Hematopoietic Stem Cell Transplantation: Current Status and Future Directions RICHARD W. CHILDS M.D. NIH, BETHESDA MD

Save this PDF as:
 WORD  PNG  TXT  JPG

Size: px
Start display at page:

Download "Hematopoietic Stem Cell Transplantation: Current Status and Future Directions RICHARD W. CHILDS M.D. NIH, BETHESDA MD"

Transcription

1 Hematopoietic Stem Cell Transplantation: Current Status and Future Directions RICHARD W. CHILDS M.D. NIH, BETHESDA MD

2 Stem cell transplantation Autologous Autologous stem cell collection Freeze Stem Cells Thaw + transplant Patient Conditioning regimen First-Line Therapy:Multiple Myeloma Prolongs PFS and survival (Attal et al-nejm-1996) Second-Line Therapy:Relapsed Hodgkin s and NHL Prolongs survival in NHL (Parma Trial-1995) Prolongs DFS in HDz (but not survival)

3 Stem cell transplantation Autologous Autologous stem cell collection Freeze Stem Cells Thaw + transplant Patient Allogeneic Tissue or HLA matched Stem cell donor Allogeneic stem cell collection Conditioning regimen transplant Patient Conditioning regimen

4 How Does Myeloablative Allogeneic BMT Cure? Allograft (PBSC + Lymphs) Remission T-Cells Leukemia cells GVL Pre-transplant intensive therapy Transplant Day 0 1) Conditioning Regimen 2) Graft-vs-Tumor

5 Hematological Malignancies Vary in Their Susceptibility To Graft-Vs-Leukemia (GVL) Effects Malignancy CML chronic phase CLL Low-grade NHL AML/ALL MDS Multiple myeloma Int/high grade NHL Hodgkin s disease Refractory ALL/AML CML blast crisis Susceptibility to GVL (response to DLI) High High High Intermediate Intermediate Intermediate/low Intermediate Intermediate Low Low

6 Most Common Indications for an Allogeneic HCT US 2010 AML ALL MDS NHL Multiple Myeloma 5,500 5,000 4,500 4,000 3,500 3,000 2,500 2,000 1,500 1, Allogeneic (Total N=8,860) Autogeneic (Total N=9,026) 0 Multiple Myeloma NHL AML ALL MDS/MPD HD CML Aplastic Anemia Other Leuk Non- Malig Disease Other Cancer

7 Allogeneic Hematopoietic Stem Cell Transplantation: Can Cure Patients With Chemotherapy Refractory Hematological Malignancies

8 Graft-vs-TumorEffects After Reduced Intensity Allogeneic Hematopoietic Cell Transplantation Can Cure 42 year female: Chemotherapy Refractory Mycosis Fungoides

9 T-cell Mediated Graft-Vs-Leukemia Effects Can Cure Chemotherapy Resistant Malignancies May month After transplant Nov months post transplant CSA Discontinued May yrs post transplant NHLBI Hematology Branch Transplant Protocol 02-H-0250

10 Allogeneic HCT for AML in CR1 Decreases Relapse Risk and Improves Survival for Select Patients Methods Cont: 2 cohorts of AML pts (n=185) in CR1 compared based on whether they went to conventional consolidation vs allogeneic HCT - All pts < 60 with AML in CR1 - Pts matched for AML subtype, cytogenetic risk, Age Allo Conv Allo Conv Results: - Survival at 7 years superior for allo-group compared to conventional consolidation (58% vs 46% (p=0.037). - Relapse lower for allo-group Conv Allo Allo Conv Stelljes et al JCO 2014:32(4)

11 Allogeneic Transplant For AML in CR1 Decreases Relapse Risk and Improves Survival for Select Patients Results: - Outcomes superior for older pts with allogeneic HCT Survival Relapse >45 conv. > 45 allo > 45 allo >45 conv

12 Complications of an Allogeneic Stem Cell Transplant 1. Toxicities related to the conditioning regimen - Mucosal inflammation (Mucositis) - Liver toxicity (Veno-occlusive disease) - Lung inflammation (pneumonitis) 2. Graft Rejection - occurs rarely with conventional transplants 3. Infection - bacterial/fungal: during neutropenic phase of transplant - Viral: first 100 days of the transplant 4. Graft vs host disease- decreases relapse risk - acute: from engraftment until day Chronic: from day 100 until 2 years post transplant Morbidity and mortality 5. Drug toxicities - many drugs given to prevent infection/gvhd have toxicities

13 Graft-vs-Host Disease (Donor immune Cells attacking patient tissues) Acute GVHD 1. GI Tract: Diarrhea 2. Liver: Jaundice 3. Skin: Rash

14 Improvement in GVHD of the Skin with Time

15 Mortality is Decreasing with Allogeneic Stem Cell Transplants 60% reduction in TRM 40% reduction in overall mortality N=1418 N=1148 Bacterial, viral and fungal infections reduced Reduction in severe Grade III-IV GVHD Dramatic reduction in day 200 transplant-related mortality (TRM) and overall TRM Gooley et al; NEJM 2010: 363;22

16 Major Improvements in Transplant Outcomes Over the Past 2 Decades Historical Problem Conditioning regimens too toxic Older patients ineligible due to prohibitive risk of mortality Solution Development of safer conditioning regimens (IV busulfan)/use of lung shielding Development of reduced intensity conditioning regimens Death from invasive fungal process and CMV frequent Lack of donors precludes the use of the procedure Advent of voriconazole, PCR to detect early CMV reactivation with use of empiric gancyclovir. Letermovir for Cytomegalovirus Prophylaxis Growth of unrelated registry, increasing use MUDS, cord transplants and haploidentical donors

17 Types of Allogeneic Transplants Conventional High Dose or Myeloablative Transplant Conditioning fully eradicates the hosts bone marrow Reduced Intensity Conditioning (RIC) Low dose or non-myeloablative transplant Immunologically eradicates host bone marrow

18 Percentage of Reduced Intensity Conditioning Allo-HCTs, Registered with CIBMTR, Reduced Intensity Conditioning, % by Year of Transplant & Disease - AML ALL CLL HD MDS Follicular LYM Mantle Cell LYM Deffuse Large B-cell LYM CLL Follicular NHL Mantle Cell NHL HD DLCL MDS AML ALL

19 Data Suggest Outcome Similar For Myelo-ablative Conditioning vs RIC For Myeloid Malignancies Dec Dec AML pts in Germany randomized 1:1 to undergo RIC vs MAC Conditioning: MAC: TBI 1200 cgy mg/kg Cytoxan RIC: Low dose TBI+ Fludarabine 150 mg/m2 NRM (all) Relapse Outcomes: 94 underwent RIC and 90 MAC NRM, PFS, and overall survival not different between cohorts when adjusted For age/cytogenetics/donor type Survival Bornhauser M et al. Lancet Oncology 2012: 13:1035-

20 Transplants Being Performed in Increasing Numbers of Older Patients Due to Safety of RIC Transplant Type and Recipient Age < 50 years >= 50 years <60 years >=60 years Transplants, % Allogeneic Transplants Autologous Transplants

21 Improving transplant outcome One-Year Survival, percent HLA-matched sibling URD Better supportive care Gentler conditioning 0 Improved mgmt of GVHD Pasquini MC, Wang Z. CIBMTR

22 Long-term Survival after HCT CIBMTR study of 10,632 allogeneic HCT recipients surviving 2 years in remission (median follow-up 9 years) Overall survival Non-relapse mortality J Wingard et al, J Clin Oncol Jun 1;29(16):2230-9

23 Number of Survivors are Increasing Estimated ~110,000 HCT survivors in the US in 2009 >~5X increase by 2030 if transplant rates stay stable Transplants Majhail et al.biol Blood Marrow Transplant Oct;19(10):

24 Special Article HLA Match Likelihoods for Hematopoietic Stem- Cell Grafts in the U.S. Registry Loren Gragert, B.S., B.A., Mary Eapen, M.B., B.S., Eric Williams, Ph.D., John Freeman, B.S., Stephen Spellman, M.B.S., Robert Baitty, M.P.P., Robert Hartzman, M.D., J. Douglas Rizzo, M.D., Mary Horowitz, M.D., Dennis Confer, M.D., and Martin Maiers, B.A. N Engl J Med Volume 371(4): July 24, 2014

25 Likelihood of Finding an 8/8 HLA Match by Year End, Based on Current Donor Availability and with Recruitment Trends Extended to Gragert L et al. N Engl J Med 2014;371:

26 Availability of a Stem Cell Donor Limits Applicability of Allogeneic Stem Cell Transplantation Chances of Finding a Stem Cell Donor HLA Matched Sibling HLA Matched Unrelated Donor No HLA Matched Donor 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100% Potential Candidates For a Cord Blood Transplant or A Haploidentical Transplant

27 Umbilical Cord Blood Transplantation (UCBT) Umbilical Cord Blood (UCB) transplants are a transplant option for patients lacking an HLA identical donor: - Cord blood is a rich source of Hematopoietic progenitor cells- more than human BM Placenta Umbilical Cord Cord Blood Unit Volume 25 mls

28 Advantages of Cord Blood Lower Graft vs. Host Disease (GvHD) HLA-mismatched Transplants Possible Off the shelf product quickly available Cord Grafts available to Patients with Rare HLA Types And Ethnic Minorities

29 Neutrophil Recovery Cord Cord Eapen 2010 Lancet Oncology

30 LFS Cord Eapen 2010 Lancet Oncology

31 Increasing World-Wide Use of URD and UCB Transplants Unrelated Cord Blood Transplants URD- Unrelated Donor UCB- Unrelated Cord Blood Pasquini MC, Wang Z. Current use and outcome of hematopoietic stem cell transplantation: CIBMTR Summary Slides, 2010

32 Adult Cord Match Rates in the Cord Blood Registry, Cell Dose 2.5/Kg NATIONAL MARROW DONOR PROGRAM Entrusted to operate the C.W. Bill Young Cell Transplantation Program, including the Be The Match Registry SM 32

33 Match Likelihoods According to Racial and Ethnic Group and Age. Conclusions Most patients likely to benefit from HSCT will have a donor. Public investment in donor recruitment and cord-blood banks has expanded access to HSCT. Gragert L et al. N Engl J Med 2014;371:

34 Haploidentical BM Transplants Transplants that utilize stem cells collected from a relative who only matches for half of the HLA tissue antigens Advantages; Virtually every patient will have a haplo-identical relative to serve as a stem cell donor Disadvantages: - Higher incidence of graft versus host disease - Obligates use of T-cell depleted transplants - T-cell depletion increases the risk of - graft rejection - infection - disease relapse.

35 Post Transplant Cyclophosphamide Following T-cell Replete Haploidentical Transplantation of BM or PBSC Fuchs E. et al JHU

36 271 patients hematological malignancies Transplanted single center Haploidentical donors 117 MRDs 101 MUDS Grade II-IV GVHD NRM Relapse Bashley et al; JCO 2013-

37 Haploidentical transplantation using T-cell replete grafts and post transplant cyclophosphamide Overall Survival Disease free Survival Conclusion: Haploidentical transplantation using T-cell replete grafts and post transplant cyclophosphamide achieves outcomes comparable to transplants using MRDs and MUDS Bashley et al; JCO 2013-

38 RAIOLA-BBMT 2014

39

40 Transplants Safer- Relapse now is the primary cause of treatment failure after allogeneic HCT 10-60% of patients experience relapse post-hct. (NCI Relapse workshop) Causes of Death after HCT (matched sibling) Primary Disease (47%) New Malignancy (1%) GVHD (14%) Majority of relapse occurs by 1 year post- HCT. (Bajwa R, BMT 2012) Other (21%) Infection (12%) Organ Failure (4%) CIBMTR Summary Slides, 2011

41 Outcomes after Post-transplant Relapse are Poor 2-year overall survival (OS) in adults with posttransplant relapse: 2-yr OS: 16% (ALL) 16% in acute lymphoblastic leukemia 2-yr OS: 14% (AML) (ALL) 14% in acute myelogenous leukemia (AML) Spyridonidis A, et al. Leukemia 2012 Schmid C, et al. Blood 2012

42 Donor Lymphocyte Infusions Have Limited Efficacy For Relapsed Acute Leukemia Overall survival in patients with relapsed hematologic malignancies, post DLI CML ALL AML Collins, JCO 1999

43 Second Transplant Has Curative Potential but Risky Median time to relapse: 10 months Median time to relapse: 5 months High-rates of transplant related mortality Curative potential is biased towards those with late relapse Overall Survival 5-30% post-second HCT Bajwa R, et al. BMT 2012

44 Novel Strategies for Treatment of Post-Transplant Relapse Preemptive therapy upon detection of post transplant MRD Donor lymphocyte infusion Abrupt withdrawal of CSA or tacro Immunomodulatory agents Interferon alpha PD-1 blockade Novel cytotoxic therapies Immunotoxins Targeted Immune based Therapies Vaccination Strategies Donor Leukemia specific T-cells- CAR T-cells (CD19 CAR for relapsed ALL)

45 Eligibility For Allogeneic Transplantation: A Moving Target Several Factors Have Increased Patient Eligibility for Transplants i.e. Age and lack of a donor source no longer prohibitive for most Reduced intensity transplants for the aged Availability of alternative donor transplants for the majority who lack an HLA identical sibs - MUDS, Haplo-transplants, Cord blood transplants Recent Factors have also reduced the application of allogeneic transplantation Break through drugs for diseases where allogeneic transplantation had previously been to established to offer superior results to conventional therapies TKIs for CML BTK/PI3K inhibitors for CML (17p del) Eculizimab for PNH

46

Hematopoietic Stem Cell Transplantation. Imad A. Tabbara, M.D. Professor of Medicine

Hematopoietic Stem Cell Transplantation. Imad A. Tabbara, M.D. Professor of Medicine Hematopoietic Stem Cell Transplantation Imad A. Tabbara, M.D. Professor of Medicine Hematopoietic Stem Cells Harvested from blood, bone marrow, umbilical cord blood Positive selection of CD34 (+) cells

More information

Pr Eliane Gluckman, MD, FRCP, Disclosure of Interest: Nothing to Disclose

Pr Eliane Gluckman, MD, FRCP, Disclosure of Interest: Nothing to Disclose Pr Eliane Gluckman, MD, FRCP, Hospital Saint Louis, University Paris- Diderot, France Should Haplo-identical transplantation be preferred to cord blood in patients without a matched donor? Disclosure of

More information

Corporate Medical Policy

Corporate Medical Policy Corporate Medical Policy Hematopoietic Stem-Cell Transplantation for CLL and SLL File Name: Origination: Last CAP Review: Next CAP Review: Last Review: hematopoietic_stem-cell_transplantation_for_cll_and_sll

More information

Myeloablative versus Reduced Intensity Conditioning Regimen Cord Blood Transplants

Myeloablative versus Reduced Intensity Conditioning Regimen Cord Blood Transplants Educational 2 Cord Blood Transplantation Myeloablative versus Reduced Intensity Conditioning Regimen Cord Blood Transplants William Arcese University of Rome Tor Vergata Rome Transplant Network 4th April

More information

Challenges of Hematopoietic Stem Cell Transplantation. Robert J. Soiffer, MD Dana Farber Cancer Institute

Challenges of Hematopoietic Stem Cell Transplantation. Robert J. Soiffer, MD Dana Farber Cancer Institute Challenges of Hematopoietic Stem Cell Transplantation Robert J. Soiffer, MD Dana Farber Cancer Institute Hematopoietic Stem Cell Transplantation Objectives Deliver sufficient chemo-radio therapy to destroy

More information

Bone Marrow, Peripheral Blood Stem Cells or Umbilical Cord Blood transplantation? Federica Giannotti, MD Eurocord-Hôpital Saint Louis, Paris

Bone Marrow, Peripheral Blood Stem Cells or Umbilical Cord Blood transplantation? Federica Giannotti, MD Eurocord-Hôpital Saint Louis, Paris Bone Marrow, Peripheral Blood Stem Cells or Umbilical Cord Blood transplantation? Federica Giannotti, MD Eurocord-Hôpital Saint Louis, Paris Background Hematopoietic stem cell transplantation (HSCT) is

More information

Selection of the Optimal Umbilical Cord Blood Unit

Selection of the Optimal Umbilical Cord Blood Unit Karen Ballen, MD Selection of the Optimal Umbilical Cord Blood Unit Massachusetts General Hospital September, 2013 OUTLINE Cell Dose HLA Match Allele Level HLA C KIR Directional Mismatch NIMA HLA Antibodies

More information

Disclosures. I have no disclosures.

Disclosures. I have no disclosures. Not Your Own Marrow Jenni Krajewski, MD Clinical Assistant Professor, Rutgers New Jersey Medical School Attending Physician, Pediatric Blood and Marrow Transplantation The Institute for Pediatric Cancer

More information

Pros and Cons of Stem Cell Sources and their availability in Africa. Dr Jaimendra Singh Inkosi Albert Luthuli Central Hospital Durban, South Africa

Pros and Cons of Stem Cell Sources and their availability in Africa. Dr Jaimendra Singh Inkosi Albert Luthuli Central Hospital Durban, South Africa Pros and Cons of Stem Cell Sources and their availability in Africa Dr Jaimendra Singh Inkosi Albert Luthuli Central Hospital Durban, South Africa Introduction The ability to perform a haematopoietic stem

More information

Cord Blood Transplant. E. Gluckman Eurocord ESH-EBMT training course Vienna 2014

Cord Blood Transplant. E. Gluckman Eurocord ESH-EBMT training course Vienna 2014 Cord Blood Transplant E. Gluckman Eurocord ESH-EBMT training course Vienna 2014 Background Since 1988, umbilical cord blood (CB) has been successfully used to treat children and adults needing stem cell

More information

The donor search: the best donor or cord blood unit

The donor search: the best donor or cord blood unit The donor search: the best donor or cord blood unit Dr Bronwen Shaw Consultant in haematopoietic cell transplantation Royal Marsden Hospital /Anthony Nolan Overview Where do we find donors/units for transplantation

More information

Bone Marrow, Peripheral Blood Stem Cells or Umbilical Cord Blood transplantation? E. Gluckman WBMT meeting Cape Town November 14-16, 2014

Bone Marrow, Peripheral Blood Stem Cells or Umbilical Cord Blood transplantation? E. Gluckman WBMT meeting Cape Town November 14-16, 2014 Bone Marrow, Peripheral Blood Stem Cells or Umbilical Cord Blood transplantation? E. Gluckman WBMT meeting Cape Town November 14-16, 2014 The ideal HSCs source Immediate availability Few HLA restrictions

More information

UMBILICAL CORD BLOOD TRANSPLANTATION: KFSH EXPERIENCE

UMBILICAL CORD BLOOD TRANSPLANTATION: KFSH EXPERIENCE UMBILICAL CORD BLOOD TRANSPLANTATION: KFSH EXPERIENCE HIND AL HUMAIDAN, MD,FRCPA Director, Blood Bank (Donor & Transfusion Services) and Stem Cell Cord Blood Bank Consultant Hematopathologist INTRODUCTION

More information

Graft Failure After HSCT

Graft Failure After HSCT Graft Failure After HSCT Vanderson Rocha, MD, PhD Professor of Haematology- Oxford University Bone Marrow Transplant Unit- Sirio Libanes Hospital- Sao Paulo Scientific Director of Eurocord-Paris Clinical

More information

Umbilical Cord Blood Transplantation

Umbilical Cord Blood Transplantation Umbilical Cord Blood Transplantation V Rocha MD, PhD Hopital Saint Louis, Paris University 7 CIBMTR Milwaukee Umbilical Cord blood transplantation Background History Clinical results in children and adults

More information

Not for publication or presentation

Not for publication or presentation MINUTES CIBMTR WORKING COMMITTEE FOR GVHD Orlando, Florida Thursday, February 25, 2010, 2:45 pm 4:45 pm Statisticians: Scientific Directors: Steven Pavletic MD, National Cancer Institute Telephone: 301-402-4899;

More information

Outcome of Unrelated HSCT in Patients Lacking HLA Matched Related Donors: Iranian Stem Cell Donor Program (ISCDP)

Outcome of Unrelated HSCT in Patients Lacking HLA Matched Related Donors: Iranian Stem Cell Donor Program (ISCDP) Outcome of Unrelated HSCT in Patients Lacking HLA Matched Related Donors: Iranian Stem Cell Donor Program (ISCDP) October 18, 2014 19th Congress of APBMT, Hangzhou, China AMIR ALI HAMIDIEH, MD Iranian

More information

Stem Cell Transplantation In Patients with Fanconi Anemia

Stem Cell Transplantation In Patients with Fanconi Anemia Stem Cell Transplantation In Patients with Fanconi Anemia FARF Annual Family Meeting 6/28/15 Casco, ME Parinda A. Mehta, M.D. Cincinnati Children s Hospital Medical Center Improvements in Unrelated Donor

More information

Hematopoietic Stem Cell Transplantation: Evolving Strategies That Have Resulted in Improved Outcomes

Hematopoietic Stem Cell Transplantation: Evolving Strategies That Have Resulted in Improved Outcomes Hematopoietic Stem Cell Transplantation: Evolving Strategies That Have Resulted in Improved Outcomes Asad Bashey, MD, PhD Blood and Marrow Transplantation Program at Northside Hospital Atlanta, Georgia

More information

Corporate Medical Policy Hematopoietic Stem-Cell Transplantation for Breast Cancer

Corporate Medical Policy Hematopoietic Stem-Cell Transplantation for Breast Cancer Corporate Medical Policy Hematopoietic Stem-Cell Transplantation for Breast Cancer File Name: Origination: Last CAP Review: Next CAP Review: Last Review: hematopoietic_stem_cell_transplantation_for_breast_cancer

More information

Cord Blood: that other stem cell source. Donna Wall, MD Director, Manitoba Blood and Marrow Transplant Program

Cord Blood: that other stem cell source. Donna Wall, MD Director, Manitoba Blood and Marrow Transplant Program Cord Blood: that other stem cell source Donna Wall, MD Director, Manitoba Blood and Marrow Transplant Program CBMTG April 2012 The problem: In order to perform a BMT from one person to another one needs

More information

Blood-Forming Stem Cell Transplants

Blood-Forming Stem Cell Transplants Blood-Forming Stem Cell Transplants What are bone marrow and hematopoietic stem cells? Bone marrow is the soft, sponge-like material found inside bones. It contains immature cells known as hematopoietic

More information

Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation: Questions and Answers. Key Points

Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation: Questions and Answers. Key Points CANCER FACTS N a t i o n a l C a n c e r I n s t i t u t e N a t i o n a l I n s t i t u t e s o f H e a l t h D e p a r t m e n t o f H e a l t h a n d H u m a n S e r v i c e s Bone Marrow Transplantation

More information

Corporate Medical Policy Hematopoietic Stem-Cell Transplantation for Breast Cancer

Corporate Medical Policy Hematopoietic Stem-Cell Transplantation for Breast Cancer Corporate Medical Policy Hematopoietic Stem-Cell Transplantation for Breast Cancer File Name: Origination: Last CAP Review: Next CAP Review: Last Review: hematopoietic_stem_cell_transplantation_for_breast_cancer

More information

Navelstrengbloed tegen kanker

Navelstrengbloed tegen kanker Navelstrengbloed tegen kanker THERAPIEDAG 2008: "Zorgtrajecten in kanker" Zaterdag 27 september 2008 Gasthuisberg, Leuven. Hélène Schoemans, MD KUL, Stem Cell Institute Leuven Cord blood Collection and

More information

What is a Stem Cell Transplantation?

What is a Stem Cell Transplantation? What is a Stem Cell Transplantation? Guest Expert: Stuart, MD Associate Professor, Medical Oncology www.wnpr.org www.yalecancercenter.org Welcome to Yale Cancer Center Answers with Drs. Ed and Ken. I am

More information

Advances in HSC Transplantation for Myelodysplasia: Cord Blood Transplantation & RIC

Advances in HSC Transplantation for Myelodysplasia: Cord Blood Transplantation & RIC Advances in HSC Transplantation for Myelodysplasia: Cord Blood Transplantation & RIC -7-6 -5-4 -3-2 -1 0 30 100 CSA/ MMF Juliet N. Barker, MBBS (Hons), FRACP Associate Attending Director Cord Blood Transplant

More information

Cord Blood Stem Cell Transplantation

Cord Blood Stem Cell Transplantation LEUKEMIA LYMPHOMA MYELOMA FACTS Cord Blood Stem Cell Transplantation No. 2 in a series providing the latest information on blood cancers Highlights Umbilical cord blood, like bone marrow and peripheral

More information

Corporate Medical Policy

Corporate Medical Policy Corporate Medical Policy File Name: Origination: Last CAP Review: Next CAP Review: Last Review: hematopoietic_stem-cell_transplantation_for_epithelial_ovarian_cancer 2/2001 11/2015 11/2016 11/2015 Description

More information

Beyond Cell Dose: Selection of the Optimal Umbilical Cord Blood Unit. Karen Ballen, MD Massachusetts General Hospital June, 2012

Beyond Cell Dose: Selection of the Optimal Umbilical Cord Blood Unit. Karen Ballen, MD Massachusetts General Hospital June, 2012 Beyond Cell Dose: Selection of the Optimal Umbilical Cord Blood Unit Karen Ballen, MD Massachusetts General Hospital June, 2012 OUTLINE Cell Dose HLA Typing HLA C and KIR HLA Antibodies ABO and Racial/Ethnic

More information

Summary of Accomplishments As of 1/21/16

Summary of Accomplishments As of 1/21/16 Summary of Accomplishments As of 1/21/16 VALUE TO THE HCT COMMUNITY The Blood and Marrow Transplant Clinical Trials Network (BMT CTN) plays a critical role in improving patient outcomes and advancing the

More information

Most Patients who Need an Allo Transplant Can Find a Well Matched Donor

Most Patients who Need an Allo Transplant Can Find a Well Matched Donor Most Patients who Need an Allo Transplant Can Find a Well Matched Donor Important Points: Most patients can find a well matched or a very well matched available adult donor in the Be The Match Registry.

More information

Stem Cell Transplantation for Acute Lymphoblastic Leukemia

Stem Cell Transplantation for Acute Lymphoblastic Leukemia Stem Cell Transplantation for Acute Lymphoblastic Leukemia Mona Shafey MD, FRCPC Bone Marrow Transplant Fellow Alberta Blood and Marrow Transplant Program 1 of 14 Stem Cell Transplantation for Acute Lymphoblastic

More information

Selecting an appropriately matched donor for hematopoietic

Selecting an appropriately matched donor for hematopoietic Transplant Outcomes in Acute Leukemia (I) Mary Eapen a and John E. Wagner b Umbilical cord blood (UCB) has gradually emerged over the last decade as an alternative source of hematopoietic cells for transplantation

More information

Narrator: Transplants using stem cells from the blood, bone marrow or umbilical cord blood

Narrator: Transplants using stem cells from the blood, bone marrow or umbilical cord blood [Track 2: What Is a Transplant?] Narrator: Transplants using stem cells from the blood, bone marrow or umbilical cord blood can be an effective treatment for people with blood cancers such as leukemia,

More information

Cord Cor Blood Banking Scott N. Furlan, MD Ellen S. Plummer, Plummer MD

Cord Cor Blood Banking Scott N. Furlan, MD Ellen S. Plummer, Plummer MD Cord Blood Banking Scott N. Furlan, MD Ellen S.Plummer, MD Overview Background Biology of Stem Cell Transplant Opportunities i at Parkland Logistics of Banking Potential Barriers Indications for HCT Cancer

More information

Corporate Medical Policy Cord Blood as a Source of Stem Cells

Corporate Medical Policy Cord Blood as a Source of Stem Cells Corporate Medical Policy Cord Blood as a Source of Stem Cells File Name: Origination: Last CAP Review: Next CAP Review: Last Review cord_blood_as_a_source_of_stem_cells 2/2001 3/2015 3/2016 3/2015 Description

More information

CHAPTER 1 BACKGROUND AND CORD BLOOD BANK (CBB) ORGANIZATION

CHAPTER 1 BACKGROUND AND CORD BLOOD BANK (CBB) ORGANIZATION CHAPTER 1 BACKGROUND AND CORD BLOOD BANK (CBB) ORGANIZATION Chapter 1 BACKGROUND AND CORD BLOOD BANK (CBB) ORGANIZATION 1.1 OVERVIEW OF THE CORD BLOOD TRANSPLANTATION STUDY Bone marrow transplantation

More information

MEDICAL COVERAGE POLICY

MEDICAL COVERAGE POLICY Important note Even though this policy may indicate that a particular service or supply is considered covered, this conclusion is not necessarily based upon the terms of your particular benefit plan. Each

More information

Fetal Maternal Immunity and Antileukemia Activity in Cord Blood Transplant. Recipients

Fetal Maternal Immunity and Antileukemia Activity in Cord Blood Transplant. Recipients Fetal Maternal Immunity and Antileukemia Activity in Cord Blood Transplant Recipients Filippo Milano, 1 J. Lee Nelson, 1, 2 Colleen Delaney 1,3 1 Clinical Research Division, Fred Hutchinson Cancer Research

More information

Blood and Marrow Stem Cell Transplantation

Blood and Marrow Stem Cell Transplantation Blood and Marrow Stem Cell Transplantation Revised 2013 A Message from Louis J. DeGennaro, PhD President and CEO of The Leukemia & Lymphoma Society The Leukemia & Lymphoma Society (LLS) is committed to

More information

Objectives. Cord Blood. Case 1. Case 1. Case 1. Case 1. To provide a framework for answering a family s questions about cord blood storage.

Objectives. Cord Blood. Case 1. Case 1. Case 1. Case 1. To provide a framework for answering a family s questions about cord blood storage. Cord Blood Should we save the baby s cord blood? Meghan A. Higman, MD, PhD Clinical Assistant Professor of Pediatrics Division of Pediatric Hematology/Oncology Assistant Professor of Oncology Pediatrics

More information

EUROCORD. in 49 countries and 484 transplant centres* 264 EBMT 4847 (73%) cases 220 Non-EBMT 1797 (27%) cases

EUROCORD. in 49 countries and 484 transplant centres* 264 EBMT 4847 (73%) cases 220 Non-EBMT 1797 (27%) cases ! 21%! EUROCORD 6756 cord blood transplantations performed from 1988 to March 2010 in 49 countries and 484 transplant centres* 264 EBMT 4847 (73%) cases 220 Non-EBMT 1797 (27%) cases * missing center

More information

In contrast to the very high transplant-related

In contrast to the very high transplant-related Cord Blood: an Alternative Stem Cell Source or a New Standard? Juliet N. BARKER Memorial Sloan-Kettering Cancer Center, NY, ABD In contrast to the very high transplant-related mortality (TRM) associated

More information

How to select a donor and product for allogeneic HCT

How to select a donor and product for allogeneic HCT How to select a donor and product for allogeneic HCT Dr Bronwen Shaw 10 February 2015 Overview Who (and where) are the donors What factors determine how we choose between them Acquisition Clinical Donor

More information

Umbilical Cord Blood Transplantation for the Treatment of Hematologic Malignancies

Umbilical Cord Blood Transplantation for the Treatment of Hematologic Malignancies Umbilical cord blood transplantation is a useful treatment in several types of hematologic malignancies. Gene Elling. St. Lucia. Photograph. Umbilical Cord Blood Transplantation for the Treatment of Hematologic

More information

Clinical Research Program Information for Patients. Transplant Creations

Clinical Research Program Information for Patients. Transplant Creations Clinical Research Program Information for Patients Transplant Creations 1 Program Focus Combination chemotherapy and transplantation of stem cells from an autologous donor (patient s own stem cells) and/or

More information

The Value of Cord Blood Stem Cells. Mona Shafey, MD, FRCPC Medical Grand Rounds October 25 th, 2011

The Value of Cord Blood Stem Cells. Mona Shafey, MD, FRCPC Medical Grand Rounds October 25 th, 2011 The Value of Cord Blood Stem Cells Mona Shafey, MD, FRCPC Medical Grand Rounds October 25 th, 2011 Objectives To discuss umbilical cord blood as a stem cell source and the role of umbilical cord blood

More information

Cord Blood Transplant Past and Future. E. Gluckman Eurocord ISCT Paris 24/04/2014

Cord Blood Transplant Past and Future. E. Gluckman Eurocord ISCT Paris 24/04/2014 Cord Blood Transplant Past and Future E. Gluckman Eurocord ISCT Paris 24/04/2014 Background Since 1988, umbilical cord blood (CB) has been successfully used to treat children and adults needing stem cell

More information

information for payers and referrers

information for payers and referrers a d u lt s t e m c e l l t r a n s p l a n tat i o n p r o g r a m information for payers and referrers Spring 2014 For more information, visit www.dfbwcc.org/bmt. o u r expertise Since its founding in

More information

Umbilical Cord Blood Stem Cells Current Status & Future Potential

Umbilical Cord Blood Stem Cells Current Status & Future Potential Umbilical Cord Blood Stem Cells Current Status & Future Potential Natasha Ali Assistant Professor Haematology Department of Pathology & Laboratory Medicine/Oncology The Aga Khan University Email: natasha.ali@aku.edu

More information

Cord Blood for Cellular Therapy: A Snapshot of this Evolving Market Landscape

Cord Blood for Cellular Therapy: A Snapshot of this Evolving Market Landscape GENReports: Market & Tech Analysis Cord Blood for Cellular Therapy: A Snapshot of this Evolving Market Landscape > Enal Razvi, Ph.D. Biotechnology Analyst, Managing Director SELECTBIO US enal@selectbio.us

More information

Infosheet. Allogeneic stem cell transplantation in myeloma. What is the principle behind stem cell transplantation?

Infosheet. Allogeneic stem cell transplantation in myeloma. What is the principle behind stem cell transplantation? Infosheet Allogeneic stem cell transplantation in myeloma High-dose therapy and autologous stem cell transplantation is currently the first-line treatment standard of care for younger/fitter myeloma patients.

More information

Haematopoietic stem cell transplantation in Hong Kong

Haematopoietic stem cell transplantation in Hong Kong S C I E N T I F I C P A P E R Haematopoietic stem cell transplantation in Hong Kong Albert KW Lie WY Au Raymond Liang 李 國 維 區 永 仁 梁 憲 孫 The first case of haematopoietic stem cell transplant (HSCT) was

More information

Corporate Medical Policy Cord Blood as a Source of Stem Cells

Corporate Medical Policy Cord Blood as a Source of Stem Cells Corporate Medical Policy Cord Blood as a Source of Stem Cells File Name: Origination: Last CAP Review: Next CAP Review: Last Review cord_blood_as_a_source_of_stem_cells 2/2001 3/2015 3/2016 3/2015 Description

More information

Hematopoietic Stem Cells, Stem Cell Processing, and Transplantation

Hematopoietic Stem Cells, Stem Cell Processing, and Transplantation Hematopoietic Stem Cells, Stem Cell Processing, and Joseph (Yossi) Schwartz, MD Director, Hemotherapy and Stem Cell Processing Facility E-mail: js2745@columbia.edu A 40-year old man with acute myelogenous

More information

Stem Cell Transplantation

Stem Cell Transplantation Harmony Behavioral Health, Inc. Harmony Behavioral Health of Florida, Inc. Harmony Health Plan of Illinois, Inc. HealthEase of Florida, Inc. Ohana Health Plan, a plan offered by WellCare Health Insurance

More information

Umbilical Cord Blood: An Alternative Allogeneic Stem Cell Source for Transplantation

Umbilical Cord Blood: An Alternative Allogeneic Stem Cell Source for Transplantation Umbilical Cord Blood: An Alternative Allogeneic Stem Cell Source for Transplantation Mary J. Laughlin, MD Associate Professor of Medicine and Pathology Dr. Donald and Ruth Weber Goodman Professor of Innovative

More information

Bone Marrow (Stem Cell) Transplant for Sickle Cell Disease

Bone Marrow (Stem Cell) Transplant for Sickle Cell Disease Bone Marrow (Stem Cell) Transplant for Sickle Cell Disease Bone Marrow (Stem Cell) Transplant for Sickle Cell Disease 1 Produced by St. Jude Children s Research Hospital Departments of Hematology, Patient

More information

Hodgkin Lymphoma Disease Specific Biology and Treatment Options. John Kuruvilla

Hodgkin Lymphoma Disease Specific Biology and Treatment Options. John Kuruvilla Hodgkin Lymphoma Disease Specific Biology and Treatment Options John Kuruvilla My Disclaimer This is where I work Objectives Pathobiology what makes HL different Diagnosis Staging Treatment Philosophy

More information

OUR JOURNEY THROUGH THE YEARS

OUR JOURNEY THROUGH THE YEARS The King Faisal Specialist Hospital and Research Centre Experience in Hematology, Oncology and Bone Marrow Transplantation OUR JOURNEY THROUGH THE YEARS REGGIE BELKHEDIM A Brief Overview: King Faisal Specialist

More information

STEM CELL TRANSPLANTATION IN MULTIPLE MYELOMA

STEM CELL TRANSPLANTATION IN MULTIPLE MYELOMA STEM CELL TRANSPLANTATION IN MULTIPLE MYELOMA Sundar Jagannath MD Professor of Medicine St. Vincent s Comprehensive Cancer Center New York, NY Where is transplant today in the management of Myeloma? Autologous

More information

Pro Cure in Multiple Myeloma. Nicolaus Kröger Dept. of Stem Cell Transplantation University Hospital Hamburg Hamburg, Germany

Pro Cure in Multiple Myeloma. Nicolaus Kröger Dept. of Stem Cell Transplantation University Hospital Hamburg Hamburg, Germany Pro Cure in Multiple Myeloma Nicolaus Kröger Dept. of Stem Cell Transplantation University Hospital Hamburg Hamburg, Germany Pro Cure in Multiple Myeloma Several hematological malignancies can be cured

More information

A Cure for Sickle Cell Anemia and Thalassemia

A Cure for Sickle Cell Anemia and Thalassemia IV Simpósio Internacional de Hemoglobinopatias A Cure for Sickle Cell Anemia and Thalassemia Bertram Lubin, MD and Mark Walters, MD 4 September 2007 Topics to be covered Cord blood: Importance and biology

More information

Blood and Marrow Stem Cell Transplantation LEUKEMIA LYMPHOMA MYELOMA

Blood and Marrow Stem Cell Transplantation LEUKEMIA LYMPHOMA MYELOMA Blood and Marrow Stem Cell Transplantation LEUKEMIA LYMPHOMA MYELOMA Table of Contents Introduction 1 Here to Help 2 Normal Blood and Marrow 4 Overview and Types of Stem Cell Transplantation 6 Stem Cell

More information

The future of unrelated Stem Cell Transplant in the UK: DOH Working Party Findings. Prof. Tony Pagliuca

The future of unrelated Stem Cell Transplant in the UK: DOH Working Party Findings. Prof. Tony Pagliuca The future of unrelated Stem Cell Transplant in the UK: DOH Working Party Findings Prof. Tony Pagliuca UK STEM CELL STRATEGIC FORUM The future of unrelated donor SCT in the UK Antonio Pagliuca, Transplant

More information

SESUG 2011 INTRODUCTION. Paper GH-12

SESUG 2011 INTRODUCTION. Paper GH-12 Paper GH-12 Development of a SAS Macro for Automated Data Cleaning of Major Outcomes of Interest in Hematopoietic Cell Transplantation Peigang Li, Min Chen and Zhiwei Wang, CIBMTR, Milwaukee, WI ABSTRACT

More information

Stem Cell Transplantation in Severe Aplastic Anemia

Stem Cell Transplantation in Severe Aplastic Anemia Stem Cell Transplantation in Severe Aplastic Anemia Dr. D. Goodyear MD, FRCPC Division of Hematology and Hematological Malignancies, University of Calgary 1 of 11 Introduction Most cases of aplastic anemia

More information

INFORMATION ON STEM CELLS/BONE MARROW AND REINFUSION/TRANSPLANTATION SUR703.002

INFORMATION ON STEM CELLS/BONE MARROW AND REINFUSION/TRANSPLANTATION SUR703.002 INFORMATION ON STEM CELLS/BONE MARROW AND REINFUSION/TRANSPLANTATION SUR703.002 COVERAGE: SPECIAL COMMENT ON POLICY REVIEW: Due to the complexity of the Peripheral and Bone Marrow Stem Cell Transplantation

More information

Relapsed or Refractory Adult Acute Lymphoblastic Leukemia (ALL): Distinct Patient Populations With Significant Unmet Medical Need

Relapsed or Refractory Adult Acute Lymphoblastic Leukemia (ALL): Distinct Patient Populations With Significant Unmet Medical Need Relapsed or Refractory Adult Acute Lymphoblastic Leukemia (ALL): Distinct Patient Populations With Significant Unmet Medical Need Hagop M. Kantarjian, MD Chairman, Leukemia Department Department of Hematology

More information

Bone Marrow Transplant Services in New Zealand for Adults

Bone Marrow Transplant Services in New Zealand for Adults Bone Marrow Transplant Services in New Zealand for Adults Citation: Ministry of Health. 2011. Bone Marrow Transplant Services in New Zealand for Adults Service Improvement Plan. Wellington: Ministry of

More information

Not All Stem Cells are the Same

Not All Stem Cells are the Same Cord Blood Banking and Transplantation Jennifer Willert, M.D. Hematology/Oncology Blood and Marrow Transplant Rady Children s Hospital San Diego Clinical Professor UCSD Not All Stem Cells are the Same

More information

Bone Marrow/Stem Cell Transplant

Bone Marrow/Stem Cell Transplant Blue Distinction Centers for Transplants Program Selection Criteria for 2010 Mid-Point Designations To qualify as a Blue Distinction Center for Transplants (), each facility must satisfy s quality based

More information

Stem Cell Transplantation in Adults

Stem Cell Transplantation in Adults Recommendation Report Stem Cell Transplantation in Adults K. Imrie, R.B. Rumble, M. Crump, the Advisory Panel on Bone Marrow and Stem Cell Transplantation, and the Hematology Disease Site Group of Cancer

More information

Stammzelltransplantation. Neues vom immunologischen Ctrl-Alt-Del

Stammzelltransplantation. Neues vom immunologischen Ctrl-Alt-Del Allogene Neues vom immunologischen Ctrl-Alt-Del Prof. Dr. med. Wolfgang Bethge Allogene am ASH Insgesamt 715 Abstracts zum Thema Auswahl: Azacitidine als Überbrückung zu allogenen SZT bei MDS Ergebnis

More information

DEPARTMENT OF BONE MARROW AND STEM CELL TRANSPLANT

DEPARTMENT OF BONE MARROW AND STEM CELL TRANSPLANT www.narayanahealth.org DEPARTMENT OF BONE MARROW AND STEM CELL TRANSPLANT About Narayana Health City Narayana Health, one of India's largest and the world's most economical healthcare service providers

More information

10 th Annual International Cord Blood Transplantation Symposium June 7-9, 2012 Preliminary Scientific Program. Thursday, June 7

10 th Annual International Cord Blood Transplantation Symposium June 7-9, 2012 Preliminary Scientific Program. Thursday, June 7 10 th Annual International Cord Blood Transplantation Symposium June 7-9, 2012 Preliminary Scientific Program Thursday, June 7 7:00 8:00 AM Breakfast in Exhibit Hall Session IA 8:00 10:00 AM Advances in

More information

Estimated New Cases of Leukemia, Lymphoma, Myeloma 2014

Estimated New Cases of Leukemia, Lymphoma, Myeloma 2014 ABOUT BLOOD CANCERS Leukemia, Hodgkin lymphoma (HL), non-hodgkin lymphoma (NHL), myeloma, myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPNs) are types of cancer that can affect the

More information

Cord Blood Biology and Transplantation

Cord Blood Biology and Transplantation Cord Blood Biology and Transplantation Yossi Cohen MD MSc and Arnon Nagler MD Institute of Hematology, Department of Bone Marrow Transplantation and Cord Blood Bank, Sheba Medical Center, Tel Hashomer,

More information

cancer cancer Hessamfar-Bonarek M et al. Int. J. Epidemiol. 2010;39:135-146

cancer cancer Hessamfar-Bonarek M et al. Int. J. Epidemiol. 2010;39:135-146 Hematopoietic Stem Cell Transplant in HIV- related lymphoma Song Zhao, MD PhD Hematology-Oncology Program University of Washington/FHCRC Underlying Causes of Death in HIV-infected Adults 2000 2005 cancer

More information

P R E S S K I T 2013 TABLE OF CONTENTS. About the European Group for Blood and Marrow Transplantation

P R E S S K I T 2013 TABLE OF CONTENTS. About the European Group for Blood and Marrow Transplantation TABLE OF CONTENTS About the European Group for Blood and Marrow Transplantation Haematopoietic Stem Cell Transplantation (HSCT): Key facts & figures EBMT Data - A foundation for cutting-edge research Clinical

More information

Cord Blood: Research Progress and Future Promise

Cord Blood: Research Progress and Future Promise Cord Blood: Research Progress and Future Promise By Al Staropoli, AABB Contributing Writer Sue Fister found out she had leukemia when she was 50 years old. Doctors suggested a bone marrow transplant as

More information

Leukemias and Lymphomas: A primer

Leukemias and Lymphomas: A primer Leukemias and Lymphomas: A primer Normal blood contains circulating white blood cells, red blood cells and platelets 700 red cells (oxygen) 1 white cell Neutrophils (60%) bacterial infection Lymphocytes

More information

Unrelated donor umbilical cord blood transplantation for the treatment of hematologic malignancies Craig Sauter and Juliet N.

Unrelated donor umbilical cord blood transplantation for the treatment of hematologic malignancies Craig Sauter and Juliet N. Unrelated donor umbilical cord blood transplantation for the treatment of hematologic malignancies Craig Sauter and Juliet N. Barker Adult Allogeneic Bone Marrow Transplantation Service, Memorial Sloan-Kettering

More information

DECISION AND SUMMARY OF RATIONALE

DECISION AND SUMMARY OF RATIONALE DECISION AND SUMMARY OF RATIONALE Indication under consideration Clinical evidence Clofarabine in the treatment of relapsed acute myeloid leukaemia (AML) The application was for clofarabine to remain in

More information

TRANSPLANT BASICS Understanding transplant and how it works

TRANSPLANT BASICS Understanding transplant and how it works TRANSPLANT BASICS Understanding transplant and how it works Thuy, transplant recipient AT EVERY STEP, WE ARE HERE TO HELP As you journey through transplant, you re not alone. Be The Match is ready to help.

More information

Hematopoietic Stem-Cell Transplantation for Waldenstrom Macroglobulinemia

Hematopoietic Stem-Cell Transplantation for Waldenstrom Macroglobulinemia Hematopoietic Stem-Cell Transplantation for Waldenstrom Macroglobulinemia Policy Number: Original Effective Date: MM.07.026 04/01/2008 Line(s) of Business: Current Effective Date: HMO; PPO 04/26/2013 Section:

More information

Project Lead: Stephen Forman, M.D. PI: Elizabeth Budde, M.D., Ph.D

Project Lead: Stephen Forman, M.D. PI: Elizabeth Budde, M.D., Ph.D Phase I study using T cells expressing a CD123-specific chimeric antigen receptor and truncated EGFR for patients with relapsed or refractory acute myeloid leukemia Project Lead: Stephen Forman, M.D. PI:

More information

Reference: NHS England B04/P/a

Reference: NHS England B04/P/a Clinical Commissioning Policy: Haematopoietic Stem Cell Transplantation (HSCT) (All Ages): Revised Reference: NHS England B04/P/a 1 NHS England Clinical Commissioning Policy: Haematopoietic Stem Cell Transplantation

More information

BIOSTATISTICS FOR TRANSLATIONAL & CLINICAL RESEARCH. Blood-&-Marrow Transplants & CANCERS

BIOSTATISTICS FOR TRANSLATIONAL & CLINICAL RESEARCH. Blood-&-Marrow Transplants & CANCERS BIOSTATISTICS FOR TRANSLATIONAL & CLINICAL RESEARCH Blood-&-Marrow Transplants & CANCERS Stem Cells Stem cells are immature body cells that act like "starter dough" because they can make identical copies

More information

Preparation of cord blood for infusion: bedside thaw, dilute and wash, or somewhere in between

Preparation of cord blood for infusion: bedside thaw, dilute and wash, or somewhere in between Preparation of cord blood for infusion: bedside thaw, dilute and wash, or somewhere in between Donna Wall, MD Director, Manitoba Blood and Marrow Transplant Program ISCT 2012 Disclosures: none The problem:

More information

Therapeutic Treatment Options: Chronic Blood Transfusions Bone Marrow Transplantation. Marianne E. McPherson Yee, MD, MSc

Therapeutic Treatment Options: Chronic Blood Transfusions Bone Marrow Transplantation. Marianne E. McPherson Yee, MD, MSc Therapeutic Treatment Options: Chronic Blood Transfusions Bone Marrow Transplantation Marianne E. McPherson Yee, MD, MSc Sickle Cell Treatment Options Supportive Care Newborn Screen PCN Immunizations Education

More information

What we will discuss today

What we will discuss today Umbilical cord blood banking It s Utility? Dr. Nita Radhakrishnan Pediatric Hematology Oncology Unit, Sir Ganga Ram Hospital, New Delhi What we will discuss today What are stem cells? What are the sources

More information

Immunoablative therapy with autologous hematopoietic stem cell transplantation in the treatment of poor risk multiple sclerosis

Immunoablative therapy with autologous hematopoietic stem cell transplantation in the treatment of poor risk multiple sclerosis Immunoablative therapy with autologous hematopoietic stem cell transplantation in the treatment of poor risk multiple sclerosis T Kozák, P Lhotáková Department of Clinical Haematology, 3r d School of Medicine,

More information

* CHAPTER 6. Choice of the donor according to HLA typing and stem cell source. Eliane Gluckman

* CHAPTER 6. Choice of the donor according to HLA typing and stem cell source. Eliane Gluckman * CHAPTER 6 Choice of the donor according to HLA typing and stem cell source Eliane Gluckman CHAPTER 6 Choice of the donor according to HLA typing and stem cell source 1. Introduction Allogeneic haematopoietic

More information

Blood and Marrow Stem Cell Transplantation

Blood and Marrow Stem Cell Transplantation Blood and Marrow Stem Cell Transplantation Printing of this publication made possible by an education grant from Table of Contents Introduction 2 Overview of Stem Cell Transplantation 3 Normal Blood and

More information

Hematology, National Research Cancer Center - Istituto Tumori Giovanni Paolo II, Bari, Italy;

Hematology, National Research Cancer Center - Istituto Tumori Giovanni Paolo II, Bari, Italy; DCTH - 3 2014-125-131 CASE REPORT An alternative strategy for cord blood stem cells transplant to reduce time of neutrophils engraftment: case report of co-infusion of haploidentical and cord blood stem

More information

GRANIX (tbo-filgrastim)

GRANIX (tbo-filgrastim) RATIONALE FOR INCLUSION IN PA PROGRAM Background Neutropenia is a hematological disorder characterized by an abnormally low number of neutrophils. A person with severe neutropenia has an absolute neutrophil

More information

Hematopoietic Stem-Cell Transplantation for Epithelial Ovarian Cancer

Hematopoietic Stem-Cell Transplantation for Epithelial Ovarian Cancer Hematopoietic Stem-Cell Transplantation for Epithelial Ovarian Cancer Policy Number: Original Effective Date: MM.07.014 04/01/2008 Line(s) of Business: Current Effective Date: HMO; PPO 01/23/2015 Section:

More information

Are CAR T-Cells the Solution for Chemotherapy Refractory Diffuse Large B-Cell Lymphoma? Umar Farooq, MD University of Iowa Hospitals and Clinics

Are CAR T-Cells the Solution for Chemotherapy Refractory Diffuse Large B-Cell Lymphoma? Umar Farooq, MD University of Iowa Hospitals and Clinics Are CAR T-Cells the Solution for Chemotherapy Refractory Diffuse Large B-Cell Lymphoma? Umar Farooq, MD University of Iowa Hospitals and Clinics Disclosure(s) I do not intend to discuss an off-label use

More information