Effects of resistant starch on blood glucose in patients with type 2 diabetes

Transcription

1 JOURNAL OF TONGJI UNIVERSITY MEDICAL SCIENCE Vol. 35 No. 2 Apr doi /j. issn resistant starch RS P < P < P < P < > 7. 8 mmol /l > mmol /l P < P < P < R A Effects of resistant starch on blood glucose in patients with type 2 diabetes WANG Bo 1 LIU Jun 2 ZHOU Zun-hai 1 1. Dept. of Endocrinology Central Hospital of Yangpu District Shanghai China 2. Dept. of Traditional Chinese Medicine Tenth People's Hospital Tongji University Shanghai China Abstract Objective To investigate the effects of resistant starch RS on blood glucose in patients w ith type 2 diabetes. Methods Sixty patients w ith type 2 diabetes w ere randomized into RS and glucobay groups. Patients were given normal diet in the first day RS diet or glucobay were given in the second and third days. Oral hypoglycemic drugs and insulin w ere the same in the course of treatment. Dynamic blood glucose monitors w ere installed before test. The average blood glucose for three days the average blood glucose after breakfast after lunch after dinner blood glucose fluctuation coefficient time scale of high blood glucose and low blood glucose were compared. Results The average blood glucose was significantly lower in the second and third days P < in two groups. Average daily blood glucose average blood glucose of fasting after break after lunch bowang13241@ 163. com. zhouzunhai5008@ 163. com

2 2 2 after dinner was significantly lower P < The maximal blood glucose levels were decreased P < minimal blood glucose level was no significant change the range between highest and lowest blood glucose was decreased P < Time scale of greater than 7. 8 mmol /l and greater than mmol /l decreased significantly P < P < blood glucose fluctuation coefficient reduced P < Conclusion Resistant starch and glucobay can significantly reduce the average blood glucose reduce postprandial blood glucose and decrease blood glucose fluctuations in patients with type 2 diabetes. Key words resistant starch type 2 diabetes continuous glucose monitoring system diagnosis treatment kj /100 g kj /100 g 50 mg 3 3 resistant starch RS d 3 60 ~ 30 min 2 h ~ 135 min 2 h ~ 135 min 1 2 h 120 ~ 135 min D = n SG 2 - SG 2 1 / n n - 1 /2 n 1. 1 SG WHO 60 SPSS x ± s α- α- 2 t 2 t P < % ~ 11% d 1 d

3 35 1 Tab. 1 Baseline data of patients t χ 2 P / 12 /18 14 / / ± ± / kg m ± ± / mmol L ± ± /% ± ± / U L ± ± / U L ± ± / mmol L ± ± / mmol L ± ± / mmol L ± ± / mmol L ± ± / μmol L ± ± / mmol L ± ± / mmol L ± ± > 7. 8 mmol /L 3 > mmol /L 28 3 P < P < < t 3. 9 mmol /L P > ~ 11 mmol /L 2 3 P < P < P < P < h P < P < Tab. 2 Comparison of blood glucose parameters x ± s / mmol L ± ± ± ± ± ± / mmol L ± ± ± ± ± ± / mmol L ± ± ± ± ± ± / mmol L ± ± ± ± ± ± / mmol L ± ± ± ± ± ± ± ± ± ± ± ± / mmol L ± ± ± ± ± ± / mmol L ± ± ± ± ± ± / mmol L ± ± ± ± ± ± > 7. 8 mmol /L ± ± ± ± ± ± > mmol /L ± ± ± ± ± ± < 3. 9 mmol /L ± ± ± ± ± ± ~ 11 mmol /L ± ± ± ± ± ± P < P <

4 2 2 Fig h Fluctuation trend chart of 72 h blood glucose in resistant starch group Fig h Fluctuation trend chart of 72 h blood glucose in glucobay group 3 10 RS 4 RS RS RS RS 9 ph continuous glucose monitoring system CGMS 9 α - 59

5 35 high glucose enhances ICAM-1 VCAM-1 and E- selectin expression in human umbilical vein endothelial cells in culture the distinct role of protein kinase C RS Atheroscle-rosis Ceriello A Esposito K Piconi L et al. Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type CGMS RS 2 diabetic patients J. Diabetes > 7. 8 mmol /L > mmol /L ~ 11 mmol /L 8 Bavenholm PN Efendic S. Postprandial hyperglyca- RS emia and vascular damage-the benefits of acarbose J. Diab Vasc Dis Res J J bread containing resistant starch on postprandial blood J J Monnier L Colette C. Glycemic variability should we and can we prevent it J. Diabetes Care Suppl 2 S Quagliaro L Piconi L Assaloni R et al. Intermittent and mitochondrial superoxide production J. 11 Devries JW. Dietary fiber the influence of definition on analysis and regulation J. J AOAC Int RS Kishida T Nogami H Himeno S et al. Heat moisture treatment of high amylase cornstarch increases its resistant starch content but not its physiologie effects in rats J. J Nutr J J. 14 Robertson MD Bickerton AS Dennis AL et a Insulin-sensitizing effects of dietary resistant starch and 2 Yang W Lu J Weng J et a1. Prevalence of diabetes effects on skeletal muscle and adipose tissue metabo- among men and women in China J. N Engl J Med lism J Am J Clin Nutr Yamada Y Hosoya S Nishimura S et a1. Effect of glucose levels in humans J. Biosci Biotechnol Biochem Park OJ Kang NE Chang MJ et al. Resistant starch supplementation influences blood lipid concentrations and glucose control in overweight subjects J. J Nutr Sci Vitaminol