtered and high temperature equipment. Software skills Windows and Linux operating systems. - Stelar programs, WIMDA, Mulab (collection and data analysis programs for NMR/μ-SR) - Xscans, Saxs, Gadds, Shelx, Eva, Debvin (collection and data analysis programs for x-ray diffraction) - Molecular modelling packages: Tinker and Materials Studio (molecular mechanics and dynamics). - Gnxas ed Excurv98 (data analysis programs for EXAFS) - Excel, Word, Power Point, Outlook, Coreldraw, Corel PhotoPaint, Origin 8.6, Sigmaplot. Research Interests - Characterization of novel magnetic multifunctional nanoparticles using Nuclear Magnetic Resonance (NMR) and Atomic/Magnetic Force Microscopy (AFM/MFM). The magnetic nanoparticles are scientifically notable as Contrast Agents for Magnetic Resonance Imaging (MRI) and as possible vectors for local pharmacological treatment (drug delivery), as well as for hypertermic treatment on tumor molecules. - Studies of magnetic properties on molecular magnets and low-dimensional magnetic clusters using NMR and Muon Spin Resonance. Systems contain a core of metallic ions (till 30) magnetically isolated one each other by an organic shield. This structural property allow fundamental studies of single molecule (single molecule magnets, SMM, or molecular nanomagnts, MNM) using bulk quantities of sample. MMM/SMM materials are interesting because they put togheter the macroscopic properties of a bulk magnet and the quantum properties of nanoscale systems opening novel possibilities for technological applications (qubit, magneto-caloric effect, etc.). The fundamental magnetic properties of these materials are deeply studied in order to give 2

3 suggestions for the synthesis process of new materials with proper characteristics for the technological applications. - Visualization, morpho-dimensional characterization and supramolecular organization of heterologous membrane proteins in Xenopus laevis oocyte by Atomic Force Microscopy (AFM), in particular proteins as possible targets for pharmacological therapy (GAT1 e CFTR). Conformational changes of these protein complex in physiological conditions were studied for correlating these changes with the biological model. - Development of novel magnetic highly-sensitive biosensors for applications in the Health Science (for instance for the detection of biological marker in everyday medical analysis) and Environmental fields. The study of the problems related to the biosensors realization (the type of analyte, magnetic nanoparticles, etc.) and the sensitivity of the detection method of the MFBs (magnetic field biosensors) using Nuclear Magnetic Resonance (NMR) and SQUID magnetometry was undertaken. In the past structural, morphological and phase transition studies on macromolecular systems for advanced applications were my research interests. A contribution to an improved comprehension of the molecular organization and the structural order of materials in the solid state was the purpose of research work. Wide Angle X-ray Scattering on powders, fibers and single crystals and Small Angle X-ray Scattering on thin films and bulk are the main techniques that were used. These X-ray diffraction techniques were supported by molecular modeling and also 13 C-NMR-MAS spectroscopy and optical and electronic microscopy data were used, obtaining results otherwise unachievable. The polythiophenic systems, the syndiotactic-1,2-polydienes systems and the polyolefins-layered silicate nanocomposites were investigated. Scientific Publications - MR Imaging and targeting of human breast cancer cells with folate decorated nanoparticles, Arosio P., Orsini F., Piras A.M., Sandrini S., Chiellini F., Corti M., Masa M., Muckova M., Schmidtova L., Ravagli C., Baldi G., Nicolato E., Conti G., Marzola P., Lascialfari A., RSC Advances, 5 (2015), 39760, doi: /c5ra04880j. - Local spin dynamics at low temperature in the slowly relaxing molecular chain [Dy(hfac)3{NIT(C6H4OPh)}]: a μ+sr study, Arosio P., Corti M., Mariani M., Orsini F., Bogani L., Caneschi A., Lago J., Lascialfari A., Journal of Applied Physics, 117 (2015), 17B310, doi:. - Electron Spin Resonance and Atomic Force Microscopy Study on Gadolinium Doped Ceria, Oliva C, Orsini F., Capelli S., Arosio P., Allieta M., Coduri M., Scavini M., J.Spectr., (2015),, doi: dx.doi.org/ /2015/ Dipolar ordering in a molecular nanomagnet detected using muon spin relaxation, Pratt F. L., Micotti E., Carretta P., A. Lascialfari, Arosio P., Lancaster T., J. Blundell S., Powell A. K., Phys. Rev. B, 89 (2014), , doi: /PhysRevB Superparamagnetic iron oxide nanoparticles stabilized by a poly(amidoamine)-rhenium complex as potential theranostic probe, Maggioni D., Arosio P., Orsini F., Ferretti A.M., Orlando T., Manfredi A., Ranucci E., Ferruti P., D Alfonso G., Lascialfari A., Dalton Trans. 43 (2014), 1172, doi: /c3dt52377b. - Magnetism and spin dynamics of novel encapsulated iron oxide superparamagnetic nanoparticles, Arosio P., Baldi G., Chiellini F., Corti M., Dessy A., Galinetto P., Gazzarri M., Grandi M.S., Innocenti C., Lascialfari A., Lorenzi G., Orsini F., Piras A.M., Ravagli C., Sangregorio C., Dalton Trans. 42 (2013), 10282, doi: /c3dt32805h. - Coexistence of plasmonic and magnetic properties in Au 89 Fe 11 nanoalloys, Amendola V., Meneghetti M., Bakr O.M., Riello P., Polizzi S., Fiameni S., Anjum D.H., Arosio P., Orlando T., de Julian Fernandez C., Pineider F., Sangregorio C., Lascialfari A., Nanoscale 5 (2013), 5611, doi: /C3NR01119D. - Hybrid Iron Oxide-Copolymer Micelles and Vesicles as Contrast Agents for MRI: Impact of the Nanostructure on the Relaxometric Properties, Arosio P., Thévenot J., Orlando T., Orsini F., Corti M., Mariani M., Bordonali L., Innocenti C., Sangregorio C., Oliveira H., Lecommandoux S., Lascialfari A., Sandre. O., Journal of Materials Chemistry B, 1 (2013), 5317, doi: /C3TB00429E. 3

4 - Zirconia-doped nanoparticles: organic coating, polymeric entrapment and application as dualimaging agents, Rebuttini V., Pucci A., Arosio P., Bai X., Locatelli E., Pinna N., Lascialfari A., Comes Franchini M., Journal of Materials Chemistry B, 1 (2013), 919, doi: /c2tb00208f. - NMR-D study of the local spin dynamics and magnetic anisotropy in different nearly monodispersed ferrite nanoparticles, Bordonali L., Kalaivani T., Sabareesh K.P.V., Innocenti C., Fantechi E., Sangregorio C., Casula M.F., Lartigue L., Larionova J., Guari Y., Corti M., Arosio P., Lascialfari A., Journal of Physics: Condensed Matter, 25 (2013), , doi: / /25/6/ Fluorescent and paramagnetic core-shell hybrid nanoparticles for bimodal magnetic resonance/luminescence imaging, Di W., Velu S.K.P., Lascialfari A., Liu C., Pinna N., Arosio P., Sakka Y., Qin, W. Journal of Materials Chemistry, 22 (2012), 20641, doi: / c2jm34508k. - Atomic force microscopy imaging of lipid rafts of human breast cancer cells, Orsini F., Cremona A., Arosio P., Corsetto P.A., Montorfano G.; Lascialfari A., Rizzo A.M., BBA - Biomembranes, 1818 (2012), 2943, - Chemical-Physical changes in cell membrane microdomains of breast cancer cells after omega-3 PUFA incorporation, Corsetto P.A., Cremona A., Montorfano G., Orsini F., Arosio P., Rizzo A.M., Cell Biochemistry and Biophysics, 64 (2012), 45, doi: /s y. - Magnetic, optical and relaxometric properties of organically coated gold-magnetite (Au-Fe 3 O 4 ) hybrid nanoparticles for potential use in biomedical applications, Umut E, Pineider F., Arosio P., Sangregorio C., Corti M., Tabak F., Lascialfari A., Ghigna P., Journal of Magnetism and Magnetic Materials, 324 (2012), 2373, doi: /j.jmmm Water-Dispersible Sugar-Coated Iron Oxide Nanoparticles. An Evaluation of their Relaxometric and Magnetic Hyperthermia Properties, Lartigue L., Innocenti C., Kalaivani T., Awwad A., Sanchez M.M., Guari Y., Larionova J., Guérin C., Montero J.L., Barragan V., Arosio P., Lascialfari A., Gatteschi D., Sangregorio C., JACS, 133 (2011), 10459, doi: dx.doi.org/ /ja111448t. - Magnetic and Relaxation Properties of Multifunctional Polymer-based Nanostructured Bioferrofluids as MRI Contrast Agents, Amiri H., Bustamante R., Millán A., Silva N.J.O., Piñol R., Gabilondo L., Palacio F., Arosio P., Corti M., Lascialfari A., Magnetic Resonance in Medicine, 66 (2011), 1715, doi: /mrm Multifunctional Nanoparticles for Dual Imaging, Ali Z., Abbasi A.Z., Zhang F., Arosio P., Lascialfari A., Casula M.F., Wenk A., Kreyling W., Plapper R., Seidel M., Niessner R., Knoll J., Seubert A., Parak W.J., Analytical Chemistry, 83 (2011), 2877, doi: dx.doi.org/ /ac103261y. - Design of Water-based Ferrofluids as contrast Agents for Magnetic Resonance Imaging, Casula M.F., Corrias A., Arosio P., Lascialfari A., Tapas S., Floris P., Bruce I.J., Journal of Colloid and Interface Science, 357 (2011), 50, doi: /j.jcis Phonon-induced relaxation in the Cr7Ni magnetic molecule probed by NMR, Bianchi A., Carretta S., Santini P., Amoretti G., Lago J., Corti M., Lascialfari A., Arosio P., Timco G., Winpenny R.E.P., Phys. Rev. B, 82 (2010), , doi: /PhysRevB Observing Xenopus laevis oocyte plasma membrane by atomic force microscopy, Orsini F., Santacroce M., Arosio P., Sacchi V.F., Methods, 51 (2010), 106, doi: /j.ymeth Magnetization and spin dynamics of a Cr-based magnetic cluster: Cr7Ni, Bianchi A., Carretta S., Santini P., Amoretti G., Furukawa Y., Kiuchi K., Ajiro Y., Narumi Y., Kindo K., Lago J., Micotti E., Arosio P., Lascialfari A., Borsa F., Timco G., Winpenny R.E.P., J. Magn. Magn. Mater., 322 (2010), 1262, doi: /j.jmmm Muon spin relaxation investigation of tetranuclear iron(iii) Fe 4 (OCH 3 ) 6 (dpm) 6 molecular cluster, Procissi D., Arosio P., Orsini F., Marinone M., Cornia A., Lascialfari A., Phys. Rev. B, 80 (2009), 94421, doi: /PhysRevB Intermittent contact mode AFM investigation of native plasma membrane of Xenopus laevis oocyte, Orsini F., Santacroce M., Arosio P., Castagna M., Lenardi C., Poletti G., Sacchi F.V., Eur. Biophys. J., 38 (2009), 903, doi: /s "Water-Soluble Rhamnose-Coated Fe 3 O 4 Nanoparticles", Lartigue L., Oumzil K., Guari Y., Larionova J., Guérin C., Montero J.L., Barragan-Montero V., Oumzil K., Sangregorio C., Caneschi A., Innocenti C., Kalaivani T., Arosio P., Lascialfari A., Organic Letters., 11 (2009), 2992, doi: /ol900949y. - Ordered Stacking of Regioregular Head-to-Tail Polyalkylthiophenes: Insights from the Crystal Structure of Form I Poly(3-n-butylthiophene), Arosio P., Moreno M., Famulari A., Raos G., Catellani M., Meille S.V., Chemistry of Materials, 21 (2009), 78, doi: /cm802168e. 4

5 - Structure and morphology of HDPE-g-MA/organoclay nanocomposites: Effects of the preparation procedures, Filippi S., Marazzato C., Magagnini P., Famulari A., Arosio P., Meille S.V., Eur. Polym. J., 44 (2008), 987, doi: /j.eurpolymj Synthesis and Structural Characterization of Syndiotactic trans-1,2 and cis-1,2 Polyhexadienes, Ricci G., Boglia A., Motta T., Bertini F., Boccia A.E., Zetta L., Alberti E., Famulari A., Arosio P., Meille S. V., Journal of Polymer Science, Part A: Polymer Chemistry,, 45 (2007), 5339, doi: /pola Structure of nanotubular titanium oxide templates prepared by electrochemical anodization in H 2 SO 4 /HF solutions, Bestetti M., Franz S., Cuzzolin M., Arosio P., Cavallotti P. L., Thin Solid Films, 515 (2007), 5253, doi: /j.tsf Clay-induced Preferred Orientation in Polyethylene/Compatibilized Clay Nanocomposites, Famulari A., Arosio P., Meille S.V., Filippi S., Marazzato C., Magagnini P., Minkova L., Journal of Macromolecular Science, Part B: Physics, 46 (2007), 355, doi: / First Detailed Determination of the Molecular Conformation and the Crystalline Packing of a Chiral Poly(3-alkylthiophene): Poly-3-(S)-2-methylbutylthiophene, Arosio P., Famulari A., Catellani M., Luzzati S., Torsi L., Meille S.V., Macromolecules, 40 (2007), 3, doi: /ma Synthesis, Characterization, and Crystalline Structure of Syndiotactic 1,2-Polypentadiene: The Trans Polymer, Ricci G., Motta T., Boglia A., Alberti E., Zetta L., Bertini F., Arosio P., Famulari A., Meille S. V., Macromolecules, 38 (2005), 8345, doi: /ma047605q. - Synthesis, Characterization and Molecular Conformation of Syndiotactic 1,2 Polypentadiene: The Cis Polymer, Ricci G., Alberti E., Zetta L., Motta T., Bertini F., Mendichi R., Arosio P., Famulari A., Meille S. V., Macromolecules, 38 (2005), 8353, doi: /ma047604y. - Stereocontrolled synthesis of hydroxyethylamine isosteres via chiral sulfoxide chemistry, Pesenti C., Arnone A., Arosio P., Frigerio M., Meille S. V., Panzeri W., Viani F., Zanda M., Tetrahedron Letters, 45 (2004), 5125, doi: /j.tetlet Hirsch index using: Web of Science H = 10, Scopus H = 10. Author of the following oral scientific communications - Magnetic nanoparticles: recent advances in biomedical applications, Arosio P., 9th INTERNATIONAL CONFERENCE OF ANTICANCER RESEARCH, Porto Carras, Sithonia, Greece, October 06-10, 2014 (as invited speaker). - Study of spin dynamics in the molecular antiferromagnetic nanomagnet Ni 7 by means of 1 H-NMR, Arosio P., Fismat 2013 Italian National Conference on Condensed Matter Physics, Milano September 09-13, Realization of novel Magnetic Field Effect Biosensors using NMR and SQUID detection, Arosio P., 3 Forum Nazionale dei Giovani Ricercatori di Scienza e Tecnologia dei Materiali, Padova March 22-24, Synthesis, characterization and crystalline structure of syndiotactic 1,2 polypentadiene: the trans polymer, Ricci G., Motta T., Boglia A., Alberti E., Zetta L., Bertini F., Arosio P., Famulari A., Meille S.V., XVII Convegno Nazionale della Società di Scienza e Tecnologia delle Macromolecole, Napoli September 11-15, Co-author of the more than 60 scientific congress communications Member of research projects: - COST ; COST action TD1402: "Multifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy (RADIOMAG). - Fondazione Cariplo ; project: "New biomimetic tools for mirna targeting (BaTMAN) ; Pricipal Investigator Prof. E. Licandro, Università degli Studi di Milano. - FIRB 2010; project: "Rete Integrata per la Nano Medicina (RINAME) ; Pricipal Investigator Prof. D. Gatteschi, Consorzio INSTM e Università degli Studi di Firenze. - Fondazione Cariplo ; project: "Chemical synthesis and characterization of magnetoplasmonic nano-heterostructures ; Pricipal Investigator Prof. P. Ghigna, Università degli Studi di Pavia. 5

6 - Royal Society International Joint Project 2009/JP090010; project: "Nanometre-resolution imaging of membrane proteins in their native environment"; Pricipal Investigators.: Dr. B.Hoogenboom, University College London; Dr. F.Orsini, Università degli Studi di Milano. - Wellcome Trust Project 2009; project: "Understanding CFTR by a combined real-time structural (AFM) and electrophysiological approach"; Pricipal Investigator Dr. B.Hoogenboom, University College London. - Seventh Framework Programme: Theme NMP-2007, Large Scale Integrating Collaborative Project; progetto: "Integration of novel NANOparticle based technology for THERapeutics and diagnosis of different types of cancer (NANOTHER)" ; coordinator: Fundacion GAIKER. - Fondazione Cariplo ; project: "Progettazione di nuovi biosensori magnetici per l'applicazione in scienze della salute e ambientali ; Pricipal Investigator Prof. A. Lascialfari, Università degli Studi di Milano. - Fondazione Banca del Monte di Lombardia ; project: Caratterizzazione tramite Risonanza Magnetica Nucleare e indagine morfo-dimensionale di nuove nanoparticelle magnetiche per applicazioni biomediche ; Pricipal Investigator Prof. A. Lascialfari, Università degli Studi di Milano. - PRISMA-INSTM ; project: Nanoparticelle magnetiche funzionali come mezzi di contrasto per Risonanza Magnetica Imaging - Pricipal Investigator Dr.ssa M.F. Casula, local Investigator Prof. A. Lascialfari. - Partecipation to FIRST/PUR: Academic years: , , , Research project submitted as P.I.: - Futuro in Ricerca 2013; project: "Una nuova metodologia per monitorare in situ il trattamento ipertermico dei tumori tramite nanoparticelle multifunzionali e metaboliti iperpolarizzati" Acronimo: HyTherPol; referee marks: 8.67/10.00, not funded. - Fondazione Cariplo 2010; project: " Nanoparticelle magnetiche per biosensoristica allo stato solido". Referee marks: 66, not funded. Referee of scientific journal: ACS Nano; ACS Applied Materials & Interfaces; ACS Inorganic Chemistry Scientific societies: - Member of Network of Excellence MAGMANET (Molecular Approach to Nanomagnets and Multifunctional Materials), European FP6, tematica "Nano-technologies and nano-sciences, knowledge-based multifunctional materials, and new production processes and devices", European Pricipal Investigator Prof. D. Gatteschi, Università di Firenze e INSTM, National Pricipal Investigator INFM-CNR Prof. Affronte, Università di Modena, since Member of INSTM (Consorzio Inter-universitario Nazionale per la Scienza e Tecnologia dei Materiali) since Member of SILS (Società Italiana Luce di Sincrotrone) since Teaching: Assistant for the following university courses at Politecnico di Milano: - Fondamenti di Chimica for Mechanical engineering (prof. Antonino Famulari) in the Academic year Chimica A for Civil engineering (prof. Antonino Famulari) in the Academic years , e Chimica B for Mechanical engineering (prof. Carlo Punta) in the Academic year Chimica A for Biomedical engineering (prof. Guido Raos) in the Academic year Since Academic year expert on the subject Physics in CdL of Pharmacy and CdL of Chemical and Technological Pharmaceutics, Università degli studi di Milano. Co-tutor of MSc thesis at Università degli studi di Pavia (Tomas Orlando) and at Università degli studi di Milano (Alberto Aiolfi and Andrea Barbaglia). Scientific tutor of PhD students at Università degli studi di Milano (K. Thangavel, H. Amiri Doumari) and Università degli studi di 6

7 Pavia (Tomas Orlando), of MSc student (Stefano Millefiorini) and bachelor student (Sergio Ravizza) at Politecnico di Milano. European Large Facilities user: Co-author of proposals at following large scale facilities: - European Synchrotron Radiation Facility (ESRF) Grenoble (France) - Paul Scherrer Institute (PSI) Villigen (Switzerland) School Participation: - Studying days on: Scienza e tecnologia dei Materiali al Politecnico di Milano date of 19/11/2003 and 28/01/ Studying days for PhD course on: Metodi di riconoscimento e caratterizzazione dei materiali, during VII Scuola Nazionale di Luce di Sincrotrone, Santa Margherita di Pula (Cagliari), 15-26/09/2003 April 30 th, 2015 Paolo Arosio Pursuant to Italian D.Lgs 196/03 7