Clinical Chemistry Methods Guide 2010

Transcription

1 Clinical Chemistry Methods Guide 2010 for Labquality Data Processing Labquality

2 Clinical Chemistry Methods Guide 2010 for Labquality Data Processing editors Ulla-Riitta Nordberg Ulla Tiikkainen design by Minna Seppä Aino Siukola How to use the Methods Guide At the beginning of the Methods Guide there are brief instructions on how to use this booklet. Every user is advised to read that section carefully. The analytes are listed in alphabetical order according to their official long name. Please note that the methods are identified by three codes: a three-digit code for the method group, a three-digit code for the ID number (e.g. reagent) and a three-digit code for the chemical principle. The method groups are listed in alphabetical order for each analyte except enzymes. For enzymes, IFCC methods and comparable methods are listed first. Methods in each method group are listed in alphabetical order. Note that an individual manufacturer may offer several reagents with different chemical principles. They can be found in either the same or a different method group. Please also note that for enzyme measurements, the same reagent with the same chemical principle can be in more than one method group. For this reason it is requested that reference values be quoted with the enzyme measurements. Calibrators and instruments are listed in alphabetical order as well. Codes for manufacturers are the same for calibrators and for instruments. If the method, chemical principle, manufacturer, calibrator or instrument that you use is not mentioned on the list, an accurate description is needed. In the case of a reagent or calibrator, please send us the kit insert. Why method data and method groups? It is necessary to divide results into method groups so that each laboratory can compare its own performance and operation with others using the same method through the external quality assessment. Each laboratory should compare its own results only with the mean value for its own method group when evaluating the performance data. As many conclusions are drawn from the EQA results, it is of the utmost importance that correct methods, calibrator and instrument data are notified to Labquality. publisher Labquality Ratamestarinkatu 11 FIN HELSINKI printed by University Press Helsinki ISSN Difference between QC sample and patient sample Quality control material manufactured commercially may contain both human and animal-based sera, as well as other components. During the manufacturing processes the control material is manipulated in different ways, although a general attempt is made to keep the material as natural as possible. Handling is known to cause differences between methods. In ideal cases, QC and patient samples behave in the same way. Helsinki, February 2010 Editorial staff

3 CONTENTS No. Page Alanine aminotransferase ALT...4 INQUIRIES ANALYTES Albumin Alb...6 Alkaline phosphatase ALP...8 Alpha-1-glycoprotein A1Glypr Amylase Amyl...12 Amylase, pancreatic AmylP...15 Antitrypsin Antitry...16 Aspartate aminotransferase AST...17 Bilirubin Bil...19 Bilirubin, neonatal Bil neo...21 C-reactive protein CRP...23 Calcium Ca...25 Calcium, ionized Ca-lon...27 Calcium, ionized, ph corrected Ca-lon, ph Chloride Cl...29 Cholesterol Chol...30 Cholesterol, HDL Chol-HDL...32 Cholesterol, LDL Chol-LDL...35 Complement C Complement C Copper Cu...38 Cortisol Cortisol...39 Creatine kinase CK...40 Creatinine Crea...42 Digitoxin Digit...44 Ferritin Ferritin...45 Glucose Glucose...47 Glutamyl transferase GT...49 Haemoglobin Hb...51 Haptoglobin Haptog...52 lmmunoglobulin A IgA...53 lmmunoglobulin E IgE...54 lmmunoglobulin G IgG...55 lmmunoglobulin M IgM...56 Iron Fe...57 Lactate dehydrogenase LD...59 Lactic acid Lactate...61 Lithium Li...62 Magnesium Mg...63 Osmolality Osmol...65 Phosphorus Pi...66 Potassium K...68 Protein Prot...70 Selenium Se...72 Sodium Na...73 Thyreotropine TSH...75 Thyroxine T Thyroxine, free FT Total iron binding capacity TIBC, UIBC...79 Transferrin Transf...80 Transferrin receptor, soluble TfR...81 Triglycerides Trigly...82 Triiodothyronine T Urea Urea...85 Uric acid Uric acid...87 Zinc Zn...89 MANUFACTURERS...90 Ulla-Riitta Nordberg tel Ulla Tiikkainen tel Labquality 2010 INSTRUMENTS...91 CALIBRATORS

4 Directions for use The methods data for the Long-term, Short-term, Haemoglobin, Neonatal bilirubin and Short-term CRP surveys remain constant from survey to survey. All results obtained from these surveys are processed using previously notified methods data (e.g. method groups). Laboratory is responsible for notifying its methods data. If you do not notify your methods data, your results will be found in the method group No method information. The variation is usually higher in the No method information method group than others because of its inhomogeneous nature. summaries, and it will be more difficult to interpret the laboratory s own results if the results are compared with the wrong group. When evaluating your results, first check the accuracy of your methods data record. If it is inaccurate, please inform Labquality what change is required. 6The method data registered for your laboratory can be seen in the report. Incorrect or out-of-date methods data may cause errors in statistical Please send the methods data A) via the Internet or B) fill in the methods data sheet A) Sending methods data via Internet Participant services Log in: enter your Client code and Password Choose Methods data Choose the analyte 1 For new data, press New 2 To change your data, press EDIT How to add and change your methods 0020 Alanine aminotransferase Reagent Method group Chemical principle Calibrator Instrument Unit in use Reference values (male, 40 years) Starting from (dd.mm.yyyy) Additional information Last update u tt NEW EDIT t 3 4 Choose 5 Choose 6 The grey buttons will appear Press the grey button and choose the reagent. Method group and chemical principle will be updated automatically. If you cannot find your reagent on the drop-down menu, please write the detailed information of your method in the box for Additional information. the calibrator and instrument and enter other information required. the right unit. SAVE 2 Labquality 2010

5 B) Filling in the methods data sheet and sending it to Labquality by fax or by post You can use methods data sheet instead of Internet. For new methods data, please always fill in the whole row for each analyte. For changes, please only fill the data that has changed. First look for your method group on the list. The methods below each method group are listed in alphabetical order for each analyte. The method consists of method group, ID number (e.g. reagent etc.) and chemical principle. Transfer all three codes onto the methods data sheet. If your method is not on the list, please enclose for example the reagent kit insert with the methods data sheet. The calibration code consists of a three-digit code for the manufacturer and a two-digit code for the calibration reagent itself. You will find the instrument data on the instrument list. It comprises two serial numbers, for manufacturer and for instrument. Please record the morning fast values of a 40-year-old male (on average medication) as reference values. Reference values are essential for all enzyme measurements. Example of how to fill in the methods data sheet ALT: The laboratory uses BioSystems reagent and BioSystems Calibrator serum. The instrument is a BioSystems A25 and the reference value is <40 U/L. Analyte Analyte Method ID Chem. Calibrator Instrument Reference no. Manufacturer ID Manufacturer ID values S-ALT U/L 0020 Alanine aminotransferase U/L ALT METHODS BY METHOD GROUP 188 BIOSYSTEMS 02 Calibrator serum 03 Human calibrator 99 Other, please specify Method ID Chemical IFCC comparable methods without P-5-P Abbott Aeroset, Architect ABX Diagnostics Beckman Coulter Biocon Biozyme Biocon Fluitest Biolabo BioMaxima BioMérieux BioSystems BPC BioSED srl Note! If you do not find the correct codes for your method, please send us the reagent kit insert with the methods data sheet. 188 BIOSYSTEMS 06 A15 05 A25 04 BTS BTS BTS BTS Other, specify Labquality

6 0020 Alanine aminotransferase U/L ALT IFCC comparable methods Abbott Aeroset, Architect ABX Diagnostics ABX Pentra AU instruments Beckman Coulter Biolabo biomerieux BioSystems Cormay Diagnosticum Diagon Dialab Diasys IL Test Invicon Medix Biochemica Merck Randox Roche Roche cobas Roche Cobas Integra Siemens Advia Siemens Dimension Thermo Fisher Scientific Konelab IFCC comparable methods without P-5-P Abbott Aeroset, Architect ABX Diagnostics ABX Pentra Alfa Wasserman Alpha Diagnostics AMP Diagnostics Analco AU instruments Audit Diagnostics Beckman Coulter Biocon Biozyme Biocon Fluitest Biolabo BioMaxima biomerieux BioSystems BPC BioSED srl BT Products Centronic Chema Diagnostica Cormay Diagnosticum Diagon Dialab Diasys Elitech Futura Systems Labquality 2010

7 Gesan Greiner Diagnostic Hemolab Hospitex Human IL Test Invicon Lachema Linear Chemicals Media MG Diagnostic Pars Azmon Pointe Scientific Quimica Clinica Aplicada Randox Randox RX Daytona Roche Roche cobas Roche Cobas Integra Roche DGKC SGM Siemens Advia Siemens Express Spinreact Thermo Fisher Scientific Konelab Thermo Trace Reflotron Reflotron Spotchem Spotchem Vitros and 5,1 Vitros and 5, Vitros DT60 Vitros DT CHEMICAL PRINCIPLES 093 Alpha-ketoglutarate, Ala / H2O2 / peroxidase / chromogen; reflectance 009 Alpha-ketoglutarate, Ala / NADH consumption; photometry 003 Alpha-ketoglutarate, Ala, P-5-P / NADH consumption; photometry 054 Alpha-ketoglutarate, Ala, P-5-P / NADH; reflectance 006 IFCC comparable methods 009 IFCC comparable methods without P-5-P 011 Reflotron 019 Spotchem 003 Vitros and 5,1 015 Vitros DT60 Labquality

8 0008 Albumin g/l Alb Bromcresol green Abbott Aeroset, Architect ABX Pentra Alpha Diagnostics AMP Diagnostics AU instruments Audit Diagnostics Biocon Fluitest biomerieux BioSystems BT Products Chema Diagnostica Cormay Diagnosticum Dialab Diasys Gesan Human I.S.E. SRL IL Test Linear Chemicals Pars Azmon Pointe Scientific Randox Randox RX Daytona Roche Roche cobas Roche Cobas Integra Siemens Advia Siemens Express Spinreact Thermo Fisher Scientific Konelab Thermo Trace Bromcresol purple Abbott Aeroset, Architect Audit Diagnostics Beckman Coulter Randox Roche Siemens Dimension Thermo Fisher Scientific Konelab Immunochemical methods Dako, (nephelometry) Dako, (turbidimetry) Roche Cobas Integra Roche cobas Tina-quant Roche Tina-quant Spotchem Spotchem Labquality 2010

9 Vitros and 5,1 Vitros and 5, Vitros DT60 Vitros DT CHEMICAL PRINCIPLES 024 Bromcresol green (BCG); photometry 068 Bromcresol green (BCG); reflectance 059 Bromcresol purple (BCP); photometry 192 Immunochemical methods; nephelometry 193 Immunochemical methods; turbidimetry 018 Bromcresol green 037 Bromcresol purple 059 Immunochemical methods 019 Spotchem 003 Vitros and 5,1 015 Vitros DT60 Labquality

10 0017 Alkaline phosphatase U/L ALP IFCC comparable methods (AMP) Abbott Aeroset, Architect ABX Pentra Alpha Diagnostics AU instruments Beckman Coulter Biolabo BioMaxima Biomed biomerieux SFBC BioSystems BT Products Chemia Diagnostics Chemitech Cormay Diagnosticum Dialab Diasys Gesan Greiner Diagnostic Human IL Test Invicon Pointe Scientific Randox Roche cobas Roche Cobas Integra Roche IFCC Siemens Advia Siemens Dimension Siemens Express Thermo Fisher Scientific Konelab Thermo Fisher Scientific Konelab (IFCC) Plus Thermo Trace Vital Diagnostics Vitalab SCE and DGKC comparable methods (DEA) Alfa Wasserman AMP Diagnostics AU instruments Audit Diagnostics Biocon Fluitest Biolabo biomerieux BioSystems Chema Diagnostica Chemitech Diagnosticum Diagon Dialab Diasys Elitech Futura Systems Labquality 2010

11 Gesan Globe Diagnostics Greiner Diagnostic Hospitex Human I.S.E. SRL Linear Chemicals Media Medix Biochemica Merck Ecoline MG Diagnostic Pars Azmon Randox Roche DEA SGM Spinreact Thermo Fisher Scientific Konelab AMP methods, calculated to SCE Abbott Aeroset, Architect AU instruments Beckman Coulter BioSystems Cormay Diasys Elitech Greiner Diagnostic Human Pars Azmon Roche Cobas Integra Roche IFCC Siemens Dimension Thermo Fisher Scientific Konelab MEG modifications Lachema Reflotron, IFCC-level Reflotron Reflotron Reflotron Reflotron Spotchem, IFCC-level Spotchem Vitros and 5,1, calculated to IFCC Vitros and 5, Vitros and 5,1, SCE level Vitros and 5, Labquality

12 Vitros DT60, calculated to IFCC Vitros DT Vitros DT60, calculated to SCE Vitros DT CHEMICAL PRINCIPLES 248 o-cresolphtalein phosphate / methylglucamine: reflectance photometry 025 pnpp, AMP buffer / pnp; photometry 042 pnpp, AMP buffer / pnp; reflectance 015 pnpp, DEA buffer / pnp; photometry 134 pnpp, MEG buffer / pnp; photometry 023 IFCC comparable methods (AMP) 013 SCE and DGKC comparable methods (DEA) 036 AMP methods, calculated to SCE 071 MEG modifications 080 Reflotron, IFCC-level 011 Reflotron 179 Spotchem, IFCC-level 095 Vitros and 5,1, calculated to IFCC 044 Vitros and 5,1, SCE level 108 Vitros DT60, calculated to IFCC 058 Vitros DT60, calculated to SCE 10 Labquality 2010

13 0052 Alpha-1-glycoprotein g/l A1Glypr Beckman Coulter nephelometry Beckman Coulter Siemens nephelometry BN instruments Turbidimetry AU instruments Dako Roche cobas Roche Cobas Integra Roche Tina-quant Thermo Fisher Scientific Konelab CHEMICAL PRINCIPLES 191 Antigen-antibody (Ag-Ab) complex; nephelometry 190 Antigen-antibody (Ag-Ab) complex; turbidimetry 039 Beckman Coulter nephelometry 022 Siemens nephelometry 005 Turbidimetry Labquality

14 0018 Amylase U/L Amyl IFCC comparable methods ABX Pentra AU instruments BioSystems BT Products Diagnosticum Diasys Greiner Diagnostic Human Invicon Randox EPS Roche cobas Roche Cobas Integra Roche EPS Siemens Advia Thermo Fisher Scientific Konelab Different methods, Scandinavian level Abbott Aeroset, Architect AU instruments Randox Roche Cobas Integra Roche EPS Different methods, Roche level Biocon Fluitest Centronic Cormay Dialab Diasys Human Lachema Linear Chemicals Siemens Advia Different methods, original level ACE Alfa Wasserman Alpha Diagnostics AMP Diagnostics Analco AU instruments Audit Diagnostics Biocon Fluitest Biolabo BioMaxima biomerieux BioSystems BioSystems Chemitech Cormay Diagnosticum Diagnosticum Diagon Labquality 2010

15 Diagon Elitech Futura Systems Gesan Hospitex Human I.S.E. SRL IL Test Lachema Media Pars Azmon Pointe Scientific Randox SGM Siemens Dimension Siemens Express Spinreact Spinreact Zeist Chemi Reflotron, IFCC-level Reflotron Different methods calculated to IFCC Abbott Aeroset, Architect Agappe Diagnostics Beckman Coulter Biolabo Cormay Diamedix Diagnostica Hospitex Siemens Dimension Spotchem, IFCC-level Spotchem Vitros and 5,1, calculated to IFCC Vitros and 5, Vitros and 5,1, Scandinavian level Vitros and 5, Vitros DT60, calculated to IFCC Vitros DT Vitros DT60, Scandinavian level Vitros DT CHEMICAL PRINCIPLES Labquality

16 146 Bents.-G7-pNP / pnp; reflectance 174 Benz.-G7-pNP / pnp; photometry 122 Blocked-G7-pNP / pnp; photometry 033 Cl-G3-pNP / Cl-pNP; photometry 135 Cl-G7-pNP / Cl-pNP; photometry 240 Cl-Gal-G2-pNP / Cl-pNP; photometry 058 Dyed starch / dyed saccarides; reflectance 020 Etyl.-G7-pNP / pnp; photometry 158 G4 / NADH; photometry 115 G6-pNP / pnp; photometry 131 G7-pNP / pnp; photometry 119 Indolyl-G7 / dye; reflectance 007 IFCC comparable methods 016 Different methods, Scandinavian level 032 Different methods, Roche level 024 Different methods, original level 080 Reflotron, IFCC-level 177 Different methods calculated to IFCC 179 Spotchem, IFCC-level 095 Vitros and 5,1, calculated to IFCC 046 Vitros and 5,1, Scandinavian level 108 Vitros DT60, calculated to IFCC 065 Vitros DT60, Scandinavian level 14 Labquality 2010

17 0037 Amylase, pancreatic U/L AmylP IFCC comparable methods Abbott Aeroset, Architect Beckman Coulter Biomed Diagnosticum Diagon Diasys Lachema Linear Chemicals Randox EPS Roche cobas Roche Cobas Integra Roche EPS Siemens Advia Different methods, Scandinavian level Roche Cobas Integra Different methods, Roche level Diasys Roche EPS Reflotron, IFCC-level Reflotron CHEMICAL PRINCIPLES 076 Antibody inhibition / Etyl-G7-pNP (EPS); photometry 156 Antibody inhibition / Indolyl-G7; reflectance 007 IFCC comparable methods 016 Different methods, Scandinavian level 032 Different methods, Roche level 080 Reflotron, IFCC-level Labquality

18 0053 Antitrypsin g/l Antitry Beckman Coulter nephelometry Beckman Coulter Other nephelometry Binding Site Siemens nephelometry BN instruments Turbidimetry AU instruments Orion Diagnostica Roche Cobas Integra Roche Cobas Integra Tina-quant Roche Tina-quant Siemens Advia Thermo Fisher Scientific Konelab Vitros 5,1 FS CHEMICAL PRINCIPLES 191 Antigen-antibody (Ag-Ab) complex; nephelometry 190 Antigen-antibody (Ag-Ab) complex; turbidimetry 185 Radial immunodiffusion 039 Beckman Coulter nephelometry 056 Other nephelometry 022 Siemens nephelometry 005 Turbidimetry 16 Labquality 2010

19 0019 Aspartate aminotransferase U/L AST IFCC comparable methods Abbott Aeroset, Architect ABX Diagnostics ABX Pentra AU instruments Beckman Coulter Biolabo BioSystems Cormay Diagnosticum Diagon Dialab Diasys IL Test Invicon Medix Biochemica Merck Randox Roche Roche cobas Roche Cobas Integra Siemens Advia Siemens Dimension Thermo Fisher Scientific Konelab IFCC comparable methods without P-5-P Abbott Abbott Aeroset, Architect ABX Diagnostics ABX Pentra Alfa Wasserman Alpha Diagnostics AMP Diagnostics Analco AU instruments Audit Diagnostics Beckman Coulter Biocon Biozyme Biocon Fluitest Biolabo BioMaxima biomerieux BioSystems BT Products Centronic Chemitech Cormay Diagnosticum Diagon Dialab Diasys Elitech Futura Systems Gesan Globe Diagnostics Labquality

20 Greiner Diagnostic Hemolab Hospitex Human I.S.E. SRL IL Test Invicon Lachema Linear Chemicals MG Diagnostic Olvex Pars Azmon Pointe Scientific Quimica Clinica Aplicada Randox Roche Roche cobas Roche Cobas Integra Roche DGKC SGM Siemens Advia Siemens Express Sinnowa Spinreact Thermo Fisher Scientific Konelab Thermo Trace Vital Diagnostics Vitalab Reflotron Reflotron Spotchem Spotchem Vitros and 5,1 Vitros and 5, Vitros DT60 Vitros DT CHEMICAL PRINCIPLES 096 Alpha-ketoglutarate, Ala-sulphinate, H2O2, peroxidase/chromogen; reflectance 199 Alpha-ketoglutarate, Asp / NADH consumption; photometry 070 Alpha-ketoglutarate, Asp, P-5-P / H2O2 / peroxidase / chromogen; reflectance 197 Alpha-ketoglutarate, Asp, P-5-P / NADH consumption; photometry 098 Alpha-ketoglutarate, Asp, P-5-P / NADH consumption; reflectance 006 IFCC comparable methods 009 IFCC comparable methods without P-5-P 011 Reflotron 019 Spotchem 003 Vitros and 5,1 015 Vitros DT60 18 Labquality 2010

21 0016 Bilirubin µmol/l Bil Photometry Abbott Aeroset, Architect Abbott Aeroset, Architect ABX Diagnostics ABX Pentra Alfa Wasserman Alpha Diagnostics AMP Diagnostics Analco AU instruments Audit Diagnostics BCP BioSed Beckman Coulter Biocon Fluitest Biolabo BioMaxima biomerieux BioSystems BioSystems BT Products Centronic Chema Diagnostica Chemlex LabKit Chemitech Cormay Cormay Diaglobe Diagnosticum Diagnosticum Diagon Diagon Dialab Diasys Diasys Elitech Elitech Futura Systems Gesan Globe Diagnostics Greiner Diagnostic Hemolab Hospitex Hospitex Hospitex Human Human DCA I.S.E. SRL IL Test Invicon Lachema Linear Chemicals Linear Chemicals Merck MG Diagnostic Labquality

22 Pars Azmon Pointe Scientific Randox Randox Randox RX Daytona Roche Roche, acid diazo DPD Roche cobas Roche Cobas Integra, acid diazo, detergent SGM Siemens Advia Siemens Advia Siemens Dimension Siemens Express Sinnowa Spinreact, acid diazo, detergent Spinreact, acid diazo Thermo Fisher Scientific Konelab Thermo Fisher Scientific Konelab NBD Thermo Trace Vitalab Wako Reflotron Reflotron Spotchem Spotchem Vitros and 5,1 Vitros and 5, Vitros DT60 Vitros TBIL DT CHEMICAL PRINCIPLES 049 Acid diazo, Caffeine, Na-benzoate (Jendrassik-Grof applications); photometry 008 Acid diazo, Detergent (Malloy-Evelyn and applications); photometry 069 Alkaline diazo, Caffeine, Na-benzoate (Jendrassik-Grof applications); photometry 237 Biliverdin, Na nitrite; photometry 201 Dyphylline, benzene diazonium hexafluorophosphate; reflectance 047 Dyphylline, diazonium salt; bichromatic reflectance 205 Jendrassik-Grof applications; reflectance 247 Vanadate oxidation, biliverdin; photometry 001 Photometry 011 Reflotron 019 Spotchem 003 Vitros and 5,1 015 Vitros DT60 20 Labquality 2010

23 0046 Bilirubin, neonatal µmol/l Bil neo Bilirubinometers Bilirubinometers Photometry Abbott Aeroset, Architect Abbott Aeroset, Architect ABX Diagnostics Alpha Diagnostics AU instruments Beckman Coulter Biolabo biomerieux BioSystems Cormay DCL Diagon Diasys Elitech Gesan Hospitex Human DCA Invicon Lachema Roche, acid diazo DPD Roche cobas Siemens Advia Siemens Advia Siemens Express Siemens Dimension Thermo Fisher Scientific Konelab Thermo Fisher Scientific Konelab NBD Wako Roche Cobas Integra Roche Cobas Integra, alkaline diazo Roche Cobas Integra, acid diazo, detergent Vitros and 5,1, TBil Vitros TBIL Vitros , BuBc Vitros BuBc Blood-gas instruments Blood-gas instruments continues on next page4 Labquality

24 CHEMICAL PRINCIPLES 049 Acid diazo, Caffeine, Na-benzoate (Jendrassik-Grof applications); photometry 008 Acid diazo, Detergent (Malloy-Evelyn and applications); photometry 069 Alkaline diazo, Caffeine, Na-benzoate (Jendrassik-Grof applications); photometry 237 Biliverdin, Na nitrite; photometry 202 Caffeine, Na-benzoate; bichromatic reflectance 094 Direct measurement; photometry 047 Dyphylline, diazonium salt; bichromatic reflectance 247 Vanadate oxidation, biliverdin; photometry 188 Bilirubinometers 001 Photometry 053 Roche Cobas Integra 100 Vitros and 5,1, TBil 101 Vitros , BuBc 189 Blood-gas instruments 22 Labquality 2010

25 0048 C-reactive protein mg/l CRP Afinion and NycoCard Afinion NycoCard Single Test Nephelometry Beckman Coulter Binding Site Orion Diagnostica Turbox Siemens nephelometry QuikRead Orion Diagnostica QuikRead Turbidimetry Abbott Aeroset, Architect ABX Diagnostics ABX Micros CRP ABX Pentra Alfa Wasserman AMP Diagnostics Aqua-Med AU instruments, Latex AU instruments Beckman Coulter Biokit quantex CRP Biomed biomerieux BioSystems Cormay Dako Diasys Elitech Fitzgerald Futura Systems Human Humatex CRP-latex Invicon Orion Diagnostica Randox Randox CRP Full Range Randox RX Daytona Randox CRP sensitive Roche cobas Roche Cobas Integra Roche cobas Tina-quant Roche Tina-quant Scil Diagnostics Siemens Advia, CRP_2 Assay Siemens Advia Siemens Dimension Siemens Turbiquant Spinreact Thermo Fisher Scientific Konelab Thermo Fisher Scientific Konelab CRP Plus Labquality

26 Vitros and 5,1 Vitros CRP Other methods Omega Diagnostics, Avitex-CRP Siemens Immulite, hscrp CHEMICAL PRINCIPLES 191 Antigen-antibody (Ag-Ab) complex; nephelometry 190 Antigen-antibody (Ag-Ab) complex; turbidimetry 195 Antigen-antibody (Ag-Ab) latex complex; nephelometry 196 Antigen-antibody (Ag-Ab) latex complex; turbidimetry 018 Luminoimmunoassay 170 Microparticle agglutination immunoassay 194 Sandwich immunometric / dye; reflectance 083 Afinion and NycoCard 060 Nephelometry 034 QuikRead 005 Turbidimetry 003 Vitros and 5,1 017 Other methods 24 Labquality 2010

27 0010 Calcium mmol/l Ca AAS and flame photometry Atomic absorption spectrophotometry Flame photometry, internal Li-standard Complexometric titration Ca-titrator Photometry Abbott Aeroset, Architect ABX Diagnostics ABX Pentra Alfa Wasserman Alpha Diagnostics, arsenazo Alpha Diagnostics, OCP AMP Diagnostics AU instruments, arsenazo AU instruments, OCP Audit Diagnostics Audit Diagnostics Beckman Coulter, arsenazo Biocon Fluitest Biocon Fluitest Biolabo Biolabo BioMaxima biomerieux, MTB biomerieux, OCP BioSystems, MTB BioSystems BioSystems BT Products Centronic Chema Diagnostica Chemlex LabKit Chemitech Cormay Cypress Diagnostics Darman Kave Diagnosticum Diagnosticum Diagon Diagon Dialab Diasis Diagnostik Sistemier Diasys Diasys Elitech Elitech Futura Systems Gesan Gesan Globe Diagnostics Greiner Diagnostic Greiner Diagnostic Hemolab Hospitex Human I.S.E. SRL IL Test Invicon Linear Chemicals Media MG Diagnostic Olvex-Diagnosticum Labquality

28 Pars Azmon Pars Azmon Pointe Scientific, OCP Prodia ProDiagnostica Quimica Clinica Aplicada Randox Randox Randox RX Daytona Randox RX Daytona Roche Roche Cobas Roche Cobas Integra SGM Siemens Advia, OCP Siemens Advia, arsenatso Siemens Dimension Siemens Express Space Spinreact Thermo Fisher Scientific Konelab Thermo Trace Vital Diagnostics Vitalab Potentiometry ISE Spotchem Spotchem Vitros and 5,1 Vitros and 5, Vitros DT60 Vitros DT CHEMICAL PRINCIPLES 036 Arsenazo III; photometry 065 Arsenazo III; reflectance 164 EGTA/Calcein; complexometric titration 032 Emission flame photometry 118 Inhibition of anion interference with lanthanium; atomic absorption spectrophotometry 132 ISE; potentiometry 090 Methylthymol blue (MTB); photometry 022 o-cresolphthalein (OCP); photometry 137 o-cresolphthalein (OCP); reflectance 066 AAS and flame photometry 084 Complexometric titration 001 Photometry 070 Potentiometry 019 Spotchem 003 Vitros and 5,1 015 Vitros DT60 26 Labquality 2010

29 0049 Calcium, ionized mmol/l Ca-Ion ISE direct ABX Diagnostics Easylite IL blood gas and electrolyte analysers Nova Biomedical electrolyte analysers Radiometer blood gas analyser Roche blood gas and electrolyte analysers Siemens blood gas and electrolyte analysers Thermo Fisher Scientific electrolyte analysers Thermo Fisher Scientific Konelab ISE direct, others Calculated Calculated CHEMICAL PRINCIPLES 038 Calculated 187 Direct potentiometry 004 ISE direct 190 Calculated Labquality

30 0054 Calcium, ionized, ph corrected mmol/l Ca-ion,pH7.4 ISE direct Easylite IL blood gas and electrolyte analysers Nova Biomedical electrolyte analysers Radiometer blood gas analyzer Roche blood gas and electrolyte analysers Siemens blood gas and electrolyte analysers Thermo Fisher Scientific electrolyte analysers Thermo Fisher Scientific Konelab ISE direct, others CHEMICAL PRINCIPLES 187 Direct potentiometry 004 ISE direct 28 Labquality 2010

31 0003 Chloride mmol/l Cl ISE direct ABX Diagnostics Easylite IL blood gas and electrolyte analysers Radiometer blood gas analyzer Roche blood gas and electrolyte analysers Roche Cobas Integra Siemens blood gas and electrolyte analysers Thermo Fisher Scientific electrolyte analysers Thermo Fisher Scientific Konelab ISE direct, others ISE indirect Abbott Aeroset Abbott Architect AU instruments Beckman Coulter Synchron Beckman Coulter UniCel Roche Roche cobas Roche Cobas Integra Siemens Advia Siemens Dimension ISE indirect, others Photometry and titrimetry Alpha Diagnostics AMP Diagnostics AMS Liasys Audit Diagnostics biomerieux Diagnosticum Dialab Gesan Hospitex Human, Human Chloride titrator Linear Chemicals Pars Azmon Pointe Scientific Randox Siemens Express Vitros and 5,1 Vitros and 5, Vitros DT60 Vitros DT CHEMICAL PRINCIPLES 114 Coulometric titration 187 Direct potentiometry 188 Indirect potentiometry 092 Mercuric thiocyanate / ferric nitrate; photometry 138 TPTZ / mercuric nitrate / ferrous sulphate; photometry. 004 ISE direct 003 Vitros and 5,1 010 ISE indirect 015 Vitros DT Photometry and titrimetry Labquality

32 0014 Cholesterol mmol/l Chol Photometry, enzymatic Abbott Aeroset, Architect ABX Diagnostics ABX Pentra Alfa Wasserman Alpha Diagnostics AMP Diagnostics Analco AU instruments Audit Diagnostics Beckman Coulter Biocon Biosub Biocon Fluitest Biolabo BioMaxima biomerieux BioSystems BT Products Centronic Chema Diagnostica Chemlex LabKit Chemitech Cormay Diagnosticum Diagon Dialab Diasys Elitech Futura Systems Gesan Globe Diagnostics Greiner Diagnostic Hemolab Hospitex Human I.S.E. SRL IL Test Invicon Lachema Linear Chemicals Medix Biochemica Merck PAP MG Diagnostic Pars Azmon Pointe Scientific Quimica Clinica Aplicada Randox Randox RX Daytona Roche Roche cobas Roche Cobas Integra SGM Siemens Advia Siemens Dimension Labquality 2010

33 Siemens Express Sinnowa Spinreact Thermo Fisher Scientific Konelab Thermo Trace Vital Diagnostics Reflotron Reflotron Spotchem Spotchem Vitros and 5,1 Vitros and 5, Vitros DT60 Vitros DT CHEMICAL PRINCIPLES 004 Cholesterol esterase, cholesterol oxidase, H2O2, peroxidase / chromogen; photometry 030 Cholesterol esterase, cholesterol oxidase, H2O2, peroxidase / chromogen; reflectance 002 Photometry, enzymatic 011 Reflotron 019 Spotchem 003 Vitros and 5,1 015 Vitros DT60 Labquality

34 0047 Cholesterol, high density liporoteins mmol/l Chol-HDL Dextran sulphate precipitation Thermo Fisher Scientific Konelab Direct Chol-HDL, Abbott Abbott Abbott Aeroset, Architect Direct Chol-HDL, Beckman Coulter AU instruments Beckman Coulter Direct Chol-HDL, BioSystems BioSystems Direct Chol-HDL, Thermo Fisher Scientific Konelab Thermo Fisher Scientific Konelab Thermo Fisher Scientific Konelab HDL Cholesterol Plus Direct Chol-HDL, other methods A.L. Instrument ABX Diagnostics ABX Pentra Alfa Wasserman AMP Diagnostics Audit Diagnostics Biolabo BioMaxima biomerieux BT Products Centronic Chema Diagnostica Cormay Diagnosticum Diagon Dialab Diasys Elitech Futura Systems Greiner Diagnostic Human I.S.E. SRL IL Test Invicon Lachema Linear Chemicals MG Diagnostic Quimica Clinica Aplicada Randox, pegme Randox RX Daytona Randox, clearance Sentinel SGM Spinreact Thermo Trace Wako Labquality 2010

35 Direct Chol-HDL, Roche systems Roche Roche cobas Roche Cobas Integra Direct Chol-HDL, Siemens Siemens Advia Siemens Dimension PEG precipitation Alpha Diagnostics Chema Diagnostica Media Pointe Scientific SGM Phosphotungstate precipitation AMP Diagnostics Analco Biocon Fluitest Biolabo biomerieux BioSystems Chemitech Cormay Diagnosticum Diagon Elitech Hospitex Human I.S.E. SRL Lachema Linear Chemicals Pars Azmon Randox Roche Spinreact Reflotron Reflotron Spotchem Spotchem Vitros and 5,1 Vitros and 5, Vitros DT60 Vitros DT Direct Chol-HDL, Vitros Vitros and 5, Labquality

36 CHEMICAL PRINCIPLES 035 Dextran sulphate/mg++ precipitation; Cholesterol determination of the supernatant 010 Direct measurement of HDL-cholesterol after decomposition of cholesterol from other lipoproteines 041 Phosphotungstate/Mg++ precipitation; Cholesterol determination of the supernatant 124 Polyethylene glycol (PEG) precipitation; Cholesterol determination of the supernatant 054 Dextran sulphate precipitation 196 Direct Chol-HDL, Abbott 198 Direct Chol-HDL, Beckman Coulter 200 Direct Chol-HDL, BioSystems 102 Direct Chol-HDL, Thermo Fisher Scientific Konelab 012 Direct Chol-HDL, other methods 186 Direct Chol-HDL, Roche systems 202 Direct Chol-HDL, Siemens 067 PEG precipitation 028 Phosphotungstate precipitation 011 Reflotron 019 Spotchem 003 Vitros and 5,1 015 Vitros DT Direct Chol-HDL, Vitros 34 Labquality 2010

37 0056 Cholesterol, low density lipoproteins mmol/l Chol-LDL Direct Chol-LDL, Abbott Abbott Abbott Aeroset, Architect Direct Chol-LDL, Beckman Coulter AU instruments Beckman Coulter Direct Chol-LDL, BioSystems BioSystems Direct Chol-LDL, Thermo Fisher Scientific Konelab Thermo Fisher Scientific Konelab Direct Chol-LDL, other methods ABX Diagnostics ABX Pentra Alfa Wasserman AMP Diagnostics Biolabo biomerieux BT Products Chema Diagnostica Cormay Diagnosticum Diagon Diasys Elitech Genzyme N-geneous Greiner Diagnostic Human I.S.E. SRL IL Test Invicon Lachema Linear Chemicals MG Diagnostic Pars Azmon Randox Sentinel Spinreact Vitalab Wako Direct Chol-LDL, Roche-systems Roche Roche cobas Roche Cobas Integra Direct Chol-LDL, Siemens Siemens Advia Siemens Dimension Labquality

38 Friedewald s formula Friedewald s formula Vitros and 5,1 Vitros and 5, CHEMICAL PRINCIPLES 038 Calculated 046 Direct measurement of LDL-cholesterol after decomposition of cholesterol from other lipoproteines 197 Direct Chol-LDL, Abbott 199 Direct Chol-LDL, Beckman Coulter 201 Direct Chol-LDL, BioSystems 105 Direct Chol-LDL, Thermo Fisher Scientific Konelab 030 Direct Chol-LDL, other methods 187 Direct Chol-LDL, Roche-systems 203 Direct Chol-LDL, Siemens 027 Friedewald s formula 003 Vitros and 5,1 36 Labquality 2010

39 0061 Complement C3 g/l C3 Nephelometry Beckman Coulter Binding Site Siemens nephelometry Turbidimetry Abbott Dako Lachema Pars Azmon Randox Roche Roche Cobas Integra Siemens Advia Thermo Fisher Scientific Konelab CHEMICAL PRINCIPLES 191 Antigen-antibody (Ag-Ab) complex; nephelometry 190 Antigen-antibody (Ag-Ab) complex; turbidimetry 060 Nephelometry 005 Turbidimetry 0062 Complement C4 g/l C4 Nephelometry Beckman Coulter Binding Site Siemens nephelometry Turbidimetry Dako Lachema Pars Azmon Randox Roche Roche Cobas Integra Siemens Advia Thermo Fisher Scientific Konelab CHEMICAL PRINCIPLES 191 Antigen-antibody (Ag-Ab) complex; nephelometry 190 Antigen-antibody (Ag-Ab) complex; turbidimetry 060 Nephelometry 005 Turbidimetry Labquality

40 0038 Copper µmol/l Cu Atomic absorption spectrophotometry Atomic absorption spectrophotometry Atomic emission spectrophotometry ICP-ES Photometry AMP Diagnostics Audit Diagnostics BioVendor Chema Diagnostica Lachema Merck Pars Azmon Randox Roche Roche Thermo Electron Co Mass spectrometry ICP-MS CHEMICAL PRINCIPLES 066 Atomic absorption spectrophotometry 121 Bathocuproin / chromogen; photometry 159 di-br-paesa; photometry 172 Emission spectrometry 251 Guanidine HCl, 5-Br-PSAA; photometry 252 Mass spectrometry 038 Atomic absorption spectrophotometry 191 Atomic emission spectrophotometry 001 Photometry 347 Mass spectrometry 38 Labquality 2010

41 0030 Cortisol nmol/l Cortisol Orion Diagnostica Orion Diagnostica SPECTRIA Roche systems Roche cobas Roche Elecsys Roche Modular E Siemens Advia Centaur & ACS Siemens Advia Centaur Siemens Immulite Siemens Immulite Other methods Abbott Architect Abbott AxSym Adaltis Beckman Coulter Access biomerieux Vidas DiaSorin Liaison DRG Diagnostics DSL Monobind ELISA Orgenics Pars Azmon Perkin Elmer Delfia / AutoDelfia Vitros ECi CHEMICAL PRINCIPLES 027 Electrochemiluminescense immunoassay 034 Enzyme immunoassay 075 Fluorescence polarization immunoassay 018 Luminoimmunoassay 085 Radioimmunoassay 062 Time-resolved fluoroimmunoassay 063 Orion Diagnostica 185 Roche systems 033 Siemens Advia Centaur & ACS 026 Siemens Immulite 017 Other methods Labquality

42 0021 Creatine kinase U/L CK IFCC comparable methods Abbott Aeroset, Architect ABX Diagnostics ABX Pentra ACE Alfa Wasserman Alpha Diagnostics AMP Diagnostics AU instruments Beckman Coulter Biocon Biolabo Biomed biomerieux BioSystems Chema Diagnostica Chemitech Cormay Diagnosticum Diagon Dialab Diasys Elitech Gesan Greiner Diagnostic Hospitex Human IL Test Invicon Linear Chemicals Merck Pars Azmon Randox Roche Roche cobas Roche Cobas Integra Rolf Greiner BioChemica SGM Siemens Advia Siemens Express Thermo Fisher Scientific Konelab Thermo Trace Other methods Audit Diagnostics Autolab Biocon Biozyme BT Products Diagnosticum Pointe Scientific Siemens Dimension Reflotron Reflotron Labquality 2010

43 Spotchem Spotchem Vitros and 5,1 Vitros and 5, Vitros DT60 Vitros DT CHEMICAL PRINCIPLES 198 Creatine-P, ADP, NAC activator / H202, peroxidase, chromogen; reflectance 013 Creatine-P, ADP, NAC activator / NADPH; photometry 056 Creatine-P, ADP, NAC activator / NADPH; reflectance 126 Other kinetic methods; photometry 007 IFCC comparable methods 042 Other methods 011 Reflotron 019 Spotchem 003 Vitros and 5,1 015 Vitros DT60 Labquality

44 0005 Creatinine µmol/l Crea Photometry, enzymatic Abbott Aeroset, Architect AU instruments Biomed Diasys Elitech Invicon Roche, Plus Roche cobas Roche Cobas Integra Sentinel Siemens Advia Thermo Fisher Scientific Konelab Photometry, Jaffe Abbott Aeroset, Architect ABX Diagnostics ABX Pentra Alfa Wasserman Alpha Diagnostics AMP Diagnostics Analco AU instruments Audit Diagnostics Beckman Coulter Biocon Fluitest Biolabo biomerieux BioSystems Biotrol BT Products Chema Diagnostica Chemitech Cormay Diagnosticum Diagon Dialab Diasys Elitech Futura Systems Gesan Globe Diagnostics Greiner Diagnostic Hemolab Hospitex Human I.S.E. SRL IL Test Invicon Lachema Linear Chemicals Merck MG Diagnostic Olvex Labquality 2010

45 Pars Azmon Pointe Scientific Quimica Clinica Aplicada Randox Randox RX Daytona Reagena Roche Roche cobas Roche Cobas Integra SGM Siemens Advia Siemens Dimension Siemens Express Sinnowa Spinreact Thermo Fisher Scientific Konelab Thermo Fisher Scientific Konelab Compens Jaffe Thermo Trace Vital Diagnostics Vitalab Reflotron Reflotron Spotchem Spotchem Vitros and 5,1 Vitros and 5, Vitros DT60 Vitros DT CHEMICAL PRINCIPLES 105 3,5-Dinitrobenzoic acid; reflectance 200 Alkaline picrate (Jaffe); photometry 130 Creatininase / PAP; photometry 241 Creatinine deiminase / NADPH; photometry 129 Enzyme / H2O2 / chromogen; photometry 039 Enzyme / H2O2 / chromogen; reflectance 002 Photometry, enzymatic 008 Photometry, Jaffe 011 Reflotron 019 Spotchem 003 Vitros and 5,1 015 Vitros DT60 Labquality

46 0051 Digitoxin nmol/l Digit Abbott Abbott Architect Abbott AxSym Abbott Quantia Abbott TDx Roche systems Roche cobas Roche Cobas Integra Roche Elecsys Siemens Advia Centaur & ACS Siemens Advia Centaur Siemens Immulite Siemens Immulite Roche ONLINE TDM Roche ONLINE TDM CHEMICAL PRINCIPLES 190 Antigen-antibody (Ag-Ab) complex; turbidimetry 027 Electrochemiluminescense immunoassay 034 Enzyme immunoassay 075 Fluorescence polarization immunoassay 018 Luminoimmunoassay 014 Abbott 185 Roche systems 033 Siemens Advia Centaur & ACS 026 Siemens Immulite 182 Roche ONLINE TDM 44 Labquality 2010

47 035 Ferritin µg/l Ferritin Abbott Abbott Architect Abbott AxSym Abbott IMx Roche systems Roche cobas Roche Cobas Integra Roche Elecsys Roche Modular E Roche Tina-quant Siemens Advia Centaur & ACS Siemens ACS Siemens Advia Centaur Siemens Immulite Siemens Immulite Siemens Immuno 1 Siemens Immuno Vitros ECi Vitros ECi Perkin Elmer Delfia/Auto Delfia Perkin Elmer Delfia / AutoDelfia Other methods Abbott Quantia ABX Pentra AccuBind Adaltis AU instruments Beckman Coulter Access biomerieux Vidas BioSystems ClinPro Cormay BN instruments DiaSorin Liaison Diasys DRG Diagnostics Linear Chemicals Novatec Orgentec Diagnostika Pars Azmon Pars Azmon Radim S.p. A. reagents Siemens Dimension Labquality

48 CHEMICAL PRINCIPLES 190 Antigen-antibody (Ag-Ab) complex; turbidimetry 195 Antigen-antibody (Ag-Ab) latex complex; nephelometry 196 Antigen-antibody (Ag-Ab) latex complex; turbidimetry 027 Electrochemiluminescense immunoassay 063 Enzym-fluoroimmunoassay 034 Enzyme immunoassay 136 Latex-immunoturbidimetry 018 Luminoimmunoassay 021 Microparticle enzyme immunoassay 085 Radioimmunoassay 062 Time-resolved fluoroimmunoassay 014 Abbott 041 Perkin Elmer Delfia/Auto Delfia 185 Roche systems 062 Roche Tina-quant 033 Siemens Advia Centaur & ACS 026 Siemens Immulite 068 Siemens Immuno Vitros ECi 017 Other methods 46 Labquality 2010

49 0009 Glucose mmol/l Glucose Amperometry Amperometric analyzer Beckman Coulter Hemocue Hemocue glucose, whole blood Hemocue glucose, plasma Photometry Abbott Aeroset, Architect ABX Diagnostics, HK ABX Diagnostics, GOD-PAP ABX Pentra Alfa Wasserman Alpha Diagnostics, GOD-PAP AMP Diagnostics Analco AU instruments Audit Diagnostics, GOD POD Beckman Coulter, HK Biocon Biosub Biocon Fluitest Biolabo BioMaxima biomerieux BioSystems BT Products Centronic Centronic, GOD-PAP Chemitech Cormay Diagnosticum Diagon Dialab Diasys, GOD-PAP Diasys Elitech Futura Systems Gesan Globe Diagnostics Greiner Diagnostic Hemolab Hospitex Human Human I.S.E. SRL IL Test IL Test Invicon Lachema Linear Chemicals Merck, GDH MG Diagnostic Pars Azmon Labquality

50 Pointe Scientific Randox, GOD-PAP Randox, HK Randox RX Daytona Roche, HK Roche cobas Roche Cobas Integra Roche GOD-PAP SGM Siemens Advia Siemens Advia Siemens Dimension Siemens Express Sinnowa Spinreact Thermo Fisher Scientific Konelab, GOD, POD Thermo Fisher Scientific Konelab, HK Thermo Trace Reflotron Reflotron Spotchem Spotchem Vitros and 5,1 Vitros and 5, Vitros DT60 Vitros DT CHEMICAL PRINCIPLES 051 Glucose dehydrogenase, mutarotase / NADH; photometry 084 Glucose dehydrogenase, mutarotase, diaphorase / NADH / MTTH; photometry 080 Glucose oxidase / H2O2- or O2-electrode; amperometry 028 Glucose oxidase, H2O2 / chromogen; photometry 037 Glucose oxidase, H2O2 / chromogen; reflectance 017 Hexokinase, glucose-6-p-dehydrogenase / NADH; photometry 035 Amperometry 048 Hemocue 001 Photometry 011 Reflotron 019 Spotchem 003 Vitros and 5,1 015 Vitros DT60 48 Labquality 2010

51 0032 Glutamyl transferase U/L GT IFCC comparable methods Abbott Aeroset, Architect ABX Diagnostics ABX Pentra Alfa Wasserman AMP Diagnostics AU instruments Beckman Coulter Biocon Biolabo Biolabo BioSystems BT Products Centronic Diagnosticum Diagon Dialab Diasys Elitech Greiner Diagnostic Human IL Test Invicon Lachema Linear Chemicals Medix Biochemica MG Diagnostic Quimica Clinica Aplicada Randox Roche Roche, IFCC Roche cobas Roche Cobas Integra Siemens Advia Siemens Dimension Siemens Express Thermo Fisher Scientific Konelab Thermo Trace GLUCANA-Tris, original level AMP Diagnostics AU instruments Audit Diagnostics, Audit Diagnostics Biocon Biozyme Biocon Fluitest Biolabo BioMaxima Chema Diagnostica Clinilab Cormay Diagnosticum Diagon Diasys Elitech Futura Systems Gesan Globe Diagnostics Hospitex Human Labquality

52 I.S.E. SRL Media Pars Azmon Pointe Scientific Randox Roche SGM Spinreact Thermo Fisher Scientific Konelab Vital Diagnostics Vitalab GLUNA, original level Alpha Diagnostics biomerieux Chemitech Futura Systems Hospitex Lachema Pointe Scientific Randox Reflotron, IFCC-level Reflotron Reflotron Reflotron Spotchem Spotchem Vitros and 5,1 Vitros and 5, Vitros DT60 Vitros DT CHEMICAL PRINCIPLES 089 GLUCA-phenylenediamine, glycylglycine / dye; reflectance 023 GLUCANA, glycylglycine / p-nitroanilin; photometry 029 GLUCANA, glycylglycine,tris / p-nitroanilin; photometry 045 GLUNA, glycylglycine / p-nitroanilin; reflectance 149 GLUNA, glycylglycine, AMP / p-nitroanilin; photometry 086 GLUNA, glycylglycine, Tris / p-nitroanilin; photometry 112 Other kinetic methods; photometry 007 IFCC comparable methods 029 GLUCANA-Tris, original level 043 GLUNA, original level 080 Reflotron, IFCC-level 011 Reflotron 019 Spotchem 003 Vitros and 5,1 015 Vitros DT60 50 Labquality 2010

53 0031 Haemoglobin g/l Hb Photometry ABX Diagnostics Baker Beckman Coulter BioSystems Biotest Hemoglobin U Cell-Dyn, Cyanide-free Cell-Dyn Diagnosticum Diasys Hemocue Labnova Linear Chemicals Mindray Nihon Kohden Reagena Siemens Siemens Advia Sysmex reagent, Instruments: K-1000, K-4500, K-800, SE-9000/9500, SF-3000, XE Sysmex reagent, Instruments: Others Sysmex reagent, Instruments: KX-21N Photometry, direct measurement Radiometer blood gas analyzer Reflotron Reflotron CHEMICAL PRINCIPLES 019 Azidmethemoglobin; photometry 110 Cyanide-free methemoglobin; photometry 011 Cyanmethemoglobin (hemoglobin cyanide); photometry 123 Cyanmethemoglobin; reflectance photometry 031 Na-laurylsulphate; photometry 142 Oxyhaemoglobin; direct measurement 001 Photometry 049 Photometry, direct measurement 011 Reflotron Labquality

54 0029 Haptoglobin g/l Haptog Beckman Coulter nephelometry Beckman Coulter Other nephelometry Orion Diagnostica Turbox Siemens nephelometry BN instruments Turbidimetry Abbott Aeroset, Architect Siemens Turbiquant Dako Roche Cobas Integra Tina-quant Roche cobas Tina-quant Roche Tina-quant Siemens Advia Thermo Fisher Scientific Konelab Vitros 5,1 FS RID RID CHEMICAL PRINCIPLES 191 Antigen-antibody (Ag-Ab) complex; nephelometry 190 Antigen-antibody (Ag-Ab) complex; turbidimetry 185 Radial immunodiffusion 039 Beckman Coulter nephelometry 056 Other nephelometry 022 Siemens nephelometry 005 Turbidimetry 184 RID 52 Labquality 2010

55 0042 Immunoglobulin A g/l IgA Beckman Coulter nephelometry Beckman Coulter Other nephelometry Binding Site Orion Diagnostica Turbox Siemens nephelometry BN instruments Turbidimetry Abbott Aeroset, Architect ABX Diagnostics AU instruments Beckman Coulter BioSystems DiAgam Diasys Futura Systems Invicon Linear Chemicals Merck Orion Diagnostica Pars Azmon Randox RX Daytona Roche Cobas Integra Roche cobas Tina-quant Roche Tina-quant Siemens Advia Siemens Dimension Siemens Turbiquant Spinreact Thermo Fisher Scientific Konelab Vitros 5,1 FS RID Biocientifica Far Diagnostics Human Institute Cantacuzino Liofilchem CHEMICAL PRINCIPLES 191 Antigen-antibody (Ag-Ab) complex; nephelometry 190 Antigen-antibody (Ag-Ab) complex; turbidimetry 185 Radial immunodiffusion 039 Beckman Coulter nephelometry 056 Other nephelometry 022 Siemens nephelometry 005 Turbidimetry 184 RID Labquality

56 0043 Immunoglobulin E ku/l IgE Abbott Abbott Aeroset, Architect Abbott IMx Phadia Phadia CAP IgE FEIA Roche Cobas Core Roche Cobas Core Roche systems Roche Elecsys Roche Modular E Siemens Advia Centaur & ACS Siemens ACS Siemens Advia Centaur Siemens Immulite Siemens Immulite Other methods AMP Diagnostics Beckman Coulter Access biomerieux Vidas ClinPro BN instruments Diasys DRG Diagnostics Human Pars Azmon Pishtaz teb Randox Roche Spinreact Trinity biotech Veda.Lab CHEMICAL PRINCIPLES 027 Electrochemiluminescense immunoassay 063 Enzym-fluoroimmunoassay 034 Enzyme immunoassay 139 Latex agglutination nephelometry and immunoassay 179 Latex-agglutination, immunoturbidimetry 018 Luminoimmunoassay 021 Microparticle enzyme immunoassay 014 Abbott 061 Phadia 057 Roche Cobas Core 185 Roche systems 033 Siemens Advia Centaur & ACS 026 Siemens Immulite 017 Other methods 54 Labquality 2010

57 0044 Immunoglobulin G g/l IgG Beckman Coulter nephelometry Beckman Coulter Other nephelometry Binding Site Orion Diagnostica Turbox Siemens nephelometry BN instruments Turbidimetry Abbott Aeroset, Architect ABX Diagnostics AU instruments Beckman Coulter BioSystems Dako DiAgam Diasys Greiner Diagnostic Invicon Linear Chemicals Merck Orion Diagnostica Pars Azmon Roche Cobas Integra Roche cobas Tina-quant Roche Tina-quant Rotest Siemens Advia Siemens Turbiquant Spinreact Thermo Fisher Scientific Konelab Vitros 5,1 FS RID Biocientifica Human Institute Cantacuzino Liofilchem CHEMICAL PRINCIPLES 191 Antigen-antibody (Ag-Ab) complex; nephelometry 190 Antigen-antibody (Ag-Ab) complex; turbidimetry 185 Radial immunodiffusion 039 Beckman Coulter nephelometry 056 Other nephelometry 022 Siemens nephelometry 005 Turbidimetry 184 RID Labquality

58 0045 Immunoglobulin M g/l IgM Beckman Coulter nephelometry Beckman Coulter Other nephelometry Binding Site Orion Diagnostica Turbox Siemens nephelometry BN instruments Turbidimetry Abbott Aeroset, Architect ABX Diagnostics AU instruments Beckman Coulter BioSystems Diasys Invicon Linear Chemicals Merck Orion Diagnostica Pars Azmon Randox RX Daytona Roche Cobas Integra Roche cobas Tina-quant Roche Tina-quant Siemens Advia Siemens Turbiquant Spinreact Thermo Fisher Scientific Konelab Vitros 5,1 FS RID Biocientifica Human Institute Cantacuzino Liofilchem CHEMICAL PRINCIPLES 191 Antigen-antibody (Ag-Ab) complex; nephelometry 190 Antigen-antibody (Ag-Ab) complex; turbidimetry 185 Radial immunodiffusion 039 Beckman Coulter nephelometry 056 Other nephelometry 022 Siemens nephelometry 005 Turbidimetry 184 RID 56 Labquality 2010

59 0023 Iron µmol/l Fe Photometry Abbott Aeroset, Architect ABX Pentra Alfa Wasserman Alpha Diagnostics AMP Diagnostics Analco Archem AU instruments Audit Diagnostics Audit Diagnostics Beckman Coulter Biocon Fluitest Biocon Fluitest Biolabo Biolabo BioMaxima biomerieux, ferrozine biomerieux, ferene BioSystems Biotrol BT Products Centronic Chema Diagnostica Chemlex LabKit Chemitech Cormay Cormay Diagnosticum Diagnosticum Diagon Diagon Dialab Diasys Elitech Elitech Futura Systems Gesan Globe Diagnostics Greiner Diagnostic Hemolab Hospitex Human Human I.S.E. SRL IL Test Invicon Lachema, ferrozine Linear Chemicals Linear Chemicals Media Media MG Diagnostic MG Diagnostic Labquality

60 Pars Azmon Pointe Scientific Prodia Quimica Clinica Aplicada Randox Randox Randox RX Daytona Roche Roche cobas Roche Cobas Integra SGM Siemens Advia Siemens Dimension Siemens Express, ferene Spinreact Spinreact Thermo DMA Thermo Fisher Scientific Konelab, ferene Thermo Fisher Scientific Konelab, ferrozine Thermo Trace Vital Diagnostics Vitalab Zeist Chemi Vitros and 5,1 Vitros and 5, Vitros DT60 Vitros DT CHEMICAL PRINCIPLES 095 Chromazurol B (CAB); photometry 055 Ferene; photometry 026 Ferrozine; photometry 245 Nitro PAPS; photometry 082 Pyridylazo chromogen; reflectance 161 Sulphonated batophenanthroline (SBP); photometry 141 TPTZ; photometry 001 Photometry 003 Vitros and 5,1 015 Vitros DT60 58 Labquality 2010

61 0022 Lactate dehydrogenase U/L LD IFCC comparable methods Abbott Aeroset, Architect ABX Pentra AU instruments Beckman Coulter BioSystems BT Products Diagnosticum Diasys Greiner Diagnostic Invicon Roche Roche cobas Roche Cobas Integra Siemens Advia Siemens Dimension Siemens Express Thermo Fisher Scientific Konelab SCE-, DGKC-, SFBC-recommendations ABX Pentra ACE AMP Diagnostics AU instruments Audit Diagnostics Beckman Coulter Biocon Biozyme Biolabo biomerieux, DGKC BioSystems Biotrol Chemitech Cormay Diagnosticum Diagon Diasys Elitech Futura Systems Gesan Giesse Diagnostics Greiner Diagnostic Hospitex Human, SCE Human DGKC I.S.E. SRL IL Test Linear Chemicals Pars Azmon Randox, SCE Randox DGKC Roche cobas Roche Cobas Integra DGKC Roche DGKC SGM Labquality

62 Thermo Fisher Scientific Konelab, SCE Thermo Trace Different methods calculated to SCE Analco Beckman Coulter Roche Roche Cobas Integra Spinreact Vitros and 5,1, calculated to IFCC level Vitros and 5, Vitros and 5,1, calculated to SCE Vitros and 5, Vitros and 5,1, original level Vitros and 5, Vitros DT60, original level Vitros DT CHEMICAL PRINCIPLES 067 Lactate, NAD / NADH; photometry 106 Other kinetic methods; photometry 061 Pyruvate, NADH / NAD; photometry 071 Pyruvate, NADH / NAD; reflectance 052 IFCC comparable methods 020 SCE-, DGKC-, SFBC-recommendations 047 Different methods calculated to SCE 098 Vitros and 5,1, calculated to IFCC level 045 Vitros and 5,1, calculated to SCE 081 Vitros and 5,1, original level 097 Vitros DT60, original level 60 Labquality 2010

63 0004 Lactic acid mmol/l Lactate Amperometry, Radiometer Blood-gas instruments Amperometry, Roche Blood-gas instruments Amperometry, others Amperometric analyzer Blood-gas instruments Photometry, enzymatic Abbott Aeroset, Architect AU instruments Beckman Coulter biomerieux Diasys Randox Roche Roche cobas Roche Cobas Integra Siemens Advia Siemens Dimension Sigma Vitros and 5,1 Vitros and 5, Vitros DT60 Vitros DT CHEMICAL PRINCIPLES 081 Lactate oxidase / H2O2 / 4-aminoantipyrene; photometry 104 Lactate oxidase / H2O2 / 4-aminoantipyrene; reflectance 088 Lactate oxidase / H2O2 electrode; amperometry 150 LD / hydrazine / NADH; photometry 192 Amperometry, Radiometer 193 Amperometry, Roche 194 Amperometry, others 002 Photometry, enzymatic 003 Vitros and 5,1 015 Vitros DT60 Labquality

64 0040 Lithium mmol/l Li Atomic absorption spectrophotometry Atomic absorption spectrophotometry Flame photometry Flame photometry, without internal standard Flame photometry, internal Cs-standard Flame photometry, internal K standard Pars Azmon ISE direct Easylite IL blood gas and electrolyte analysers Roche blood gas and electrolyte analysers Roche Cobas Integra Siemens blood gas and electrolyte analysers Thermo Fisher Scientific electrolyte analysers Thermo Fisher Scientific Konelab ISE direct, others ISE indirect Roche cobas Roche Cobas Integra ISE indirect, others Photometry Abbott Aeroset, Architect Diazyme Roche cobas Siemens Advia Siemens Dimension Thermo Electron Co Vitros and 5,1 Vitros and 5, Vitros DT60 Vitros DT CHEMICAL PRINCIPLES 066 Atomic absorption spectrophotometry 171 Chromogen 204 Crown-ether azo dye / dye complex; reflectance 187 Direct potentiometry 032 Emission flame photometry 169 Enzymatic method; absorption photometry 188 Indirect potentiometry 038 Atomic absorption spectrophotometry 025 Flame photometry 004 ISE direct 010 ISE indirect 001 Photometry 003 Vitros and 5,1 015 Vitros DT60 62 Labquality 2010

65 0011 Magnesium mmol/l Mg Atomic absorption spectrophotometry Atomic absorption spectrophotometry Photometry Abbott Aeroset, Architect ABX Pentra Alfa Wasserman Alpha Diagnostics, arsenazo Alpha Diagnostics, calmagite AMP Diagnostics AMP Diagnostics Analco AU instruments Beckman Coulter Biocon Fluitest Biolabo Biolabo BioMaxima biomerieux BioSystems BT Products Centronic Chema Diagnostica Chemlex LabKit Chemitech Cormay Diagnosticum Diagon Dialab Dialab Diasys Diasys Elitech Futura Systems Gesan Globe Diagnostics Greiner Diagnostic Hemolab Hospitex Human I.S.E. SRL IL Test Invicon Linear Chemicals MG Diagnostic Pars Azmon Pointe Scientific Quimica Clinica Aplicada Randox, xylidyl blue Randox, calmagite Roche Roche cobas Roche Cobas Integra SGM Labquality

66 Siemens Advia Siemens Dimension Siemens Express, xylidyl blue Siemens Express, magonsulphonate Spinreact Thermo Fisher Scientific Konelab, xylidyl blue Thermo Trace Vital Diagnostics Vitalab Zeist Chemi Spotchem Spotchem Vitros and 5,1 Vitros and 5, Vitros DT60 Vitros DT CHEMICAL PRINCIPLES 036 Arsenazo III; photometry 060 Calmagite; photometry 083 Chlorophosphonazo III (CPZ III); photometry 079 Formazan; reflectance 148 Glucokinase / G-6-PDH / NADPH; photometry 118 Inhibition of anion interference with lanthanium; atomic absorption spectrophotometry 163 Magonsulphonate; photometry 090 Methylthymol blue (MTB); photometry 137 o-cresolphthalein (OCP); reflectance 044 Xylidyl blue; photometry 038 Atomic absorption spectrophotometry 001 Photometry 019 Spotchem 003 Vitros and 5,1 015 Vitros DT60 64 Labquality 2010

67 0050 Osmolality mosm/kg Osmol All Vapour pressure method Freezing point method CHEMICAL PRINCIPLES 053 Freezing point depression osmometry 166 Vapour pressure osmometry 031 All Labquality

68 0012 Phosphorus mmol/l Pi Photometry Abbott Aeroset, Architect ABX Pentra Alpha Diagnostics AMP Diagnostics Analco AU instruments Audit Diagnostics Beckman Coulter Biocon Fluitest Biolabo BioMaxima biomerieux, UV-photometry BioSystems BT Products Cormay Diagnosticum Diagon Dialab Diasys Elitech Gesan Greiner Diagnostic Hospitex Human I.S.E. SRL IL Test Lachema Linear Chemicals Pars Azmon Pointe Scientific Randox Roche, UV-photometry Roche cobas Roche Cobas Integra SGM Siemens Advia Siemens Dimension Siemens Express Spinreact Thermo Fisher Scientific Konelab Thermo Trace Spotchem Spotchem Vitros and 5,1 Vitros and 5, Vitros DT60 Vitros DT Labquality 2010

69 CHEMICAL PRINCIPLES 014 Ammonium molybdate, phosphomolybdate complex, without reducing agent or deproteinization; photometry 165 Ammonium molybdate, reducing agent / molybdenum blue, deproteinization: photometry 152 Ammonium molybdate, reducing agent / molybdenum blue, without deproteinization: photometry 243 Ammonium molybdate, reducing agent; photometry 073 Ammonium molybdate, reducing agent; reflectance 001 Photometry 019 Spotchem 003 Vitros and 5,1 015 Vitros DT60 Labquality

70 0002 Potassium mmol/l K Flame photometry Flame photometry, without internal standard Flame photometry, internal Cs-standard Flame photometry, internal Li-standard Pars Azmon ISE direct Abbott i-stat ABX Diagnostics Easylite IL blood gas and electrolyte analysers Radiometer blood gas analyzer Roche blood gas and electrolyte analysers Roche Cobas Integra Siemens blood gas and electrolyte analysers Thermo Fisher Scientific electrolyte analysers Thermo Fisher Scientific Konelab ISE direct, others ISE indirect Abbott Aeroset Abbott Architect AU instruments Beckman Coulter Synchron Beckman Coulter UniCel Roche Roche cobas Roche Cobas Integra Siemens Advia Siemens Dimension ISE indirect, others Photometry Centronic Futura Systems Futura Systems Greiner Diagnostic Hospitex Human Linear Chemicals Randox Spinreact Reflotron Reflotron Spotchem Spotchem Vitros and 5,1 Vitros and 5, Vitros DT60 Vitros DT Labquality 2010

71 CHEMICAL PRINCIPLES 057 Chromogenic ionophore: Complex Valinomycin-pH indicator-k; reflectance 187 Direct potentiometry 032 Emission flame photometry 188 Indirect potentiometry 246 TPB-Na, without deproteinization; turbidimetry 127 TPB-Na; deproteinisation; turbidimetry 025 Flame photometry 004 ISE direct 010 ISE indirect 001 Photometry 011 Reflotron 019 Spotchem 003 Vitros and 5,1 015 Vitros DT60 Labquality

72 0007 Protein g/l Prot Photometry Abbott Aeroset, Architect ABX Diagnostics ABX Pentra Alfa Wasserman Alpha Diagnostics AMP Diagnostics AU instruments Audit Diagnostics Beckman Coulter Biocon Fluitest Biolabo BioMaxima biomerieux BioSystems BT Products Centronic Chema Diagnostica Chemitech Cormay Cromatest Diagnosticum Diagon Dialab Diasys Elitech Futura Systems Gesan Globe Diagnostics Greiner Diagnostic Hemolab Hospitex Human I.S.E. SRL IL Test Invicon Lachema Linear Chemicals MG Diagnostic Olvex Pars Azmon Pointe Scientific Randox Randox RX Daytona Roche Roche cobas Roche Cobas Integra SGM Siemens Advia Siemens Dimension Siemens Express Spinreact Thermo Fisher Scientific Konelab Thermo Trace Labquality 2010

73 Refractometry Refractometrical method Spotchem Spotchem Vitros and 5,1 Vitros and 5, Vitros DT60 Vitros DT CHEMICAL PRINCIPLES 016 Biuret method; photometry 077 Biuret method; reflectance 144 Refractometry 001 Photometry 074 Refractometry 019 Spotchem 003 Vitros and 5,1 015 Vitros DT60 Labquality

74 0039 Selenium µmol/l Se Atomic absorption spectrophotometry Atomic absorption spectrophotometry Graphite furnace AAS Atomic emission spectrophotometry Thermo Electron Co Fluorometry Fluorimetric method Mass spectrometry ICP-MS CHEMICAL PRINCIPLES 066 Atomic absorption spectrophotometry 239 Diaminonaphthalene; fluorimetry 250 ICP-AES hybride 252 Mass spectrometry 038 Atomic absorption spectrophotometry 191 Atomic emission spectrophotometry 173 Fluorometry 347 Mass spectrometry 72 Labquality 2010

75 0001 Sodium mmol/l Na Flame photometry Flame photometry, without internal standard Flame photometry, internal Cs-standard Flame photometry, internal Li-standard Pars Azmon ISE direct Abbott i-stat ABX Diagnostics Easylite IL blood gas and electrolyte analysers Radiometer blood gas analyzer Roche blood gas and electrolyte analysers Roche Cobas Integra Siemens blood gas and electrolyte analysers Thermo Fisher Scientific electrolyte analysers Thermo Fisher Scientific Konelab ISE direct, others ISE indirect Abbott Aeroset Abbott Architect AU instruments Beckman Coulter Synchron Beckman Coulter UniCel Roche Roche cobas Roche Cobas Integra Siemens Advia Siemens Dimension ISE indirect, others Photometry Biolabo Centronic Futura Systems Greiner Diagnostic Hospitex Human Linear Chemicals Spinreact Spotchem Spotchem Vitros and 5,1 Vitros and 5, Vitros DT60 Vitros DT Labquality

76 CHEMICAL PRINCIPLES 187 Direct potentiometry 032 Emission flame photometry 180 Enzymatic method; photometry 188 Indirect potentiometry 147 Mg-uranylacetate method; photometry 025 Flame photometry 004 ISE direct 010 ISE indirect 001 Photometry 019 Spotchem 003 Vitros and 5,1 015 Vitros DT60 74 Labquality 2010

77 0033 Thyreotropine mu/l TSH Abbott Abbott Architect Abbott AxSym Abbott AxSym 3rd Generation TSH Abbott IMx Beckman Coulter Access Beckman Coulter Access Orion Diagnostica Orion Diagnostica SPECTRIA Roche Cobas Core Roche Cobas Core Roche systems Roche cobas Roche Elecsys Roche Modular E Siemens Advia Centaur & ACS Siemens ACS Siemens Advia Centaur Siemens Immulite Siemens Immulite Vitros ECi Vitros ECi Perkin Elmer Delfia/Auto Delfia Perkin Elmer Delfia / AutoDelfia Other methods Adaltis Adaltis EIAgen biomerieux Vidas Clinotech ClinPro Diagnostic Systems Laboratories Dialab DiaSorin Liaison DIMA DRG Diagnostics DRG Diagnostics ultrasensitive ELISA DSL EIA General Biologicals Corporation Human MG Diagnostic Mobind Pars Azmon Radim S.p. A. reagents Teco Diagnostics ELISA Tosoh AIA Labquality

78 CHEMICAL PRINCIPLES 027 Electrochemiluminescense immunoassay 063 Enzym-fluoroimmunoassay 034 Enzyme immunoassay 018 Luminoimmunoassay 021 Microparticle enzyme immunoassay 085 Radioimmunoassay 062 Time-resolved fluoroimmunoassay 014 Abbott 077 Beckman Coulter Access 063 Orion Diagnostica 041 Perkin Elmer Delfia/Auto Delfia 057 Roche Cobas Core 185 Roche systems 033 Siemens Advia Centaur & ACS 026 Siemens Immulite 055 Vitros ECi 017 Other methods 76 Labquality 2010

79 0028 Thyroxine nmol/l T4 Abbott Abbott Architect Abbott AxSym Abbott IMx Roche systems Roche cobas Roche Elecsys Roche Modular E Siemens Advia Centaur & ACS Siemens ACS Siemens Advia Centaur Siemens Immulite Siemens Immulite Vitros ECi Vitros ECi Perkin Elmer Delfia/Auto Delfia Perkin Elmer Delfia / AutoDelfia Other methods Adaltis Beckman Coulter Access biomerieux Vidas DiaSorin Liaison DRG Diagnostics DSL EIA Human Mobind Pars Azmon Pishtaz teb Radim S.p. A. reagents Roche Cobas Core Teco Diagnostics ELISA Tosoh AIA CHEMICAL PRINCIPLES 027 Electrochemiluminescense immunoassay 063 Enzym-fluoroimmunoassay 034 Enzyme immunoassay 075 Fluorescence polarization immunoassay 018 Luminoimmunoassay 085 Radioimmunoassay 062 Time-resolved fluoroimmunoassay 014 Abbott 041 Perkin Elmer Delfia/Auto Delfia 185 Roche systems 033 Siemens Advia Centaur & ACS 026 Siemens Immulite 055 Vitros ECi 017 Other methods Labquality

80 0034 Thyroxine, free pmol/l T4 free Abbott Abbott Architect Abbott AxSym Abbott IMx Beckman Coulter Access Beckman Coulter Access Roche Cobas Core Roche systems Roche cobas Roche Elecsys Roche Modular E Siemens Advia Centaur & ACS Siemens ACS Siemens Advia Centaur Siemens Immulite Vitros ECi Perkin Elmer Delfia / AutoDelfia Other methods AccuBind Adaltis Adaltis EIAgen biomerieux Vidas Clinotech Diagnostic Systems Laboratories DiaSorin Liaison DIMA DRG Diagnostics DSL EIA Human Mobind Teco Diagnostics ELISA Tosoh AIA CHEMICAL PRINCIPLES 027 Electrochemiluminescense immunoassay 063 Enzym-fluoroimmunoassay 034 Enzyme immunoassay 018 Luminoimmunoassay 021 Microparticle enzyme immunoassay 062 Time-resolved fluoroimmunoassay 014 Abbott 077 Beckman Coulter Access 041 Perkin Elmer Delfia/Auto Delfia 057 Roche Cobas Core 185 Roche systems 033 Siemens Advia Centaur & ACS 026 Siemens Immulite 055 Vitros ECi 017 Other methods 78 Labquality 2010

81 0024 Total iron binding capacity µmol/l TIBC Calculated from transferrin Calculated from transferrin Photometry Abbott Aeroset, Architect Aqua-Med AU instruments Beckman Coulter biomerieux BT Products Cormay Darman Kave Darman Kave Diagnosticum Human Lachema Linear Chemicals Pars Azmon Pars Azmon Roche Roche Roche cobas Roche Cobas Integra Siemens Advia Siemens Dimension Thermo DMA Vitros and 5,1 Vitros and 5, CHEMICAL PRINCIPLES 091 Calculated from transferrin 102 Direct measurement of UIBC (LIBC); photometry 203 Iron saturation of transferrin, removal of excess Fe with alumina column; reflectance 113 Iron saturation of transferrin, removal of excess free Fe with aluminium oxid; photometry 074 Iron saturation of transferrin, removal of excess free Fe with MgCO3; photometry 051 Calculated from transferrin 001 Photometry 003 Vitros and 5,1 Labquality

82 0025 Transferrin g/l Transf Beckman Coulter nephelometry Beckman Coulter Other nephelometry Binding Site Orion Diagnostica Turbox Siemens nephelometry BN instruments Turbidimetry Abbott Aeroset, Architect ABX Pentra AU instruments Beckman Coulter Biokit quantex Transferin biomerieux Dako DiAgam Diasys Linear Chemicals Orion Diagnostica Pars Azmon Roche Cobas Integra Tina-quant Roche cobas Tina-quant Roche Tina-quant Siemens Advia Siemens Dimension Siemens Turbiquant Thermo Fisher Scientific Konelab Vitros 5,1 FS CHEMICAL PRINCIPLES 191 Antigen-antibody (Ag-Ab) complex; nephelometry 190 Antigen-antibody (Ag-Ab) complex; turbidimetry 039 Beckman Coulter nephelometry 056 Other nephelometry 022 Siemens nephelometry 005 Turbidimetry 80 Labquality 2010

83 0060 Transferrin receptor, soluble mg/l TfR Orion Diagnostica Orion Diagnostica IDeA stfr-it Roche systems Roche Cobas Integra Roche Cobas Integra Tina-quant Roche cobas Tina-quant Roche Tina-quant Siemens nephelometry Siemens N Latex stfr Thermo Fisher Scientific Konelab Thermo Fisher Scientific Konelab stfr CHEMICAL PRINCIPLES 191 Antigen-antibody (Ag-Ab) complex; nephelometry 190 Antigen-antibody (Ag-Ab) complex; turbidimetry 196 Antigen-antibody (Ag-Ab) latex complex; turbidimetry 063 Orion Diagnostica 185 Roche systems 022 Siemens nephelometry 195 Thermo Fisher Scientific Konelab Labquality

84 0015 Triglycerides mmol/l Trigly Photometry, enzymatic Abbott Aeroset, Architect ABX Pentra Alfa Wasserman Alpha Diagnostics AMP Diagnostics Analco AU instruments Audit Diagnostics Beckman Coulter Biocon Fluitest Biolabo BioMaxima biomerieux BioSystems BT Products Centronic Chema Diagnostica Chemitech Cormay Diagnosticum Diagon Dialab Diasys Elitech Futura Systems Greiner Diagnostic Hemolab Hospitex Human I.S.E. SRL IL Test Invicon Lachema Linear Chemicals Merck Ecoline Pars Azmon Pointe Scientific Randox Randox RX Daytona Roche Roche cobas Roche Cobas Integra SGM Siemens Advia Siemens Dimension Siemens Express Spinreact Thermo Fisher Scientific Konelab, GPO, Trinder Thermo Trace Reflotron Reflotron Labquality 2010

85 Spotchem Spotchem Vitros and 5,1 Vitros and 5, Vitros DT60 Vitros DT CHEMICAL PRINCIPLES 108 Ascorbate oxidase, lipase, G-3-P-oxidase, H2O2, peroxidase / chromogen; reflectance 120 Lipase, GDH / NADH; photometry 006 Lipase, GK/G-3-P-oxidase, H2O2, peroxidase / chromogen; photometry 043 Lipase, GK/G-3-P-oxidase, H2O2, peroxidase / chromogen; reflectance 002 Photometry, enzymatic 011 Reflotron 019 Spotchem 003 Vitros and 5,1 015 Vitros DT60 Labquality

86 0026 Triiodothyronine nmol/l T3 Abbott Abbott Architect Abbott AxSym Abbott IMx Roche systems Roche cobas Roche Elecsys Roche Modular E Siemens Advia Centaur & ACS Siemens ACS Siemens Advia Centaur Siemens Immulite Vitros ECi Perkin Elmer Delfia/Auto Delfia Other methods Adaltis Beckman Coulter Access biomerieux Vidas Clinotech DiaSorin Liaison DIMA DRG Diagnostics DSL EIA Pars Azmon Pars Azmon Pishtaz teb Radim S.p. A. reagents Roche Cobas Core Teco Diagnostics ELISA Tosoh AIA CHEMICAL PRINCIPLES 027 Electrochemiluminescense immunoassay 063 Enzym-fluoroimmunoassay 034 Enzyme immunoassay 018 Luminoimmunoassay 021 Microparticle enzyme immunoassay 085 Radioimmunoassay 062 Time-resolved fluoroimmunoassay 014 Abbott 041 Perkin Elmer Delfia/Auto Delfia 185 Roche systems 033 Siemens Advia Centaur & ACS 026 Siemens Immulite 055 Vitros ECi 017 Other methods 84 Labquality 2010

87 0006 Urea mmol/l Urea Photometry, enzymatic Abbott Aeroset, Architect ABX Diagnostics ABX Pentra Alfa Wasserman Alpha Diagnostics AMP Diagnostics Analco AU instruments Audit Diagnostics Beckman Coulter, UV-photometry Beckman Coulter, conductometry Biocon Biosub Biocon Fluitest Biolabo BioMaxima biomerieux BioSystems BioSystems, UV Centronic Chema Diagnostica Chemlex LabKit Chemitech Cormay Diagnosticum Diagon Dialab Diasys Elitech Futura Systems Gesan Globe Diagnostics Greiner Diagnostic Hospitex Human, VIS-photometry Human, UV-photometry I.S.E. SRL IL Test Invicon Lachema Linear Chemicals Linear Chemicals MG Diagnostic Pars Azmon Pointe Scientific Randox Randox RX Daytona Roche Roche cobas Roche Cobas Integra SGM Siemens Advia Siemens Dimension Siemens Express Labquality

88 Spinreact Spinreact Thermo Fisher Scientific Konelab Thermo Trace Vital Diagnostics Reflotron Reflotron Spotchem Spotchem Vitros and 5,1 Vitros and 5, Vitros DT60 Vitros DT CHEMICAL PRINCIPLES 167 Phtalaldehyde / chromogen; reflectance 064 Urease / ammonia indicator; reflectance 157 Urease / ions; conductometry 103 Urease / phenolate hypochlorite (Berthelot s method); photometry 012 Urease, glutamate dehydrogenase / NADH; photometry 002 Photometry, enzymatic 011 Reflotron 019 Spotchem 003 Vitros and 5,1 015 Vitros DT60 86 Labquality 2010

89 0013 Uric acid µmol/l Uric acid Photometry, enzymatic Abbott Aeroset, Architect ABX Diagnostics ABX Pentra ABX Pentra Alfa Wasserman Alpha Diagnostics AMP Diagnostics Analco AU instruments Audit Diagnostics Beckman Coulter Biocon Biosub Biocon Fluitest Biocon Fluitest Biolabo Biolabo BioMaxima biomerieux BioSystems BioSystems BT Products Centronic Chema Diagnostica Chemlex LabKit Chemitech Cormay Cormay Diagnosticum Diagnosticum Diagon Diagon Dialab Diasys Diasys Elitech Elitech Futura Systems Greiner Diagnostic Greiner Diagnostic Hemolab Hospitex Human I.S.E. SRL IL Test Labor+Technik Eberhard Lehmann Lachema Linear Chemicals Merck Pars Azmon Pars Azmon Pointe Scientific Randox Randox RX Daytona Labquality

90 Roche Roche cobas Roche Cobas Integra SGM Siemens Advia Siemens Dimension Siemens Express Spinreact Thermo Fisher Scientific Konelab, AOX Thermo Fisher Scientific Konelab, TBHBA Thermo Trace Reflotron Reflotron Spotchem Spotchem Vitros and 5,1 Vitros and 5, Vitros DT60 Vitros DT CHEMICAL PRINCIPLES 116 Uricase / allantoin; photometry 007 Uricase, H2O2, peroxidase / chromogen; photometry 040 Uricase, H2O2, peroxidase / chromogen; reflectance 002 Photometry, enzymatic 011 Reflotron 019 Spotchem 003 Vitros and 5,1 015 Vitros DT60 88 Labquality 2010

91 0041 Zinc µmol/l Zn Atomic absorption spectrophotometry Atomic absorption spectrophotometry Atomic emission spectrophotometry ICP-ES Photometry Chema Diagnostica Randox Sentinel Wako Mass spectrometry ICP-MS CHEMICAL PRINCIPLES Bromo-PAPS / chromogen; photometry 066 Atomic absorption spectrophotometry 172 Emission spectrometry 252 Mass spectrometry 249 Nitro-PAPS; photometry 038 Atomic absorption spectrophotometry 191 Atomic emission spectrophotometry 001 Photometry 347 Mass spectrometry Labquality

92 Manufacturers 001 ABBOTT 331 ADALTIS 078 ADVANCED INSTRU- MENTS 422 AGILENT TECHNOLO- GIES 399 ALFA WASSERMANN 153 ALPHA DIAGNOSTIC 019 AMERICAN OPTICAL 359 AMERSHAM BIO- SCIENCES 193 AMP Diagnostics 327 AMS 159 ANALCO 006 ARKRAY (KYOTO DAI- ICHI) 325 AUDIT DIAGNOSTICS AVL (see Roche) 377 AWARENESS TECHNOLOGY U.S.A 396 AXIS SHIELD 181 BCR IRMM 051 BECKMAN COULTER 397 BINDING SITE 373 BIO-MEDICALS 346 BIOCHEMICAL SYSTEMS 112 BIOCLIN 161 BIOCON 115 BIOLABO 336 BIOMAXIMA 302 BIOMED 342 BIOMERICA 095 BIOMERIEUX 337 BIOMETRIA 188 BIOSYSTEMS 334 BIOTECNICA 320 BIOTEK 185 BIOTEST MEDIZINTECH- NIK GMBH 139 BIOTROL 356 BPC BIOSED SRL 094 BYK-SANGTEC DIAG- NOSTICA 425 CAMSPEC 376 CARE DIAGNOSTICA 179 CENTRONIC 367 CGA STRUMENT SCIENTIFICI 369 CHEMITECH 148 CORMAY 347 CRONY INSTRUMENTS 332 CYPRESS DIAGNOS- TICS 122 DAKO 175 DEKS 191 DIAGNOSTICUM 324 DIAGON 167 DIALAB 361 DIASIS DIAGNOSTIK SISTEMIER (DDS) 335 DIASORIN 158 DIASYS 410 DIATRON 045 DR LANGE 343 DRG DIAGNOSTIC 391 ELECTA Lab 386 ELICO 319 ELITECH 010 EPPENDORF 378 EUROLAB 409 EUROLYSER 086 FISKE ASSOCIATES 404 FUTURA SYSTEMS 435 GARNI MEDICAL 417 GDV 160 GENZYME 424 GESAN 084 GONOTEC 081 GREINER DIAGNOSTICS 048 HEMOCUE 082 HORIBA ABX DIAGNOS- TICS 170 HOSPITEX 102 HUMAN 195 HYCEL 163 HYDREX 420 I.S.E. S.r.l. 171 IMMUNOTECH 150 IMUNA 381 INNOMED 014 INSTRUMENTATION LABORATORY (IL) 349 INVICON 096 IONETICS 407 IZOTOP 406 JENWAY 056 KNAUER 432 KPSONTECH 121 LACHEMA 018 LIC 344 LINEAR CHEMICALS 431 LIOFILCHEM DIAGNOS- TICI 383 MARCEL 322 MAXMAT 107 MEDICA 091 MEDINOR 109 MERCK 419 METROLAB 413 MINDRAY 145 NIHON KOHDEN 363 NOBIS 020 NOVA BIOMEDICAL OLYMPUS (see Beckman Coulter) 055 ORION DIAGNOSTICA 072 ORTHO-CLINICAL DIAG- NOSTICS 387 PARS AZMON 021 PERKIN ELMER 131 PHADIA 157 POINTE SCIENTIFIC 149 POLL 177 R&D 024 RADIOMETER 117 RANDOX 124 REAGENA 341 ROBERT RIELE 026 ROCHE 062 ROEBLING 104 RUBY 061 SCIENTIFIC INSTRU- MENTS (LEICA) 368 SEAC RADIM GROUP 303 SENTINEL CH. 028 SHIMADZU 057 SIEMENS 421 SINNOWA 199 SPINREACT 172 STRECK LAB. 154 SWELAB 030 SYSMEX 384 TECAN 017 THERMO FISCHER SCI- ENTIFIC 357 TOKYO BOEKI 166 TRIDENT MED S.C. 434 UNICAM 200 VITAL SCIENTIFIC 032 VITALAB 031 VITATRON 118 WAKO 080 YSI INC. 033 ZEISS 393 ZEIST CHEMI 90 Labquality 2010

93 Instruments 001 ABBOTT Aeroset Alcyon Alcyon 300i Architect Architect c Architect ci Architect i Architect i2000sr AxSYM Cell-Dyn Cell-Dyn Cell-Dyn Cell-Dyn Cell-Dyn Cell-Dyn Cell-Dyn Cell-Dyn Cell-Dyn Cell-Dyn Cell-Dyn Cell-Dyn Cell-Dyn Ruby Cell-Dyn Saphire i-stat IMx Spectrum TDxFLx VP 331 ADALTIS Eclectica 078 ADVANCED INSTRUMENTS Cryomatic 3C Digimatic Micro Osmometer (3MO, 30 plus, 3300) Osmometer Osmometer 3D3 399 ALFA WASSERMANN ACE Alera ACE system 153 ALPHA DIAGNOSTIC Airone Jolly-100 CRONY 019 AMERICAN OPTICAL Bilirubinometer 193 AMP Diagnostics PLATOS R Tecan Sunrise 327 AMS AIRONE 200RA AMS Liasys AUTOLAB AUTOLAB Autolab PM Fully SABA ARKRAY (KYOTO DAIICHI) LactatePro OM OM Spotchem EL SE Spotchem SE Spotchem SP Spotchem SP Spotchem SP AVL (see Roche) 377 AWARENESS TECHNOLOGY U.S.A Chemwell Chemwell Stat Fax Stat Fax Stat Fax Stat Fax Stat Fax 303 PLUS Stat Fax Stat Fax1904 Plus 396 AXIS SHIELD Afinion AS BECKMAN COULTER Access AcT 2 Diff AcT 5 Diff Array Protein System AU AU AU AU AU AU AU300i Coulter AcT 18 Diff Coulter AcT Coulter CBC Coulter GEN-S Coulter HmX Coulter LH Coulter M Coulter M Coulter MaxM Coulter MD Coulter MD Coulter MD II Coulter Micro Diff Coulter Onyx Coulter STKS Coulter T Coulter T Coulter T Glucose Analyzer Immage Synchron CX Synchron CX Synchron CX Synchron CX Synchron EL-ISE Synchron LX System UniCel DxC UniCel DxI Unicel Dxl BINDING SITE Minineph 373 BIO-MEDICALS SmartLab ERBA 346 BIOCHEMICAL SYSTEMS FULLY Fully RM Fully Smart MAP-LAB PLUS Screen Master 3000 Labquality

94 342 BIOMERICA Genesis A BIOMERIEUX Alize Clinilab Mini Vidas Reader 230S UV-VIS Vidas VIS Visual 337 BIOMETRIA Genesis A BIOSYSTEMS A A BTS BTS BTS BTS BIOTECNICA BT BT BT 3000 T.A.R.G.A Plus 320 BIOTEK ELX BIOTEST MEDIZIN- TECHNIK GMBH Biotest Hemoglobin Tester 356 BPC BIOSED SRL KUADRO 094 BYK-SANGTEC DIAGNOSTICA LIA-mat Liaison 425 CAMSPEC M CARE DIAGNOSTICA Eco Twenty 179 CENTRONIC Eurolyser 007 CHRISTIAN NISSEN Hb CORMAY Accent Accent Liasys MULTI MuRH Plus Prestige 24i 347 CRONY INSTRUMENTS Airone 200 RA Jolly Saturno Saturno DIAGON D-CHEM DIALAB Autolyser Diatron DIASORIN Liaison 158 DIASYS Star Dust Star Dust MC Super G 045 DR LANGE LP LP LP ELECTA Lab Minilab Turbi-Quick 010 EPPENDORF Chloride meter EBIO EBIO Compact EBIO Plus ECOM EFOX ESAT FCM PCP EUROLAB Eurolyser 086 FISKE ASSOCIATES Micro Osmometer Multi Sample Osmometer One-Ten Osmometer OStm Osmometer 084 GONOTEC Osmomat Osmomat auto 048 HEMOCUE Hemocue Hemocue Gluc meter Hemocue Gluc meter Hemocue Hb meter 013 HITACHI Hitachi Hitachi HORIBA ABX DIAGNOSTICS Argos Cobas Bio Fara Micros (60) Micros CRP Micros CRP Mira Mira Plus Mira S Pentra Pentra DX Labquality 2010

95 170 HOSPITEX EOS 880c EOS Bravo EOS Bravo Forte EOS Bravo Plus Eos Bravo W Screen Master Screen Master Plus Screen Master Point Screen Master Seac Screen Point Stat Fax SEAC 102 HUMAN S plus Elisys Uno Humalyzer Humalyzer Humalyzer Humalyzer 900 F Plus Humalyzer Junior Human Humareader Single HumaStar HumaStar HumaStar HumaStar Star HYCEL Hycel Lisa Lisa 300 Plus Lisa 500 Plus 420 I.S.E. S.r.l Echo Echo Plus Miura Miura INNOMED VIS INSTRUMENTATION LABORATORY (IL) GEM Premier ILab ILab 300 Plus ILab ILab ILyte Synthesis 25 Labquality JENWAY PFP Clinical 056 KNAUER Osmometer 344 LINEAR CHEMICALS Croma Line AR PLus GEA Microplate Reader 383 MARCEL EURO 107 MEDICA EasyLyte 091 MEDINOR NycoCard READER 109 MERCK Magia Mega Vitatron 419 METROLAB Plus 413 MINDRAY BC BC-2800 Plus BC-3000 Plus BS BS NIHON KOHDEN Celltac alfa Celltac MEK 7222 K MEK MEK 5105 K MEK 6108 K MEK 6318 K MEK 8118 K MEK 8222K Celltac F 363 NOBIS Nobilyzer PM NOVA BIOMEDICAL Nova Nova Phox Plus Stat Profile ORION DIAGNOSTICA QuikRead Turbox Turbox Plus 072 ORTHO-CLINICAL DIAGNOSTICS Vitros Vitros Vitros 5,1 FS Vitros Vitros Vitros 750 XRC Vitros Vitros DT Vitros ECi 021 PERKIN ELMER B AAnalyst AAnalyst AAnalyst AutoDELFIA Delfia 1232/ ELAN DRC-e Wizard PHADIA ImmunoCAP ImmunoCAP ImmunoCAP Pharmacia CAP System FEIA Pharmacia CAP System RIA 157 POINTE SCIENTIFIC POLL Epoll Epoll-20 93

96 024 RADIOMETER ABL ABL ABL ABL ABL ABL ABL ABL ABL ABL ABL 800 Flex ABL ABL 825 Flex ABL 835 Flex EML EML FLM ICA ICA2 117 RANDOX RX Daytona 341 ROBERT RIELE PM PM PM ROCHE Autolab AVL AVL AVL AVL AVL AVL AVL 983-S AVL 984-S AVL 985-S AVL AVL BM cobas c cobas c cobas c Cobas Core cobas e cobas e cobas h Elecsys Elecsys Hitachi Hitachi Hitachi Hitachi Hitachi Hitachi Hitachi Integra Integra 400 Plus Integra Integra Keysys Modular E Modular E Modular P/D Omni Omni S / cobas b Photometer Reflotron (II) Reflotron (I) Reflotron IV Reflotron Plus 062 ROEBLING Osmometer Automatic 061 SCIENTIFIC INSTRUMENTS (LEICA) Leica Unistat Bilirubinometer 368 SEAC RADIM GROUP Screen Master Seac Slim 352 SHERWOOD M SHIMADZU AA AA BioSpec CL CL CL UV UV-160A UV1700 Pharma- Spec 057 SIEMENS Express Express Advia Advia Advia Advia Advia Advia Advia Advia Centaur Advia Centaur XP Advia CentaurCP BN II BN ProSpec Dimension XPand Dimension AR Dimension ARx Dimension ES Dimension RxL Dimension XL FL Immulite Immulite Immulite Immulite ISE ISE ISE ISE ISE Rapid Point Rapidchem Rapidchem RapidLab RapidLab RapidLab RapidLab RapidLab RapidLab SINNOWA B B BS-3000P Z-003 elektrode Z SYSMEX Sysmex CC Sysmex CC Sysmex F Sysmex F Sysmex F Sysmex K Sysmex K Sysmex K Sysmex KX Sysmex poch-100i Sysmex SF Sysmex XE Sysmex XS 1000i Sysmex XT 1800i Sysmex XT 2000i 94 Labquality 2010

97 154 SWELAB AC AC TECAN Sunrise 017 THERMO FISCHER SCIENTIFIC Delta Konelab 20i Konelab 20XT Konelab 20XTi Konelab 30i Konelab 60i Konelab Prime Microlyte Microlyte Optima PRO Specific Supra 031 VITATRON IFP ISP 080 YSI INC YSI 1500 Lactate Analyzer (portable) YSI 2300GL Lact/ Gluc Analyzer 033 ZEISS AAS Abbe Refractometer Spekol Spekol Spekol Spekol EK TOKYO BOEKI Biolis 24i Prestige 24i 093 TOSOH AIA AIA TRIDENT MED S.C Osmometer 800 Cl 200 VITAL SCIENTIFIC Microlab Selectra XL 032 VITALAB Eclipse Flexor E Flexor Junior Flexor XL Microlab Microlab Selectra Selectra E Selectra junior Selectra XL Labquality

98 Calibrators 001 ABBOTT rd Generation TSH Standard calibrators Abbott CRP Abbott Master cal / std cal Aeroset c 8000 Cal set Architect Fe calibrator Architect Ferritin Calibrators Architect Free T4 Calibrators Architect T3 Calibrators Architect T4 Calibrators Architect TSH Calibratos AxSYM Cortisol Standard Calibrators Axsym Digitoxin Calibrator Bilirubin calibrator Bilirubin Calibrator (Architect) C-Reactive Protein Calibrator Cell-Dyn calibrators Chem. calibrators A, B, C Clin Chem Cal Cortisol Calibrator Digitoxin Fe/Mg calibrator Ferritin calibrator FT4 Calibrator HDL calibrator HDL/LDL Calibrator ICT cal low and high ISE calibrator Lact cal LDL Calibrator MC Cal 12 Multiconstituent calibrator (MCC) Quantia Digitoxin Standard Quantia IgE Standard Specific Proteins Multiconstituent Calibrator Total IgE calibrators TSH Standard Calibrators 078 ADVANCED INSTRUMENTS Calibration Standards 399 ALFA WASSERMANN C-Reactive Protein Calibration Set Direct HDL/LDL Cholesterol Calibrator Gemcal 153 ALPHA DIAGNOSTIC Albumin Standard 4.0 g/dl Magnesium Standard 3.6 mg/dl Multicalibrators Phosphorus Standard 5.0 mg/dl Uric Acid Standard 6.0 mg/dl 193 AMP Diagnostics AMP-Multical BR BR BR BR BR ARKRAY (KYOTO DAIICHI) Arkray Standard Spotchem Calibrator Kit Spotchem E-plate calibrator Spotchem ISE Reference AVL (see Roche) 396 AXIS SHIELD Afinion 051 BECKMAN COULTER ALT 5 diff AU System Calibrator Bilirubin calibrator C-RP Calibrator Set Calibrator (ARRAY, Immage) Calibrators 1, 2, 3 for Synchron CX systems Cortisol calibrator Access Coulter S-Cal kit CRP calibrator Electrolyte calibration Kit El lyt, Calibrators 1, 2 and/or Enzyme calibrator Ferritin calibrator Access Ferritin calibrator, Immage HDL calibrator Iron/TIBC calibrator LDLD calibrator Lipid Calibrator Multicalibrator Olympus CRP Calibrator Olympus Ferritin calibrator Olympus HDL Cholesterol Calibrator 96 Labquality 2010

99 50... Olympus ISE Low/High Olympus LDL Cholesterol Calibrator Olympus Serum Protein Multicalibrator Olympus Serum Protein Multicalibrator Protein calibrator Protein calibrator level 1&2 (TP) Protein Calibrator, Immage Synchron LX AQUA Cal Synchron LX Calibrator T3 Calibrator Access T4 calibrator Accsess T4V calibrator Access Total IgE TSH calibrator Access 112 BIOCLIN Bilirubin calibrator CRP calibrators Glucose calibrator 5 mmol/l 161 BIOCON Bio-Cal L Multicalibrator Bio-Cal Multicalibrator Bio-Cal E 115 BIOLABO Multiparametric Calibrator 336 BIOMAXIMA BioCal HDL Cholesterol Calibrator 302 BIOMED CRP-Dynamik Standardset Multical 095 BIOMERIEUX Bilitrol Calcium standard solution Calimat Multiparammetric calibrator Cholesterol Calibrator Glucose standard solution HLD Cholesterol Calibrator LDL Cholesterol Calibrator Multicalibrator Protiline CRP Calibrator Vidas Cortisol Calibrator Vidas FER Standard Vidas FT4 Calibrator Vidas TSH Calibrator 188 BIOSYSTEMS Calibrator serum Human Calibrator Protein calibrators 334 BIOTECNICA INSTRUMENTS ISE calibrator 185 BIOTEST MEDIZINTECHNIK GMBH Standard cuvette 139 BIOTROL BioTrol Multicalibrator 179 CENTRONIC Centrocal Centronorm 369 CHEMITECH Autocal Chemitrol N 148 CORMAY Albumin Standard Bilirubin Standards Calcium Standards Cholesterol Standard Cholesterol Standards Creatinine Standard Glucose Standard HDL Cholesterol standard HDL Direct Calibrator Iron Standards Mulicalibrator Phosphorus Standard Protein Standards Triglycerides Standard Urea Standard Uric Acid Standard 122 DAKO CRP Calibrator CRP Calibrator Human Protein Calibrator 191 DIAGNOSTICUM Calcium Standard 10 mg/dl Cholesterol Standard 200 mg/dl Creatinine Standard 2 mg/dl Duna Cal Gucose Standard 100 mg/dl Magnesium Standard 2 mg/dl Multicomponent calibrator Protein Standard 6000 mg/dl Labquality

100 10... Triglycerid Standard 200 mg/dl Urea Standard 50 mg/dl Uric acid Standard 6 mg/dl 324 DIAGON Human calibrator / level Human calibrator / level Multical 167 DIALAB Creatinine Standard Diacal auto Glucose Standard Magnesium Standard Phosphorus Standard Total Protein Standard Urea Standard Uric Acid Standard 158 DIASYS Calibrator for Lipids Glucose std 5,55 mmol/l Multicalibrator TruCal CRP TruCal HDL-LDL TruCal IgE TruCal Protein TruCal U Universsal Calibration Serum 319 ELITECH Bilical Elical Elical Elitrol HDL Calibrator LDL Calibrator 010 EPPENDORF EBIO/ESAT Glucose-Standard EBIO/ESAT LACTAT STANDARD Na, K, Cl standard Serum Standard 086 FISKE ASSOCIATES Calibration Standards (osmolality) 404 FUTURA SYSTEMS HDL/LDL Calibrator Multicalibrator 160 GENZYME N-geneous HDL-c N-geneous LDL-c 424 GESAN Calibrator Normal 084 GONOTEC Calibration Standard 300 mosmol/kg 048 HEMOCUE Standard cuvette 082 HORIBA ABX DIAGNOSTICS Bilirubin Calibrator Calibrator CBC-3D CRP Standard GlucoseCalibrator HDL Cholesterol Calibrator LDL Cholesterol Calibrator Pentra CRP Cal Pentra Ferritin Cal Pentra HDL Cholesterol calibrator Pentra Multical Pentra Protein Cal Triglycerides Calibrator 102 HUMAN Autocal Calcium standard 8 mg/dl Calibration Serum Cholesterol standard 200 mg/dl Cholesterol standard 50 mg/dl Creatinine standard 2 mg/dl Glucose standard 100 mg/dl Humatrol N Iron Standard 100 µg/dl Multicomponent calibrator Phosphor standard 10 mg/dl Potassium standard 5.0 mmol/l Protein standard 8 g/dl Serodos Plus Serum protein calibrator X Sodium standard 150 mmol/l Triglycerides standard 200 mg/dl Urea standard 80 mg/dl Uric Acid standard 8 mg/dl 420 I.S.E. S.r.l HDL Calibrator Multicalibrator 98 Labquality 2010

101 014 Instrumentation Laboratory (IL) IL Calibration Standards (ISE) ISE Calibrator Litium Standard Na/K Standards Photometer standards, IL quantex Proteins standard multipoint ReferrIL A ReferrIL B ReferrIL G ReferrIL HDL-Cholesterol ReferrIL LDL-Cholesterol Solution Pack - ILyte Synthesis Cal 1 and Cal INVICON HDL Calibrator Ig-MultiCal IgE Calibratorset KC-Cal LDL Calibrator 121 LACHEMA Bilirubin Standard LDL-Cholesterol calibrator Lyonorm Calibrator Solunorm Glucose 344 LINEAR CHEMICALS Cromatest Human Multitest Calibrator Multicalibrator CC / H 091 MEDINOR Seronorm Seronorm Human Seronorm Lipid Seronorm Protein Seronorm Trace elements / serum 109 MERCK Cholesterol standard solution Creatinine standard solution Glucose standard solution 100 mg/dl System Multi-Test Calibrator (Substrates and electrolytes) System Multi-Test N Immunoglobulin Calibrator Titrisol 020 NOVA BIOMEDICAL Calibrator Pack Nova 8 OLYMPUS see Beckman Coulter 055 ORION DIAGNOSTICA CRP Calibrator Set CRP calibrator Protein Calibrator Set TfR Calibrator 072 ORTHO-CLINICAL DIAGNOSTICS Vitros Chemistry Calibrator Kit Vitros Chemistry Calibrator Kit Vitros Chemistry Calibrator Kit Vitros Chemistry Calibrator Kit Vitros Chemistry Calibrator Kit Vitros Chemistry Calibrator Kit Vitros Chemistry Calibrator Kit Vitros Chemistry Calibrator Kit Vitros Chemistry Calibrator Kit Vitros Chemistry Calibrator Kit Vitros Chemistry Calibrator Kit Vitros DT Specialty Calibrator Vitros DT-Plus Calibrator Vitros Immunodiagnostics Calibrator Ferritin Vitros Immunodiagnostics Calibrator Free T Vitros Immunodiagnostics Calibrator Total T Vitros Immunodiagnostics Calibrator Total T Vitros Immunodiagnostics Calibrator TSH 131 PHADIA UniCAP Total IgE Calibrators ( ku/l) 157 POINTE SCIENTIFIC Chemistry Calibrator 024 RADIOMETER Cal G/L Lactate calibrator Radiometer Calibrator solution 1& Radiometer calibrators (ISE) Radiometer Lithium calibrator thb Calibration Solution 117 RANDOX Calcium Standard 2,5 mmol/l Calibration serum level Calibration serum level Calibration serum level CHOD-POD Liiquid Cholesterol calibrator Cholesterol standard 5,17 mmol/l 99 Labquality 2010

102 01... CRP calibrator Direct LDL/HDL cholesterol calibrator Electrolyte CAL Fe, ferrozin GPO-POD Liquid IG Calibrator IgE Calibrator Series Iron standard 35,8 umol/l Magnesium Standard Potassium Standard 5 mmol/l Urea Standard 13,3 mmol/l Ureaz. Color Uric Acid Standard Urikaz-POD Liquid 026 ROCHE AVL Electrolyte systems AVL ISE Calibrators AVL ISE SnapPak Calibrator for automated systems (c.f.a.s.) Calibrator for automated systems (c.f.a.s.)hdl/ldl Chol Calibrator for automated systems (c.f.a.s.) Lipids Calibrator for automated systems (c.f.a.s.) Proteins Calibrator HDL-Direct Calibrator Human Calibrator LDL-Direct Calibrators for Omnic Cardiotrol CRP-T Standard Elecsys CalSet Cortisol Elecsys CalSet Digitoxin Elecsys CalSet Ferritin Elecsys CalSet FT Elecsys CalSet IgE Elecsys CalSet T Elecsys CalSet T Elecsys CalSet TSH Ferr T Standard ISE calibrator direct ISE calibrator indirect/ur ISE Standard Low / High L-Lactate standard NoviCal Multi Plasmaproteins T Standard Precibil Precimat Creatinine Precimat D-glucose Precimat Glucose Precimat Glycerol Precimat Uric Acid Precinorm HDL Precinorm U Preciset Ferritin Preciset IgE Preciset Serum Proteins Preciset stfr Preciset TDM Calibrators Roche-TDM Online Digitoxin Calibrator Serumprotein T Standard Standards for ISE 062 ROEBLING Standardlösung 303 SENTINEL CH K Acto set C800 HDL/LDL Clin Chem Cal HDL Calibrator HDL/LDL Calibrator HDL/LDL Cholesterol Calibrator Iron standard Sentinel Zink Standard Sentinel Clin Chem Cal 057 SIEMENS Advia Chemistry ISE Standard set Advia CRP calibrator HDL cholesterol calibrator Advia HDL/LDL-Cholesterol calibrator Advia SETpoint Hematology Calibrator Advia Spec. Prot. Cal. Set Bayer SET Point Cortisol Calibrator A Calibrator B CBC-3D Cel-Pak Chemistry Calibrator Creatine Kinase Verifer Dimension ADHL Calibrator Dimension ALDL Calibrator Dimension Chemistry I Calibrator Dimension Chemistry II Calibrator Dimension CHOL Calibrator Dimension Enzyme Verifier Dimension HDL Calibrator Dimension IRN/TIBC Calibrator Dimension Revised C-Reactive Protein Calibrator Dimension TBIL/DBIL Calibrator Drug calibrator Drug calibrator II Express calibrators 1 & Ferritin Calibrator ISE calibrators ISE Reference (Advia) N CRP Standard N Ferritin Standard N Protein Standard SL High sensit.crp IDN Rheum St. SL QuikLyte Standard A/B SERA-PAK Immuno Calibrator SETpoint TSH 100 Labquality 2010

103 02... SETpoint (ISE) SETpoint Chemistry calibrator SETpoint Ferritin SETpoint Free T SETpoint Transferrin Special protein calibrator Specific Protein Reference Serum Total Protein/Albumin Calibrator 199 SPINREACT CRP Turbilatex calibrator HDL Calibrator LDL Calibrator Serum Protein Calibrator Spintrol Trucal N 030 SYSMEX e-check SCS THERMO FISCHER SCIENTIFIC Albumin Calibrator (in reagent kit) Calibrator I / II Multicalibrator Copper Standard TR CRP Calibration set mg/l CRP Plus Calibrator ecal HDL-Cholesterol Calibrator HDL/LDL Calibrator ISE calibrators ISE Calibrators 2& Lithium Infinity Lithium Standard scal SpeciCal (Protein multicalibrator) 032 VITALAB Calibrator Kit 118 WAKO HDL-C direct Calibrator Zinc calibrator Labquality