How to treat cough associated with common cold
|
|
- Angelica Bailey
- 7 years ago
- Views:
Transcription
1 How to treat cough associated with common cold Professor Ron Eccles Common Cold Centre Cardiff School of Biosciences Cardiff University Pneumology around the clock Alberobello October
2 Common Cold Centre Part of Cardiff University, Wales, UK Main interest is in understanding mechanisms of symptoms and symptomatic treatments Common Cold centre established 1988 to conduct clinical trials on new treatments for common cold and flu 2
3 Cough ---- a vital protective reflex cerebral cortex Urge to cough Voluntary control sensation of irritation NTS respiratory area of brainstem +ve / -ve MECHANICAL OSMOTIC ph vagus nerve Aspirated food and fluid respiratory muscles cough! 3
4 Acute cough due to common cold is the most common type of cough and one of the most common symptoms Defined as cough < 3weeks Boujaoude ZC, Pratter MR. Clinical approach to acute cough. Lung. 2010;188 Suppl 1:S Pratter MR. Cough and the common cold: ACCP evidence-based clinical practice guidelines. Chest. 2006;129(1 Suppl):72S-74S. Acute cough is caused by respiratory viral infection which causes hypersensitivity of airway receptors 4
5 1976 Empey DW et al. Mechanisms of bronchial Hyperreactivity in normal subjects after upper respiratory tract infection. Am Rev Respir Dis. 1976;113(2): Our study demonstrates that spontaneous, presumably viral, upper respiratory tract infections cause striking increases in bronchial reactivity to inhaled histamine and citric acid aerosols in otherwise normal subjects. This bronchial hyperreactivity was present during infection and for several weeks after recovery, but all the subjects returned to normal within 7 weeks. 5
6 2016 Zaccone EJ, Lieu T, Muroi Y, Potenzieri C, Undem BE, Gao P, et al. Parainfluenza 3- Induced Cough Hypersensitivity in the Guinea Pig Airways. PLoS One. 2016;11(5):e In summary, PIV3 infection leads to elevations in TRPV1 expression in the two key cough evoking nerve subtypes in the guinea pig trachea, and this is associated with a hypertussive state with respect to various TRPV1 activating stimuli. 6
7 Acute cough cerebral cortex Urge to cough Voluntary control sensation of irritation NTS respiratory area of brainstem +ve / -ve hypersensitivity vagus nerve TRPV1 INFECTION airway inflammation and irritation respiratory muscles cough! 7
8 Treatments for acute cough can work at three levels cerebral cortex (psychological)r brainstem (cough control) peripheral actionsr 8
9 Treatments for acute cough peripheral actionsr 9
10 1 peripheral actionsr NORMAL COUGH (reflex?) ACUTE HYPERSENSITIVE COUGH (voluntary?) INCREASED TRPV1 EXPRESSION VIRAL INFECTION MECHANICAL CHEMICAL ph inflammatory mediators bradykinin, prostaglandins, cytokines, Substance P etc. 10
11 Peripherally acting treatments ACUTE COUGH EFFECT ON NERVE ENDINGS guaifenesin levodropropozine EFFECT ON MEDIATORS NSAID s corticosteroids leukotriene antagonists HYPERSENSITIVITY 11
12 Efficacy of levodropropizine This analysis indicates that levodropropizine is an effective antitussive drug in children and adults Zanasi A, Lanata L, Fontana G, Saibene F, Dicpinigaitis P, De Blasio F. Levodropropizine for treating cough in adult and children: a meta-analysis of published studies. Multidisciplinary respiratory medicine. 2015;10(1):19. 12
13 Cough scores over 3 evenings, honey and milk, dextromethorphan, levodropropizine Milk and honey mixture seems to be at least as effective as DM or LDP in non-specific acute cough in children. Miceli Sopo S, Greco M, Monaco S, Varrasi G, Di Lorenzo G, Simeone G, et al. Effect of multiple honey doses on non-specific acute cough in children. An open randomised study and literature review. Allergol Immunopathol (Madr). 2015;43(5):
14 Treatments for acute cough brainstem (cough control) 14
15 TREATMENTS acting on brainstem codeine dextromethorphan antihistamines Urge to cough sensation of irritation Voluntary control sweet syrups NTS respiratory area of brainstem +ve / -ve vagus nerve INFECTION airway irritation respiratory muscles cough! 15
16 codeine placebo Mean cough frequency before and after treatment with a single dose of codeine syrup B.P (30mg/10ml) n= 46 and placebo syrup vehicle n = 45 Eccles, R., Morris, S. & Jawad, M. (1992) Lack of effect of codeine in the treatment of cough associated with acute upper respiratory tract infection. Journal of Clinical Pharmacy and Therapeutics, 17,
17 Subjective scores for cough placebo versus 30mg codeine Eccles R, Morris S, Jawad M Lack of effect of codeine in the treatment of cough associated with acute upper respiratory tract infection. J Clin Pharm Ther. 1992;17:
18 Severity scores over 3 days for cough, placebo versus 30mg codeine Eccles R, Morris S, Jawad M Lack of effect of codeine in the treatment of cough associated with acute upper respiratory tract infection. J Clin Pharm Ther. 1992;17:
19 Lack of effect of codeine as an antitussive BOLSER, D. C. & DAVENPORT, P. W. (2007) Codeine and cough: an ineffective gold standard. Current opinion in allergy and clinical immunology, 7, Recent placebo-controlled studies have shown that codeine is no more effective than placebo in suppressing cough caused by either upper respiratory disorders or chronic obstructive pulmonary disease. These recent reports are not consistent with several older placebo-controlled studies that demonstrated the efficacy of codeine. 19
20 Most cough medicines are viscous sweet syrups Sweet taste may modulate cough by generation of endogenous opioid compounds in brainstem. This mechanism is accepted for analgesic effects of sweet substances ECCLES, R. (2006) Mechanisms of the placebo effect of sweet cough syrups. Respiratory physiology & neurobiology, 152,
21 Antitussive effect of sweet taste ECCLES, R. (2006) Mechanisms of the placebo effect of sweet cough syrups. Respiratory physiology & neurobiology, 152,
22 Effect of taste sensation on cough Rinsing mouth with sweet solution inhibited capsaicin induced cough but rinsing with bitter tasting solution had no effect Wise PM, Breslin PA, Dalton P. Effect of taste sensation on cough reflex sensitivity. Lung. 2014;192(1):
23 Treatments for acute cough cerebral cortex (psychological)r 23
24 TREATMENTS acting on cerebral cortex Urge to cough Voluntary control Placebo effect sensation of irritation of ALL cough treatments NTS respiratory area of brainstem +ve / -ve vagus nerve INFECTION airway irritation respiratory muscles cough! 24
25 Placebo The placebo is the most effective medication known to science, subjected to more clinical trials than any other medicine yet nearly always does better than anticipated O Donnel M, Monitor Weekly
26 Placebo versus no treatment No treatment Received only a glass of water cough 30 frequency 15 minutes minutes placebo Received a glass of water and a capsule of vitamin E 0 pre pre treatment post post treatment Patients were told that the study was designed to investigate the effects of vitamin E on cough associated with common cold Lee et al 2005 Psychosomatic Medicine
27 Factors influencing psychological effects of cough medicine Side effects of medicine Environment Doctor-patient interaction Culture Advertising and branding Conditioned response Formulation and dose Physiological effect Personality of patient Faith, hope, belief 27
28 Treatments for acute cough can work at three levels cerebral cortex (psychological)r brainstem (cough control) peripheral actionsr 28
29 ALL SWEET SYRUPS ARE EFFECTIVE ANTITUSSIVES FOR ACUTE COUGH Sweet placebo syrups containing honey etc. are effective antitussives and until we have a safe and effective pharmacological treatment to reverse cough hypersensitivity associated with viral infection sweet syrups are still my preferred treatment for pediatric and adult acute cough 29
30 THANK YOU Cardiff bay 30
Compare the physiologic responses of the respiratory system to emphysema, chronic bronchitis, and asthma
Chapter 31 Drugs Used to Treat Lower Respiratory Disease Learning Objectives Describe the physiology of respirations Compare the physiologic responses of the respiratory system to emphysema, chronic bronchitis,
More informationASTHMA IN INFANTS AND YOUNG CHILDREN
ASTHMA IN INFANTS AND YOUNG CHILDREN What is Asthma? Asthma is a chronic inflammatory disease of the airways. Symptoms of asthma are variable. That means that they can be mild to severe, intermittent to
More informationOn completion of this chapter you should be able to: discuss the stepwise approach to the pharmacological management of asthma in children
7 Asthma Asthma is a common disease in children and its incidence has been increasing in recent years. Between 10-15% of children have been diagnosed with asthma. It is therefore a condition that pharmacists
More information2.06 Understand the functions and disorders of the respiratory system
2.06 Understand the functions and disorders of the respiratory system 2.06 Understand the functions and disorders of the respiratory system Essential questions What are the functions of the respiratory
More informationNIMULID MD. 1. Introduction. 2. Nimulid MD Drug delivery system
NIMULID MD 1. Introduction Nimulid MD is a flavoured dispersible Nimesulide tablet with fast mouth dissolving characteristics thereby providing immediate relief. Nimesulide is a non-steroidal antiinflammatory
More informationCough, as a leading symptom, would certainly be in the top 10 of reasons for seeing a GP.
COUGH Cough, as a leading symptom, would certainly be in the top 10 of reasons for seeing a GP. A cough in a child seems to cause more concern, even when it has not been present very long, whereas in adults
More informationTests. Pulmonary Functions
Pulmonary Functions Tests Static lung functions volumes Dynamic lung functions volume and velocity Dynamic Tests Velocity dependent on Airway resistance Resistance of lung tissue to change in shape Dynamic
More informationPharmacology of the Respiratory Tract: COPD and Steroids
Pharmacology of the Respiratory Tract: COPD and Steroids Dr. Tillie-Louise Hackett Department of Anesthesiology, Pharmacology and Therapeutics University of British Columbia Associate Head, Centre of Heart
More informationDRUG UTILISATION STUDY IN BRONCHIAL ASTHMA IN A TERTIARY CARE HOSPITAL
International Journal of Pharmaceutical Applications ISSN 0976-2639, Online ISSN 2278 6023 Vol 3, Issue 2, 2012, pp 297-305 http://www.bipublication.com DRUG UTILISATION STUDY IN BRONCHIAL ASTHMA IN A
More informationBreathe Easy: Asthma and FMLA
This article was published in the FMLA Policy, Practice, and Legal Update newsletter, by Business & Legal Reports, Inc. (BLR). BLR is a nationally recognized publisher of regulatory and legal compliance
More informationPATIENT INFORMATION ABOUT TREATMENTS FOR ASTHMA AND ALLERGIC RHINITIS, PRESCRIPTIONS & OVER THE COUNTER MEDICINE
PATIENT INFORMATION ABOUT TREATMENTS FOR ASTHMA AND ALLERGIC RHINITIS, PRESCRIPTIONS & OVER THE COUNTER MEDICINE The content of this booklet was developed by Allergy UK. MSD reviewed this booklet to comment
More informationRespiratory Concerns in Children with Down Syndrome
Respiratory Concerns in Children with Down Syndrome Paul E. Moore, M.D. Associate Professor of Pediatrics and Pharmacology Director, Pediatric Allergy, Immunology, and Pulmonary Medicine Vanderbilt University
More informationBackground information
Background information Asthma Asthma is a complex disease affecting the lungs that can be managed but cannot be cured. 1 Asthma can be controlled well in most people most of the time, although some people
More informationObjectives COPD. Chronic Obstructive Pulmonary Disease (COPD) 4/19/2011
Objectives Discuss assessment findings and treatment for: Chronic Obstructive Pulmonary Disease Bronchitis Emphysema Asthma Anaphylaxis Other respiratory issues Provide some definitions Chronic Obstructive
More informationYOU VE BEEN REFERRED TO AN ASTHMA SPECIALIST...
YOU VE BEEN REFERRED TO AN ASTHMA SPECIALIST... ...HERE S WHAT TO EXPECT You have been referred to an allergist because you have or may have asthma. The health professional who referred you wants you to
More informationYour Lungs and COPD. Patient Education Pulmonary Rehabilitation. A guide to how your lungs work and how COPD affects your lungs
Patient Education Your Lungs and COPD A guide to how your lungs work and how COPD affects your lungs Your lungs are organs that process every breath you take. They provide oxygen (O 2 ) to the blood and
More informationNursing 113. Pharmacology Principles
Nursing 113 Pharmacology Principles 1. The study of how drugs enter the body, reach the site of action, and are removed from the body is called a. pharmacotherapeutics b. pharmacology c. pharmacodynamics
More informationPrior Authorization Guideline
Prior Authorization Guideline Guideline: CSD - Suboxone Therapeutic Class: Central Nervous System Agents Therapeutic Sub-Class: Analgesics and Antipyretics (Opiate Partial Agonists) Client: County of San
More informationThis clinical study synopsis is provided in line with Boehringer Ingelheim s Policy on Transparency and Publication of Clinical Study Data.
abcd Clinical Study for Public Disclosure This clinical study synopsis is provided in line with s Policy on Transparency and Publication of Clinical Study Data. The synopsis which is part of the clinical
More informationunderstanding the professional guidelines
SEVERE ASTHMA understanding the professional guidelines This guide includes information on what the European Respiratory Society (ERS) and the American Thoracic Society (ATS) have said about severe asthma.
More informationThe Annual Direct Care of Asthma
The Annual Direct Care of Asthma The annual direct health care cost of asthma in the United States is approximately $11.5 billion; indirect costs (e.g. lost productivity) add another $4.6 billion for a
More informationMedicines Use Review Supporting Information for Asthma Patients
Medicines Use Review Supporting Information for Asthma Patients What is asthma? Asthma is a chronic inflammatory disorder of the airways. The inflammation causes an associated increase in airway hyper-responsiveness,
More informationIn non-hodgkin s lymphoma, MabThera is used to treat two types of the disease, both of which affect B-lymphocytes:
EMA/614203/2010 EMEA/H/C/000165 EPAR summary for the public rituximab This is a summary of the European public assessment report (EPAR) for. It explains how the Committee for Medicinal Products for Human
More informationPrevention of Acute COPD exacerbations
December 3, 2015 Prevention of Acute COPD exacerbations George Pyrgos MD 1 Disclosures No funding received for this presentation I have previously conducted clinical trials with Boehringer Ingelheim. Principal
More informationACTIVITY #3: LUNG HEALTH ASTHMA AND ALLERGIES
ACTIVITY #3: LUNG HEALTH ASTHMA AND ALLERGIES TIME 50 minutes, computer lab REQUIRED RESOURCES Activity Computer lab with internet access for student research Notepaper and pencil for research Poster board
More information9/16/2014. Anti-Immunoglobulin E (IgE) Omalizumab (Xolair ) Dosing Guidance
Disclosure Statement of Financial Interest New Therapies for Asthma Including Omalizumab and Anti-Cytokine Therapies Marsha Dangler, PharmD, BCACP Clinical Pharmacy Specialist James H. Quillen VA Medical
More informationUNIT VIII NARCOTIC ANALGESIA
UNIT VIII NARCOTIC ANALGESIA Objective Review the definitions of Analgesic, Narcotic and Antagonistic. List characteristics of Opioid analgesics in terms of mechanism of action, indications for use and
More informationInformation for Behavioral Health Providers in Primary Care. Asthma
What is Asthma? Information for Behavioral Health Providers in Primary Care Asthma Asthma (AZ-ma) is a chronic (long-term) lung disease that inflames and narrows the airways. Asthma causes recurring periods
More informationCOPD. Information brochure for chronic obstructive pulmonary disease.
COPD Information brochure for chronic obstructive pulmonary disease. CONTENTS What does COPD mean?...04 What are the symptoms of COPD?...06 What causes COPD?...09 Treating COPD...10 Valve therapy in COPD...12
More informationWHEN COPD* SYMPTOMS GET WORSE
WHEN COPD* SYMPTOMS GET WORSE *Includes chronic bronchitis, emphysema, or both. Boehringer Ingelheim Pharmaceuticals, Inc. has no ownership interest in any other organization that advertises or markets
More information5. Treatment of Asthma in Children
Treatment of sthma in hildren 5. Treatment of sthma in hildren 5.1 Maintenance Treatment 5.1.1 rugs Inhaled Glucocorticoids. Persistent wheezing in children under the age of three can be controlled with
More informationSevere rheumatoid arthritis (a disease that causes inflammation of the joints),where MabThera is given intravenously together with methotrexate.
EMA/614203/2010 EMEA/H/C/000165 EPAR summary for the public rituximab This is a summary of the European public assessment report (EPAR) for. It explains how the Committee for Medicinal Products for Human
More informationUpdate and Review of Medication Assisted Treatments
Update and Review of Medication Assisted Treatments for Opiate and Alcohol Use Disorders Richard N. Whitney, MD Medical Director Addiction Services Shepherd Hill Newark, Ohio Medication Assisted Treatment
More informationSore Throat. Definition. Causes. (Pharyngitis; Tonsillopharyngitis; Throat Infection) Pronounced: Fare-en-JY-tis /TAHN-sill-oh-fare-en-JY-tis
Sore Throat (Pharyngitis; Tonsillopharyngitis; Throat Infection) Pronounced: Fare-en-JY-tis /TAHN-sill-oh-fare-en-JY-tis by Jennifer Lewy, MSW En Español (Spanish Version) Definition A sore throat is the
More informationEpidemiological Studies on Environmental Stressors from Tobacco to Pesticides
Epidemiological Studies on Environmental Stressors from Tobacco to Pesticides W. Susan Cheng, PhD, MPH Rebecca Carlstrom, MPH Sukaina Hussain, MPH Healthy Lawn Symposium Oct 31, 2014 Two Presentations
More informationWhooping Cough. The Lungs Whooping cough is an infection of the lungs and breathing tubes, both of which are parts of the respiratory system.
Whooping Cough Introduction Whooping cough is a serious bacterial infection of the lungs and breathing tubes. It is also called pertussis. About 16 million cases of whooping cough happen worldwide each
More informationPanadol Extra (paracetamol and caffeine) for pain
Panadol Extra (paracetamol and caffeine) for pain This Medicine Update is for people who are taking, or thinking about taking, Panadol Extra. Summary Panadol Extra is a pain reliever available from pharmacies.
More informationRiociguat Clinical Trial Program
Riociguat Clinical Trial Program Riociguat (BAY 63-2521) is an oral agent being investigated as a new approach to treat chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension
More informationEMPHYSEMA THERAPY. Information brochure for valve therapy in the treatment of emphysema.
EMPHYSEMA THERAPY Information brochure for valve therapy in the treatment of emphysema. PATIENTS WITH EMPHYSEMA With every breath, lungs deliver oxygen to the rest of the body to perform essential life
More informationInfluenza (Flu) Influenza is a viral infection that may affect both the upper and lower respiratory tracts. There are three types of flu virus:
Respiratory Disorders Bio 375 Pathophysiology General Manifestations of Respiratory Disease Sneezing is a reflex response to irritation in the upper respiratory tract and is associated with inflammation
More informationAcupuncture in Back Pain Management. Victoria Chan Harrison M.D. Assistant Professor of Rehabilitation Medicine Weill Cornell Medical College
Acupuncture in Back Pain Management Victoria Chan Harrison M.D. Assistant Professor of Rehabilitation Medicine Weill Cornell Medical College Objective Review the roots of acupuncture theory and basic Traditional
More informationMedications for chronic pain
Medications for chronic pain When it comes to treating chronic pain with medications, there are many to choose from. Different types of pain medications are used for different pain conditions. You may
More informationUnderstanding Cough, Wheezing and Noisy Breathing in Children. Introduction
Understanding Cough, Wheezing and Noisy Breathing in Children Introduction Symptoms such as cough, wheezing or noisy breathing can be caused by a number of conditions. When these occur, it is natural for
More information"Respiratory Problems in Swimmers: How to keep Swimmers Afloat" and in the Pool!
"Respiratory Problems in Swimmers: How to keep Swimmers Afloat" and in the Pool! Charles Siegel, MD Associate Clinical Professor University of Missouri @ Kansas City School of Medicine USA Swimming does
More informationThe Right Medicines Can Help You Get Control of Asthma. BlueCare SM TennCareSelect
The Right Medicines Can Help You Get Control of Asthma BlueCare SM TennCareSelect WHEEZING. COUGHING. SHORTNESS OF BREATH. CHEST TIGHTNESS. If you or a family member has asthma, you know these symptoms
More informationChoosing a placebo EAPC Research Forum Trondheim 2008
Choosing a placebo EAPC Research Forum Trondheim 2008 Claudia Bausewein Department of Palliative Care, Policy & Rehabilitation King s College London History Religious context Psalm 116: Placebo Domine
More informationUltram (tramadol), Ultram ER (tramadol extended-release tablets); Conzip (tramadol extended-release capsules), Ultracet (tramadol / acetaminophen)
Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.02.35 Subject: Tramadol Acetaminophen Page: 1 of 8 Last Review Date: September 18, 2015 Tramadol Acetaminophen
More informationREAD THIS FOR SAFE AND EFFECTIVE USE OF YOUR MEDICINE PATIENT MEDICATION INFORMATION. [new-ka la]
READ THIS FOR SAFE AND EFFECTIVE USE OF YOUR MEDICINE PATIENT MEDICATION INFORMATION Pr NUCALA [new-ka la] mepolizumab lyophilized powder for subcutaneous injection Read this carefully before you start
More informationMEDICATION GUIDE. SYMBICORT 80/4.5 (budesonide 80 mcg and formoterol fumarate dihydrate 4.5 mcg) Inhalation Aerosol
MEDICATION GUIDE SYMBICORT 80/4.5 (budesonide 80 mcg and formoterol fumarate dihydrate 4.5 mcg) Inhalation Aerosol SYMBICORT 160/4.5 (budesonide 160 mcg and formoterol fumarate dihydrate 4.5 mcg) Inhalation
More informationmedicineupdate to find out more about this medicine
medicineupdate Asking the right questions about new medicines Seretide for chronic obstructive pulmonary disease What this medicine is 1 What this medicine treats 2 Other medicines available for this condition
More informationAsthma (With a little SCID to start) Disclosures Outline Starting with the Immune System The Innate Immune System The Adaptive Immune System
1 2 3 4 5 6 7 8 9 Asthma (With a little SCID to start) Lauren Smith, MD CHKD Pediatric Allergy/Immunology Disclosures None Will be discussing some medications that are not yet FDA approved Outline SCID
More informationAsthma Care. Of course, your coach is there to answer any questions you have about your asthma, such as:
Asthma Care All Health Coaches in the Asthma Care Management program are registered or certified respiratory therapists. Your coach will listen to your story of living with asthma. This will help your
More informationSinusitis. Health Promotion and Education Program. Rev. 2014 MP-HEP-PPT-766-01-050514-E
Sinusitis Health Promotion and Education Program Rev. 2014 2014, MMM Healthcare, Inc. - PMC Medicare Choice, Inc. Reproduction of this material is prohibited. MP-HEP-PPT-766-01-050514-E M&P-PRD-TEM-030-032511-S
More informationUNIVERSIDAD DE GUAYAQUIL DEPARTMENT OF CHEMICAL SCIENCES
CODE: 38/05 TITLE: Establishment of the potential anti-inflammatory effect of the product known as CUMANDA, originating from NutraMedix Laboratories, LLC, Florida OBJECTIVES: To study the possible anti-inflammatory
More informationAn Overview of Asthma - Diagnosis and Treatment
An Overview of Asthma - Diagnosis and Treatment Asthma is a common chronic disorder of the airways that is complex and characterized by variable and recurring symptoms, airflow obstruction, bronchial hyperresponsiveness,
More informationDisclosures. Consultant and Speaker for Biogen Idec, TEVA Neuroscience, EMD Serrono, Mallinckrodt, Novartis, Genzyme, Accorda Therapeutics
Mitzi Joi Williams, MD Neurologist MS Center of Atlanta, Atlanta, GA Disclosures Consultant and Speaker for Biogen Idec, TEVA Neuroscience, EMD Serrono, Mallinckrodt, Novartis, Genzyme, Accorda Therapeutics
More informationCOPD PROTOCOL CELLO. Leiden
COPD PROTOCOL CELLO Leiden May 2011 1 Introduction This protocol includes an explanation of the clinical picture, diagnosis, objectives and medication of COPD. The Cello way of working can be viewed on
More informationMontelukast 10mg film-coated tablets PL 17907/0474
Montelukast 10mg film-coated tablets PL 17907/0474 UKPAR TABLE OF CONTENTS Lay Summary Page 2 Scientific Discussion Page 4 Steps Taken for Assessment Page 11 Steps Taken After Initial Authorisation Page
More informationMANAGEMENT OF CHRONIC NON MALIGNANT PAIN
MANAGEMENT OF CHRONIC NON MALIGNANT PAIN Introduction The Manitoba Prescribing Practices Program (MPPP) recognizes the important role served by physicians in relieving pain and suffering and acknowledges
More informationPHENYLEPHRINE HYDROCHLORIDE INJECTION USP
PRESCRIBING INFORMATION PHENYLEPHRINE HYDROCHLORIDE INJECTION USP 10 mg/ml Sandoz Canada Inc. Date of Preparation: September 1992 145 Jules-Léger Date of Revision : January 13, 2011 Boucherville, QC, Canada
More informationAcute Pain Management in the Opioid Dependent Patient. Maripat Welz-Bosna MSN, CRNP-BC
Acute Pain Management in the Opioid Dependent Patient Maripat Welz-Bosna MSN, CRNP-BC Relieving Pain in America (IOM) More then 116 Million Americans have pain the persists for weeks to years $560-635
More informationadrenoceptor agonists and the Olympic Games in Turin
Beta 2 adrenoceptor agonists and the Olympic Games in Turin 1. INTRODUCTION Article 4 of the World Anti-Doping Code refers to the Prohibited List as the international standard. This List, which came into
More informationUnderstanding and Controlling Asthma Attacks. Information for parents
Understanding and Controlling Asthma Attacks Information for parents Your child was recently seen by a doctor for asthma. This guide will help you gain a better understanding about your child's recent
More informationPulsating Aerosol. The New Wave in SINUSitis Therapy. Cystic Fibrosis. Focus on. For the precise, effective and gentle treatment of sinusitis
The New Wave in SINUSitis Therapy Focus on Cystic Fibrosis Pulsating Aerosol For the precise, effective and gentle treatment of sinusitis PARI SINUS Inhalation treatment for acute and chronic diseases
More informationUNIVERSIDAD DE GUAYAQUIL DEPARTMENT OF CHEMICAL SCIENCES
CODE: 38/05 TITLE: Establishment of the potential anti-inflammatory effect of the product known as SAMENTO, originating from NutraMedix Laboratories, LLC, Florida OBJECTIVES: To study the possible anti-inflammatory
More informationA HISTORICAL PERSPECTIVE ON HUMAN ABUSE LIABILITY STUDIES. Donald R Jasinski, MD
A HISTORICAL PERSPECTIVE ON HUMAN ABUSE LIABILITY STUDIES Donald R Jasinski, MD Origin of methods Modify morphine molecule Develop a selective analgesic lacking abuse potential Reduce public health and
More informationPrior Authorization Guideline
Prior Authorization Guideline Guideline: PDP IBT Inj - Vivitrol Therapeutic Class: Central Nervous System Agents Therapeutic Sub-Class: Opiate Antagonist Client: 2007 PDP IBT Inj Approval Date: 2/20/2007
More informationBetter Breathing with COPD
Better Breathing with COPD People with Chronic Obstructive Pulmonary Disease (COPD) often benefit from learning different breathing techniques. Pursed Lip Breathing Pursed Lip Breathing (PLB) can be very
More informationThis module reviews the following: Opioid addiction and the brain Descriptions and definitions of opioid agonists,
BUPRENORPHINE TREATMENT: A Training For Multidisciplinary Addiction Professionals Module II Opioids 101 Goals for Module II This module reviews the following: Opioid addiction and the brain Descriptions
More informationRSPT 2317 Non-steroidal anti-asthma agents
RSPT 2317 Non-steroidal Anti-asthma Agents Mechanisms of Inflammation in Asthma Mechanisms of Inflammation in Asthma Asthma is a chronic inflammatory disorder of the airways It is divided into extrinsic
More informationOutcome of Drug Counseling of Outpatients in Chronic Obstructive Pulmonary Disease Clinic at Thawangpha Hospital
Mahidol University Journal of Pharmaceutical Sciences 008; 35(14): 81. Original Article Outcome of Drug Counseling of Outpatients in Chronic Obstructive Pulmonary Disease Clinic at Thawangpha Hospital
More informationHAWAII BOARD OF MEDICAL EXAMINERS PAIN MANAGEMENT GUIDELINES
Pursuant to section 453-1.5, Hawaii Revised Statutes, the Board of Medical Examiners ("Board") has established guidelines for physicians with respect to the care and treatment of patients with severe acute
More informationSARCOIDOSIS. Signs and symptoms associated with specific organ involvement can include the following:
SARCOIDOSIS Sarcoidosis is a disease that occurs when areas of inflammation develop in different organs of the body. Very small clusters of inflammation, called granulomas, are seen with sarcoidosis. They
More informationCOPD and Asthma Differential Diagnosis
COPD and Asthma Differential Diagnosis Chronic Obstructive Pulmonary Disease (COPD) is the third leading cause of death in America. Learning Objectives Use tools to effectively diagnose chronic obstructive
More informationMILITARY (ACTIVE DUTY)-SPECIFIC ISSUES
RECOMMENDATIONS MILITARY (ACTIVE DUTY)-SPECIFIC ISSUES Evaluation for possible asthma 1. Active duty service members should be diagnosed with asthma or exerciseinduced bronchospasm on the basis of the
More information- Canine Chronic Bronchitis cannot be cured, but can be controlled
MD-096A-0211 1 2 - The symptoms of asthma can mimic other diseases such as heartworm, pneumonia and congestive heart failure (Padrid, Use of Inhaled Medications to Treat Respiratory Diseases in Dogs and
More information10 questions to consider. before you smoke your next joint.
10 questions to consider before you smoke your next joint. 1 2 You ve probably heard conflicting opinions about marijuana and its risks. The statistics and health information included here are not opinions.
More informationEphedrine Sulphate. Peter Thackray," MB, BS, D Obst, RCOG, Medical Director, Vick International Division of Richardson-Merrell Ltd.
J Int Med Res (1978) 6,161 A Double-Blind, Crossover Controlled Evaluation of a Syrup for the Night-Time Relief ofthe Symptoms of the Common Cold, Containing Paracetamol, Dextromethorphan Hydrobromide,
More informationRELAPSE MANAGEMENT. Pauline Shaw MS Nurse Specialist 25 th June 2010
RELAPSE MANAGEMENT Pauline Shaw MS Nurse Specialist 25 th June 2010 AIMS OF SESSION Relapsing/Remitting MS Definition of relapse/relapse rate Relapse Management NICE Guidelines Regional Clinical Guidelines
More informationSponsor Novartis Pharmaceuticals
Clinical Trial Results Database Page 1 Sponsor Novartis Pharmaceuticals Generic Drug Name Indacaterol Therapeutic Area of Trial Chronic Obstructive Pulmonary Disease (COPD) Indication studied: COPD Study
More informationMedical Nutrition Therapy for Upper Gastrointestinal Tract Disorders. By: Jalal Hejazi PhD, MSc.
Medical Nutrition Therapy for Upper Gastrointestinal Tract Disorders By: Jalal Hejazi PhD, MSc. Digestive Disorders Common problem; more than 50 million outpatient visits per year Dietary habits and nutrition
More informationRevised Protocol: Criteria for Designating Substances as. Occupational Asthmagens on the AOEC List of. Exposure Codes
Revised Protocol: Criteria for Designating Substances as Occupational Asthmagens on the AOEC List of Exposure Codes Revised October 2008 1 I. Introduction This is a project to evaluate the current AOEC
More informationNursing. Management of Spinal Trauma. Content. Objectives. Objectives
7 cervical vertebrae Content 12 thoracic vertebrae Nursing 5 sacral vertebrae Management of Spinal Trauma Kwai Fung Betty Siu Ward Manager O&T Dept TKOH Date : 22nd April 2007 5 lumbar vertebrae 4 coccygeal
More informationBarbara St. Marie, PhD Candidate Nurse Practitioner Supervisor Pain and Palliative Care Fairview Ridges Hospital Minneapolis, MN
Barbara St. Marie, PhD Candidate Nurse Practitioner Supervisor Pain and Palliative Care Fairview Ridges Hospital Minneapolis, MN Pain Physiology Objectives: Explain how pain is transmitted through the
More informationDependence and Addiction. Marek C. Chawarski, Ph.D. Yale University David Metzger, Ph.D. University of Pennsylvania
Dependence and Addiction Marek C. Chawarski, Ph.D. Yale University David Metzger, Ph.D. University of Pennsylvania Overview Heroin and other opiates The disease of heroin addiction or dependence Effective
More informationWheezing in Children. Prof RJ Green Department of Paediatrics
Wheezing in Children Prof RJ Green Department of Paediatrics Adventitious Airway Sounds Snoring Stridor Wheezing Crepitations Airway Diameter Cause of Wheezing Not from obstruction of small airways Surface
More informationDEVELOPING MANUFACTURING SUPPLYING. Naltrexone Implants. Manufactured by NalPharm Ltd WWW.NALPHARM.COM
DEVELOPING MANUFACTURING SUPPLYING Naltrexone Implants Background to Nalpharm NalPharm is a specialist pharmaceutical company supplying proprietary branded medications and generic drugs in the area of
More informationFood allergy /anaphylaxis
Food allergy /anaphylaxis A food allergy or hypersensitivity is an abnormal response to a food that is triggered by the immune system. Allergic reactions are often mild, but can be sometimes very dangerous.
More informationAsthma and COPD Awareness
Asthma and COPD Awareness Molina Breathe with Ease sm and Chronic Obstructive Pulmonary Disease Molina Healthcare of Michigan Fall 2012 Importance of Controller Medicines Asthma is a disease that causes
More informationSmell and Taste Disorders
Smell and Taste Disorders Delivering the best in care UHB is a no smoking Trust To see all of our current patient information leaflets please visit www.uhb.nhs.uk/patient-information-leaflets.htm What
More informationagainst allergic symptoms thought to be histaminic during a period of 1% minutes. No side effects When a dose of 30 mgm. of benadryl in 50 ml.
THE EFFECT OF ANTIHISTAMINE SUBSTANCES AND OTHER DRUGS ON HISTAMINE BRONCHOCONSTRICTION IN ASTHMATIC SUBJECTS' By JOHN J. CURRY (From the Evans Memorial and Massachusetts Memorial Hospitals, and the Department
More informationMedication and Devices for Chronic Obstructive Pulmonary Disease (COPD)
Medication and Devices for Chronic Obstructive Pulmonary Disease (COPD) Patients with COPD take a wide variety of medicines to manage their symptoms these include: Inhaled Short Acting Bronchodilators
More informationMedical Policy An independent licensee of the Blue Cross Blue Shield Association
Afrezza Page 1 of 6 Medical Policy An independent licensee of the Blue Cross Blue Shield Association Title: Afrezza (human insulin) Prime Therapeutics will review Prior Authorization requests Prior Authorization
More information400,000 people in the United States die every year due to smoking-related illnesses.
How To Stop Smoking Ugly Facts about Smoking: 52 million Americans smoke cigarettes. 400,000 people in the United States die every year due to smoking-related illnesses. Every cigarette you smoke shortens
More informationOriginal article: Sumito Inoue*, Yoko Shibata, Noriaki Takabatake, Akira Igarashi, Shuichi Abe, Isao Kubota
Original article: INFLUENCE OF CORTICOSTEROID THERAPY ON THE SERUM ANTIBODY RESPONSE TO INFLUENZA VACCINE IN ELDERLY PATIENTS WITH CHRONIC PULMONARY DISEASES Sumito Inoue*, Yoko Shibata, Noriaki Takabatake,
More informationMarilyn Borkgren-Okonek, APN, CCNS, RN, MS Suburban Lung Associates, S.C. Elk Grove Village, IL
Marilyn Borkgren-Okonek, APN, CCNS, RN, MS Suburban Lung Associates, S.C. Elk Grove Village, IL www.goldcopd.com GLOBAL INITIATIVE FOR CHRONIC OBSTRUCTIVE LUNG DISEASE GLOBAL STRATEGY FOR DIAGNOSIS, MANAGEMENT
More informationThioctacid 600 T Solution for Injection contains 600 mg alpha-lipoic acid
Package Leaflet: Information for the User Thioctacid 600 T Solution for Injection contains 600 mg alpha-lipoic acid For use in adults Active substance: Alpha-lipoic acid, Trometamol salt (1:1) Read all
More informationHeadaches. This chapter will discuss:
C H A P T E R Headaches 1 1 Almost everyone gets an occasional headache at some time or another. Some people get frequent headaches. Most people do not worry about headaches and learn to live with them
More informationWhat You Should Know About ASTHMA
What You Should Know About ASTHMA 200 Hospital Drive Galax, VA 24333 (276) 236-8181 www.tcrh.org WHAT IS ASTHMA? It s a lung condition that makes breathing difficult. The cause of asthma is not known.
More informationYour Go-to COPD Guide
Your Go-to COPD Guide Learning how to live with chronic obstructive pulmonary disease (COPD) Inside, you ll learn: COPD facts COPD symptoms and triggers How to talk with your doctor Different treatment
More information