Clinical study of Zi Gui Nv Zhen capsule to treat the sterility caused by thin endometrium

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1 Journal of Capital Medical University Apr Vol. 35 No. 2 doi /j. issn * pulsation index I resistance index RI A < RI I I RI < R Clinical study of Zi Gui Nv Zhen capsule to treat the sterility caused by thin endometrium Wang Haiwen Ruan Xiangyan * Department of Gynecological Endocrinology Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing China Abstract Objective To evaluate the effectiveness of Zi Gui Nv Zhen capsule on the sterility due to thin endometrium. Methods One hundred and eleven sterility patients with thin endometrium were randomly divided into two groups observation group of 59 cases and control group of 52 cases. The control group was treated with estradiol valerate. Besides the treatment given to the control group patients of observation group were given Zi Gui Nv Zhen capsule for treatment. Endometrium thickness endometrial spiral artery blood flow pulsation index I and endometrial spiral artery blood flow resistance index RI luteal phase serum estradiol E2 and progesterone of after ovulation were observed. Results proportion of type A endometrium of patients with endometrial thickness increased significantly < compared with the control group. Uterus artery RI in ovulation day of patients who took Zi Gui Nv Zhen capsule was significantly lower than that of the control group < and uterine artery I was significantly lower than that of the control group < The herbal medicine may reduce uterine artery I and RI reduce the uterine artery blood flow resistance and increase the uterine artery blood flow thus increase blood supply of endometrium and enhance the receptivity of endometrium. That is beneficial to early embryonic implantation and development. Clinical pregnancy rate of the observation group increased significantly compared to the control group < Conclusion Taking oral Zi Gui Nv Zhen capsule and estradiol valerate treatment on daily basis can enrich the blood supply to the uterus improve endometrial thickness and type as well as the receptivity of endometrium increase the luteal phase of progesterone and estrogen levels and improve the function of corpus luteum so as to increase the clinical pregnancy rate. Key words Zi Gui Nv Zhen capsule thin endometrium sterility 10% ~ 15% This study was supported by Beijing Municipality Health Technology High-level Talent roject of Discipline Leader Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing Maternal and Child Health Care Hospital * Corresponding author ruanxiangyan@ 163. com http www. cnki. net /kcms /detail / R html

2 2 249 E 1 ~ 2 d A B C body mass index BMI > pulsation index I resistance index RI d HCG > 10 IU /L 14 ~ 16 6 luteinizing hormone LH 18 mm mm 2 SSS ~ 8 mg /d ± x 珋 ± s t < ~ mg 9 mm 9 mm 10 mg 14 d estradiol E2 folliclestimulating hormone FSH LH prolactin gonadotrophin HCG > 10 IU /L RL testosterone T human chorionic > ~ 10 1 Tab. 1 Clinical characteristics of the two groups x 珋 ± s 2 mg 9 mm 9 mm 10 mg 14 d Age /a ± ± Sterility time /a ± ± HCG > 10 IU /L BMI / kg m ± ± WC /cm ± ± HC /cm ± ± ~ 10 FSH / IU L ± ± E2 / pg ml ± ± mm LH LH / miu ml ± ± RL / ng ml ± ± ~ 48 h T / ng ml ± ± HCG IU BMI body mass index WC waist circumference HC hip circu-

3 mference FSH follicle-stimulating hormone E2 estradiol LH d E2 luteinizing hormone RL prolactin T testosterone. Tab. 4 Comparison of E2 and in 1-2 days after 2. 2 ovulation between two groups after treatment x 珋 ± s > < * < vs control group E2 estradiol progesterone. A 5 Tab. 5 Comparision of number of pregnancy between < two groups after treatment n % 2 Tab. 2 Both groups before and after treatment in patients with endometrial thickness and ovulation day type n % Count of pregnancy * n = 59 n = 52 Before treatment Count of type A Count of type B + C Endometrial thickness /cm ± ± After treatment Count of type A * Count of type B + C Endometrial thickness /cm ± * ± * < vs control group. n = 59 n = 52 I ± * ± * RI ± * ± * * < vs control group I pulsation index RI resistance index E2 4 E2 progesterone < E2 / pg ml ± * ± / ng ml ± * ± Count of no pregnancy * < vs control group. 3 RI I ~ 1. 2 cm 2. 3 I RI A 3 3 I < RI < I RI Tab. 3 Comparison of uterine artery I and RI in ovulation day between two groups after treatment 4 ~ 8 mg /d % 52 7 ~ 9 d 21 ~ % d 7 <

4 I RI 9 < Cs g 2. 2 g 7. 4 g g 5. 1 mg 10 4 luteinizing hormone releasing hormone LHRH LH FSH E2 1. J B Ardaems Y Gougeon A Ldebvre C et al. Contribution of ovarian and uterine color Doppler in medically assisted reproduction technique ART J. Gynecol Obstet Fertil Dain L Bider D Levron J et al. Thin endometrium in donor oocyte recipients enigma or obstacle for implantation J. Fertil Steril Satirapod C Wingprawat S Jultanmas R et al. Effect of estradiol valerate on endometrium thickness during clomi- phene citrate-stimulated ovulation J. J Obstet Gynaecol Res Myers E M Hurst B S. Comprehensive management of se- icariin ICA 8 ~ 10 vere Asherman syndrome and amenorrhea J. Fertil Steril I Lidegaard Edstr m B Kreiner S. Oral contraceptives and venous thromboembolism a five-year national case-con- trol study J. Contraception Rg1 Rb J Casper R F. It's time to pay attention to the endometrium J. Fertil Steril J J J A J RI J I 14.

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