Hematopoietic Stem Cell Transplantation: Evolving Strategies That Have Resulted in Improved Outcomes
|
|
- Nathaniel Thomas
- 8 years ago
- Views:
Transcription
1 Hematopoietic Stem Cell Transplantation: Evolving Strategies That Have Resulted in Improved Outcomes Asad Bashey, MD, PhD Blood and Marrow Transplantation Program at Northside Hospital Atlanta, Georgia
2 Transplant Activity in the U.S Transplants Center for International Blood & Marrow Transplant Research
3 Challenges In Allogeneic HCT in 2015 Lack of donor availability Treatment-related mortality/morbidity Regimen-related toxicity Infections Graft versus host disease (GVHD) Relapse of malignancy Late effects
4
5 Only One in 4 Siblings Will Be HLA-Identical
6 No Donor 40% Matched Sibling Donor 30% Matched Unrelated Donor 30%
7 7/8 and 8/8 Allele, Available-Match Rates in the Adult Donor Registry National Marrow Donor Program 7
8 Alternative Donor Sources Cord blood (CBT) Rapidly available Low cell dose necessitates double CBT in most adult patients ($$) Delayed immune reconstitution, infection Partially matched related donor (haploidentical) Almost universally available (quickly) Less expensive Post-transplant cyclophosphamide (Cy) has revolutionized its use
9 Prior Attempts at Haploidentical Donor Transplantation T-cell replete (Seattle ) Graft failure >20% Severe acute GVHD >50% Survival <10% Ex vivo T-cell depletion (Perugia 1980-) High rates of graft rejection Abrogated by megadoses of stem cells/intense conditioning Severe post-bmt immunoparesis - high death rate from infections
10 Anasetti C, et al. Hum Immunol. 1990;29(2): Reisner Y, et al. Blood. 201;118(23):
11 Post-Transplantation Cy = Selective Allodepletion Signal 1: Peptide-MHC recognition by TCR Peptide-MHC T-cell activation CD80/CD86 TCR CD28 Signal 3: T-cell growth factors Receptor T-cell proliferation Dendritic Cell CD40 CD40L Signal 2: Co-stimulation
12 Memory/Effector T con and et reg Are Preserved, but Naïve T con Are Depleted Following Posttransplantation Cyclophosphamide Kanakry CG, et al. Science Translational Medicine. 2013;5(211):211ra157. Ross D, et al. Biol Blood Marrow Transplant. 2013;19(10):
13 Nonmyeloablative T-Replete Haploidentical Transplant Utilizing Post-Transplant Cyclophosphamide Johns Hopkins University (JHU) Regimen O Donnell PV, et al. Biol Blood Marrow Transplant. 2002;8(7): Luznik L, et al. Biol Blood Marrow Transplant. 2008;14(6):
14 Results of Nonmyeloablative Haplo-BMT at JHU McCurdy SR, et al. Blood March 26 [epub ahead of print].
15 Results of Nonmyeloablative Haplo-BMT at JHU McCurdy SR, et al. Blood March 26 [epub ahead of print].
16 Tony D. 44 years old Oct /2003 Ph-positive ALL Hyper-CVAD A + imatinib -Refractory, 30% Blasts Hyper-CVAD B+ imatinib -CR-1 Completed HCVAD + imatinib (1A through 4B) No matched related donor No 8 of 8 or 7 of 8 matched unrelated donors (MUD) No adequate cord blood unit (CBU) option Maintenance imatinib started May 2004 Jun 2006 hematologic relapse of Ph-positive ALL ME+ imatinib 800 mg/day Aug 2006 <5% blasts, flow negative, cytogenetics normal, PCR + Sept 2006 nonmyeloablative haploidentical BMT Day 30 chimerism 100 donor CD3 and CD33 No GVHD 2014 continued molecular CR, KPS 100, no active GVHD, off all immunosuppression
17 Myeloablative Transplants With T-Replete Haploidentical Donors and Post Transplant Cy Two consecutive single-institution phase II trials Use of myeloablative conditioning+ G-CSF mobilized PBSC graft NSH 864 (Busulfan based) 1/3/09 through 3/2/11 (n = 20) (Solomon SR, et al. Biol Blood Marrow Transplant. 2012;18(12): ) NSH 922 (Total body irradiation [TBI]-based) 5/13/11 through 2/11/14 (n = 35) (Solomon SR, et al. Biol Blood Marrow Transplant Mar 19 [epub ahead of print].) NSH, Northside Hospital
18 NSH 864 i.v. Busulfan 110mg/m 2 /day Cy 14.5mg/ kg/day T cell replete PBSC Fludarabine 25 mg/m 2 /d Cy 50mg/ kg/d MMF Tacrolimus NSH 922 TBI 150cGy T cell replete bid/day PBSC (total 1200cGy) Fludarabine 30 mg/m 2 /d Cy 50mg/ kg/d MMF Tacrolimus
19 Results of TBI-Based Myeloablative Haplo Transplants at NSH Solomon SR, et al. Biol Blood Marrow Transplant Mar 19 [epub ahead of print].
20 Incidence and Severity of BK Virus Cystitis After Myeloablative Haploidentical Transplantation TBI-Based vs Busulfan-Based Conditioning Solomon SR, et al. Biol Blood Marrow Transplant Mar 19 [epub ahead of print].
21 Comparison of Myeloablative Haplo vs MUD DFS GVHD Solomon SR, et al. Biol Blood Marrow Transplant Mar 19 [epub ahead of print].
22 Allele Level Matching of HLA-A, B, C, and DRB1 Is Important Pidala J, et al. Blood. 2014;124(16)
23 Improvement in Outcomes Related to Better Matching of MUD Transplants
24 DPB1 Mismatching Affects Outcomes of MUD Transplants Pidala J, et al. Blood. 2014;124(16)
25
26 Prevention of Visceral Acute GVHD By CCR5 Inhibition With Maraviroc 38 patients RIC- Flu/Bu PBSC graft MRD or MUD Maraviroc given d -2 to +30 Reshef R, et al. N Engl J Med. 2012;367(2):
27 Immunomodulatory Effects of Proteasome Inhibition With Bortezomib During Allogeneic HCT Selective depletion of proliferating alloreactive T-cells (NF-kB inhibition) Inhibition of Th1 cytokine production/differentiation Blocks activation of APC Preserves T reg function Sensitized tumor cells to killing by immune effector cells Direct antitumor activity against some malignancies
28 Phase I/II Study of Bortezomib + Tacrolimus and MTX for GVHD Prophylaxis of HLA-Mismatched Transplants Koreth J, et al. J Clin Oncol. 2012;30(26):
29 BMT CTN 1203: Study Outline 18-75y Malignant Diseases Matched donor RIC Tac/Cy/MMF Tac/MTX/ Maraviroc Tac/MTX/ Bortezomib Tac/MTX Control (CIBMTR)
30 Rationale For Use of Ixazomib Post Haplo-HCT Ixazomib (MLN9708) Orally-bioavailable, selective, second-generation proteasome inhibitor Shorter proteasome dissociation T1/2 than bortezomib Improved PK, PD, and anti-tumor activity over bortezomib Improved safety profile lower risk of peripheral neuropathy than bortezomib Once weekly fixed dosing
31 Multicenter Phase II, Double-Blind Placebo Controlled Trial of Maintenance Ixazomib After Allogeneic Hematopoietic Stem Cell Transplantation for High-Risk Multiple Myeloma BMTCTN 1302
32 NSH 1074 Ixazomib Maintenance Following Non-Myeloablative Haploidentical Transplantation Ixazomib weekly 3 weeks x 12 m
33 NSH 1074 A Phase II Trial of Nonmyeloablative Haploidentical Peripheral Blood Stem Cell Transplantation Followed By Maintenance Therapy With the Novel Oral Proteasome Inhibitor, Ixazomib (MLN9708) in Patients With High-Risk Hematologic Malignancies Cy 14.5mg/ kg/day TBI 200cGy T cell replete PBSC (KIR selected) Busulfan Cy 110mg/mFludarabine 2 /day 14.5mg/ 30 mg/mkg/day 2 T Cy cell replete PBSC 50mg/ infusion kg/d Tacrolimus Ixazomib Ixazomib 4mg d 1,8, 15 q monthly x 12
34 High Risk of Relapse and Poor Survival Following Chemotherapy for FLT3 ITD Positive AML Bornhäuser M, et al. Blood. 2007;109(5):
35 Risk of Relapse Is Higher Following Allogeneic HCT for FLT3 ITD Positive Than Negative AML FLT3 ITD+ FLT3 ITD- Brunet S, et al. J Clin Oncol. 2012;30(7):
36 Clinical Trial of Sorafenib Maintenance Following Allogeneic Transplantation in FLT3 ITD Positive AML Dose escalation trial of sorafenib x 12 m starting d post allotransplant 22 patients enrolled 400mg bid established as MTD No increase in GVHD 1 year PFS 85% (all patients) 95% (patients in CR) Chen YB, et al. Biol Blood Marrow Transplant. 2014;20(12):
37 Trial of Midostaurin Versus Placebo Post Allogeneic HCT in FLT3 ITD+ AML
38 Immunological Synapse/Checkpoint
39 Single-Dose Anti-CTLA4 Mab (Ipilimumab) For Relapse of Malignancy After Allogeneic HCT Bashey A, et al. Blood. 2009;113(7): before 6 weeks post
40 Phase I/Ib Clinical Trial of Anti-CTLA4 MAb Ipilimumab in Patients Who Relapse Post Allogeneic HCT Multicenter single-arm trial 3mg/kg or 10mg/kg q 3 weeks x 4 Maintenance dosing q 12 weeks up to 1 year 27 patients treated to date MTD not reached 10mg/kg used for phase 1b Immune adverse events in 4 patients - reversible 8 of 20 patients (40%) treated at 10 mg/kg demonstrated antitumor activity. Six had >PR. 1 chl PR, 1 MM PR 4 AML CR
41
42 Conclusions Allogeneic HCT is the most effective curative therapy for several hematologic malignancies In 2015 Use of Alternative Donors esp. Haploidentical Donors allows almost universal donor availability irrespective of ethnicity Allogeneic HCT is becoming safer TRM now <10% at 1 year ~15% at 2 years Relapse of malignancy remains a challenge Use of novel targeted and immune based therapies post transplant is promising
43 The Blood and Marrow Transplant Program at Northside Hospital
Pr Eliane Gluckman, MD, FRCP, Disclosure of Interest: Nothing to Disclose
Pr Eliane Gluckman, MD, FRCP, Hospital Saint Louis, University Paris- Diderot, France Should Haplo-identical transplantation be preferred to cord blood in patients without a matched donor? Disclosure of
More informationHematopoietic Stem Cell Transplantation. Imad A. Tabbara, M.D. Professor of Medicine
Hematopoietic Stem Cell Transplantation Imad A. Tabbara, M.D. Professor of Medicine Hematopoietic Stem Cells Harvested from blood, bone marrow, umbilical cord blood Positive selection of CD34 (+) cells
More informationHematopoietic Stem Cell Transplantation: Current Status and Future Directions RICHARD W. CHILDS M.D. NIH, BETHESDA MD
Hematopoietic Stem Cell Transplantation: Current Status and Future Directions RICHARD W. CHILDS M.D. NIH, BETHESDA MD Stem cell transplantation Autologous Autologous stem cell collection Freeze Stem Cells
More informationPros and Cons of Stem Cell Sources and their availability in Africa. Dr Jaimendra Singh Inkosi Albert Luthuli Central Hospital Durban, South Africa
Pros and Cons of Stem Cell Sources and their availability in Africa Dr Jaimendra Singh Inkosi Albert Luthuli Central Hospital Durban, South Africa Introduction The ability to perform a haematopoietic stem
More informationCord Blood Transplant. E. Gluckman Eurocord ESH-EBMT training course Vienna 2014
Cord Blood Transplant E. Gluckman Eurocord ESH-EBMT training course Vienna 2014 Background Since 1988, umbilical cord blood (CB) has been successfully used to treat children and adults needing stem cell
More informationBone Marrow, Peripheral Blood Stem Cells or Umbilical Cord Blood transplantation? Federica Giannotti, MD Eurocord-Hôpital Saint Louis, Paris
Bone Marrow, Peripheral Blood Stem Cells or Umbilical Cord Blood transplantation? Federica Giannotti, MD Eurocord-Hôpital Saint Louis, Paris Background Hematopoietic stem cell transplantation (HSCT) is
More informationIn contrast to the very high transplant-related
Cord Blood: an Alternative Stem Cell Source or a New Standard? Juliet N. BARKER Memorial Sloan-Kettering Cancer Center, NY, ABD In contrast to the very high transplant-related mortality (TRM) associated
More informationChallenges of Hematopoietic Stem Cell Transplantation. Robert J. Soiffer, MD Dana Farber Cancer Institute
Challenges of Hematopoietic Stem Cell Transplantation Robert J. Soiffer, MD Dana Farber Cancer Institute Hematopoietic Stem Cell Transplantation Objectives Deliver sufficient chemo-radio therapy to destroy
More informationHow to select a donor and product for allogeneic HCT
How to select a donor and product for allogeneic HCT Dr Bronwen Shaw 10 February 2015 Overview Who (and where) are the donors What factors determine how we choose between them Acquisition Clinical Donor
More informationSelection of the Optimal Umbilical Cord Blood Unit
Karen Ballen, MD Selection of the Optimal Umbilical Cord Blood Unit Massachusetts General Hospital September, 2013 OUTLINE Cell Dose HLA Match Allele Level HLA C KIR Directional Mismatch NIMA HLA Antibodies
More informationThe donor search: the best donor or cord blood unit
The donor search: the best donor or cord blood unit Dr Bronwen Shaw Consultant in haematopoietic cell transplantation Royal Marsden Hospital /Anthony Nolan Overview Where do we find donors/units for transplantation
More informationBeyond Cell Dose: Selection of the Optimal Umbilical Cord Blood Unit. Karen Ballen, MD Massachusetts General Hospital June, 2012
Beyond Cell Dose: Selection of the Optimal Umbilical Cord Blood Unit Karen Ballen, MD Massachusetts General Hospital June, 2012 OUTLINE Cell Dose HLA Typing HLA C and KIR HLA Antibodies ABO and Racial/Ethnic
More informationAdvances in HSC Transplantation for Myelodysplasia: Cord Blood Transplantation & RIC
Advances in HSC Transplantation for Myelodysplasia: Cord Blood Transplantation & RIC -7-6 -5-4 -3-2 -1 0 30 100 CSA/ MMF Juliet N. Barker, MBBS (Hons), FRACP Associate Attending Director Cord Blood Transplant
More informationDisclosures. I have no disclosures.
Not Your Own Marrow Jenni Krajewski, MD Clinical Assistant Professor, Rutgers New Jersey Medical School Attending Physician, Pediatric Blood and Marrow Transplantation The Institute for Pediatric Cancer
More informationA Cure for Sickle Cell Anemia and Thalassemia
IV Simpósio Internacional de Hemoglobinopatias A Cure for Sickle Cell Anemia and Thalassemia Bertram Lubin, MD and Mark Walters, MD 4 September 2007 Topics to be covered Cord blood: Importance and biology
More informationUMBILICAL CORD BLOOD TRANSPLANTATION: KFSH EXPERIENCE
UMBILICAL CORD BLOOD TRANSPLANTATION: KFSH EXPERIENCE HIND AL HUMAIDAN, MD,FRCPA Director, Blood Bank (Donor & Transfusion Services) and Stem Cell Cord Blood Bank Consultant Hematopathologist INTRODUCTION
More informationMyeloablative versus Reduced Intensity Conditioning Regimen Cord Blood Transplants
Educational 2 Cord Blood Transplantation Myeloablative versus Reduced Intensity Conditioning Regimen Cord Blood Transplants William Arcese University of Rome Tor Vergata Rome Transplant Network 4th April
More informationBone Marrow, Peripheral Blood Stem Cells or Umbilical Cord Blood transplantation? E. Gluckman WBMT meeting Cape Town November 14-16, 2014
Bone Marrow, Peripheral Blood Stem Cells or Umbilical Cord Blood transplantation? E. Gluckman WBMT meeting Cape Town November 14-16, 2014 The ideal HSCs source Immediate availability Few HLA restrictions
More informationNot for publication or presentation
MINUTES CIBMTR WORKING COMMITTEE FOR GVHD Orlando, Florida Thursday, February 25, 2010, 2:45 pm 4:45 pm Statisticians: Scientific Directors: Steven Pavletic MD, National Cancer Institute Telephone: 301-402-4899;
More informationStem Cell Transplantation In Patients with Fanconi Anemia
Stem Cell Transplantation In Patients with Fanconi Anemia FARF Annual Family Meeting 6/28/15 Casco, ME Parinda A. Mehta, M.D. Cincinnati Children s Hospital Medical Center Improvements in Unrelated Donor
More informationCorporate Medical Policy
Corporate Medical Policy Hematopoietic Stem-Cell Transplantation for CLL and SLL File Name: Origination: Last CAP Review: Next CAP Review: Last Review: hematopoietic_stem-cell_transplantation_for_cll_and_sll
More informationUnrelated donor umbilical cord blood transplantation for the treatment of hematologic malignancies Craig Sauter and Juliet N.
Unrelated donor umbilical cord blood transplantation for the treatment of hematologic malignancies Craig Sauter and Juliet N. Barker Adult Allogeneic Bone Marrow Transplantation Service, Memorial Sloan-Kettering
More informationUmbilical Cord Blood Transplantation
Umbilical Cord Blood Transplantation V Rocha MD, PhD Hopital Saint Louis, Paris University 7 CIBMTR Milwaukee Umbilical Cord blood transplantation Background History Clinical results in children and adults
More informationHow To Treat Multiple Myeloma With A Stem Cell Transplant
A Trial of Tandem Autologous Stem Cell Transplants +/- Post Second Autologous Transplant Maintenance Therapy Versus Single Autologous Stem Cell Transplant Followed by Matched Sibling Nonmyeloablative Allogeneic
More informationGraft Failure After HSCT
Graft Failure After HSCT Vanderson Rocha, MD, PhD Professor of Haematology- Oxford University Bone Marrow Transplant Unit- Sirio Libanes Hospital- Sao Paulo Scientific Director of Eurocord-Paris Clinical
More informationStem Cell Transplantation in Severe Aplastic Anemia
Stem Cell Transplantation in Severe Aplastic Anemia Dr. D. Goodyear MD, FRCPC Division of Hematology and Hematological Malignancies, University of Calgary 1 of 11 Introduction Most cases of aplastic anemia
More informationFetal Maternal Immunity and Antileukemia Activity in Cord Blood Transplant. Recipients
Fetal Maternal Immunity and Antileukemia Activity in Cord Blood Transplant Recipients Filippo Milano, 1 J. Lee Nelson, 1, 2 Colleen Delaney 1,3 1 Clinical Research Division, Fred Hutchinson Cancer Research
More informationAllogeneic stem cell transplant in HIV-1-infected individuals
Allogeneic stem cell transplant in HIV-1-infected individuals Javier Martinez-Picado UNIVERSITAT DE VIC Barriers to cure HIV infection Residual Replication Immune activation Inflammation Latent Infection
More informationTelephone: 414 805 0700; Fax: 414 805 0714; E mail: meapen@mcw.edu
Not for publication or presentation A G E N D A CIBMTR WORKING COMMITTEE FOR GRAFT SOURCES & MANIPULATION Grapevine, TX Thursday, February 27, 2014, 2:45 4:45 pm Co Chair: Co Chair: Co Chair: Statisticians:
More informationCord Blood Transplant Past and Future. E. Gluckman Eurocord ISCT Paris 24/04/2014
Cord Blood Transplant Past and Future E. Gluckman Eurocord ISCT Paris 24/04/2014 Background Since 1988, umbilical cord blood (CB) has been successfully used to treat children and adults needing stem cell
More informationStem Cell Transplantation for Acute Lymphoblastic Leukemia
Stem Cell Transplantation for Acute Lymphoblastic Leukemia Mona Shafey MD, FRCPC Bone Marrow Transplant Fellow Alberta Blood and Marrow Transplant Program 1 of 14 Stem Cell Transplantation for Acute Lymphoblastic
More informationImmunoablative therapy with autologous hematopoietic stem cell transplantation in the treatment of poor risk multiple sclerosis
Immunoablative therapy with autologous hematopoietic stem cell transplantation in the treatment of poor risk multiple sclerosis T Kozák, P Lhotáková Department of Clinical Haematology, 3r d School of Medicine,
More informationCord Blood: that other stem cell source. Donna Wall, MD Director, Manitoba Blood and Marrow Transplant Program
Cord Blood: that other stem cell source Donna Wall, MD Director, Manitoba Blood and Marrow Transplant Program CBMTG April 2012 The problem: In order to perform a BMT from one person to another one needs
More informationNarrator: Transplants using stem cells from the blood, bone marrow or umbilical cord blood
[Track 2: What Is a Transplant?] Narrator: Transplants using stem cells from the blood, bone marrow or umbilical cord blood can be an effective treatment for people with blood cancers such as leukemia,
More informationNews. The Blood and Marrow Transplant Program at Northside Hospital. New Clinical Trial Assesses Use of CTLA-4 Blockade with Ipilimumab IN THIS ISSUE:
IN THIS ISSUE: Winter 2014 www.bmtga.com www.northside.com The Blood and Marrow Transplant Program at Northside Hospital News New Clinical Trial Assesses Use of Ipilimumab Page 1 NSH-BMT, Leukemia & Lymphoma
More informationHaematopoietic stem cell transplantation in Hong Kong
S C I E N T I F I C P A P E R Haematopoietic stem cell transplantation in Hong Kong Albert KW Lie WY Au Raymond Liang 李 國 維 區 永 仁 梁 憲 孫 The first case of haematopoietic stem cell transplant (HSCT) was
More informationSelecting an appropriately matched donor for hematopoietic
Transplant Outcomes in Acute Leukemia (I) Mary Eapen a and John E. Wagner b Umbilical cord blood (UCB) has gradually emerged over the last decade as an alternative source of hematopoietic cells for transplantation
More information10 th Annual International Cord Blood Transplantation Symposium June 7-9, 2012 Preliminary Scientific Program. Thursday, June 7
10 th Annual International Cord Blood Transplantation Symposium June 7-9, 2012 Preliminary Scientific Program Thursday, June 7 7:00 8:00 AM Breakfast in Exhibit Hall Session IA 8:00 10:00 AM Advances in
More informationNavelstrengbloed tegen kanker
Navelstrengbloed tegen kanker THERAPIEDAG 2008: "Zorgtrajecten in kanker" Zaterdag 27 september 2008 Gasthuisberg, Leuven. Hélène Schoemans, MD KUL, Stem Cell Institute Leuven Cord blood Collection and
More informationInfosheet. Allogeneic stem cell transplantation in myeloma. What is the principle behind stem cell transplantation?
Infosheet Allogeneic stem cell transplantation in myeloma High-dose therapy and autologous stem cell transplantation is currently the first-line treatment standard of care for younger/fitter myeloma patients.
More informationHematology, National Research Cancer Center - Istituto Tumori Giovanni Paolo II, Bari, Italy;
DCTH - 3 2014-125-131 CASE REPORT An alternative strategy for cord blood stem cells transplant to reduce time of neutrophils engraftment: case report of co-infusion of haploidentical and cord blood stem
More informationPro Cure in Multiple Myeloma. Nicolaus Kröger Dept. of Stem Cell Transplantation University Hospital Hamburg Hamburg, Germany
Pro Cure in Multiple Myeloma Nicolaus Kröger Dept. of Stem Cell Transplantation University Hospital Hamburg Hamburg, Germany Pro Cure in Multiple Myeloma Several hematological malignancies can be cured
More informationStammzelltransplantation. Neues vom immunologischen Ctrl-Alt-Del
Allogene Neues vom immunologischen Ctrl-Alt-Del Prof. Dr. med. Wolfgang Bethge Allogene am ASH Insgesamt 715 Abstracts zum Thema Auswahl: Azacitidine als Überbrückung zu allogenen SZT bei MDS Ergebnis
More informationCHAPTER 1 BACKGROUND AND CORD BLOOD BANK (CBB) ORGANIZATION
CHAPTER 1 BACKGROUND AND CORD BLOOD BANK (CBB) ORGANIZATION Chapter 1 BACKGROUND AND CORD BLOOD BANK (CBB) ORGANIZATION 1.1 OVERVIEW OF THE CORD BLOOD TRANSPLANTATION STUDY Bone marrow transplantation
More informationPrior Authorization Guideline
Prior Authorization Guideline Guideline: PS Inj - Velcade Therapeutic Class: Antineoplastic Agents Therapeutic Sub-Class: Antineoplastic Client: PS Inj Approval Date: 10/2/2004 Revision Date: 5/22/2007
More informationCAR T cell therapy for lymphomas
CAR T cell therapy for lymphomas Sattva S. Neelapu, MD Associate Professor and Deputy Chair ad interim Department of Lymphoma and Myeloma UT MD Anderson Cancer Center, Houston, TX CAR T cell therapy What
More informationHAPLO-CORD HEMATOPOIETIC STEM CELL TRANSPLANTATION
HAPLO-CORD HEMATOPOIETIC STEM CELL TRANSPLANTATION Frequency, Risk Factors and Outcomes of Cord Graft Failure (CGF) After Haplo-Cord Transplantation Stephanie B. Tsai, MD Fellow in Hematology-Oncology
More informationProject Lead: Stephen Forman, M.D. PI: Elizabeth Budde, M.D., Ph.D
Phase I study using T cells expressing a CD123-specific chimeric antigen receptor and truncated EGFR for patients with relapsed or refractory acute myeloid leukemia Project Lead: Stephen Forman, M.D. PI:
More informationCytoreductive Therapy for Autologous Cell Therapy in HIV
Cytoreductive Therapy for Autologous Cell Therapy in HIV Ronald Mitsuyasu, MD Professor of Medicine UCLA Center for Clinical AIDS Research and Education (CARE Center) HSC Transfer from CCR5-delta 32 Donor
More information* CHAPTER 6. Choice of the donor according to HLA typing and stem cell source. Eliane Gluckman
* CHAPTER 6 Choice of the donor according to HLA typing and stem cell source Eliane Gluckman CHAPTER 6 Choice of the donor according to HLA typing and stem cell source 1. Introduction Allogeneic haematopoietic
More informationUmbilical Cord Blood: An Alternative Allogeneic Stem Cell Source for Transplantation
Umbilical Cord Blood: An Alternative Allogeneic Stem Cell Source for Transplantation Mary J. Laughlin, MD Associate Professor of Medicine and Pathology Dr. Donald and Ruth Weber Goodman Professor of Innovative
More informationNEW CLINICAL RESEARCH OPTIONS IN PANCREATIC CANCER IMMUNOTHERAPY. Alan Melcher Professor of Clinical Oncology and Biotherapy Leeds
NEW CLINICAL RESEARCH OPTIONS IN PANCREATIC CANCER IMMUNOTHERAPY Alan Melcher Professor of Clinical Oncology and Biotherapy Leeds CANCER IMMUNOTHERAPY - Breakthrough of the Year in Science magazine 2013.
More informationReference: NHS England B04/P/a
Clinical Commissioning Policy: Haematopoietic Stem Cell Transplantation (HSCT) (All Ages): Revised Reference: NHS England B04/P/a 1 NHS England Clinical Commissioning Policy: Haematopoietic Stem Cell Transplantation
More informationCorporate Medical Policy
Corporate Medical Policy File Name: Origination: Last CAP Review: Next CAP Review: Last Review: hematopoietic_stem-cell_transplantation_for_epithelial_ovarian_cancer 2/2001 11/2015 11/2016 11/2015 Description
More informationNatural Killer cells and Hematopoietic Stem Cell Transplantation Jeffrey S. Miller, M.D.
Natural Killer cells and Hematopoietic Stem Cell Transplantation Jeffrey S. Miller, M.D. University of Minnesota Cancer Center Associate Director of Experimental Therapeutics Division of Heme/Onc/Transplant
More informationSibling Donor Cord Blood Transplantation for Thalassemia Major: Experience of the Sibling Donor Cord Blood Program
Sibling Donor Cord Blood Transplantation for Thalassemia Major: Experience of the Sibling Donor Cord Blood Program MARK C. WALTERS, LYNN QUIROLO, ELIZABETH T. TRACHTENBERG, SANDIE EDWARDS, LISA HALE, JOANNA
More informationCancer Immunotherapy: Can Your Immune System Cure Cancer? Steve Emerson, MD, PhD Herbert Irving Comprehensive Cancer Center
Cancer Immunotherapy: Can Your Immune System Cure Cancer? Steve Emerson, MD, PhD Herbert Irving Comprehensive Cancer Center Bodnar s Law Simple Things are Important Very Simple Things are Very Important
More informationREVIEW ARTICLE. Introduction
REVIEW ARTICLE Reduced intensity conditioning allogeneic hematopoietic cell transplantation for adult acute myeloid leukemia in complete remission - a review from the Acute Leukemia Working Party of the
More informationClinical Outcomes of Unrelated Donor Umbilical Cord Blood Transplantation for 30 Adults with Hematological Malignancies
Clinical Outcomes of Unrelated Donor Umbilical Cord Blood Transplantation for 30 Adults with Hematological Malignancies KOICHIRO KOBAYASHI 1, YOSHINOBU MAEDA 1, YOSHITAKA HARA 1, MIYUKI NISHIE-KATAOKA
More informationStem Cell Transplantation in Adults
Recommendation Report Stem Cell Transplantation in Adults K. Imrie, R.B. Rumble, M. Crump, the Advisory Panel on Bone Marrow and Stem Cell Transplantation, and the Hematology Disease Site Group of Cancer
More informationBone Marrow/Stem Cell Transplant
Blue Distinction Centers for Transplants Program Selection Criteria for 2010 Mid-Point Designations To qualify as a Blue Distinction Center for Transplants (), each facility must satisfy s quality based
More informationThe immune system. Bone marrow. Thymus. Spleen. Bone marrow. NK cell. B-cell. T-cell. Basophil Neutrophil. Eosinophil. Myeloid progenitor
The immune system Basophil Neutrophil Bone marrow Eosinophil Myeloid progenitor Dendritic cell Pluripotent Stem cell Lymphoid progenitor Platelets Bone marrow Thymus NK cell T-cell B-cell Spleen Cancer
More informationOne-Unit versus Two-Unit Cord-Blood Transplantation for Hematologic Cancers
The new england journal of medicine Original Article One-Unit versus Two-Unit Cord-Blood Transplantation for Hematologic Cancers John E. Wagner, Jr., M.D., Mary Eapen, M.B., B.S., Shelly Carter, D.Sc.,
More informationCurative Treatment for Severe Sickle Cell Disease: Allogeneic Transplantation
Curative Treatment for Severe Sickle Cell Disease: Allogeneic Transplantation Benjamin Oshrine, MD, and Julie-An Talano, MD Dr Oshrine is in the Division of Pediatric Hematology/Oncology and Blood & Marrow
More informationUmbilical Cord Blood Transplantation for the Treatment of Hematologic Malignancies
Umbilical cord blood transplantation is a useful treatment in several types of hematologic malignancies. Gene Elling. St. Lucia. Photograph. Umbilical Cord Blood Transplantation for the Treatment of Hematologic
More informationTherapeutic Treatment Options: Chronic Blood Transfusions Bone Marrow Transplantation. Marianne E. McPherson Yee, MD, MSc
Therapeutic Treatment Options: Chronic Blood Transfusions Bone Marrow Transplantation Marianne E. McPherson Yee, MD, MSc Sickle Cell Treatment Options Supportive Care Newborn Screen PCN Immunizations Education
More informationTHE INFLUENCE OF TISSUE (IN)COMPATIBILITY IN UMBILICAL CORD BLOOD TRANSPLANTATION
THE INFLUENCE OF TISSUE (IN)COMPATIBILITY IN UMBILICAL CORD BLOOD TRANSPLANTATION Matjaž Jeras Blood Transfusion Centre of Slovenia Tissue Typing Center Šlajmerjeva 6, 1000 Ljubljana, Slovenia matjaz.jeras@ztm.si
More informationCancer: A Comparison of Cord Blood and Bone-marrow transplantation
UMBILICAL-CORD BLOOD TRANSPLANTATION FOR THE TREATMENT OF CANCER Juliet N. Barker* and John E. Wagner Haematopoietic stem-cell transplantation is used to treat many haematological cancers, but is limited
More informationOUR JOURNEY THROUGH THE YEARS
The King Faisal Specialist Hospital and Research Centre Experience in Hematology, Oncology and Bone Marrow Transplantation OUR JOURNEY THROUGH THE YEARS REGGIE BELKHEDIM A Brief Overview: King Faisal Specialist
More informationFuture strategies for myeloma: An overview of novel treatments In development
Future strategies for myeloma: An overview of novel treatments In development Dr. Matthew Streetly Guys and St. Thomas NHS Trust How far have we come? Melphalan and prednisolone VAD Autologous SCT Thalidomide
More informationLEUKEMIA LYMPHOMA MYELOMA Advances in Clinical Trials
LEUKEMIA LYMPHOMA MYELOMA Advances in Clinical Trials OUR FOCUS ABOUT emerging treatments Presentation for: Judith E. Karp, MD Advancements for Acute Myelogenous Leukemia Supported by an unrestricted educational
More informationPreparation of cord blood for infusion: bedside thaw, dilute and wash, or somewhere in between
Preparation of cord blood for infusion: bedside thaw, dilute and wash, or somewhere in between Donna Wall, MD Director, Manitoba Blood and Marrow Transplant Program ISCT 2012 Disclosures: none The problem:
More informationEBMT Sunday 30th March 2014
EBMT Sunday 30th March 2014 Satellite Symposium: ATIR as immunotherapy following haploidentical HSCT: No need for prophylactic immunosuppressants due to low risk of GvHD Chair: Dr. Armand Keating (Toronto,
More informationEUROCORD. in 49 countries and 484 transplant centres* 264 EBMT 4847 (73%) cases 220 Non-EBMT 1797 (27%) cases
! 21%! EUROCORD 6756 cord blood transplantations performed from 1988 to March 2010 in 49 countries and 484 transplant centres* 264 EBMT 4847 (73%) cases 220 Non-EBMT 1797 (27%) cases * missing center
More informationHematopoietic Stem-Cell Transplantation for Waldenstrom Macroglobulinemia
Hematopoietic Stem-Cell Transplantation for Waldenstrom Macroglobulinemia Policy Number: Original Effective Date: MM.07.026 04/01/2008 Line(s) of Business: Current Effective Date: HMO; PPO 04/26/2013 Section:
More informationHematopoietic Stem Cell Transplantation
Hematopoietic Stem Cell Transplantation Koh Liang Piu Adult Stem Cell Transplant Program Department of Hematology Oncology National University Hospital 27 Feb 2009 Year 2007 52 SCT in 45 patients Type
More informationRole of allogeneic stem cell transplantation in relapsed or refractory Hodgkin s disease
Symposium article Annals of Oncology 13 (Supplement 1): 128 132, 2002 DOI: 10.1093/annonc/mdf626 Role of allogeneic stem cell transplantation in relapsed or refractory Hodgkin s disease A. Sureda 1 & N.
More informationSTEM CELL TRANSPLANTATION IN MULTIPLE MYELOMA
STEM CELL TRANSPLANTATION IN MULTIPLE MYELOMA Sundar Jagannath MD Professor of Medicine St. Vincent s Comprehensive Cancer Center New York, NY Where is transplant today in the management of Myeloma? Autologous
More informationAre CAR T-Cells the Solution for Chemotherapy Refractory Diffuse Large B-Cell Lymphoma? Umar Farooq, MD University of Iowa Hospitals and Clinics
Are CAR T-Cells the Solution for Chemotherapy Refractory Diffuse Large B-Cell Lymphoma? Umar Farooq, MD University of Iowa Hospitals and Clinics Disclosure(s) I do not intend to discuss an off-label use
More informationMantle Cell Lymphoma Understanding Your Treatment Options
New Developments in Mantle Cell Lymphoma John P. Leonard, M.D. Richard T. Silver Distinguished Professor of Hematology and Medical Oncology Associate Dean for Clinical Research Vice Chairman, Department
More informationINFORMATION ON STEM CELLS/BONE MARROW AND REINFUSION/TRANSPLANTATION SUR703.002
INFORMATION ON STEM CELLS/BONE MARROW AND REINFUSION/TRANSPLANTATION SUR703.002 COVERAGE: SPECIAL COMMENT ON POLICY REVIEW: Due to the complexity of the Peripheral and Bone Marrow Stem Cell Transplantation
More informationBone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation: Questions and Answers. Key Points
CANCER FACTS N a t i o n a l C a n c e r I n s t i t u t e N a t i o n a l I n s t i t u t e s o f H e a l t h D e p a r t m e n t o f H e a l t h a n d H u m a n S e r v i c e s Bone Marrow Transplantation
More informationSESUG 2011 INTRODUCTION. Paper GH-12
Paper GH-12 Development of a SAS Macro for Automated Data Cleaning of Major Outcomes of Interest in Hematopoietic Cell Transplantation Peigang Li, Min Chen and Zhiwei Wang, CIBMTR, Milwaukee, WI ABSTRACT
More informationCure versus control: Which is the best strategy?
Cure versus control: Which is the best strategy? Barcelona 8-9-2012 Mario Boccadoro DIVISIONE UNIVERSITARIA DI EMATOLOGIA AZIENDA OSPEDALIERA SAN GIOVANNI TORINO, ITALY MULTIPLE MYELOMA Cure versus control
More informationThe Value of Cord Blood Stem Cells. Mona Shafey, MD, FRCPC Medical Grand Rounds October 25 th, 2011
The Value of Cord Blood Stem Cells Mona Shafey, MD, FRCPC Medical Grand Rounds October 25 th, 2011 Objectives To discuss umbilical cord blood as a stem cell source and the role of umbilical cord blood
More informationProgress in Haploidentical Stem Cell Transplantation
REVIEW Progress in Haploidentical Stem Cell Transplantation Ulas D. Bayraktar, Richard E. Champlin, Stefan O. Ciurea Haploidentical stem cell transplantation is an attractive form of transplantation because
More informationOutcome of Unrelated HSCT in Patients Lacking HLA Matched Related Donors: Iranian Stem Cell Donor Program (ISCDP)
Outcome of Unrelated HSCT in Patients Lacking HLA Matched Related Donors: Iranian Stem Cell Donor Program (ISCDP) October 18, 2014 19th Congress of APBMT, Hangzhou, China AMIR ALI HAMIDIEH, MD Iranian
More informationThe future of unrelated Stem Cell Transplant in the UK: DOH Working Party Findings. Prof. Tony Pagliuca
The future of unrelated Stem Cell Transplant in the UK: DOH Working Party Findings Prof. Tony Pagliuca UK STEM CELL STRATEGIC FORUM The future of unrelated donor SCT in the UK Antonio Pagliuca, Transplant
More informationCord Blood: Research Progress and Future Promise
Cord Blood: Research Progress and Future Promise By Al Staropoli, AABB Contributing Writer Sue Fister found out she had leukemia when she was 50 years old. Doctors suggested a bone marrow transplant as
More informationHistocompatibility Matching for Hematopoietic Stem Cell Transplant: Can we Close the Gaps? Michael Aubrey, CHS http://www.clinimmune.
Histocompatibility Matching for Hematopoietic Stem Cell Transplant: Can we Close the Gaps? Michael Aubrey, CHS http://www.clinimmune.com HLA Matching Is Like ABO Matching (but Much More Difficult) ABO
More informationCord Blood for Cellular Therapy: A Snapshot of this Evolving Market Landscape
GENReports: Market & Tech Analysis Cord Blood for Cellular Therapy: A Snapshot of this Evolving Market Landscape > Enal Razvi, Ph.D. Biotechnology Analyst, Managing Director SELECTBIO US enal@selectbio.us
More informationPlacental and Umbilical Cord Blood as a Source of Stem Cells
Placental and Umbilical Cord Blood as a Source of Stem Cells Policy Number: 7.01.50 Last Review: 12/2014 Origination: 12/2001 Next Review: 12/2015 Policy Blue Cross and Blue Shield of Kansas City (Blue
More informationBMT CTN PROTOCOL 0202 VERSION 4.0. Study Co-Chairpersons Ginna Laport, M.D. 1 Robert Negrin, M.D. 1. Protocol Team
Autologous vs. Non-Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) for Patients with Chemosensitive Follicular Non-Hodgkin s Lymphoma Beyond First Complete Response or First Partial
More informationTransplantation of cord blood stem cells from related or unrelated donors is considered investigational in all other situations.
MEDICAL POLICY POLICY RELATED POLICIES POLICY GUIDELINES DESCRIPTION SCOPE BENEFIT APPLICATION RATIONALE REFERENCES CODING APPENDIX HISTORY Placental and Umbilical Cord Blood as a Source of Stem Cells
More informationHematopoietic Stem Cells, Stem Cell Processing, and Transplantation
Hematopoietic Stem Cells, Stem Cell Processing, and Joseph (Yossi) Schwartz, MD Director, Hemotherapy and Stem Cell Processing Facility E-mail: js2745@columbia.edu A 40-year old man with acute myelogenous
More informationPerspectives on HCT Program Challenges in a Changing Reimbursement Environment The good, the bad, and the ugly
Perspectives on HCT Program Challenges in a Changing Reimbursement Environment The good, the bad, and the ugly Richard T Maziarz, MD Oregon Health & Science Univ February 27, 2014 THE GOOD Provider Principles
More informationBlood-Forming Stem Cell Transplants
Blood-Forming Stem Cell Transplants What are bone marrow and hematopoietic stem cells? Bone marrow is the soft, sponge-like material found inside bones. It contains immature cells known as hematopoietic
More informationLEUCEMIA MIELOIDE ACUTA. A.M. Carella U.O.C. Ematologia IRCCS AOU San Martino IST, Genova
LEUCEMIA MIELOIDE ACUTA A.M. Carella U.O.C. Ematologia IRCCS AOU San Martino IST, Genova Impact of mutational analysis in AML C. Thiede Optimal acute myeloid leukemia therapy in 2012 H. Dombret Acquired
More informationMEDICAL COVERAGE POLICY
Important note Even though this policy may indicate that a particular service or supply is considered covered, this conclusion is not necessarily based upon the terms of your particular benefit plan. Each
More informationCancer Treatments Subcommittee of PTAC Meeting held 18 September 2015. (minutes for web publishing)
Cancer Treatments Subcommittee of PTAC Meeting held 18 September 2015 (minutes for web publishing) Cancer Treatments Subcommittee minutes are published in accordance with the Terms of Reference for the
More information