1389 (56 ) 3 18 **** *** ** * * ** *** **** : 88/12/24: 88/3/26 :. : : :. (RA) 20 (OA) -.. (TIB

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1 17 JQUMS, Vol.14, No.3, Autumn 2010 Comparison of serum ferritin level between patients with systemic lupus erythematosus, rheumatoid arthritis and osteoarthritis M. Saghafi * M. Abbasi ** T. Karimzadeh *** M. Sahebari **** *Associate Professor of Rheumatology, Rheumatic Diseases Research Center, Mashhad, University of Medical Sciences, Mashhad, Iran **Assistant Professor of rheumatology, Metabolic Disease Research Center, Qazvin, Iran ***General Practitioner, Metabolic Disease Research Center, Qazvin, Iran ****Assistant Professor of Rheumatology, Rheumatic Diseases Research Center, Mashhad, University of Medical Sciences, Mashhad, Iran Abstract Background: Systemic Lupus Erytematosus (SLE) is a chronic and relapsing disorder affecting several organs. Objective: To compare serum ferritin level between patients with systemic lupus erythematosus, rheumatoid arthritis, and osteoarthritis Methods: This cross-sectional study was conducted on 60 patients with SLE (divided into two groups with low and high disease activity), 20 patients with osteoarthritis (OA), and 20 patients with rheumatoid arthritis (RA). After having received informed consent, the blood and urine samples were collected from all patients to be tested for iron, TIBC, and serum ferritin levels and also to calculate the lupus disease activity. Patients with iron deficiency anemia were excluded. Data were analyzes by independent t- test, ANOVA, logistic regression and correlation tests. Findings: There was no significant difference between three study groups regarding the sex however, the age and duration of disease showed significant differences among 3 groups (p< 0.001). High serum ferritin level was seen in 61.7% of SLE, 15% of RA, and 5% of OA patients (p< 0.001). Increase in ESR levels demonstrated significant differences among study groups (p< 0/001). In patients with SLE, no significant correlation between serum ferritin and the decreased serum complement level and increased anti dsdna titer was observed. Both serum ferritin and CRP levels increased in patients with serositis (p=0.019) and neurological complication (p=0.04). Conclusion: Serum ferritin level was significantly higher in patients with SLE compared to those with OA and RA. There was no significant difference between serum ferritin level and SLE activity. Keywords: Ferritin, Systemic Lupus Erythematosus, Disease Activity, Rheumatoid Arthritis, Osteoarthritis Corresponding address: Metabolic Disease Research Center, Qazvin University of Medical Sciences, Qazvin, Iran mah.sky1348@yahoo.com Tel: Received: 2009/06/16 Accepted: 2010/03/15

2 1389 (56 ) 3 18 **** *** ** * * ** *** **** mah.sky1348@yahoo.com : 88/12/24: 88/3/26 :. : : :. (RA) 20 (OA) -.. (TIBC). : OA 5% RA 5% 61/7%.(p<0/001).(p<0/001) ESR.(p<0/001) CRP. dsdna.(p=0/04) (p=0/019). :. :. dsdna. C (CRP) CRP. :. (1).

3 19 /... (CRP) C (ESR) Anti dsdna (C4 C3). TIBC. (11) (SLEDAI) (SLEDAI 11) (SLEDAI 10).... : 4 ( 93/3) ( 6/7 ( 15) 3 ( 85) 17 7 ( 65) 13. ( 35). 30/57± 1/32 ( ) ) 45/95± 1/53 49/15± 1/44 ( ( ).(p<0/001).(p<0/001) (2-6).. (7-10).. : (ACR) (1).. :. (U/A) (CBC) (BUN) (LFT)

4 1389 (56 ) /2 ESR 30/7 56/5 15/7 ESR.(p<0/001) (p=0/01) (p<0/001). (p=0/013) CRP. (p=0/003) (p=0/001) (p=0/004).(2 ) -2 0/66 0/41 0/004 0/28 95% 0/095-1/029 %83-1/07 2/ /34-40/0 OR 99% 0/94 24/3 3/6-0/008-0/055 3/1 1/ ( 70) 42 ( 30). ( 58/3) 35 ( 41/7) ( 61/7) 37 ( 15) 3 ( 5) 1 ESR (p<0/001) 66/7) ( CRP.(p<0/001) ( 65) ) (p<0/01).(1 ESR -1 CRP / / /3 ESR / CRP /7 2/75 0/35. 0/1 (p<0/001) (p<0/001) (p<0/001)

5 21 /....(p=0/019) CRP (p=0/417) (p=0/976) 6 (p=0/417) (p=0/765) CRP.(p=0/057) CRP :.. 20 (7). 72 (SLEDAI 10) SLEDAI 31 (SLEDAI 11). (8). dsdna ( 75) 45 ( 25) 15 dsdna 45. dsdna 28 dsdna (p=0/04).(3 ) -3 0/283 0/791 0/426 0/077 0/04 0/ /3 63/3 56/6 58/ / /7 36/7 43/3 41/2 0 30/ (p=0/131) CRP 15 dsdna 15.(p=0/435) CRP 17 CRP 9

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7 23 / Cetinkaya R, Odabas AR, Selcuk Y. Relationship of the disease activity between ferritin levels in patients with systemic lupus erythematosus. MJAU 2001; 33: Beyan E, Beyan C, Demirezer A, et al. The relationship between serum ferritin levels and disease activity in systemic lupus erythematosus. Scand J Rheumatol 2003; 32(4): Nishiya K, Hashimoto K. Evaluation of serum ferritin levels as a marker for active systemic lupus erythematosus. Clin Exp Rheumatol 1997 Jan-Feb; 15(1): Lim MK, Lee CK, Ju YS, et al. Serum ferritin as a serologic marker of activity in systemic lupus erythematosus. Rheumatol Int 2001 Apr; 20(3): Tassiulas IC, Boumpos DT. Clinical features and treatment of SLE. In: Firestein GS, Budd RC, Harris ED Jr, et al. Kelley's textbook of rheumatology. 8 th ed. Philadelphia: Saunders;