Moving Forward in the Diagnosis of Infectious Diseases in Resource Limited Countries:

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Rosalyn Dina Walters
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1 Moving Forward in the Diagnosis of Infectious Diseases in Resource Limited Countries: Diagnostic Technology Advances Organized by Fondation Mérieux & the American Academy of Microbiology Les Pensières Fondation Mérieux Conference Center Veyrier du Lac - France September 12 to 14,

2 Steering Committee Institutions Ahimsa Partners American Academy of Microbiology American Academy of Microbiology APHP Bill and Melinda GATES Foundation FIND Fondation Mérieux Fondation Mérieux Fondation Mérieux Institute Pasteur of Dakar London School of Hygiene & Tropical Medicine Malaria Research and Treatment Center PATH RollBack Malaria Partnership Stop TB Department - WHO UNAIDS Université Cheik Anta Diop Proposed Representatives Jean François de Lavison Ann Reid Keith Klugman François Simon TBC Giorgio Roscigno Christophe Longuet Guy Vernet Valentina Picot Amadou A Sall Rosanna Peeling Ogobara Doumbo Bernhard Weigl Jan Van Erps Mario C. Raviglione Paul De Lay Souleymane Mboup 2

3 Background A critical factor in reducing the infectious disease burden in developing countries is the ability to provide accurate diagnosis and monitor response to treatment. New technologies are emerging to improve the diagnosis and monitoring of infectious diseases. Rapid molecular methods and integrated diagnostic platforms are among the most promising approaches, having an important role in the global control of infectious diseases. International organizations and governments of developing countries realize that strengthening laboratory capacity both at the central and point-ofcare levels is necessary to reduce the burden of infectious disease and achieve the Millennium Development Goals. In recognition of the critical constraints on the diagnosis of many infectious diseases affecting the developing world, Fondation Mérieux organizes an annual forum to discuss the current state and future potential of diagnostic technologies to address the pressing needs of developing countries. After three successful forums Moving Forward on tuberculosis, malaria and HIV organized respectively with the Global Laboratory initiative of the STOP TB Partnership & the World Health Organization in 2008, with the Roll Back Malaria Partnership in 2009 and with UNAIDS in 2010, the 2011 forum co-organized with the American Academy of Microbiology will focus on Current Diagnostic Technology Advances on infectious diseases. The format of the forum will provide with an opportunity to share knowledge and experiences, identify connections between fields that may rarely interact, generate new ideas, and identify promising areas for future research and introduction of these technologies in the needed settings. Among the questions to be addressed at the forum are: What are the greatest challenges and problems with respect to current laboratory technologies in the developing laboratory setting? What scientific and technological advances are on the horizon that might allow developing countries to leapfrog over current hurdles and radically expand laboratory capacity? How to facilitate integration of new tools? The Moving Forward Forum will provide a comprehensive look at the current state and future potential of diagnostic technologies to address the needs of developing countries. The objectives of this annual forum are to: Increase awareness of the importance of adequate diagnosis of infectious diseases in resource limited countries; Highlight the specific needs and the new perspectives in all dimensions to address appropriately diagnostics in these regions of the world; Learn about the diagnostic tools available and those in development Exchange lessons learned from ongoing initiatives and disciplines Agree on priorities and on how all actors can interact to move forward 3

4 September 12, h30-18h15 Registration 18h15-18h30 Welcome Address 18h30-19h30 Keynote Lectures: -Burden of Infectious Diseases in Developing Countries -Global Diagnostics Landscape Kevin M. De Cock TBC 19h30 Welcome Dinner September 13, 2011 Challenges and Needs SESSION I 9h00 12h00 Chair by: Ann Reid Co- chair : TBC Diagnostic technologies for public health reference laboratories Niel Constantine Giorgio Roscigno Diagnostic technologies for the point of care setting Rosanna Peeling Joseph Fair 10h30 11h10 Coffee Break Delivery and adoption of new diagnostic technologies in resource limited settings Oyewale Tomori Integration of vertical disease programs into horizontal health systems Gates - TBC New business models for developing countries Jean François de Lavison 12h30 14h00 Lunch 4

5 SESSION II 14h00 18h30 Building from Successful Field Experiences in applied diagnostics Chair by: Jan Van Erps Co- chair : Souleymane Mboup TB field experiences Malaria field experiences Leopold Blanc Ogobara Doumbo HIV field experiences Rasmata Ouedraougo 15h30 16h00 Coffee Break (Other Disease field experiences) (Other Disease field experiences) HPV field experiences Marleen Boelaert Amadou A Sall Susan Keese Clinical trials in applied diagnostics John T. McDevitt 19h30 Dinner September 14, 2011 Research & Development: New approaches in diagnostics SESSION III 9h00 16h00 Chair by: Keith Klugman Co-chair: TBC Approaching high tech affordable diagnostics in low tech settings Wendy Stevens Sustainable diagnostics and diagnosis interventions: Promoting what works and best ways to deliver TBC 10h00 10h30 Coffee Break 5

6 New approaches at the reference laboratory level Resistance testing Pathogens Identification Ron Ballard Jean Noel New approaches at the point-of-care level RDTs: What is new? POC Molecular Diagnostics Arman Nabatiyan William Rodriguez Cephid-TBC 12h45 14h00 Lunch Emerging Diagnostic Technologies: Nano/Microfluidics technology Other technologies Robert S. Marks George Whitesides- TBC 15h30 Conclusion / Recommendations Meeting Cloture 6

EBOLA VACCINE: Where are we? How to move forward?

EBOLA VACCINE: Where are we? How to move forward? Co-Organized by Fondation Mérieux, AVIESAN, and WHO Les Pensières, Fondation Mérieux Conference Center Veyrier du Lac - France 12-13 January 2015 1 About