10h15 - The finite element method (FEM) and biomechanical models. Augusta Neto ( Fac. de Ciências e Tecnologia da Universidade de Coimbra )

Transcription

1 17 th May- Monday Dental Biomechanics Biomechanics is a science that uses the principles of mechanics to explore biological problems. This includes bioengineering, the research and analysis of the mechanics of living organisms and the application of engineering principles to and from biological systems. Analytical, as well as experimental research in Dental Biomechanics is a trend in the current literature, many journals accept and publish original articles, surveys and perspective articles on dental biomechanics: design and analysis of dental tissues and prostheses; mechanics of chewing and temporomandibular joint simulation; mechanics of implants (geometry) and implant osseointegration. Analytical research with the finite element method (FEM) when coupled with clinical data, for ex: computed tomography (CT) is a powerful tool in Dental biomechanics. However, substantial data is required for patient-specific modelling, therefore experimental methods can also supply data and validation to the FEM. The aim of this module is to provide an overview on Dental Biomechanics. The topics addressed in this four hour PhD module programme are expected to provide the background needed to integrate this knowledge in a research project. 9h30 - Mechanical principles of stress and strain on dental implants and prosthesis. 10h15 - The finite element method (FEM) and biomechanical models. Augusta Neto ( Fac. de Ciências e Tecnologia da Universidade de Coimbra ) 11h00 - Experimental methods in biodental engineering. Mário Augusto Pires Vaz (Fac. de Engenharia da Universidade do Porto) 12h15 - Methods of generating clinical data for FEM studies. - Natali A. Dental Biomechanics, publ. Taylor & Francis, 2003 pp 1-17; Nicolau P. Implantes Endoósseos com Carga Imediata- Avaliação Clínica e Biomecânica. Tese de Doutoramento apresentada à Faculdade de Medicina da Universidade de Coimbra, Ed. Autor, Faculdade de Medicina, Departamento de Medicina Dentária, Universidade de Coimbra. 2007, pp

2 17 th May- Monday Clinical Research in Dental Biomaterials Clinical research and randomized clinical trials (RCT) in particular are generators of a high level of evidence in the field of dental biomaterials, but have to follow strict rules in order to: bridge the gap between research and dental practice. The overwhelming number of new materials on the market in recent years bring more uncertainty to the dentist with less time to judge what material serves better in his practice. Therefore more RCTs are needed for this purpose. However, these type of clinical studies, impose ethical issues, that follow the declaration of Helsinkia, and seek to gain ethic commissions approval. Study designs must follow tight protocols from patient recruitment to study termination. Reports should be performed accordingly to the guidelines in the Consolidated Standards of Reporting Trials (CONSORT) statement. Adequate reporting of clinical trials improves transparency, enables the interpretation and replication of studies and reduces the risk of bias. For this reason, many journals now require trials conformed to the guidelines in CONSORT statement. The aim of this module is to provide an overview on clinical research on dental Biomaterials and how to design RCTs. The topics addressed in this Five hour PhD module programme are expected to provide the background needed to integrate this knowledge in a research project. 14h00 - Study design and ethical commission approval. 14h45 - Evidence based research in RCTs in the literature. António Mata (Faculdade de Medicina Dentária da Universidade de Lisboa) 16h00 - Expertise background in multicenter RCTs with bone graft materials and dental implants Fernando Guerra (Faculdade de Medicina da Universidade de Coimbra) 16h45 - Reporting clinical data according to CONSORT guidelines. - Juni P, Altman DG, Egger M. Systematic reviews in health care: Assessing the quality of controlled trials. BMJ 2001;323: Campbell MK, Elbourne DR, Altman DG; CONSORT group. CONSORT statement: extension to cluster randomised trials. BMJ. 2004;328(7441): Mata AD, Marques D, Silveira J, Marques J. Medicina Dentária Baseada na Evidência: Novas Opções para Velhas Práticas. Rev Port Estomatol Cir Maxilofac 2008;49:31-37.

3 18 th May - Tuesday Biomaterials in Operative Dentistry The aims of this course are: 1. Presenting the most important biomaterials and research lines in Operative Dentistry 2. Presenting the microscopic techniques for ultramorphological evaluations of tooth tissues, restorative materials and respective interfaces. 3. Making a workshop with laboratory evaluations of tooth/restorations interfaces, namely with some adhesion tests and and electronic microscopic observations. Seminars 9.00 Adhesive interfaces evaluation in Operative Dentistry - João Carlos Ramos 9.45 Scanning electronic microscopy techniques Augusto Barros Lopes Transmission electronic microscopy techniques Vanda Lopes Practical workshops Workshop with laboratory demonstrations of tooth/materials interface adhesion tests Workshop with laboratory demonstrations of electronic microscopy observations of tooth tissues, dental materials and tooth/restorative materials interfaces. João Carlos Ramos Assistant Professor, Coimbra Medical School, University of Coimbra Augusto Barros Lopes Assistant Professor, Dep. of Ceramics and Glass Engineering, University of Aveiro Vanda Lopes IBILI Investigator, IBILI, Coimbra Medical School, University of Coimbra References - Bitter K, Paris S, Mueller J, Neumann K, Kielbassa AM. Correlation of scanning electron and confocal laser scanning microscopic analyses for visualization of dentin/adhesive interfaces in the root canal. J Adhes Dent Feb;11(1): Bayne SC. Dental restorations for oral rehabilitation - testing of laboratory properties versus clinical performance for clinical decision making. J Oral Rehabil Dec;34(12): Review.

4 19 th May - Wednesday Biomaterials in periodontal regeneration 9h00 - Characterization of pre-clinical periodontal lesions Isabel Poiares Baptista - Faculty of Medicine, Coimbra University 10h00 - Enamel Matrix Derivative from biological principals to systematic reviews Isabel Poiares Baptista - Faculty of Medicine, Coimbra University 11h30 - Tissue engineering in periodontal regeneration new perspectives Carlos Viegas - Faculty of Veterinary Sciences, Trás-os-Montes e Alto Douro University 14h00 16h00 Apresentação e discussão de artigos - Pellegrini G, Seol YJ, Gruber R, Giannobile WV. Pre-clinical models for oral and periodontal reconstructive therapies. J Dent Res 2009;88(12): Polimeni G, Xiropaidis AV, Wikesjö UME. Biology and principles of periodontal wound healing/regeneration. Periodontology ;41:30-47.

5 20 st May - Thursday Experimental Models in Dentistry Experimental Models in Bone Regeneration 9h00 Characteristics of Bone Tissue Maria Helena Figueiredo, Faculty of Medicine, Coimbra University 10h00 Bone Graft Characterization (morphology, particle size, porosity, surface area) Margarida Figueiredo, Chemical Engineering Department, FCTUC 11h00 - Bone grafts and bone substitutes Sérgio Matos, Faculty of Medicine, Coimbra University - Figueiredo M, Henriques J, Martins G, Guerra F, Judas F, Figueiredo H. Physicochemical characterization of biomaterials commonly used in dentistry as bone substitutes comparison with human bone. J Biomed Mater Res. Part B:Appl Biomater 2010;92B:

6 21 nd May Friday Biocompatibility tests for evaluation of dental materials 10h00 - Initial tests (cytotoxicity, mutagenicity) Helena Raposo Fernandes 11h00 Usage tests in animal model for pulpdentinal complex João Carlos Ramos Practical workshop Workshop with laboratory demonstrations of tissue histological processing. In this concept, newly developed materials should be subjected to the three steps in the given sequence from the simple to the more complex test methods, from in vitro to in vivo animal tests, and from preclinical to clinical testing in humans. Helena Raposo Fernandes Faculty of Dental Medicine, Oporto University João Carlos Ramos Faculty of Medicine, Coimbra University - Biocompatibility of Dental Materials. Gottfried Schmalz e Dorthe Arenholtbindslev. Ed Springer Verlag, ISBN Protecções pulpares directas avaliação histopatológica; João Carlos Ramos; dissertação de tese de Doutoramento Experimental models in Endodontics 14h00 - In vitro microleakage with dies and microbial tracers João Miguel Santos 15h00 - Secondary tests and usage tests to evaluate endodontic materials - João Miguel Santos João Miguel Santos Faculty of Medicine, Coimbra University - Shemesh H, Souza EM, Wu MK, Wesselink PR. (2008). Glucose reactivity with filling materials as a limitation for using the glucose leakage model. Int Endod J;4(10): Garcia LF, Marques AA, Roselino LM, Souza FC, Consani S (2010). Biocompatibility evaluation of Epiphany/Resilon root canal filling system in subcutaneous tissue of rats. J Endod ;36(1): Friedman S, Torneck CD, et al. (1997). "In vivo model for assessing the functional efficacy of endodontic filling materials and techniques." J Endod ;23(9):