Autologous CD34+ and CD133+ stem cells transplantation in patients with end stage liver disease

Size: px
Start display at page:

Download "Autologous CD34+ and CD133+ stem cells transplantation in patients with end stage liver disease"

Transcription

1 Autologous CD34+ and CD133+ stem cells transplantation in patients with end stage liver disease Overview Yasser A. Abdelghani, 2012 Tropical Medicine Department, Minia University, EGYPT Until now, liver transplantation has been considered the only curative treatment for decompensated cirrhosis. However, this procedure is limited by technical difficulties, high cost, and also by a lack of donors. Stem cells have recently shown promise in cell therapy because they have the capacity for self-renewal and multilineage differentiation, and are applicable to human diseases. Basis of Stem Cell Transplantation Stem cells are present in different tissues, with a rich source in the bone marrow. Different manipulation techniques, such stimulation with as granulocyte colony stimulating factor, enabled the scientists to use stem cells effectively to treat different diseases with different etiologies. Endogastrohep Emagazine ; 1

2 There are two types of stem cells in the human bone marrow; mesenchymal stem cells, and haematopoeitic stem cells (HSCs). HSCs are CD34, CD133. Hematopoietic CD34, CD133 Stem cells are specialized in forming different blood elements and being stem cells, they have the character of plasticity and can change into hepatocyte-like cells either by transdifferentiation or by cell fusion. Benefits of Stem Cell Transplantation Transplantation of BMSCs can restore liver mass and function, alleviate fibrosis, and correct inherited liver diseases. Therefore, it can significantly improve the liver function of patients with terminal liver disease, with good safety and effectiveness. Routes of delivery of the stem cells to the liver BMSCs can be delivered via The intraportal vein, Systemic infusion, Intraperitoneal, Intrahepatic, and Intrasplenic routes. 2

3 Indications for Stem Cell Transplantation Stem Cell Transplantation is indicated for end-stage liver disease, with the following inclusion criteria: Patients aged from 20 to 60 years with evidence of chronic liver insufficiency decreased serum albumin and/or increased bilirubin and/or increased international normalized ratio-(inr), child turcott pugh score of 7 or more, patients unlikely to receive a liver transplant and who had a World Health Organization (WHO) performance score of less than 2 with an ability to give a written consent. Contraindications for Stem Cell Transplantation Patients below the age of 20 or above the age of 60 years, Pregnant or lactating women, Those with recent recurrent gastrointestinal bleeding, Hepatocellular carcinoma, Presence of hepatic, portal, or splenic vein thrombosis Spontaneous bacterial peritonitis, An evidence of human immunodeficiency virus or other life threatening infection, Unable to give a written consent, or History of hypersensitivity to G-CSF. 3

4 Preparation of the patient for Stem Cell Transplantation Daily subcutaneous injection of granulocyte colony stimulating factor (G- CSF at 300 g- 300 g/vials) for five days to increase the number of circulating hematopoietic cells. BM stem cell aspiration One day before stem cell infusion, patient s skin was cleaned with 70% alcohol at the iliac crest, which is the usual site for puncture in adults. Skin, subcutaneous tissues, and periosteum overlying the selected site for puncture were infiltrated with xylocaine local anesthesia, and Serial punctures from multiple sites were performed. With a boring movement, needles (Salah and Klima) were passed perpendicularly into the cavity of the ileum at a point just posterior to anterior superior iliac spine or 2 cm posterior and 2 cm inferior to the anterior superior iliac spine to aspirate 250 ml of the BM. Preparation of bone marrow-enriched CD34+ and CD133+ cells Following collection, the BM products were transferred to the stem cell laboratory for immuno-magnetic purification of the CD34+ and CD133+ stem cell population. 4

5 CD34+ and CD133+ cells were isolated using the positive cell selection kit. Collected cells were washed twice with phosphate buffered saline ph 7.4, supplemented with 0.5% bovine serum albumin and 5 mmol/l EDTA, and centrifuged at 1500 r/min for 10 min at 4. The cell suspension was counted, adjusted to , centrifuged, and resuspended in 100 ml physiological saline. Infusion of the stem cells to the patient Intraporal vein infusion is the most preferred route of delivery. Choice of the portal vein infusion was based on a preclinical model, which reported that HSCs, if applied to the portal vein, demonstrate a high percentage of firstpass entrapment in the liver. Intraportal infusion: patients were admitted to hospital and infused. While fasting, with the purified human stem cells into the portal vein (as previously determined by duplex Doppler scan to assess its potency) under ultrasound guidance using, diazepam 10 mg IV for sedation and xylocaine local infiltration anesthesia. Intraarterial infusion: after local anathesia, puncture of right femoral arery was performd, and ² French sheaths were inserted. Simon catheter advanced to the descending aorta, and catheterization of celiac axis and then 5

6 hepaticartery was performed. Nonionic low osmolal radiocontrast agent was used to visualize the hepatic artery. Then the stem cells infusd to the hepatic artery. After that, the catheter was flushd with 10cc of normal saline and the procedure was finished. Follow up Improvement in the hepatic functional reserve of transplanted patients is gradual, as assessed by the Child-Pugh score. The maximum improvement in the Child-Pugh score occurs after 6 months. There was an improvement in the transplanted patients, as regards WHO performance score, and the quality of life starting from the 1st month after the HSCs. Complications Infections Radiocontast nephropathy (if radiocontrst is used as in intraarterial infusion) 6

7 Conclusion Autologous stem cell transplantation may be safely administered and appears to offer some therapeutic benefit to patients with end-stage liver disease. NB HCV is a hepatotropic virus. Therefore low viral load is noted in patients with end-sage liver disease.thus, one month after stem cell transplantation, higher levels of viral replication were restored due to regeneration of liver after stem cell transplantation NB Autologous: means from the patient himself. Heterologous: means from different patient Allogenic: means genetically different although obtained from the same patient Yasser A. Abdelghani

Blood & Marrow Transplant Glossary. Pediatric Blood and Marrow Transplant Program Patient Guide

Blood & Marrow Transplant Glossary. Pediatric Blood and Marrow Transplant Program Patient Guide Blood & Marrow Transplant Glossary Pediatric Blood and Marrow Transplant Program Patient Guide Glossary Absolute Neutrophil Count (ANC) -- Also called "absolute granulocyte count" amount of white blood

More information

Vascular Access. Chapter 3

Vascular Access. Chapter 3 Vascular Access Chapter 3 Vascular Access Introduction Obtaining vascular access in infants and children can be difficult even under optimal conditions. Attempting emergent access in a hypotensive, struggling

More information

STANDARDIZED PROCEDURE BONE MARROW ASPIRATION

STANDARDIZED PROCEDURE BONE MARROW ASPIRATION I. Definition: This protocol covers the task of bone marrow aspiration by an Allied Health Professional. The purpose of this standardized procedure is to allow the Allied Health Professional to safely

More information

MANAGEMENT OF LIVER CIRRHOSIS

MANAGEMENT OF LIVER CIRRHOSIS MANAGEMENT OF LIVER CIRRHOSIS Information Leaflet Your Health. Our Priority. Page 2 of 6 What is cirrhosis? Cirrhosis is a result of long-term, continuous damage to the liver and may be due to many different

More information

PERIPHERAL STEM CELL TRANSPLANT INTRODUCTION

PERIPHERAL STEM CELL TRANSPLANT INTRODUCTION PERIPHERAL STEM CELL TRANSPLANT INTRODUCTION This booklet was designed to help you and the important people in your life understand the treatment of high dose chemotherapy with stem cell support: a procedure

More information

Evaluation and Prognosis of Patients with Cirrhosis

Evaluation and Prognosis of Patients with Cirrhosis Evaluation and Prognosis of Patients with Cirrhosis Marion G. Peters, MD John V. Carbone, MD, Endowed Chair Professor of Medicine Chief of Hepatology Research University of California San Francisco Recorded

More information

HEPATITIS C DIAGNOSIS AND MANAGEMENT

HEPATITIS C DIAGNOSIS AND MANAGEMENT HEPATITIS C DIAGNOSIS AND MANAGEMENT Introduction The hepatitis C virus (HCV) is one of six viruses (A, B, C, D, E, G) that account for the majority of cases of viral hepatitis. It is responsible for about

More information

HEMATOLOGY/ONCOLOGY CLINICAL PRIVILEGES

HEMATOLOGY/ONCOLOGY CLINICAL PRIVILEGES Name: Page 1 dinitial Appointment Reappointment All new applicants must meet the following requirements as approved by the governing body effective: 8/5/2015. Applicant: Check off the Requested box for

More information

Hepatitis C Prior Authorization Criteria and Policy Texas Medicaid Vendor Drug Program

Hepatitis C Prior Authorization Criteria and Policy Texas Medicaid Vendor Drug Program Hepatitis C Prior Authorization Criteria and Policy Texas Medicaid Vendor Drug Program I. Patient Eligibility Patient is a Texas Medicaid Patient greater than or equal to 18 years of age Patient must have

More information

Information for patients (and their families) waiting for liver transplantation

Information for patients (and their families) waiting for liver transplantation Information for patients (and their families) waiting for liver transplantation Waiting list? What is liver transplant? Postoperative conditions? Ver.: 4/2016 1 What is a liver transplant? Liver transplantation

More information

Hepatitis A, B, C. This material is intended for insurance informational purposes only and is not personal medical advice for clients.

Hepatitis A, B, C. This material is intended for insurance informational purposes only and is not personal medical advice for clients. Hepatitis A, B, C Hepatitis is a general term referring to inflammation of the liver. The usual cause is viral, either Hepatitis A, B, or C. However, toxins and drugs may also induce a hepatitis. The onset

More information

After the Cure: Long-Term Management of HCV Liver Disease Norah A. Terrault, MD, MPH

After the Cure: Long-Term Management of HCV Liver Disease Norah A. Terrault, MD, MPH After the Cure: Long-Term Management of HCV Liver Disease Norah A. Terrault, MD, MPH Professor of Medicine Department of Gastroenterology Director, Viral Hepatitis Center University of California San Francisco

More information

LIVER TRANSPLANTATION Update on Allocation Living Donor Liver Tx.

LIVER TRANSPLANTATION Update on Allocation Living Donor Liver Tx. LIVER TRANSPLANTATION Update on Allocation Living Donor Liver Tx. Steven L. Flamm MD Associate Professor of Medicine Medical Director, Liver Transplantation Northwestern University Medical School 1958

More information

DEPARTMENT OF BONE MARROW AND STEM CELL TRANSPLANT

DEPARTMENT OF BONE MARROW AND STEM CELL TRANSPLANT www.narayanahealth.org DEPARTMENT OF BONE MARROW AND STEM CELL TRANSPLANT About Narayana Health City Narayana Health, one of India's largest and the world's most economical healthcare service providers

More information

Clinical Research Program Information for Patients. Transplant Creations

Clinical Research Program Information for Patients. Transplant Creations Clinical Research Program Information for Patients Transplant Creations 1 Program Focus Combination chemotherapy and transplantation of stem cells from an autologous donor (patient s own stem cells) and/or

More information

HBV & HCV induced. Liver Cirrhosis Iradj Maleki MD Gut & Liver Research Center Mazandaran University of Medical Sciences

HBV & HCV induced. Liver Cirrhosis Iradj Maleki MD Gut & Liver Research Center Mazandaran University of Medical Sciences HBV & HCV induced Liver Cirrhosis Iradj Maleki MD Gut & Liver Research Center Mazandaran University of Medical Sciences Definition of Cirrhosis Final pathway for a wide variety of chronic liver diseases

More information

4. All cord blood banks should be subject to the same standards, regulations and accreditation requirements.

4. All cord blood banks should be subject to the same standards, regulations and accreditation requirements. WMDA Policy Statement on the Utility of Autologous or Family Cord Blood Unit Storage The WMDA Board adopted this policy on 25 th of May 2006. Policy updated _April 2011 The Cord Blood Working Group and

More information

SEARCHING FOR A BONE MARROW DONOR

SEARCHING FOR A BONE MARROW DONOR SEARCHING FOR A BONE MARROW DONOR Angela received a bone marrow transplant from an unrelated donor to treat her non-hodgkin s lymphoma. INFORMATION FOR PATIENTS AND THEIR FAMILIES For patients who need

More information

CANCER OF THE LIVER HEPATOCELLULAR CARCINOMA

CANCER OF THE LIVER HEPATOCELLULAR CARCINOMA CANCER OF THE LIVER HEPATOCELLULAR CARCINOMA WHAT IS CANCER OF THE LIVER? Hepatocellular carcinoma is the most common form and it comes from the main type of liver cell, the hepatocyte. About 3 out 4

More information

Orthopaedic Stem Cell Treatment

Orthopaedic Stem Cell Treatment Orthopaedic Stem Cell Treatment Stem Cell Injections Surgically Implanted Stem Cells Learn about the treatment option that is best for you. Emory Healthcare patients can benefit from surgical implantation

More information

X-Plain Subclavian Inserted Central Catheter (SICC Line) Reference Summary

X-Plain Subclavian Inserted Central Catheter (SICC Line) Reference Summary X-Plain Subclavian Inserted Central Catheter (SICC Line) Reference Summary Introduction A Subclavian Inserted Central Catheter, or subclavian line, is a long thin hollow tube inserted in a vein under the

More information

Cord Blood Collections for the Texas Cord Blood Bank. Obstetrical Providers Training Module

Cord Blood Collections for the Texas Cord Blood Bank. Obstetrical Providers Training Module Cord Blood Collections for the Texas Cord Blood Bank Obstetrical Providers Training Module The Texas Cord Blood Bank The Texas Cord Blood Bank is a network of maternity hospitals and a central laboratory

More information

STEM CELL TRANSPLANTS

STEM CELL TRANSPLANTS UAMS Information on STEM CELL TRANSPLANTS What is a Stem Cell Transplant? A stem cell transplant is an infusion of stem cells following high-dose chemotherapy. The infused cells effectively rescue the

More information

STEM CELL FELLOWSHIP

STEM CELL FELLOWSHIP Module I: The Basic Principles of Stem Cells 1. Basics of Stem Cells a. Understanding the development of embryonic stem cells i. Embryonic stem cells ii. Embryonic germ cells iii. Differentiated stem cell

More information

Red Blood Cell Transfusions for Sickle Cell Disease

Red Blood Cell Transfusions for Sickle Cell Disease Red Blood Cell Transfusions for Sickle Cell Disease Red Blood Cell Transfusions for Sickle Cell Disease 1 Produced by St. Jude Children s Research Hospital, Departments of Hematology, Patient Education,

More information

Top Ten Things to Know About Stem Cell Treatments

Top Ten Things to Know About Stem Cell Treatments Top Ten Things to Know About Stem Cell Treatments Many clinics that are offering stem cell treatments make claims about what stem cells can and cannot do that are not supported by our understanding of

More information

Basic Science in Medicine

Basic Science in Medicine Medical Journal of th e Islamic Republic of Iran Volume 18 Number 3 Fall 1383 November 2004 Basic Science in Medicine ] EXPANSION OF HUMAN CORD BLOOD PRIMITIVE PROGENITORS IN SERUM-FREE MEDIA USING HUMAN

More information

INFORMATION ON STEM CELLS/BONE MARROW AND REINFUSION/TRANSPLANTATION SUR703.002

INFORMATION ON STEM CELLS/BONE MARROW AND REINFUSION/TRANSPLANTATION SUR703.002 INFORMATION ON STEM CELLS/BONE MARROW AND REINFUSION/TRANSPLANTATION SUR703.002 COVERAGE: SPECIAL COMMENT ON POLICY REVIEW: Due to the complexity of the Peripheral and Bone Marrow Stem Cell Transplantation

More information

10 ml of the ascitic fluid were aspirated from each patient and they were divided as the following:

10 ml of the ascitic fluid were aspirated from each patient and they were divided as the following: Summary The objective of the present work was to study the utility of serum procalcitonin for rapid and early diagnosis of bacterial infection in chronic liver diseases and to compare between serum PCT

More information

Dr Paul Turner. Research Scientist Dunedin

Dr Paul Turner. Research Scientist Dunedin Dr Paul Turner Research Scientist Dunedin Spinal Cord Society NZ Inc. Who: Aim: Started by Noela & Keith Vallis & people with spinal cord injury (SCI), their families and care-givers in 1988. To support

More information

The most serious symptoms of this stage are:

The most serious symptoms of this stage are: The Natural Progression of Hepatitis C The natural history of hepatitis C looks at the likely outcomes for people infected with the virus if there is no medical intervention. However, the process of trying

More information

5. All cord blood banks should be subject to the same standards, regulations and accreditation requirements.

5. All cord blood banks should be subject to the same standards, regulations and accreditation requirements. WMDA Policy Statement for the Utility of Autologous or Family Cord Blood Unit Storage (This policy statement has been approved and adopted by the WMDA board on the 25 th of May 2006) The Cord Blood Registries

More information

Helping you find the one match.. Guide for Unrelated Stem Cell Transplant Patients OneMatch Stem Cell and Marrow Network BLOOD.

Helping you find the one match.. Guide for Unrelated Stem Cell Transplant Patients OneMatch Stem Cell and Marrow Network BLOOD. Helping you find the one match.. Guide for Unrelated Stem Cell Transplant Patients OneMatch Stem Cell and Marrow Network BLOOD.CA WWW This guide is intended for patients in need of an unrelated volunteer

More information

PERCUTANEOUS PD CATHETER IMPLANTATION SYSTEM

PERCUTANEOUS PD CATHETER IMPLANTATION SYSTEM Place on Patient s Cranial Border of the Pubic Symphysis IMPLANTATION STENCIL Classic Exit Cuff Site PERCUTANEOUS PD CATHETER IMPLANTATION SYSTEM INSTRUCTIONS FOR USE VP 511 and VP-511M Implantation System

More information

Stem Cell Transplantation

Stem Cell Transplantation Harmony Behavioral Health, Inc. Harmony Behavioral Health of Florida, Inc. Harmony Health Plan of Illinois, Inc. HealthEase of Florida, Inc. Ohana Health Plan, a plan offered by WellCare Health Insurance

More information

Chronic Kidney Disease

Chronic Kidney Disease Chronic Kidney Disease Introduction Chronic kidney disease, also known as CKD, is the gradual loss of kidney function. When CKD reaches an advanced stage, dangerous levels of fluid, electrolytes and wastes

More information

GRANIX (tbo-filgrastim)

GRANIX (tbo-filgrastim) RATIONALE FOR INCLUSION IN PA PROGRAM Background Neutropenia is a hematological disorder characterized by an abnormally low number of neutrophils. A person with severe neutropenia has an absolute neutrophil

More information

Hepatitis C Infections in Oregon September 2014

Hepatitis C Infections in Oregon September 2014 Public Health Division Hepatitis C Infections in Oregon September 214 Chronic HCV in Oregon Since 25, when positive laboratory results for HCV infection became reportable in Oregon, 47,252 persons with

More information

Liver Failure. Symptoms and Causes Acute versus chronic liver disease. Writer: Maya Chaddah Editor: Lisa Willemse Reviewer: Gordon Keller

Liver Failure. Symptoms and Causes Acute versus chronic liver disease. Writer: Maya Chaddah Editor: Lisa Willemse Reviewer: Gordon Keller Liver Failure About Liver Failure Symptoms and Causes Diagnosis and Treatment How Can Stem Cells Help? Research directions Hepatocyte transplantation Autologous bone marrow stem cells Mesenchymal stem

More information

Ankle Block. Indications The ankle block is suitable for the following: Orthopedic and podiatry surgical procedures of the distal foot.

Ankle Block. Indications The ankle block is suitable for the following: Orthopedic and podiatry surgical procedures of the distal foot. Ankle Block The ankle block is a common peripheral nerve block. It is useful for procedures of the foot and toes, as long as a tourniquet is not required above the ankle. It is a safe and effective technique.

More information

Laboratory diagnosis of viral infections. Specimen collection and transport

Laboratory diagnosis of viral infections. Specimen collection and transport Laboratory diagnosis of viral infections Specimen collection and transport Steps in Pathogenesis of Viral Diseases 1. Entry through skin through mucosa (respiratory, gastrointestinal or genital) through

More information

House Resolution No. 37

House Resolution No. 37 california legislature regular session House Resolution No. Introduced by Assembly Member Hill August, House Resolution No. Relative to umbilical cord blood banking. WHEREAS, Since the first umbilical

More information

Thinking about donating stem cells or bone marrow? Information for potential donors

Thinking about donating stem cells or bone marrow? Information for potential donors Thinking about donating stem cells or bone marrow? Information for potential donors From the Bone Marrow Transplant Team at Hamilton Health Sciences, 2015. Thinking about donating stem cells? Reading this

More information

PERITONEAL (ABDOMINAL) PARACENTESIS

PERITONEAL (ABDOMINAL) PARACENTESIS PERITONEAL (ABDOMINAL) PARACENTESIS Indications 1. To determine the cause of ascites. 2. To determine if ascites is infected. 3. For therapeutic removal of fluid: (a) (b) When distention is pronounced

More information

Executive summary of recommendations

Executive summary of recommendations MOH CLINICAL PRACTICE GUIDELINES 2/2011 Chronic Hepatitis B Infection College of Family Physicians, Singapore Academy of Medicine, Singapore Singapore Medical Association Executive summary of recommendations

More information

Purification and Expansion of Hematopoietic Stem Cells Based on Proteins Expressed by a Novel Stromal Cell Population

Purification and Expansion of Hematopoietic Stem Cells Based on Proteins Expressed by a Novel Stromal Cell Population Purification and Expansion of Hematopoietic Stem Cells Based on Proteins Expressed by a Novel Stromal Cell Population Our bodies are constantly killing old, nonfunctional, and unneeded cells and making

More information

14.0 Stem Cell Laboratory Services

14.0 Stem Cell Laboratory Services Laboratory Services Contact Information: To inquire about assisting with surgical harvesting of bone marrow, cellular therapy (CT) product processing, cryopreservation, storage, or any other lab services,

More information

Liver Cancer And Tumours

Liver Cancer And Tumours Liver Cancer And Tumours What causes liver cancer? Many factors may play a role in the development of cancer. Because the liver filters blood from all parts of the body, cancer cells from elsewhere can

More information

RITMIR024 - STEM CELL RESEARCH IN CARDIOLOGY

RITMIR024 - STEM CELL RESEARCH IN CARDIOLOGY 1. SCOPE AND METHODOLOGY 2. REPORT SYNOPSIS 2.1 General Definitions Myoblasts Pluripotent Cells Multipotent Cells Progenitor Cells Role of Stem Cells in Repairing the Heart Stem Cell Therapy Stem Cells

More information

Narrator: Transplants using stem cells from the blood, bone marrow or umbilical cord blood

Narrator: Transplants using stem cells from the blood, bone marrow or umbilical cord blood [Track 2: What Is a Transplant?] Narrator: Transplants using stem cells from the blood, bone marrow or umbilical cord blood can be an effective treatment for people with blood cancers such as leukemia,

More information

Liver Imaging. Liver Imaging/Cirrhosis. Signs of Liver Failure and Portal Hypertension. Methods of Imaging the Liver. CT Workhorse of Imaging

Liver Imaging. Liver Imaging/Cirrhosis. Signs of Liver Failure and Portal Hypertension. Methods of Imaging the Liver. CT Workhorse of Imaging Liver Imaging Patricia Lipford Abbitt,, MD Professor and Chief - Body Imaging Section Department of Radiology College of Medicine University of Florida Liver Imaging/Cirrhosis Number of patients with hepatitis

More information

Blood cells are vital to the human body

Blood cells are vital to the human body Candide FONT-SALA Blood cells are vital to the human body Red cells transport oxygen From http://www.english-online.at/biology/blood/blood-supply-and-blood-diseases.htm Red cell life span 120 days 200

More information

Types of treatment for liver cancer

Types of treatment for liver cancer Useful information for cancer patients Contents This information is an overview of treatments for primary liver cancer. There are sections on Primary or secondary cancer The main treatments for primary

More information

A Gift for life. HTA Licence No. 22653

A Gift for life. HTA Licence No. 22653 A Gift for life HTA Licence No. 22653 2 3 the best possible gift for your new born child. 4 6 8 9 10 12 14 16 19 what is cord blood current treatments services contents properties for treatment process

More information

Liver Cancer What is the liver? What is liver cancer?

Liver Cancer What is the liver? What is liver cancer? Liver Cancer What is the liver? The liver is the largest internal organ in the body and is important in digesting food. The liver performs many other functions, including collecting and filtering blood

More information

The following should be current within the past 6 months:

The following should be current within the past 6 months: EVALUATION Baseline Labs Obtain at time or prior to initial evaluation CBC with diff PT/INR CMP HCV Genotype (obtained PRIOR TO consult visit) HCV RNA (obtained PRIOR TO consult visit) Hep A IgG Hep BsAg,

More information

Appropriate Use Criteria (By Rating) Table 1. Venous Duplex of the Upper Extremities for Patency and Thrombosis

Appropriate Use Criteria (By Rating) Table 1. Venous Duplex of the Upper Extremities for Patency and Thrombosis ACCF 2013 Use Criteria for Peripheral Vascular Ultrasound and Physiological Testing Part II: Testing for Venous Disease and Evaluation of Hemodialysis Access Section 1: Upper Extremity Venous Evaluation

More information

Policies & Procedures. I.D. Number: 1073

Policies & Procedures. I.D. Number: 1073 Policies & Procedures Title:: CENTRAL VENOUS CATHETERS INSERTION ASSISTING I.D. Number: 1073 Authorization [] Pharmacy Nursing Committee [] MAC Motion #: [x] SHR Nursing Practice Committee Source: Nursing

More information

PRACTICE GUIDELINE TITLE: INTRAVENOUS LINE INSERTION: PERIPHERAL AND CENTRAL

PRACTICE GUIDELINE TITLE: INTRAVENOUS LINE INSERTION: PERIPHERAL AND CENTRAL PRACTICE GUIDELINE Effective Date: 9-17-04 Manual Reference: Deaconess Trauma Services TITLE: INTRAVENOUS LINE INSERTION: PERIPHERAL AND CENTRAL PURPOSE: To outline the indications and options for intravenous

More information

STEM CELLS FROM THE UMBLICAL CORD BLOOD AND UMBLICAL CORD TISSUE

STEM CELLS FROM THE UMBLICAL CORD BLOOD AND UMBLICAL CORD TISSUE STEM CELLS FROM THE UMBLICAL CORD BLOOD AND UMBLICAL CORD TISSUE What are Stem Cells? Stem cells are the basic building blocks of all the cells, tissues and organs in the human body. The role of the stem

More information

What are Stem Cells? How can they be used in medicine?

What are Stem Cells? How can they be used in medicine? What are Stem Cells? How can they be used in medicine? What is a stem cell????... What is a stem cell????......a cell with the ability to differentiate into specialized cells and renew to become more stem

More information

Patterns of abnormal LFTs and their differential diagnosis

Patterns of abnormal LFTs and their differential diagnosis Patterns of abnormal LFTs and their differential diagnosis Professor Matthew Cramp South West Liver Unit and Peninsula Schools of Medicine and Dentistry, Plymouth Summary liver function / liver function

More information

STEM CELL FACTS. The ISSCR is an independent, nonproft organization providing a global forum for stem cell research and regenerative medicine.

STEM CELL FACTS. The ISSCR is an independent, nonproft organization providing a global forum for stem cell research and regenerative medicine. STEM CELL FACTS The ISSCR is an independent, nonproft organization providing a global forum for stem cell research and regenerative medicine. WHAT ARE STEM CELLS? Stem cells are the foundation cells for

More information

Mohamed Akoad, MD, FACS Chair, Department of Transplantation Alicia Parrott, RN Living Donor Nurse Coordinator

Mohamed Akoad, MD, FACS Chair, Department of Transplantation Alicia Parrott, RN Living Donor Nurse Coordinator Mohamed Akoad, MD, FACS Chair, Department of Transplantation Alicia Parrott, RN Living Donor Nurse Coordinator Living Donor Liver Transplantation is a surgical innovation that has been developed to address

More information

HIV and Hepatitis Co-infection. Martin Fisher Brighton and Sussex University Hospitals, UK

HIV and Hepatitis Co-infection. Martin Fisher Brighton and Sussex University Hospitals, UK HIV and Hepatitis Co-infection Martin Fisher Brighton and Sussex University Hospitals, UK Useful References British HIV Association 2010 http://www.bhiva.org/documents/guidelines/hepbc/2010/ hiv_781.pdf

More information

Multiple Myeloma. This reference summary will help you understand multiple myeloma and its treatment options.

Multiple Myeloma. This reference summary will help you understand multiple myeloma and its treatment options. Multiple Myeloma Introduction Multiple myeloma is a type of cancer that affects white blood cells. Each year, thousands of people find out that they have multiple myeloma. This reference summary will help

More information

Hepatitis C Treatment Criteria Commercial & Minnesota Health Care Programs

Hepatitis C Treatment Criteria Commercial & Minnesota Health Care Programs Last update: February 23, 2015 Hepatitis C Treatment Criteria Commercial & Minnesota Health Care Programs Please see healthpartners.com for Medicare coverage criteria. Table of Contents 1. Harvoni 2. Sovaldi

More information

Information about hepatitis C for patients and carers

Information about hepatitis C for patients and carers Information about hepatitis C for patients and carers What is hepatitis C? Hepatitis C is an illness caused by a virus which can be passed through blood from one person to another. It mainly affects the

More information

Medications or therapeutic solutions may be injected directly into the bloodstream

Medications or therapeutic solutions may be injected directly into the bloodstream Intravenous Therapy Medications or therapeutic solutions may be injected directly into the bloodstream for immediate circulation and use by the body. State practice acts designate which health care professionals

More information

Peripherally Inserted Central Catheter (PICC) for Outpatient

Peripherally Inserted Central Catheter (PICC) for Outpatient Peripherally Inserted Central Catheter (PICC) for Outpatient Introduction A Peripherally Inserted Central Catheter, or PICC line, is a thin, long, soft plastic tube inserted into a vein of the arm. It

More information

Chapter 5. Chapter 5. BMT Survivor. This chapter is key in helping you prepare for your transplant. Preparing for Your Transplant

Chapter 5. Chapter 5. BMT Survivor. This chapter is key in helping you prepare for your transplant. Preparing for Your Transplant This chapter is key in helping you prepare for your transplant. BMT Survivor Chapter 5 Preparing for Your Transplant Evaluation Tests for Eligibility, Preadmission Central Vascular Access Device Fertility

More information

Smoking and misuse of certain pain medicines can affect the risk of developing renal cell cancer.

Smoking and misuse of certain pain medicines can affect the risk of developing renal cell cancer. Renal cell cancer Renal cell cancer is a disease in which malignant (cancer) cells form in tubules of the kidney. Renal cell cancer (also called kidney cancer or renal adenocarcinoma) is a disease in which

More information

Before your child has a stem cell transplant (SCT)

Before your child has a stem cell transplant (SCT) Before your child has a stem cell transplant (SCT) A guide for families The information contained within this leaflet is the property of Imperial College London Healthcare NHS Trust. Introduction This

More information

15 Stem Cell Research

15 Stem Cell Research 15 Stem Cell Research t a l k it o v e r 1 c l a s s se s s i o n Overview Students read about current scientific research on and the social controversy over embryonic stem cells. On a KWL literacy strategy

More information

Stem cells now and in the future: regulation in Australia

Stem cells now and in the future: regulation in Australia John Skerritt National Manager Therapeutic Goods Administration ARCS Scientific Congress 2015 5 May 2015 n biologicals regulatory scheme introduced May 2011 (fully in place by 2014) to: Sets standards

More information

A. ADMINISTERING SUBCUTANEOUS MEDICATIONS INTERMITTENTLY/CONTINUOUSLY B. (SUBCUTANEOUS INFUSION) HYDRODERMOCLYSIS

A. ADMINISTERING SUBCUTANEOUS MEDICATIONS INTERMITTENTLY/CONTINUOUSLY B. (SUBCUTANEOUS INFUSION) HYDRODERMOCLYSIS SUBCUTANEOUS THERAPY A. ADMINISTERING SUBCUTANEOUS MEDICATIONS INTERMITTENTLY/CONTINUOUSLY B. (SUBCUTANEOUS INFUSION) HYDRODERMOCLYSIS PARTS I. Purposes II. General Information III. Responsibilities IV.

More information

Obstructive Jaundice. Dr Eyad Alqarqaz

Obstructive Jaundice. Dr Eyad Alqarqaz Obstructive Jaundice Dr Eyad Alqarqaz Objectives - Know the definition of jaundice - Have an idea about the causes of jaundice in general - Know the causes, investigations and management of obstructive

More information

Caption: Portal vein, coloured ultrasound scan. The portal vein (red) transports nutrient-rich blood from the digestive organs to the liver.

Caption: Portal vein, coloured ultrasound scan. The portal vein (red) transports nutrient-rich blood from the digestive organs to the liver. Caption: Portal vein, coloured ultrasound scan. The portal vein (red) transports nutrient-rich blood from the digestive organs to the liver. This scan shows the point at which the portal vein enters the

More information

Enzyme Replacement Therapies for UCD (Liver/ Liver Cell / Stem Cell Transplantation) Pat McKiernan Birmingham Children s Hospital

Enzyme Replacement Therapies for UCD (Liver/ Liver Cell / Stem Cell Transplantation) Pat McKiernan Birmingham Children s Hospital Enzyme Replacement Therapies for UCD (Liver/ Liver Cell / Stem Cell Transplantation) Pat McKiernan Birmingham Children s Hospital Survival following liver transplantation for Biliary Atresia at BCH (n=195)

More information

PRIOR AUTHORIZATION PROTOCOL FOR HEPATITIS C TREATMENT

PRIOR AUTHORIZATION PROTOCOL FOR HEPATITIS C TREATMENT PRIOR AUTHORIZATION PROTOCOL FOR HEPATITIS C TREATMENT HARVONI (90mg ledipasvir/400mg sofosbuvir): tablet (PREFERRED AGENT) SOVALDI (sofosbuvir ): 400mg tablets (PREFERRED AGENT ) OLYSIO (simeprivir) PEG-INTRON

More information

Donating bone marrow or peripheral blood stem cells Information for the donor family

Donating bone marrow or peripheral blood stem cells Information for the donor family Donating bone marrow or peripheral blood stem cells Information for the donor family Introduction This information has been written for you as a brother, sister or parent and potential bone marrow or stem

More information

Lymphoma is a cancer that develops in the white blood cells (lymphocytes) of the lymphatic system, which is part of the body's immune system.

Lymphoma is a cancer that develops in the white blood cells (lymphocytes) of the lymphatic system, which is part of the body's immune system. Scan for mobile link. Lymphoma Lymphoma is a cancer that develops in the white blood cells of the lymphatic system. Symptoms may include enlarged lymph nodes, unexplained weight loss, fatigue, night sweats

More information

190.25 - Alpha-fetoprotein

190.25 - Alpha-fetoprotein Other Names/Abbreviations AFP 190.25 - Alpha-fetoprotein Alpha-fetoprotein (AFP) is a polysaccharide found in some carcinomas. It is effective as a biochemical marker for monitoring the response of certain

More information

OHTAC Recommendation

OHTAC Recommendation OHTAC Recommendation Radiofrequency Ablation for hepatocellular carcinoma or primary June 17, 2004 1 The Ontario Health Technology Advisory Committee (OHTAC) met on June 17, 2003 and reviewed a recommendation

More information

Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation: Questions and Answers. Key Points

Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation: Questions and Answers. Key Points CANCER FACTS N a t i o n a l C a n c e r I n s t i t u t e N a t i o n a l I n s t i t u t e s o f H e a l t h D e p a r t m e n t o f H e a l t h a n d H u m a n S e r v i c e s Bone Marrow Transplantation

More information

Facts About Kidney Disease

Facts About Kidney Disease American Kidney Fund 6110 Executive Boulevard, Suite 1010 Rockville, MD 20852 Phone: (301) 881-3052, Fax: (301) 881-0898 Toll-Free: (800) 638-8299 Informacion En Español: (866) 300-2900 HelpLine@kidneyfund.org

More information

Cord blood donation is a painless and free gesture, helping others and saving lives. Cord blood, a bond for life.

Cord blood donation is a painless and free gesture, helping others and saving lives. Cord blood, a bond for life. Cord blood donation is a painless and free gesture, helping others and saving lives. Cord blood, a bond for life. What is cord blood? Cord blood (or placental blood) is the blood that remains in the placenta

More information

Excess iron may accumulate in these 3 normal storage sites and also in other organs that don t normally store iron, such as the:

Excess iron may accumulate in these 3 normal storage sites and also in other organs that don t normally store iron, such as the: What is Iron Overload? Iron overload occurs when you have too much iron in your body. This can be a problem for people who get lots of red blood cell transfusions. Red blood cells contain iron. Each time

More information

LIVER TRANSPLANTATION IN ALAGILLE SYNDROME

LIVER TRANSPLANTATION IN ALAGILLE SYNDROME LIVER TRANSPLANTATION IN ALAGILLE SYNDROME Ronald J. Sokol, MD Children s Hospital Colorado University of Colorado School of Medicine Treatment of Liver Disease in Improve bile flow ALGS Ursodeoxycholic

More information

ANTERIOR LUMBAR INTERBODY FUSION (ALIF) Basic Anatomical Landmarks: Anterior Lumbar Spine

ANTERIOR LUMBAR INTERBODY FUSION (ALIF) Basic Anatomical Landmarks: Anterior Lumbar Spine (ALIF) Anterior In human anatomy, referring to the front surface of the body or the position of one structure relative to another Lumbar Relating to the loins or the section of the back and sides between

More information

Acute myeloid leukemia (AML)

Acute myeloid leukemia (AML) Acute myeloid leukemia (AML) Adult acute myeloid leukemia (AML) is a type of cancer in which the bone marrow makes abnormal myeloblasts (a type of white blood cell), red blood cells, or platelets. Adult

More information

Stem Cell Background Paper

Stem Cell Background Paper Stem Cell Background Paper Introduction...2 Stem Cell Basics...3 Stem Cell Process Flow...9 Comparison of Blood, Stem Cells, Tissues and Organs Processes...10 Responsibilities for the Blood, Stem Cells,

More information

Hepatocellular Carcinoma (HCC)

Hepatocellular Carcinoma (HCC) Abhishek Vadalia Introduction Chemoembolization is being used with increasing frequency in the treatment of solid hepatic tumors such as Hepatocellular Carinoma (HCC) & rare Cholangiocellular Carcinoma

More information

guides BIOLOGY OF AGING STEM CELLS An introduction to aging science brought to you by the American Federation for Aging Research

guides BIOLOGY OF AGING STEM CELLS An introduction to aging science brought to you by the American Federation for Aging Research infoaging guides BIOLOGY OF AGING STEM CELLS An introduction to aging science brought to you by the American Federation for Aging Research WHAT ARE STEM CELLS? Stem cells are cells that, in cell cultures

More information

Pluripotent: Can differentiate into blood cells of all three lineages (erythroid, myeloid, and megakaryoblastic) Express CD 34+ antigen CD34 most

Pluripotent: Can differentiate into blood cells of all three lineages (erythroid, myeloid, and megakaryoblastic) Express CD 34+ antigen CD34 most Shan Yuan, MD May 11, 2011 Pluripotent: Can differentiate into blood cells of all three lineages (erythroid, myeloid, and megakaryoblastic) Express CD 34+ antigen CD34 most likely an adhesion molecule

More information

Guide to the New CPT Codes for Hematopoietic Stem Cell Transplant and Apheresis

Guide to the New CPT Codes for Hematopoietic Stem Cell Transplant and Apheresis Guide to the New CPT Codes for Hematopoietic Stem Cell Transplant and Apheresis A major overhaul of the Current Procedural Terminology (CPT) codes for hematopoietic stem cell collection and transplantation

More information

Other treatments for chronic myeloid leukaemia

Other treatments for chronic myeloid leukaemia Other treatments for chronic myeloid leukaemia This information is an extract from the booklet Understanding chronic myeloid leukaemia. You may find the full booklet helpful. We can send you a copy free

More information

ALLOMATRIX INJECTABLE PUTTY, ALLOMATRIX C BONE PUTTY, ALLOMATRIX CUSTOM BONE PUTTY, ALLOMATRIX DR BONE PUTTY, AND ALLOMATRIX RCS BONE PUTTY

ALLOMATRIX INJECTABLE PUTTY, ALLOMATRIX C BONE PUTTY, ALLOMATRIX CUSTOM BONE PUTTY, ALLOMATRIX DR BONE PUTTY, AND ALLOMATRIX RCS BONE PUTTY ALLOMATRIX INJECTABLE PUTTY, ALLOMATRIX C BONE PUTTY, ALLOMATRIX CUSTOM BONE PUTTY, ALLOMATRIX DR BONE PUTTY, AND ALLOMATRIX RCS BONE PUTTY MIXING INSTRUCTIONS 131048-5 The following languages are included

More information

Stem Cell Research: Adult or Somatic Stem Cells

Stem Cell Research: Adult or Somatic Stem Cells Chiang 1 Stem Cell Research: Adult or Somatic Stem Cells Abstract Kelly Chiang Cluster 7 Dr. LeFebvre 07/26/10 Over the past few decades, stem cells have been a controversial topic in the scientific field.

More information

Stem cells possess 2 main characteristics: Sources of pluripotent stem cells: -Long-term self renewal. -The inner cell mass of the blastocyst.

Stem cells possess 2 main characteristics: Sources of pluripotent stem cells: -Long-term self renewal. -The inner cell mass of the blastocyst. Stem cells possess 2 main characteristics: -Long-term self renewal. - They give rise to all types of differentiate cells. Sources of pluripotent stem cells: -The inner cell mass of the blastocyst. - Fetal

More information