Macofar Romaco Packaging New Microdosing machine series
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1 Macofar Romaco Packaging New Microdosing machine series
2 Macofar Sterile Powder / Liquid Lines Liquid Filling Washing machine Sterilisation tunnel Micro Dosing Capping Machine 2
3 Macofar Micro dosing machines Production range MICRO 6 single shotup to v/h double shot up to v/h triple shot up to v/h MICRO 9 single shot up to v/h double shot up to v/h triple shot up to v/h MICRO 18 single shot up to v/h double shot up to v/h triple shot up to v/h 3
4 Micro dosing machines: Micro 9/18 vacuum-pressuresystem Slug forming Accurate volume chamber Slug keeping Slug ejection Dosing chamber cleaning Powder aspiration and recovery No vial -No dosing 4
5 Macofar Micro dosing machines Dosing machine Key Benefits Vial sampling achieved without machine production stopping Nitrogen flushing unit, before and after filling Liquid filling unit for media fill test Air drying unit to reduce humidity percentage in the filling area. Integrated sealing station available. Vertical laminar flow over the dosing, stoppering and capping stations Laminar flow air speed control. Vacuum creation inside the vial before placing the stopper Possibility to dose 2 different powders into the same vial Single tray vial discharge 5
6 Macofar New Micro dosing machines 6
7 Macofar New Micro dosing machines New Dosing machine Key Benefits Total linear filling and stoppering machine Easy access from both sides of the line In line100% IPC with no impact on speed of the line Liquid filling unit for media fill test Linear stoppering station Linear Nitrogen flushing unit, before and after filling Laminar flow air speed control with return air ducts Suitable for isolator design machine Possibility to dose 2 different powders 7
8 Macofar Micro dosing machines Powder dosing unit Stoppering unit 8
9 Macofar Micro dosing machines: Micro 9/18 LAMINAR FLOW BALCONY DESIGN CHECK WEIGHING SYSTEM (opt.) LIQUID FILLING FOR VALIDATION (OPT.) 9
10 Micro dosing machines: Micro 9/18 key point overview CHECK WEIGHING SYSTEM (opt.) CHARACTERISTICS high accuracy in operational feedback and controls sampling and rejecting plans availability of data 10
11 Micro dosing machines: Micro 9/18 powder feeding MANUAL/AUTOMATIC Powder feeding from client s system MAIN HOPPER: Independent stirrer minimum level Conical shape to minimize residuals CONNECTING CHUTE LOWER HOPPER: Stirrer in phase with machine minimum level end-ofbatch residuals: < 0.8 l. (Micro18) < 0,5 l. (Micro9) DOSING CHAMBER: One dosing disc with one or two sets of twelve chambers (Micro 18). One vacuum-pressure system adjustments: manual, automatic, via feed-back from C.W. 11
12 Micro dosing machines: Micro 9/18 vial transport system Main path POSITIVE TRANSPORT: movement in phase with machine PLC knows which chamber will dose into this vial INLET BELT 3rd STARWHEEL: transport only 4th STARWHEEL: liquid filling (opt.) for media-fill testing with powder dosing unit in place 5th STARWHEEL: possibility of nitrogen flushing (opt.) STOPPERING STATION stopper-on-vial presence 1st STARWHEEL: transport to dosing station 2nd STARWHEEL: POWDER DOSING STATION OUTLET BELT REJECTING/SAMPLING 12
13 New Micro dosing machines: vial transport system INFEED TUNRTABLE LINEAR INTERMITENT OR CONTINUOUS BELT SYSTEM TARE WEIGHT CELL FINAL WEIGHT CELL STOPPERING STATION FALLEN VIALS IN TURN TABLE: 13 VACUUM WHEEL DOSING UNIT: POWDER HOPPER: OUTLET BELT
14 Micro dosing machines: Micro 9/18 closingunit POWDER STOPPER VIALS CENTERING BY NECK AND BODY 14
15 New Micro dosing machines: Stoppering unit VACUUM PICK&PLACE STOPPERING UNIT 15
16 Micro dosing machines: Micro 9/18 closingunit CHECK WEIGHING STARWHEELS SYSTEM: movement in phase with machine motion by Brushless motors same principles for Tare and Gross stations 16
17 Micro dosing machines: Micro 9/18 vials transport system: check weighing path CHECK WEIGHING STATION: vertical movements pneumatically driven vial mouth always protected by LAF Load Cells-PC-PLC comunication Tare Gross 17
18 New Micro dosing machines: 100% IPC in line check weighting system Tare CHECK WEIGHTHING STATION: CHECK WEIGTHING STATION: Gross 18
19 New Micro dosing machines: 100% IPC in line check weighting system RETRACTABLE VIAL HOLDER: RETRACTABLE VIAL HOLDER 19
20 Micro dosing machines: Micro 9/18 line competence Our lines configurations can be tailored according to your facility layout, your materials handling and personnel flow. A dedicated engineering study is usually performed at the very beginning of our mutual cooperation in order to help you defining the final User Requirements Specifications and the Design of your new fill-finish facility. Our machines can be interfaced with any kind of pre-existing upstream and downstream equipment such as freeze-dryers, external washing machines, automatic inspection machines and so on. 20
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