LABORATORY NORMAL RANGES. Prepared by Date Adopted Supersedes Procedure #/Dated William Pope, PhD &

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1 Prepared by Date Adopted Supersedes Procedure #/Dated William Pope, PhD & QM-000 / Elizabeth Holland, MT (ASCP) GENERAL CHEMISTRY Acetone None detected Albumin, g/dl Alk, Phosphatase, u/l years years 2 12 years 0 2 years Ammonia, um/l Amylase, u/l Serum Bilirubin, Total, mg/dl s Bilirubin, Neonatal, mg/dl s >18 Bilirubin, Conjugated BUN, mg/dl months Calcium, mg/dl Chloride meq/l Serum Cholesterol, mg/dl years 0 1 year < 6.0, > 12.0 Cholesterol, HDL, mg/dl > 60 Low CHD Risk Cholesterol, LDL, mg/dl Desirable < 100 Optimal / Low Risk CO2, meq/l < 10, > 40 CPK, u/l Creat., mg/dl years years years QM-000 Page 1 of 17

2 Normal (95% of population) Low CHD Risk Average CHD Risk High CHD Risk Suspect Acute Inflammation, repeat hscrp for CHD Risk assessment in 2 wks CRP hs, mg/dl < > 0.30 > 1.0 CSF FI. Prot., mg/dl < 1 month Glucose, mg/dl Impaired fasting glucose GGT, u/l 6 39 > 3 months months < 1 month Iron, ug/dl Iron TIBC Iron - % Sat K+, meq/l months Lactic Acid mmol/l > 4.0 Lipase, u/l LDH, u/l HDL Chol > 60 LDL Chol years 1 6 years 0-1 year Low CHD Risk Desirable Optimal / Low Risk < 40 Outpatient, < 1 mth, < 50 Inpatient, > 500 All < 2.5, >6.5 < 100 Magnesium, mg/dl < 1.2, > 4.9 Na+, meq/l <120, > 155 Osmolality, mosm/kg < 250, > 320 PCHE k u/l Phosphorus, mg/dl > 12 yrs 3 12 yrs 1 3 yrs < 1 yr < 1.0 QM-000 Page 2 of 17

3 SGOT (AST), u/l months SGPT (ALT), u/l 5 37 Total Protein, g/dl Triglycerides, mg/dl Uric Acid, mg/dl > 3 yrs 1 3 yrs 0 1 yr 9 13 yrs 0 9 yrs CALCULATED VALUES BUN/Creatinine Ratio 6 22 Anion Gap (Na-(Cl+CO2)) Albumin/Globulin Ratio TIBC, ug/ml % SAT, % LDL, mg/dl yrs yrs, <100 optimal > 29 yrs, <100 optimal BLOOD GAS ph PCO2, mm/hg PO2, mm/hg < 6 mths, < 7.2, > 7.6, 6 mths < 7.3, > 7.6 -arterial- < 20, > 60 < 50 QM-000 Page 3 of 17

4 COOX The Medical Central Georgia Quality Management Total Hb, g/dl % O2 Hb, % CO Hb, % < 5.0 Met Hb, % O2, vol % 15-23,, Non-smokers Smokers > 20 > 20 IONIZED CALCIUM Calcium, mmol/l < 0.8, >1.6 ph TEST THERAPEUTIC RANGE TOXIC (CRITICAL RANGE) TDM & TOXICOLOGY Acetaminophen, mg/dl < 20 > 150 (4 hr, post dose) or > 40 (12 hr. post dose) Amikacin, ug/ml Peak Trough > 30 > Severe Infections Carbamazepine, ug/ml 8 12 > 20 Digoxin, ug/ml > 2.4 Gentamicin, ug/ml 5 10 Peak > Trough > 2.0 Lithium, meq/l > 1.5 Pentobarbital, ug/ml 1 5 > Treatment of intracranial pressure with supportive therapy. Phenobarbital, ug/ml > 50 Phenytoin, ug/ml (Dilantin) > 30 Phenytoin, Free, ug/ml > 2.5 QM-000 Page 4 of 17

5 TEST THERAPEUTIC RANGE TOXIC (CRITICAL RANGE) Quindine, ug/ml 2 5 > 10 Salicylate, mg/dl 2 29 >34 mg/dl Theophylline, gu/ml s Neonates (< 6 mos. old) > 25 > 20 Tobramycin, ug/ml Peak Trough > 12 > 2 Valproic Acid, ug/ml > 200 Vancomycin, ug/ml Peak Trough > 80 > 24 Ethanol, mg/dl None Detected > 300 Ethylene Glycol, mg/dl 0 5 > 20 Isopropanol None Detected > 150 Methanol None Detected > 50 Urine Drug Screening None Detected URINE CHEMISTRIES Acetone None Detected Creatinine, urine, g/24 hrs Creatinine Clearance, > 3 years mg/min Calcium, urine, mg/24 hrs Avg. calorie diet High Calorie diet Magnesium, urine, mg/ hrs Microalbumin, urine, mg/dl <30 mg/24 hr Osmolality, urine, mosm/kg Protein, urine, mg/dl g/24 hrs < QM-000 Page 5 of 17

6 Urea nitrogen, urine, 5 20 g/24 hrs Uric Acid, urine, mg/24 hrs Urine Protein/Urine Creatinine Ratio < 0.20 Sodium, urine meq/24 hr Potassium (K), urine meq/24 hr Chloride (Cl), urine, meq/24 hr OTHER FLUID CHEMISTRIES Sweat Chloride, meq/l L/S Ratio, Amniotic Fluid > 2.3 Consistent with fetal lung maturity < 1.5 Suggestive of fetal lung immaturity Phosphotidyl Glycerol, Amniotic Fl, ug/ml Lamellar Body Count (LBC), particles/ul > 1.9 < < 0.5 > 50k <15 Positive fetal lung maturity Wk Pos suggests fetal lung maturity indeterminate for lung maturity Mature Transitional Immature IMMUNOASSAY / IMMUNOLOGY ACTH, pg/ml AFP (tumor, marker), ng/ml < 9 Alpha 1 antitrypsin, mg/dl Anti-CCP, U/mL <5.0 Anti-Thyroid Peroxidase <5.61 AB, IU/ml B12, pg/ml < 130 > percentile Deficiency No Deficiency BNP, pg/ml < 100 C-Peptide, ng/ml 1 5 CA-125, U/ml < 35 CA 19-9, U/ml 0 34 CEA, ng/ml < 3 Non smoker QM-000 Page 6 of 17

7 < 5 Smoker Ceruloplasmin, mg/dl CKMB, ng/ml Complement C-3, mg/dl Complement C-4, mg/dl Cortisol, ug/dl 7 25 AM (collected between 6-8 am) 2 14 PM (collected between 4-6 pm) DHEA Sulphate, ug/dl and, 0-6 days and, 1-4 weeks and, 1-11 mths 0-19 and, 1-4 yrs 3-85 and, 5-9 yrs , yrs , yrs , yrs , yrs , yrs , yrs , yrs , yrs , >65 yrs , yrs , yrs , yrs >55 yrs Estradiol, pg/ml ND 75 < Haptoglobin, mg/dl : Post-menopausal Mid-follicular Mid-luteal Peri-ovulatory Ferritin, ng/ml Folate, ng/ml Suggestive of deficiency FSH, MIU/ml : Mid-follicular Mid-cycle peak Mid-luteal Post-menopausal QM-000 Page 7 of 17

8 HCG, mlu/ml 0 5, s < 40 yrs 7 > 40 yrs Hemoglobin A1C, % Increased risk 6.5 Consistent with Diabetes Homocysteine, umol/l < 7.2 Desirable IgA, mg/dl IgG, mg/dl IgM, mg/dl Insulin, ulu/ml Fasting Kappa Free Light Chain, Serum, mg/l Kappa Free Light Chain, Urine, mg/l Lambda Free Light Chain, Serum, mg/l Lambda Free Light Chain, Urine, mg/l K/L Serum Ratio K/L Urine Ratio LH, MIU/ml Myoglobin, ng/ml PTH, pg/ml PTH, Intraoperative, pg/ml Prealbumin, mg/dl Procalcitonin, ng/ml Child : Mid-follicular Mid-cycle peak Mid-luteal Post-menopausal > 2.0 High risk of sepsis Progesterone, ng/ml : Mid-follicular Mid-luteal QM-000 Page 8 of 17

9 ND 0.78 Post-menopausal Preg. 1 st Trimester Preg. 2 nd Trimester Prolactin, ng/ml Prostate Specific Antigen, (PSA), ng/ml Rheumatoid Factor, u/ml 0 25 RBC Folate, ng/ml Testosterone, ng/dl : Pre-menopausal Post-menopausal years years years > 69 years 0 5 years, 5 11 years, years, 14 16, 17, 5 11 years, years T3, Free, pg/ml T3, Total, ng/dl days T4, ug/dl T4, Free (measured), ng/dl FTI, ug/ml T-Uptake, T-Uptake Units TSH, UlU/ml Thyroglobulin, ng/ml < 33 (tumor marker) <5 Thyroglobulin Antibodies, IU/ml <4.11 Transferrin, mg/dl Troponin, ng/ml Vitamin D, gn/ml <12 <20 >60 >80 > 16 yrs Athyrotic Cardiac Injury Severe Deficiency Deficiency Potential for Adverse Effects Toxicity > 0.50, first incident only within 24 hrs QM-000 Page 9 of 17

10 ELECTROPHORESIS Hemoglobin Elect. Fetal Hemoglobin AA Pattern 55 85% 2.1% Protein Elect Total protein, g/dl Albumin, g/dl Alpha 1, g/dl Alpha 2, g/dl Beta, g/dl Gamma, g/dl At birth > 2 years 3 12 months > 3 years 0 3 months 3 12 months months > 2 years 0 2 months > 2 months 1 3 months 3 12 months >12 months 1 3 months 3 12 months month > 2 years 1 3 months 3 12 months months > 2 years HEPATITIS & HIV MARKERS Hepatitis B Surface Ag Positive Hepatitis B Surface Ab Positive = Immune = Non-immune HIV 1/2 Positive Hepatitis C Virus Ab Hepatitis B Core Ab Hepatitis B Core IgM Ab Hepatitis A Virus IgM QM-000 Page 10 of 17

11 SEROLOGY Rubella Positive = Immune = Non-immune Infectious Mononucleosis Mycoplasma pneumoniae ASO <200 IU/mL Cryptococcal Antigen Positive ANA Screen Sm Antibody RNP Jo1 SSA SSB SCL70 dsdna Centromere Histone HEp2NA HSV IgM Type 1/2 HSV IgG Type 1 HSV IgG Type 2 PF4 (Platelet Factor 4) Positive RPR TP-PA Non-Reactive VDRL Non-Reactive H. pylori Breath Test H. pylori IgG Fetal Fibronectin QM-000 Page 11 of 17

12 HEMATOLOGY WBC, K/mm RBC, M/mm Hemoglobin, gm/dl Hematocrit, % MCV, fl MCH, pg MCHC, % month < 2 years 2 < 9 years 9 < 18 years 18 years 1 month < 2 years 2 < 9 years, 9 < 18 years, 9 < 18 years, 18 years, 18 years 1 month < 2 years 2 < 9 years, 9 < 18 years, 9 < 18 years, 18 years, 18 years 1 month < 2 years 2 < 9 years, 9 < 18 years, 9 < 18 years, 18 years, 18 years 1 month < 2 years 2 < 9 years, 9 < 18 years, 9 < 18 years 18 years 1 month < 2 years 2 < 9 years 9 < 18 years 18 years 1 month < 2 years 2 < 18 years 18 years < 2.00, > 7.00 < 6.9, > 25.0 < 6.0, > 20.0 < 20.0, > 75.0 < 19.0, > 60.0 QM-000 Page 12 of 17

13 RDW, % The Medical Central Georgia Quality Management 1 month < 2 years 2 < 9 years 9 < 18 years 18 years Platelet, K/mm < 20, > 1,000 MPV, fl NRBC, % 0 Differential Neutrophils, % Bands, % 0 10 Lymphocytes, % Monocytes, % 0 10 Eosinophils, % 0 7 Basophils, % 0 2 Automated Reticulocyte Absolute Retic, M/mm % Retic, % Immature Retic Fraction (IRF), M/mm OTHER HEMATOLOGY Manual Reticulocyte Retic % Manual Absolute Retic, M/mm Retic Index, % Sedimentation Rate (ESR), mm/hr Eosinophil Blood, mm Leukocyte Alkaline Phosphatase (LAP score) Kleihauer-Betke, % fetal 0.00 cells Malaria Smear No parasites seen, 0 < 50 years, 0 < 50 years, 50 years, 50 years 0 < 1 year 1 year Positive for malaria or other parasite QM-000 Page 13 of 17

14 Myeloperoxidase Normal peroxidase activity COAGULATION Antithrombin III Activity, % D-Dimer, µg/ml FEU < 0.46 Factor VIII, % Factor IX, % Fibrinogen, mg/dl Heparin, IU/ml LMW, Therapeutic LMW, Prophylactic Unfractionated, Therapeutic P2Y12, PRU PT, sec INR PTT, sec PFA, sec Epinephrine ADP Protein C Activity, % Protein S Activity, % Thrombin Time, sec Thromboelastograph (TEG) R, min K, min AA, Deg MA, mm URINALYSIS Specific Gravity ph Protein Glucose Ketones Bilirubin Nitrite Leukocyte Esterase Blood Urobilinogen RBC, hpf 0 4 WBC, hpf 0 4 Hyaline cast, lpf 0 7 Squamous Epithelial, hpf 0 3 QM-000 Page 14 of 17

15 Bacteria None seen - Occasional HCG Qualitative, Urine Eosinophils, Urine None seen BODY FLUIDS CSF Cell Count / Diff Color Clear Turbidity Colorless Xanthochromia WBC, /mm RBC, /mm Neutrophils, % 0 6 Lymphocytes, % Monocytes, % Eosinophils, % 0 Basophils, % 0 Fluid Cell Count / Diff Color Clear Turbidity Colorless WBC, /mm RBC, /mm Neutrophils, % 0 6 Lymphocytes, % Monocytes, % Eosinophils, % 0 Mesothelials, % 0 Group A Strep Wet Prep, Vaginal Epithelial Cells None seen White Blood Cells None seen Yeast None seen Trichomonas None seen Clue Cells None seen POINT OF CARE i-stat SYSTEM Sodium, meq/l Capillary Children 0 1 month Potassium, mmol/l *(0-3 mos) *(0-6 mos) QM-000 Page 15 of 17 <120, >155 <120, >158 <120, >158

16 Capillary *for all, <2.5, >6.5 Chloride, mmol/l Ionized Calcium, mmol/l Capillary *for all, <0.8, >1.6 ph pco2, mm/hg po2, mm/hg BE, mmoi/l Hematocrit, % PCV Capillary Capillary Capillary (-2) (+2) (-2) (+2) (1 mo-adult) & (0-1 ms) & ACT (k), Seconds Troponin I, ng/ml Creatinine, mg/dl Capillary Lactate, mmol/l PT, INR Capillary TCO2 on the i-stat Cartridge (measured) 24 29, Children, 0 1 Month QM-000 Page 16 of 17 <7.30, >7.60 <7.20, >7.60 <7.20, >7.60, < 20, > 60, Children, Children 0 1 Month > 180 Children > 4.0 Children < 50 < 50 < 20, > 60 < 20, > 60 < 20, > 75 > 7.4 > 3.8 < 11, > 40 < 11, >39 MICROBIOLOGY APT ADULT Hgb Chlamydia DNA Probe Clostridium difficile toxin Cryptosporodium Antigen Fecal Fat (Qualitative) Normal Fecal ph Flu A/B Antigen Giardia Antigen Gonorrhoeae DNA probe Herpes viral culture

17 Ova and Parasite Exam, Comprehensive Fecal Reducing Substance Rotavirus Antigen Respiratory Syncytial Virus Antigen Fecal Trypsin No amoeba, ova, or parasite seen Positive Positive Semen Volume ml Viscosity Normal Motility % Normal Forms >60% Count sperm/million/ml NOTE: The lab s policy for reporting critical values can be found in the Lab Policy Manual III.309 Critical Values. This is a restatement of those values. A copy of this procedure is also located in the Central Georgia Cancer Care Manual. Approved Reviewed Reviewed Reviewed Reviewed Reviewed Date Signature QM-000 Page 17 of 17