Film Coating Equipment - Continuous Coating
|
|
- Leo Hoover
- 7 years ago
- Views:
Transcription
1 Film Coating Equipment - Continuous Coating Barry Friend Technical Manager
2 Agenda Batch Manufacture Machine types Scale up problems Continuous Coaters Advantages Recent developments Operation Test Cases
3 Film coater types Fully perforated pans Partially perforated pans Non-perforated (conventional) pans Modified conventional pans Fluid bed coaters Continuous coaters
4 Insect screen Pre-heater Dehumidifier Typical Air Handling Requirements HEPA filter 99.99% Pre-filter 96% 5µ Exhaust fan Thermostat Secondary Filter 96% 5µ HEPA Filter 99.99% Humidifier Prefilter 86% 5µ DP DP DP DP DP Inlet fan Main heater Airflow gauge Bypass damper Airflow gauge Exhaust damper Inlet damper DP = Differential Pressure Monitor
5 Fully Perforated Pans Scale Up Pan Diameter (in/cm) Capacity (Litres) Airflow Volume (cu.m/hr) 12"/ " / "/ " / " / " / / / " /75m Continuous 2000L/hr 17000
6 Pan Diameter - Bed Depth Comparison 75 cm (30 ) Pan Pan Load ~45-55 kg 150cm (60 ) Pan Pan Load ~ kg <30cm Bed Depth >60 cm Bed Depth
7 Continuous Coating - Advantages Variable output capability depending on machine size Shorter product dwell times in the coating pan (i.e min) More uniform distribution of coating material due to: Shallow bed depth More frequent presentation of product to the spray zone Potential for less tablet attrition Simpler scale up Potential for PAT application and QbD One continuous coater could replace several batch coaters
8 Continuous Coating - Advantages Scale up from 30 batch pan to 30 continuous pan Batch Continuous Common parameters Atomizing air (Bar) Pattern air (Bar) Inlet temp. ( C) Exhaust temp. ( C) Gun to bed distance (in) 8 8 Gun to Gun distance (in) Nozzle qty 2 28 Pan speed (RPM) 20* 12 Scalable parameters Pan load (kg) Airflow (CFM) Solution flow (L/min) Coating time (mins) 15.5 N/A Residence time (mins) N/A 15.5 Weight gain (%)
9 Continuous Coating - Advantages Capacities and throughputs Models FC C250 FC C500 FC C1200 Process 3% kg/h Air volume m 3 /h Temperature range C Type of spray nozzles Anti-bearding Anti-bearding Anti-bearding Spray rate g/min Pan diameter mm (inches) 380 (15) 480 (19) 760 (30) Width mm (inches) 815 (32) 915 (36) 1350 (53) Depth mm (inches) 2500 (100) 3050 (120) 5260 (207) Height mm (inches) 1850 (72) 2135 (84) 2590 (102)
10 Continuous Coating - Recent Developments Spray gun design improvements Software controlled spray gun and process sequencing Continuous processing with minimal losses More flexibility for different product volumes Coating options Batch coating Batch/continuous coating
11 Spray gun design - Gun "Bearding" Turbulent Airstream Around Air Cap Inlet Airstream
12 Spray gun design - ABC Principle Smooth Flow Airstream Around Air Cap Inlet Airstream
13 ABC spray gun setup
14 Operation of the Continuous Coater Extended, small diameter, cylindrical, perforated coating pan
15 Operation of the Continuous Coater Discharge into dryer/cooler Product Container Controlled feeder Coating Pan
16 FC C- Rotary Drum Coater
17 Loading and Discharge Equipment Spiral cooling elevator (not shown) can be integrated for rapid cooling of tablets at discharge of coater Tablet feeding and discharge conveying systems to reduce or eliminate manual tablet handling
18 Continuous Coating - Original Process LOAD "Click" to start loading Only suitable for large volume products Weight gains limited to approximately 3-4% w/w of core weight Product waste at start up and shutdown Restricted use to high volume single product situations No ethical pharma use due to validation complexity and high volume restrictions Spray gun control and blockage
19 Continuous Coating - Original Process COAT "Click" to stop coating Partly Fully coated product to for reject sale
20 Continuous Coating - Original Process PROCESS END Partly coated/uncoated Fully Process end product to for reject sale
21 Batch/Continuous Coating - New Process LOAD "Click" to start loading "Click" to start coating In batch mode, the pan exit is sealed and the machine filled with tablets. Tablets are spraying to end point. At this point, tablets can either be discharged just as in a normal batch coating or the process can be converted to a continuous process by opening the pan exit and feeding more uncoated tablets.
22 Batch/Continuous Coating - New Process BATCH COAT "Click" to start continuous coating Colour change indicates the coating build up. Spraying stops at end point
23 Batch/Continuous Coating - New Process CONTINUOUS COAT "Click" to stop coating Collect fully coated product for sale New tablets are fed in and guns start sequentially
24 Batch/Continuous Coating - New Process PROCESS END Collect Process fully coated end product for sale At end point guns stop sequentially
25 Continuous Coating Trials
26 Trial 1- Comparison Immediate Release coatings Reason for trial: To evaluate the color uniformity and tablet appearance in both batch and continuous modes. To evaluate product loss typically associated with previous continuous coating technology. Opadry II 85F series high performance film coating system polymer system PVA Suspension solids 20% Opadry II 57U series film coating system polymer system HPMC Suspension solids 17% Substrate Calcium/Vitamin D tablets End point 3% weight gain.
27 Trial 1- Comparison of Immediate Release coatings Target coating process conditions Batch mode process parameters Continuous mode process parameters Inlet temperature ( C) Exhaust temperature ( C) Product temperature ( C) Airflow (CFM) Pan pressure ( P) Pan speed (rpm) Bed depth (in.) Weigh belt feed rate (kg / hr) n/a Solution flow rate (g/min.) Coating solids concentration (%) Batch size (kg) initial fill - continuous thereafter
28 Trial 1: Color Development and Uniformity Opadry II 57U - O'Hara Batch Mode Total Color Difference from Reference E (n=20) Uncoated core = E from target color reference 250 kg Batch size Limit of visual color detection E = Elapsed Coating Time (min)
29 Trial 1: Color Development and Uniformity Opadry II 57U - O'Hara Batch/Continuous Mode Total Color Difference from Reference E (n=20) Batch mode 1450 kg Batch size Continuous mode Limit of visual color detection E = 2 Discharge mode Elapsed Coating Time (min)
30 Trial 1: Color Development and Uniformity Opadry II 85F - O'Hara Batch Mode Total Color Difference from Reference E (n=20) Uncoated core = DE from target color reference 250 kg Batch size Limit of visual color detection E = Elapsed Coating Time (min)
31 Trial 1: Color Development and Uniformity Opadry II 85F - O'Hara Batch/Continuous Mode Total Color Difference from Reference E (n=20) Batch mode 1450 kg Batch size Continuous mode Limit of visual color detection E = 2 Discharge mode Elapsed Coating Time (min)
32 Trial 1 Conclusions No product waste Batch mode operation has immediate use in the pharmaceutical industry Significantly reduced process time and exposure of tablets to the coating environment Potential for reduced coating weight gains compared to traditional batch coaters At high solids concentration, both PVA based and HPMC based Opadry II systems were well suited for continuous coater operations
33 Trial 2 Delayed Release Coating Reason for trial: To evaluate the delayed release performance in continuous mode. To evaluate product loss typically associated with previous continuous coating technology. Nutrateric, nutritional enteric coating system Polymer system Ethylcellulose, Suspension solids 10% Substrate Mineral oil (placebo) softgel capsules End point 3.5% weight gain Throughput 200 kg/hr Samples taken for testing directly from discharge point.
34 Trial 2 Delayed Release Coating Target coating process conditions Continuous mode process parameters Batch size (Kg) 100 Weigh belt feed rate (kg / hr) Coating solids concentration (%) Suspension Quantity (Kg) Suspension flow rate (g/min.) Suspension flow rate (g/min/gun.)
35 Trial 2: Delayed Release Testing Mineral oil (placebo) softgel capsules Uncoated - 5 minutes in SGF* Nutrateric coated - 60 minutes in SGF* *Simulated Gastric Fluid
36 Trial 2: Delayed Release Testing Samples taken when product discharge begins, then every 5 minutes for 30 minutes Immersed in simulated gastric fluid (SGF) for 60 minutes. Then selected samples immersed in simulated intestinal fluid (SIF) until disintegrated. Sample time from 1st exit from coater (min) Disintegration time in SGF (n=6), (min) > 60 > 60 > 60 > 60 > 60 > 60 > 60 Disintegration time in SIF (n=6), (min) 27.0 Not tested 37.0 Not tested 31.5
37 Trial 2: Conclusions No product waste at start-up or shut-down Consistent enteric performance was achieved from start-to-finish The Nutrateric coating provided acid resistance at 3.5% weight gain with a throughput of 200 kg/hr Process was trouble-free
38 Continuous Coating - Overall Conclusions Recent advances in continuous coating control allow for batch and continuous operation with consistency from start-to-finish and no product waste Opadry II systems (PVA and HPMC) and Nutrateric delayed release coating system well suited for continuous coater applications High speed production Immediate applications for OTC and nutritional products Potential applications for continuous coating of pharma products dependant on GMP/validation issues Batch mode possibilities for large volume pharma products immediately available.
39 Trial 3 Tablet Migration DoE Reason for trial: To evaluate tablet migration through the Ohara FCC1200 pan without the use of directional mixing baffles to determine an optimal material flow range. Substrate Placebo caplets Marker placebo Coated cores were fed through the system at various rates. During each feed rate, 100 marker tablets were introduced and timed through the machine.
40 Trial 3 Tablet Migration DoE Measuring Methods: Multiple web cameras with multi-pc interface and custom software for analysis of video with marker tablets. 100 colored marker tablets with white tablet bed background started just ahead of spray zone for each set of conditions. 8 cameras running at 5 frames/second in the first half of the drum. Large quantities of raw data (200+ GB) Custom analysis software to look at pixel counts in each frame (post processed). Individual frame analysis to get information to improve exit data. (accurate start times and process lengths) 1 Time recorder tracking time that the marker tablets exit in relation to the test start time with use of Excel macro. DOE to see main effects Monte Carlo simulation model to tease out relationships
41 Trial 3 Tablet Migration DoE Images showing recognition (in green) of red marker tablets
42 Trial 3 Tablet Migration DoE Design-Expert Software SD/Rev X1 = A: Feed Rate X2 = C: Bed Depth POOR Uniformity Actual Factors B: Tilt = 1.50 D: Atomazation = 0.50 SD/Rev BETTER Uniformity C: Bed Depth A: Feed Rate 1200
43 Trial 3 Tablet Migration DoE Conclusion The relationship of bed depth and feed rate (axial transport speed) is the major driver for tablet diffusion/distribution growth rate and the resulting coating uniformity performance at a particular drum speed. Impact of atomization and pattern air is a visible but minor impact on uniformity performance. The variation of time in coating zone is what affects the tablet to tablet uniformity, not total residence time. (Allows mixing at ends for Batch mode start up). Bed tilt has an indirect effect on diffusion, it is needed to maintain flat/uniform depth at specified feed rate. Bed tilt needs to change From batch to continuous.
44 The information contained herein, to the best of Colorcon, Inc. s knowledge, is true and accurate. Any recommendations or suggestions of Colorcon, Inc. with regard to the products provided by Colorcon, Inc. are made without warranty, either implied or expressed, because of the variations in methods, conditions and equipment which may be used in commercially processing the products, and no such warranties are made for the suitability of the products for any applications that you may have disclosed. Colorcon, Inc. shall not be liable for loss of profit or for incidental, special or consequential loss or damages. Colorcon, Inc. makes no warranty, either expressed or implied, that the use of the products provided by Colorcon, Inc., will not infringe any trademark, trade name, copyright, patent or other rights held by any third person or entity when used in the customer s application. All trademarks, except where noted, are property of BPSI Holdings LLC. BPSI Holdings LLC, 2010
Advancements in continuous tablet coating Jim Marjeram O Hara Technologies
Advancements in continuous tablet coating Jim Marjeram O Hara Technologies 16 October 2008 0 Agenda Background on tablet coating Motivation for continuous processing Current continuous coating capability
More informationThe Effect of Coating Process Conditions and Coating Formula Type on the Quantity and Location of Water in Film Coated Tablets
OPADRY II Application Data High Performance Film Coating System The Effect of Coating Process Conditions and Coating Formula Type on the Quantity and Location of Water in Film Coated Tablets OBJECTIVES
More informationScuffing Measurement Methodology and Improved Film Coating Systems
OPADRY II Application Data High Performance Film Coating System Scuffing Measurement Methodology and Improved Film Coating Systems PURPOSE Scuffing is a term used to describe coated tablet defects consisting
More informationOpadry II / Opadry / Opaglos 2
Opadry II / Opadry / Opaglos 2 Application Data High Productivity Film Coating / Complete Film Coating System / High Gloss Film Coating Systems Modern Tablet Film Coatings and Influence on Ease of Swallowing
More informationNEBB STANDARDS SECTION-8 AIR SYSTEM TAB PROCEDURES
NEBB STANDARDS SECTION-8 AIR SYSTEM TAB PROCEDURES 8.1 INTRODUCTION Testing, adjusting, and balancing of HVAC systems can best be accomplished by following a series of systematic procedures. The NEBB TAB
More informationColours in Pharmaceutical Products
Colour Management For Formulators 23 rd October 2013 Colours in Pharmaceutical Products Marcel Cimpan Senior Manager Customer and Technical Services Agenda Uses for colours in the Pharmaceutical industry
More informationPortable Air Conditioner. OWNER S MANUAL Read these instructions before use. Model: MM14CHCSCS
Portable Air Conditioner OWNER S MANUAL Read these instructions before use Model: MM14CHCSCS Voltage rating: 120V~60Hz Power rating : 1400W(Cooling) Power rating : 1350W(Heating) Customer Support : 1-800-474-21477
More informationWell Water Iron Removal Using Quantum DMI-65 Granular Filter Media
Well Water Iron Removal Using Quantum DMI-65 Granular Filter Media ASME Research Committee Power Plant and Environmental Chemistry Overland Park, Kansas April 2-4, 2007 Prepared by: W. H. Stroman Primary
More informationetape Continuous Fluid Level Sensor Operating Instructions and Application Notes
etape Continuous Fluid Level Sensor Operating Instructions and Application Notes TM 1 Table of Contents 1.0 Specifications... 3 2.0 Theory of Operation... 3 3.0 Connection and Installation... 4 4.0 Technical
More informationFASCINATION 700 HVLP TANNING PRO SYSTEM USER MANUAL
FASCINATION 700 HVLP TANNING PRO SYSTEM USER MANUAL Congratulations on choosing the Fascination 700 HVLP Tanning Pro System! Your system includes the following items: 1 Fascination 700 HVLP Tanning Pro
More informationCentrifugal Fans and Pumps are sized to meet the maximum
Fans and Pumps are sized to meet the maximum flow rate required by the system. System conditions frequently require reducing the flow rate. Throttling and bypass devices dampers and valves are installed
More informationPerformance Evaluation of Actimask 92S Ibuprofen: A Novel Taste-Masked Ibuprofen for Use in Orally-Dispersible Dosage Forms
Performance Evaluation of Actimask 92S Ibuprofen: A Novel Taste-Masked Ibuprofen for Use in Orally-Dispersible Dosage Forms Author: Brian D. Wilson Background Recently, orally-dispersible dosage forms,
More informationUnderstanding Plastics Engineering Calculations
Natti S. Rao Nick R. Schott Understanding Plastics Engineering Calculations Hands-on Examples and Case Studies Sample Pages from Chapters 4 and 6 ISBNs 978--56990-509-8-56990-509-6 HANSER Hanser Publishers,
More informationPortable Air Conditioner. OWNER S MANUAL Read these instructions before use. Model: MF08CESWW. Voltage rating: 115V~60Hz Power rating : 800W
MODE ALARM Portable Air Conditioner OWNER S MANUAL Read these instructions before use 8 Model: MF08CESWW Voltage rating: 115V~60Hz Power rating : 800W Customer Support : 1-800-474-2147 For product inquiries
More informationVinod et al., ARPB, 2013; Vol 3 (II) ISSN 2250-0774
Vinod et al., ARPB, 2013; Vol 3 (II) ISSN 2250- (RESEARC ARTICLE) QUALIFICATION OF EQUIPMENT: SAIZONER MIXER GRANULATOR, COMPRESSION MACINE AND COATING PAN * J. Vinod and A. Chenthilnathan Department of
More informationTitan Makina Ltd. Şti. 1160. Sok. No: 9 Ostim 06370 Ankara Tel: + 90 312 354 9977 Fax: + 90 312 385 5611 Web: www.titanltd.com.
IS26 Concrete Spraying Machine IS26 Concrete Spraying Machine TECHNICAL SPECIFICATIONS Manipulator Max. vertical spraying reach : Max. horizontal spraying reach : Working lights : Spraying Head Rotation
More informationSession 2: Hot Water Supply
MEBS6000 Utility Services http://www.hku.hk/mech/msc-courses/mebs6000/index.html Session 2: Hot Water Supply Dr. Benjamin P.L. Ho Department of Mechanical Engineering The University of Hong Kong E-mail:
More informationCooling kw 5.2 6.0 7.1 Heating kw 5.65 6.35 7.75
Specifications COOLING ONLY / HEAT PUMP 005 006 007 Capacity (Eurovent) Cooling kw 5.2 6.0 7.1 Heating kw 5.65 6.35 7.75 Nominal input (Eurovent) Cooling kw 1.89 2.35 2.95 Heating kw 1.97 2.24 2.83 EER
More informationBasic Selection & Proper Application of Overhead Air Distribution Devices
Basic Selection & Proper Application of Overhead Air Distribution Devices GRD Selection & Application Terms Selection Throw Sound Installation Variations affect Performance Inlet Effects Basics Return
More informationMachine bolt shut-off nozzle type BHP pneumatically or hydraulically controlled
Machine bolt shut-off nozzle type BHP pneumatically or hydraulically controlled Applications: Thermoplastics (not applicable for PVC) Shut-off mechanism: Bolt shut-off with integrated 2-way actuator pneumatically
More informationMH 3M & 4M. High pressure washers with hot benefits
MH 3M & 4M High pressure washers with hot benefits The EcoPower boiler provides high efficiency and lowest equivalent fuel consumption as certified by EUnited. All key functions placed for optimal ease-of-use.
More informationHow To Order A Direct Flow Air Cleaner
Reduced Volume - Improved Performance - Flexible Packaging The patented Direct Flow technology provides the flexibility to optimize the air system performance to size ratio, meeting the demands of today
More informationPortable Air Conditioner. OWNER S MANUAL Read these instructions before use. Model: MM14CCS. Voltage rating: 115V~60Hz Power rating : 1400W
Portable Air Conditioner OWNER S MANUAL Read these instructions before use Model: MM14CCS Customer Support : 1-800-474-2147 Voltage rating: 115V~60Hz Power rating : 1400W For product inquiries or support
More informationEvaluating the Effects of Tablet Characteristics on Enteric Tablet Coating in the Novel Supercell TM Coater
Evaluating the Effects of Tablet Characteristics on Enteric Tablet Coating in the Novel Supercell TM Coater 1. Abstract A Birkmire and K Walter Niro Pharma Systems, Columbia, MD USA In the pharmaceutical
More informationHEAVY DUTY STORAGE GAS
Multi-Fin flue technology Flue damper saves energy Electronic controls HEAVY DUTY STORAGE GAS Dependability The Rheem heavy duty gas range is the work horse of the industry having proved itself over many
More informationHigh Capacity Hot Air Dryer
High Capacity Hot Air Dryer MADE IN AUSTRIA autumn 2015 www.zimmer-austria.com page 1 Hot air dryer type: Compact HC The modular construction of the high efficiency and powerful hot air nozzle dryer is
More informationHVAC Checklist - Long Form
HVAC Checklist - Long Form Page 1 of 14 Appendix B discusses HVAC system components in relation to indoor air quality. utside Air Intake Location pen during occupied hours? Unobstructed? Standing water,
More informationExample Retrocommissioning Measure: Opening Throttled Discharge Valves
Opening Throttled Discharge Valves This 21-story building, constructed in 1997, is located in Oregon and contains 589,000 gross square feet of mostly office occupancy. The HVAC system includes six large
More informationCooking at the Speed of light!
Cooking at the Infrared Cooking & Colouring Infrabaker is a modular infrared continuous cooking system developed by Infrabaker International. The machine is designed to cook and/or put colour on a wide
More informationPos. Qty. Article Description Price / Clamping surface 1.300 x 430 mm Additional table load 1200 kg 3 T-slots 14 H12 for mounting on fixture, etc..
Offer 1 1 Vertical CNC-machining centre model STAMA MC 531 Completely refurbished pre-owned machine Year of construction: 1998, Weight: 8.000 kg Machine-No. 1113 (Picture similiar) Scope of delivery: Technical
More informationASTACEA4 Inspect complex/central air conditioning systems
Overview This Unit covers the competences required to inspect complex/central air conditioning systems as defined by the CIBSE TM 44 Figure 1.1: Summary of system types and their component parts. The air
More informationDisco Purge Procedure
Page 1 of 6 Disco Purge Procedure Click to print. For more information, e-mail us at: packaging@dupont.com The Disco Purge Procedure for Extrusion Coaters Surlyn packaging resin Nucrel acid copolymer resin
More informationPortable Air Conditioner. OWNER S MANUAL Read these instructions before use. Model: MN12CES / MN10CESWW
Portable Air Conditioner OWNER S MANUAL Read these instructions before use 8 Model: MN12CES / MN10CESWW Voltage rating: 120V~60Hz Power rating : 1100W (MN12CES) Power rating : 900W (MN10CESWW) Customer
More informationFilter Fan Unit SILENT. Type SILENT AC Type SILENT EC
Technical Concept Filter Fan Unit SILENT Type SILENT AC Type SILENT EC Filter Fan Unit SILENT Technical Concept Product Description Filter Fan Units (FFUs) from M+W Products are designed to provide clean
More informationEfficiency on a large scale CFB Steam Boilers
Efficiency on a large scale CFB Steam Boilers Circulating Fluidized Bed Steam Boiler The Circulating Fluidized Bed Steam Boiler is an offering from Bosch Thermotechnology a member of the worldwide Bosch
More informationBroadBand PowerShield. User Manual
BroadBand PowerShield User Manual 990-0375G 12/2006 Chapter 1 General Information The PowerShield provides a power source for broadband telephony and other DC applications. Safety This Safety Guide contains
More informationAIRLESS SPRAY SYSTEMS
AIRLESS SPRAY SYSTEMS The Efficient Choice For Many Liquid Painting Applications Published by Nordson Corporation Conventional Air vs. Airless Systems: Selecting the Best Method Introduction Most paint
More informationHVAC Characteristics. Test Space HVAC Characteristics
HVAC Characteristics Information on the characteristics of the heating, ventilation, and air conditioning (HVAC) system(s) in the entire BASE building including types of ventilation, equipment configurations,
More informationDIESEL-FUELED, BLOWN AIR, DUCTABLE HEATERS
DIESEL-FUELED, BLOWN AIR, DUCTABLE HEATERS Electronic thermostatically controlled Low power consumption Compact space saving size Short heat-up times Dehumidification of the cabin Quiet when running Combustion
More informationSTARCH 1500. Application Data
STARCH 1500 Application Data Partially Pregelatinized Maize Starch Starch 1500, Partially Pregelatinized Maize Starch, Used as a Binder Disintegrant in High Shear Wet Granulation Comparison to Povidone
More informationExplosion-Proof Electric Unit Heaters
Type FX4 FX4 Explosion-Proof Electric Air Heaters FX4 heaters are UL listed and/or CSA certified for use in hazardous locations. They are designed for dry indoor industrial applications such as oil refineries,
More informationIntroducing AUDIT-BUDDY
Introducing AUDIT-BUDDY Optimize the Data Center with AUDIT-BUDDY Executive Summary Proper temperature and humidity for the inlet air into the servers is essential to efficient data center operation. Several
More informationMachine nozzle with needle shut-off type HP pneumatically or hydraulically controlled
Machine nozzle with needle shut-off type HP pneumatically or hydraulically controlled Applications: Thermoplastics (not applicable for PVC) Shut-off mechanism: Needle shut-off with integrated 2-way actuator
More informationModeling and Simulation of Complex Multiphase Flows in the Pharmaceutical Industry
SIMNET Days 2010 Februar 10, 2010 Modeling and Simulation of Complex Multiphase Flows in the Pharmaceutical Industry D. Suzzi a, G. Toschkoff a, S. Radl a,b, Th. Hörmann a, M. Schaffer a, D. Machold a,
More informationVisions become real. Temperature control and cooling systems. The innovative and reliable solution
Temperature control and cooling systems The innovative and reliable solution With our PulseTemp equipment you have the option of up to 72 cooling circuits in the impulse cooling, temperature control, temperature
More informationKALPANA INDUSTRIES LTD. TECHNICAL DATA SHEET
1 KALPANA INDUSTRIES LTD. TECHNICAL DATA SHEET KI XL - 03 / KI-SC 10 TWO COMPONENT AMBIENT CURABLE POLYETHYLENE COMPOUND FOR INSULATION OF LOW VOLTAGE POWER CABLE DESCRIPTION : KI polyethylene compound
More informationSCP 012-130 ISO. Other advantages: SCP 012-130 ISO is a series of piston pumps with a fixed displacement for mobile and stationary hydraulics.
SCP 012-130 ISO is a series of piston pumps with a fixed displacement for mobile and stationary hydraulics. SCP 012-130 ISO covers the entire displacement range 12-130 cmᶟ rev. at a maximum pressure of
More informationproduct application guide
Understanding Fan System Effects Fan Application FA/101-99 product application guide A technical bulletin for engineers, contractors and students in the air movement and control industry. The air moving
More information3516 Industrial Engine
CAT ENGINE SPECIFICATIONS V-16, 4-Stroke-Cycle Diesel Bore...170.0 mm (6.69 in) Stroke...190.0 mm (7.48 in) Displacement... 69.06 L (4,214.3 in 3 ) Aspiration...Turbocharged / Aftercooled Compression Ratio...13.0:1
More informationSWIMMING POOL AIR-HANDLING UNITS KU-DB Series
SWIMMING POOL AIR-HANDLING UNITS KU-DB Series ME20 proklima 2 SWIMMING POOL AIR-HANDLING UNITS - KU-DB Series proklima 3 TABLE OF CONTENTS 1 Introduction page 3 2 Features page 4 SWIMMING POOL AREA t =
More informationApproval Standard for Plastic Suspended Ceiling Panels
Approval Standard for Plastic Suspended Ceiling Panels Class Number 4651 February 1978 2002 FM Approvals LLC. All rights reserved. Foreword The FM Approvals certification mark is intended to verify that
More informationTechnical Data Sheet L1.05.03 Top coats. Mat Clear
Description Lesonal Mat clear provides a matt appearance over Lesonal Basecoat SB or may be intermixed with other suitable Lesonal clears to provide various gloss levels, for the protection and durability
More informationChapter 3.5: Fans and Blowers
Part I: Objective type questions and answers Chapter 3.5: Fans and Blowers 1. The parameter used by ASME to define fans, blowers and compressors is a) Fan ration b) Specific ratio c) Blade ratio d) Twist
More informationAir Conditioners Technical Data
Air Conditioners Technical Data O u t d o o r U n i t E E D E N 2-0 0 RX-JV Outdoor Unit RX-JV TABLE OF CONTENTS RX-JV Features............................................................. 2 2 Specifications.......................................................
More informationIn-Line Filters and Coalescers with Automatic Drains
Instructions/Parts In-Line Filters and Coalescers with Automatic Drains 310611G EN Air Filter with Automatic Drain Part No. 22601, Series B Maintenance To maintain maximum filtering efficiency and to avoid
More informationPOLYOX. Application Data
POLYOX Application Data Water Soluble Resins The Influence of In Vitro Dissolution Method on the Release of a Highly Water Soluble Drug from Polyethylene Oxide and Hypromellose Hydrophilic Extended Release
More informationSIMPLIFIED BOILER START UP METHOD FOR FLUIDISED BED COMBUSTION BOILERS
SIMPLIFIED BOILER START UP METHOD FOR FLUIDISED BED COMBUSTION BOILERS 1.0 SYNOPSIS The start up of fluidised bed combustion boilers has always been a subject of the most difficult operation. Many boiler
More informationQbD in der Praxis systematisches Vorgehen bei der Entwicklung pharmazeutischer Herstellprozesse. Adrian Funke
QbD in der Praxis systematisches Vorgehen bei der Entwicklung pharmazeutischer Herstellprozesse Adrian Funke Symposium der Fachgruppe Arzneimittelkontrolle / Pharmazeutische Analytik der DPhG Freiburg
More informationCDS TROUBLESHOOTING SECTION I. VACUUM. 1.0. Weak vacuum at wand. Gauge reads normal (10hg to 14hg)
CDS TROUBLESHOOTING SECTION I. VACUUM 1.0. Weak vacuum at wand. Gauge reads normal (10hg to 14hg) 1.1. Clogged hoses or wand tube. Disconnect hoses and carefully check for an obstruction. 1.2. Excessive
More informationTechnical Concept. Filter Fan Unit COMPACT. Type COMPACT AC Type COMPACT EC
Technical Concept Filter Fan Unit COMPACT Type COMPACT AC Type COMPACT EC Ultra Filter Fan Unit COMPACT Technical Concept Product Description Filter Fan Units (FFUs) from M+W Products are designed to provide
More information- White Paper - Data Centre Cooling. Best Practice
- White Paper - Data Centre Cooling Best Practice Release 2, April 2008 Contents INTRODUCTION... 3 1. AIR FLOW LEAKAGE... 3 2. PERFORATED TILES: NUMBER AND OPENING FACTOR... 4 3. PERFORATED TILES: WITH
More informationCE6500 Energy Recovery Ventilator
ADVANCED COMMERCIAL Energy Recovery Ventilator PRODUCT SPECIFICATIONS & TECHNICAL DATA Features NOMINAL CAPACITY 5500-7000 CFM CASING Double-wall cabinet White exterior paint, -gauge galvanized steel -gauge
More informationHVAC Simplified Approach Option
HVAC Simplified Approach Option Part I Project Address: City: HVAC System Designer of Record: Date: Zip: Qualification The building is 2 stories or less in height and has a gross floor area is less than
More informationData Center Design Guide featuring Water-Side Economizer Solutions. with Dynamic Economizer Cooling
Data Center Design Guide featuring Water-Side Economizer Solutions with Dynamic Economizer Cooling Presenter: Jason Koo, P.Eng Sr. Field Applications Engineer STULZ Air Technology Systems jkoo@stulz ats.com
More informationSavant Systems LLC Technical Application Note How to Guide: HVAC Scheduling Setup
Savant Systems LLC Technical Application Note How to Guide: HVAC Scheduling Setup Technical Description: This document describes how to schedule HVAC services. The HVAC Schedule allows the end user to
More informationInstant Messaging Nokia N76-1
Instant Messaging Nokia N76-1 NO WARRANTY The third-party applications provided with your device may have been created and may be owned by persons or entities not affiliated with or related to Nokia. Nokia
More informationMixing in the process industry: Chemicals Food Pharmaceuticals Paper Polymers Minerals Environmental. Chemical Industry:
Mixing Notes: Chapter 19 Robert P. Hesketh Mixing in the process industry: Chemicals Food Pharmaceuticals Paper Polymers Minerals Environmental Chemical Industry: Paints and Coatings Synthetic Rubbers
More informationLiebert Hiross HPW The High Performance Wallmount Cooling Solutions for Telecom Mobile Remote Access Nodes
Precision Cooling for Business-Critical Continuity Liebert Hiross HPW The High Performance Wallmount Cooling Solutions for Telecom Mobile Remote Access Nodes We re Emerson Network Power, backed by Emerson,
More informationIPACK2005-73273 DISTRIBUTED LEAKAGE FLOW IN RAISED-FLOOR DATA CENTERS
Proceedings of IPACK5 ASME InterPACK '5 July 17-, San Francisco, California, USA IPACK5-7373 DISTRIBUTED LEAKAGE FLOW IN RAISED-FLOOR DATA CENTERS Amir Radmehr Innovative Research, Inc. Plymouth, MN, USA
More informationProcess Validation Protocol (Reference: SOP )
Project Name Equipment Manufacturer Process Line/Location Project Number Serial Number Model Number Protocol number [Enter Product Title, Number & Strength] MULTI VITAMIN TABLETS PRODUCT CODE: Name: Position:
More informationCenter Thermal Management Can Live Together
Network Management age e and Data Center Thermal Management Can Live Together Ian Seaton Chatsworth Products, Inc. Benefits of Hot Air Isolation 1. Eliminates reliance on thermostat 2. Eliminates hot spots
More informationServer Chassis and Triplet Hardware v1.0
Server Chassis and Triplet Hardware v1.0 Author: Steve Furuta, Mechanical Designer 1 Scope This document describes the technical specifications for the custom chassis used in Open Compute Project servers
More informationSIGMACOVER 300. PRODUCT DATA SHEET December 12, 2014 (Revision of November 1, 2013) DESCRIPTION
DESCRIPTION Two-component, high-build, polyamine adduct-cured, coal tar epoxy coating PRINCIPAL CHARACTERISTICS Outstanding (sea)water resistance (outside hull and ballast tanks) Outstanding water- and
More informationUltra Coolant. The Best Performance. The Best Cost. The Best Coolant.
Ultra Coolant The Best Performance. The Best Cost. The Best Coolant. Ultra Coolant is not an oil. Ultra Coolant is an engineered synthetic coolant specifically designed to help rotary screw compressors
More informationKINGDOM OF SAUDI ARABIA SAUDI ARABIAN STANDARDS ORGANIZATION SASO. SAUDI STANDARD DRAFT No. 3457/2005
KINGDOM OF SAUDI ARABIA SAUDI ARABIAN STANDARDS ORGANIZATION SASO SAUDI STANDARD DRAFT No. 3457/2005 NON-DUCTED AIR CONDITIONERS AND HEAT PUMPS TESTING AND RATING PERFORMANCE This standard is developed
More informationA Guide to Trouble-Free Cooling Towers
A Guide to Trouble-Free Cooling Towers A basic understanding of cooling tower operation and maintenance will help keep a cooling water system running in top condition, year after year By David M. Suptic
More informationFusion Pro QbD-aligned DOE Software
Fusion Pro QbD-aligned DOE Software Statistical Experimental Design Analysis & Modeling Robustness Simulation Numerical & Graphical Optimization 2D, 3D, & 4D Visualization Graphics 100% aligned with Quality
More informationSense. 3D Scanner. User Guide. See inside for use and safety information.
Sense 3D Scanner User Guide See inside for use and safety information. 1 CONTENTS INTRODUCTION.... 3 IMPORTANT SAFETY INFORMATION... 4 Safety Guidelines....4 SENSE 3D SCANNER FEATURES AND PROPERTIES....
More information(This report is endorsed) Industrivej 20, 9900 Frederikshavn, Danmark
Spectrum Laboratories Ltd is accredited by International Accreditation New Zealand (formerly Telarc). The tests reported herein have been performed in accordance with the terms of our accreditation. This
More informationHeat Recovery Dehumidification (HRD) system. Designed for municipal swimming pools
Heat Recovery Dehumidification (HRD) system Designed for municipal swimming pools A dehumidification and ventilation system with dynamic heat pump heat recovery to swimming pool water and air ENVIRONMENTAL
More informationInnovent LASER Packaged Fresh Air Conditioning Units
LASER Latent And Sensible Energy Reduction Latent And Sensible Energy Reduction For Outside Air Innovent LASER Packaged Fresh Air Conditioning Units Innovent LASER units provide both sensible and latent
More informationSIGMAFAST 210. PRODUCT DATA SHEET December 12, 2014 (Revision of April 1, 2013) DESCRIPTION
DESCRIPTION Two-component, high-build zinc phosphate polyurethane primer/finish PRINCIPAL CHARACTERISTICS Specially designed for in-shop application Fast-curing Easy application by airless spray Unlimited
More informationSUN ORACLE DATABASE MACHINE
SUN ORACLE DATABASE MACHINE FEATURES AND FACTS FEATURES From 1 to 8 database servers From 1 to 14 Sun Oracle Exadata Storage Servers Each Exadata Storage Server includes 384 GB of Exadata Smart Flash Cache
More informationRMF TANDEM 900 OFF-LINE FILTER SYSTEMS
RMF TANDEM 900 OFF-LINE FILTER SYSTEMS RMF Tandem 900 Off-line filter Systems can be applied to every imaginable industrial application where hydraulic or lubrication systems are present. An integrated
More informationQuick Guide to Injection Molding
Quick Guide to Injection Molding Amodel polyphthalamide (PPA) Equipment Amodel PPA resins can be processed on conventional injection molding equipment. Estimated clamp tonnage of 5.5 kn/cm 2 (4 T/in 2
More informationHelp. Help Software Tutorial. Building a load sizing project with an ME Series Humidifier
Help Help Software Tutorial Building a load sizing project with an ME Series Humidifier 502-B 18 Aug 2015 Help Tutorials provide step-by-step examples of complete load sizing projects and browser projects
More informationHow To Improve Energy Efficiency Through Raising Inlet Temperatures
Data Center Operating Cost Savings Realized by Air Flow Management and Increased Rack Inlet Temperatures William Seeber Stephen Seeber Mid Atlantic Infrared Services, Inc. 5309 Mohican Road Bethesda, MD
More informationCoolTeg Plus Chilled Water (CW) version: AC-TCW
version: 12-04-2013 CONTEG DATASHEET TARGETED COOLING CoolTeg Plus Chilled Water (CW) version: AC-TCW CONTEG, spol. s r.o. Czech Republic Headquarters: Na Vítězné pláni 1719/4 140 00 Prague 4 Tel.: +420
More informationOperation and Installation Manual. Max Series
Operation and Installation Manual Max Series Models 95MAX 155MAX 155ECM 155MAXRX 200MAX 200MAXRX MAXTOP 195DCS 300DCS 200ERV 200ERVD New Auto Dehumidistat Function prevents unwanted use of the dehumidistat
More informationCURBING THE COST OF DATA CENTER COOLING. Charles B. Kensky, PE, LEED AP BD+C, CEA Executive Vice President Bala Consulting Engineers
CURBING THE COST OF DATA CENTER COOLING Charles B. Kensky, PE, LEED AP BD+C, CEA Executive Vice President Bala Consulting Engineers OVERVIEW Compare Cooling Strategies in Free- Standing and In-Building
More informationDIESEL FUEL CONDITIONING
COD FILTRATION DIESEL FUEL CONDITIONING REMOVE WATER & PARTICLES TO EXTEND FUEL INJECTOR LIFE & INCREASE COMBUSTION ENGINE FUEL EFFICIENCY Remove free water to saturation point with high single pass efficiency
More informationRapid Application Development for Machine Vision A New Approach
Rapid Application Development for Machine Vision A New Approach Introduction Converging technologies, such as the PCI-bus and Intel MMX, have created so much bandwidth and computing power that automation
More informationAstellas Ireland Company Ltd. (Kerry Plant) Ampoule Inspection Machine. Eoin O Sullivan 5th June 2014
Astellas Ireland Company Ltd. (Kerry Plant) Ampoule Inspection Machine Eoin O Sullivan 5th June 2014 Facility History Location. AICL-Dublin Plant AICL-Kerry Plant AICL-Kerry Plant Establishment September
More informationAKRON EDUCTORS TROUBLESHOOTING GUIDE OPERATION & THEORY OF EDUCTORS GENERAL OPERATING AND MAINTENANCE INSTRUCTIONS
AKRON EDUCTORS TROUBLESHOOTING GUIDE OPERATION & THEORY OF EDUCTORS GENERAL OPERATING AND MAINTENANCE INSTRUCTIONS Products Include: 60 gpm eductors Style 3060, 3061, 3062 & 3070 95 gpm eductors Style
More informationC18 ACERT Fire Pump Tier 3 448 bkw/600 bhp @ 1750 rpm
CATERPILLAR ENGINE SPECIFICATIONS I-6, 4-Stroke-Cycle Diesel Bore...145.0 mm (5.71 in) Stroke...183.0 mm (7.2 in) Displacement... 18.1 L (1,104.53 in3) Aspiration...Turbocharged Aftercooled Compression
More informationDIESEL-FUELED, BLOWN AIR, DUCTABLE HEATERS
DIESEL-FUELED, BLOWN AIR, DUCTABLE HEATERS Electronic thermostatically controlled Low power consumption Compact space saving size Short heat-up times Dehumidification of the cabin Quiet when running Combustion
More informationPrecision Humidity Measurement for Pharmaceutical Fluid Bed Tablet Coating
Precision Humidity Measurement for Pharmaceutical Fluid Bed Tablet Coating are several reasons why tablet cores are coated, including: Alpharma/Purepac is one of the largest global generic pharmaceutical
More informationSATAjet 5000 B. Spray Guns I Cup Systems I Breathing Protection I Air Filtration I Accessories. As versatile as you
SATAjet 5000 B Spray Guns I Cup Systems I Breathing Protection I Air Filtration I Accessories As versatile as you Supreme fl exibility The SATAjet 5000 B The premium spray gun SATAjet 5000 B sets new quality
More informationSpray Nozzles. Spray Control. Spray Fabrication. Spray Analysis. A Guide to Optimizing In-Tank Agitation and Mixing Using Eductors
s Control Analysis Fabrication A Guide to Optimizing In-Tank Agitation and Mixing Using Eductors Eductors Ensure Thorough Mixing to Improve Product Quality and Reduce Maintenance Time Tank mixing eductors
More information