Age Related Macular Degeneration (ARMD)
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- Ronald Hamilton
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1 Age Related Macular Degeneration (ARMD) What is age related macular degeneration? Age related macular degeneration is the commonest cause of visual loss in the Western world in those over 50 years old. The damage in wet ARMD principally involves the macula area which is responsible for seeing colour and fine detail. The macula area affected in ARMD is extremely small in size (approximately 0.5 millimetre), however as it contains densely packed collection of important light sensitive cells (cones), minimal damage can result in significant symptoms. A person with wet macular degeneration loses the ability to see fine detail centrally for near and far, however it is important to realise that the patient does not become blind completely and the peripheral vision remains preserved. Are there different types of macular degeneration? There are two types of age related macular degeneration. A dry type and a wet type. The dry type results from the gradual breakdown of cells in the macula, resulting in a gradual blurring of central vision. Single or multiple, small, round, yellow-white spots called drusen are the key identifiers for the dry type. The former (dry type) is present in majority (85%-90%) of patients with macular degeneration. In early phase of dry ARMD, the patients may even be unaware that these changes are present in the macula area and patients have normal vision. In a minority of cases these early dry changes can progress and cause significant visual loss. Fortunately dry ARMD is not as aggressive as wet ARMD, although there is currently no effective treatment to halt or reverse these changes. Furthermore dry ARMD can change and become the wet form. Wet macular degeneration affects only about 15% of people who have age-related macular degeneration but accounts for two-thirds of the people who have significant visual loss. In this form of macular degeneration abnormal new blood vessels grow under the retina area and begin to leak and bleed. The result is displacement of the highly organized photosensitive cells in the macula area resulting in visual distortion and central visual loss. In later stages scarring may develop and limit the success of injections into the eye. Unfortunately wet macular degeneration can affect both eyes and treatment in one eye does not protect the other eye against development of macular degeneration. Patients should be aware that if symptoms develop in the good eye they should consult the eye department immediately. 0464/01/Jun 2014 Page 1 of 6
2 How is ARMD treated? Lucentis and Eylea are given by injections into the white of eye and currently licensed in UK and approved by the National Institute for Health and Clinical Excellence (NICE) for treatment of wet ARMD as long as certain clinical criteria are met (e.g your level of vision at presentation and absence of scarring at the macula). This injection therapy aims to primarily halt progression of these new blood vessels and stop the leaking and bleeding in the retina. These drugs prevent significant visual loss in 90% of cases and at times even improve vision (up to 30-40%). Are there any alternatives? Without this injection treatment, the vision can worsen very quickly and significant visual loss can ensue within few days to few months depending on severity of your condition. Prior to development to these injections, other modes of therapy such as conventional Argon laser or special type of macular laser known as PDT laser have been performed. Currently these modes of therapy are still available for certain types of wet ARMD. Clinical trials suggest that injection therapy is superior to laser treatment in management of majority of cases of ARMD patients, although the case of continued and repeated injections should be argued against PDT laser which requires fewer treatment sessions in patients with ARMD. This needs to be discussed with your ophthalmologist. How is the injection given? The injections are adminstered through a fine needle into your eye. You may have minimal discomfort from the injection (similar to having your blood taken from your arm). The actual process of the injection takes few seconds however the whole procedure is expected to last about 10 minutes from the time you enter the injection room. The injection is administered whilst the patient is laying flat on a comfortable reclining chair. Local anaesthetic drops are applied to numb your eye to minimise discomfort. The eyelids of the eye marked to be injected are cleaned and a drape is placed on your face in order to minimise risk of infection. This area should remain sterile throughout the procedure. A small clip (speculum) will be used to keep your eye open. More local anaesthetic drops are applied and the site for injection marked with callipers. Once the intravitreal injection is administered, topical antibiotics are installed and your vision is checked using hand movements. The drape is then removed and the eye is cleaned. Some patients may need injection in both eyes. We can do this the same day for you however if you wish to have the second eye a week later, this can be arranged. Page 2 of 6
3 What happens after the injection? Your GP will receive a letter about your visit. You will then be given your next appointment on the day or the appointment will be sent to you later. Once the decision has been reached for you to receive the injections, a course of 3 injections (loading dose one injection per month) will be given. Administration of further injections will be decided on your review visit depending on the leakiness of the blood vessels and which injecting agent you are started on. What are the potential risks and side effects? Like any medical procedure there is a small risk of a complication from these injections. For the majority of patients the benefit of the injection outweights the risk of the procedure. The following are possible complications from the procedure although it must be stressed that such events are unusual and permamant loss of vision as a result of the injection is rare (list not including evey potential risk). Major risks (uncommon) Serious eye infection resulting in complete blindness (1 in every 1000 people) Raised pressure in the eye Tear in the retina Detachment of the retina Cataracts Blood clots or bleeding inside the eye Inflammation in the eye High blood pressure Potential for developing stroke Minor risks (common) Red eye (bleed at the superficial surface of the eye) Sore gritty eye (usually first 48 hours post injection) Small specks (floaters ) or transient flashing lights may be seen in your vision for few days Who should not receive injection treatment? If you have allergy to the injecting agent or any of its ingredents If you have any active infection in particular in or around the eye If you are pregnant, breastfeeding or activly trying to get pregnant Page 3 of 6
4 Caution must be used: If you have had a heart attack or stroke in the last 3 months If you have uncontrolled high blood ptessure or angina Can other medicines or food affect injection treatment? Certain medication can interact with injection treatment. You must tell us names of all the medication you take in particular verteporin injection for PDT laser, blood pressure tablets and blood thinners such as warfarin or aspirin. Please let us know if you ever change your medication. If you take warfarin please bring your anticoagulation book for us and it would be very useful if you have had a blood test within a week before your visit to us. When should I be concerned and what should I do? The day after your injection your eye should be comfortable but may appear red due to a small haemorrhage from the injection. If your eye appearance changes i.e. becoming more red, sensitive to light, swollen and painful or you note misty vision after the injection, you should suspect an infection and contact the hospital immediately. Conquest patients: please telephone (01424) Ext: 8714 Monday to Friday to 17.00, after and at weekends telephone (01424) and ask to speak to the Eye Doctor on call. Please have name, hospital number and telephone number available. Dowling Unit Bexhill: please telephone (01424) Ext: Monday to Friday to Eastbourne patients: please telephone (01323) and ask for the eye nurse on call prior to 21.00hrs in the first instance, after 21.00hrs the Ophthalmology doctor on call is available for emergency situations. What should I do before I come into hospital? Please allow several hours for the appointment as you may undergo investigations, leading to treatment which, if indicated will be commenced on the day of your first appointment. After the initial course of three injections, your condition will be monitored approximately 4 to 8 weekly (depending on type of injecting agent) and we will determine if you need a further injection on the day.you are able to eat and drink and take your normal medication on the day of the injection. No specific treatment is usually required before the injections. Page 4 of 6
5 When can I return to work? We would advise you to avoid rubbing your eye, or immersing your eye in water (e.g. swimming) for a few days. Otherwise, normal activities can be resumed straight after the injection. Please ask your doctor in clinic about your eligibilty for driving. Important information The information in this leaflet is for guidance purposes only and is not provided to replace professional clinical advice from a qualified practitioner. Although you will sign a consent form for this treatment, you may at any time after withdraw such consent.your consent will be reveiwed on a yearly basis. Please discuss this with your medical team. Your comments We are always interested to hear your views about our leaflets. If you have any comments please contact our Patient Advice and Liaison Service (PALS) details below. Hand hygiene The trust is committed to maintaining a clean, safe environment. Hand hygiene is very important in controlling infection. Alcohol gel is widely available in all clinic rooms for staff use and at the entrance of each clinical area for visitors to clean their hands before and after entering. Other formats This information is available in alternative formats such as large print or electronically on request. Interpreters can also be booked. Please contact the Patient Advice and Liaison Service (PALS) offices, found in the main reception areas: Conquest Hospital palsh@esht.nhs.uk - Telephone: Eastbourne District General Hospital palse@esht.nhs.uk - Telephone: After reading this information are there any questions you would like to ask? Please list below and ask your nurse or doctor. Page 5 of 6
6 Reference Written by : Mr Shahram Kashani The directorate group that have agreed this patient information leaflet: Ophthalmology The following clinicians have been consulted and agreed this patient information: Mr Shahram Kashani, Ophthalmology Consultant, Eastbourne District General Hospital Mr Kashif Qureshi, Ophthalmology Consultant, Conquest Hospital Mr Hickman Casey, Ophthalmology Consultant, Eastbourne District General Hospital Mr Wearne, Ophthalmology Consultant, Eastbourne District General Hospital Mr Gouws, Ophthalmology Consultant, Conquest Hospital Date agreed: June 2014 Review date: June 2016 Responsible clinician: Sue Allen, Head of Nursing, Eastbourne DGH Matron: Beverley Attridge Page 6 of 6
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