Medical Policy Anti-CCP Testing for Rheumatoid Arthritis
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1 Medical Policy Anti-CCP Testing for Rheumatoid Arthritis Table of Contents Policy: Commercial Coding Information Information Pertaining to All Policies Policy: Medicare Description References Authorization Information Policy History Policy Number: 142 BCBSA Reference Number: Related Policies None Policy Commercial Members: Managed Care (HMO and POS), PPO, and Indemnity Medicare HMO Blue SM and Medicare PPO Blue SM Members Measurement of anti-ccp, when used as part of the diagnostic workup for rheumatoid arthritis, may be considered MEDICALLY NECESSARY. Measurement of anti-ccp, when used to monitor disease activity and/or treatment response, is INVESTIGATIONAL. Prior Authorization Information Commercial Members: Managed Care (HMO and POS) Prior authorization is NOT required. Commercial Members: PPO, and Indemnity Prior authorization is NOT required. Medicare Members: HMO Blue SM Prior authorization is NOT required. Medicare Members: PPO Blue SM Prior authorization is NOT required. CPT Codes / HCPCS Codes / ICD-9 Codes The following codes are included below for informational purposes. Inclusion or exclusion of a code does not constitute or imply member coverage or provider reimbursement. Please refer to the member s contract benefits in effect at the time of service to determine coverage or non-coverage as it applies to an individual member. A draft of future ICD-10 Coding related to this document, as it might look today, is included below for your reference. 1
2 Providers should report all services using the most up-to-date industry-standard procedure, revenue, and diagnosis codes, including modifiers where applicable. CPT codes CPT codes: Code Description Cyclic citrullinated peptide (CCP), antibody ICD-9 Diagnosis Codes ICD-9-CM diagnosis codes: Code Description Rheumatoid arthritis Felty's syndrome Other rheumatoid arthritis with visceral or systemic Polyarticular juvenile rheumatoid arthritis, chronic or unspecified Polyarticular juvenile rheumatoid arthritis, acute Pauciarticular juvenile rheumatoid arthritis Monoarticular juvenile rheumatoid arthritis ICD-10 Diagnosis Codes ICD-10-CM Diagnosis codes: Code Description M05.40 Rheumatoid myopathy with rheumatoid arthritis of unspecified site M05.00 Felty's syndrome, unspecified site M Felty's syndrome, right shoulder M Felty's syndrome, left shoulder M Felty's syndrome, unspecified shoulder M Felty's syndrome, right elbow M Felty's syndrome, left elbow M Felty's syndrome, unspecified elbow M Felty's syndrome, right wrist M Felty's syndrome, left wrist M Felty's syndrome, unspecified wrist M Felty's syndrome, right hand M Felty's syndrome, left hand M Felty's syndrome, unspecified hand M Felty's syndrome, right hip M Felty's syndrome, left hip M Felty's syndrome, unspecified hip M Felty's syndrome, right knee M Felty's syndrome, left knee M Felty's syndrome, unspecified knee M Felty's syndrome, right ankle and foot M Felty's syndrome, left ankle and foot M Felty's syndrome, unspecified ankle and foot M05.09 Felty's syndrome, multiple sites M05.20 Rheumatoid vasculitis with rheumatoid arthritis of unspecified site M Rheumatoid vasculitis with rheumatoid arthritis of right shoulder M Rheumatoid vasculitis with rheumatoid arthritis of left shoulder M Rheumatoid vasculitis with rheumatoid arthritis of unspecified shoulder 2
3 M Rheumatoid vasculitis with rheumatoid arthritis of right elbow M Rheumatoid vasculitis with rheumatoid arthritis of left elbow M Rheumatoid vasculitis with rheumatoid arthritis of unspecified elbow M Rheumatoid vasculitis with rheumatoid arthritis of right wrist M Rheumatoid vasculitis with rheumatoid arthritis of left wrist M Rheumatoid vasculitis with rheumatoid arthritis of unspecified wrist M Rheumatoid vasculitis with rheumatoid arthritis of right hand M Rheumatoid vasculitis with rheumatoid arthritis of left hand M Rheumatoid vasculitis with rheumatoid arthritis of unspecified hand M Rheumatoid vasculitis with rheumatoid arthritis of right hip M Rheumatoid vasculitis with rheumatoid arthritis of left hip M Rheumatoid vasculitis with rheumatoid arthritis of unspecified hip M Rheumatoid vasculitis with rheumatoid arthritis of right knee M Rheumatoid vasculitis with rheumatoid arthritis of left knee M Rheumatoid vasculitis with rheumatoid arthritis of unspecified knee M Rheumatoid vasculitis with rheumatoid arthritis of right ankle and foot M Rheumatoid vasculitis with rheumatoid arthritis of left ankle and foot M Rheumatoid vasculitis with rheumatoid arthritis of unspecified ankle and foot M05.29 Rheumatoid vasculitis with rheumatoid arthritis of multiple sites M05.30 Rheumatoid heart disease with rheumatoid arthritis of unspecified site M Rheumatoid heart disease with rheumatoid arthritis of right shoulder M Rheumatoid heart disease with rheumatoid arthritis of left shoulder M Rheumatoid heart disease with rheumatoid arthritis of unspecified shoulder M Rheumatoid heart disease with rheumatoid arthritis of right elbow M Rheumatoid heart disease with rheumatoid arthritis of left elbow M Rheumatoid heart disease with rheumatoid arthritis of unspecified elbow M Rheumatoid heart disease with rheumatoid arthritis of right wrist M Rheumatoid heart disease with rheumatoid arthritis of left wrist M Rheumatoid heart disease with rheumatoid arthritis of unspecified wrist M Rheumatoid heart disease with rheumatoid arthritis of right hand M Rheumatoid heart disease with rheumatoid arthritis of left hand M Rheumatoid heart disease with rheumatoid arthritis of unspecified hand M Rheumatoid heart disease with rheumatoid arthritis of right hip M Rheumatoid heart disease with rheumatoid arthritis of left hip M Rheumatoid heart disease with rheumatoid arthritis of unspecified hip M Rheumatoid heart disease with rheumatoid arthritis of right knee M Rheumatoid heart disease with rheumatoid arthritis of left knee M Rheumatoid heart disease with rheumatoid arthritis of unspecified knee M Rheumatoid heart disease with rheumatoid arthritis of right ankle and foot M Rheumatoid heart disease with rheumatoid arthritis of left ankle and foot M Rheumatoid heart disease with rheumatoid arthritis of unspecified ankle and foot M05.39 Rheumatoid heart disease with rheumatoid arthritis of multiple sites M Rheumatoid myopathy with rheumatoid arthritis of right shoulder M Rheumatoid myopathy with rheumatoid arthritis of left shoulder M Rheumatoid myopathy with rheumatoid arthritis of unspecified shoulder M Rheumatoid myopathy with rheumatoid arthritis of right elbow M Rheumatoid myopathy with rheumatoid arthritis of left elbow M Rheumatoid myopathy with rheumatoid arthritis of unspecified elbow M Rheumatoid myopathy with rheumatoid arthritis of right wrist M Rheumatoid myopathy with rheumatoid arthritis of left wrist M Rheumatoid myopathy with rheumatoid arthritis of unspecified wrist 3
4 M Rheumatoid myopathy with rheumatoid arthritis of right hand M Rheumatoid myopathy with rheumatoid arthritis of left hand M Rheumatoid myopathy with rheumatoid arthritis of unspecified hand M Rheumatoid myopathy with rheumatoid arthritis of right hip M Rheumatoid myopathy with rheumatoid arthritis of left hip M Rheumatoid myopathy with rheumatoid arthritis of unspecified hip M Rheumatoid myopathy with rheumatoid arthritis of right knee M Rheumatoid myopathy with rheumatoid arthritis of left knee M Rheumatoid myopathy with rheumatoid arthritis of unspecified knee M Rheumatoid myopathy with rheumatoid arthritis of right ankle and foot M Rheumatoid myopathy with rheumatoid arthritis of left ankle and foot M Rheumatoid myopathy with rheumatoid arthritis of unspecified ankle and foot M05.49 Rheumatoid myopathy with rheumatoid arthritis of multiple sites M05.50 Rheumatoid polyneuropathy with rheumatoid arthritis of unspecified site M Rheumatoid polyneuropathy with rheumatoid arthritis of right shoulder M Rheumatoid polyneuropathy with rheumatoid arthritis of left shoulder M Rheumatoid polyneuropathy with rheumatoid arthritis of unspecified shoulder M Rheumatoid polyneuropathy with rheumatoid arthritis of right elbow M Rheumatoid polyneuropathy with rheumatoid arthritis of left elbow M Rheumatoid polyneuropathy with rheumatoid arthritis of unspecified elbow M Rheumatoid polyneuropathy with rheumatoid arthritis of right wrist M Rheumatoid polyneuropathy with rheumatoid arthritis of left wrist M Rheumatoid polyneuropathy with rheumatoid arthritis of unspecified wrist M Rheumatoid polyneuropathy with rheumatoid arthritis of right hand M Rheumatoid polyneuropathy with rheumatoid arthritis of left hand M Rheumatoid polyneuropathy with rheumatoid arthritis of unspecified hand M Rheumatoid polyneuropathy with rheumatoid arthritis of right hip M Rheumatoid polyneuropathy with rheumatoid arthritis of left hip M Rheumatoid polyneuropathy with rheumatoid arthritis of unspecified hip M Rheumatoid polyneuropathy with rheumatoid arthritis of right knee M Rheumatoid polyneuropathy with rheumatoid arthritis of left knee M Rheumatoid polyneuropathy with rheumatoid arthritis of unspecified knee M Rheumatoid polyneuropathy with rheumatoid arthritis of right ankle and foot M Rheumatoid polyneuropathy with rheumatoid arthritis of left ankle and foot M Rheumatoid polyneuropathy with rheumatoid arthritis of unspecified ankle and foot M05.59 Rheumatoid polyneuropathy with rheumatoid arthritis of multiple sites M05.60 Rheumatoid arthritis of unspecified site with of other organs and systems M Rheumatoid arthritis of right shoulder with of other organs and systems M Rheumatoid arthritis of left shoulder with of other organs and systems M Rheumatoid arthritis of unspecified shoulder with of other organs and systems M Rheumatoid arthritis of right elbow with of other organs and systems M Rheumatoid arthritis of left elbow with of other organs and systems M Rheumatoid arthritis of unspecified elbow with of other organs and systems M Rheumatoid arthritis of right wrist with of other organs and systems M Rheumatoid arthritis of left wrist with of other organs and systems M Rheumatoid arthritis of unspecified wrist with of other organs and systems M Rheumatoid arthritis of right hand with of other organs and systems M Rheumatoid arthritis of left hand with of other organs and systems M Rheumatoid arthritis of unspecified hand with of other organs and systems 4
5 M Rheumatoid arthritis of right hip with of other organs and systems M Rheumatoid arthritis of left hip with of other organs and systems M Rheumatoid arthritis of unspecified hip with of other organs and systems M Rheumatoid arthritis of right knee with of other organs and systems M Rheumatoid arthritis of left knee with of other organs and systems M Rheumatoid arthritis of unspecified knee with of other organs and systems M Rheumatoid arthritis of right ankle and foot with of other organs and systems M Rheumatoid arthritis of left ankle and foot with of other organs and systems M Rheumatoid arthritis of unspecified ankle and foot with of other organs and systems M05.69 Rheumatoid arthritis of multiple sites with of other organs and systems M05.70 Rheumatoid arthritis with rheumatoid factor of unspecified site without organ or systems M Rheumatoid arthritis with rheumatoid factor of right shoulder without organ or systems M Rheumatoid arthritis with rheumatoid factor of left shoulder without organ or systems M Rheumatoid arthritis with rheumatoid factor of unspecified shoulder without organ or systems M Rheumatoid arthritis with rheumatoid factor of right elbow without organ or systems M Rheumatoid arthritis with rheumatoid factor of left elbow without organ or systems M Rheumatoid arthritis with rheumatoid factor of unspecified elbow without organ or systems M Rheumatoid arthritis with rheumatoid factor of right wrist without organ or systems M Rheumatoid arthritis with rheumatoid factor of left wrist without organ or systems M Rheumatoid arthritis with rheumatoid factor of unspecified wrist without organ or systems M Rheumatoid arthritis with rheumatoid factor of right hand without organ or systems M Rheumatoid arthritis with rheumatoid factor of left hand without organ or systems M Rheumatoid arthritis with rheumatoid factor of unspecified hand without organ or systems M Rheumatoid arthritis with rheumatoid factor of right hip without organ or systems M Rheumatoid arthritis with rheumatoid factor of left hip without organ or systems M Rheumatoid arthritis with rheumatoid factor of unspecified hip without organ or systems M Rheumatoid arthritis with rheumatoid factor of right knee without organ or systems M Rheumatoid arthritis with rheumatoid factor of left knee without organ or systems M Rheumatoid arthritis with rheumatoid factor of unspecified knee without organ or systems M Rheumatoid arthritis with rheumatoid factor of right ankle and foot without organ or systems M Rheumatoid arthritis with rheumatoid factor of left ankle and foot without organ or 5
6 systems M Rheumatoid arthritis with rheumatoid factor of unspecified ankle and foot without organ or systems M05.79 Rheumatoid arthritis with rheumatoid factor of multiple sites without organ or systems M05.80 Other rheumatoid arthritis with rheumatoid factor of unspecified site M Other rheumatoid arthritis with rheumatoid factor of right shoulder M Other rheumatoid arthritis with rheumatoid factor of left shoulder M Other rheumatoid arthritis with rheumatoid factor of unspecified shoulder M Other rheumatoid arthritis with rheumatoid factor of right elbow M Other rheumatoid arthritis with rheumatoid factor of left elbow M Other rheumatoid arthritis with rheumatoid factor of unspecified elbow M Other rheumatoid arthritis with rheumatoid factor of right wrist M Other rheumatoid arthritis with rheumatoid factor of left wrist M Other rheumatoid arthritis with rheumatoid factor of unspecified wrist M Other rheumatoid arthritis with rheumatoid factor of right hand M Other rheumatoid arthritis with rheumatoid factor of left hand M Other rheumatoid arthritis with rheumatoid factor of unspecified hand M Other rheumatoid arthritis with rheumatoid factor of right hip M Other rheumatoid arthritis with rheumatoid factor of left hip M Other rheumatoid arthritis with rheumatoid factor of unspecified hip M Other rheumatoid arthritis with rheumatoid factor of right knee M Other rheumatoid arthritis with rheumatoid factor of left knee M Other rheumatoid arthritis with rheumatoid factor of unspecified knee M Other rheumatoid arthritis with rheumatoid factor of right ankle and foot M Other rheumatoid arthritis with rheumatoid factor of left ankle and foot M Other rheumatoid arthritis with rheumatoid factor of unspecified ankle and foot M05.89 Other rheumatoid arthritis with rheumatoid factor of multiple sites M05.9 Rheumatoid arthritis with rheumatoid factor, unspecified M06.00 Rheumatoid arthritis without rheumatoid factor, unspecified site M Rheumatoid arthritis without rheumatoid factor, right shoulder M Rheumatoid arthritis without rheumatoid factor, left shoulder M Rheumatoid arthritis without rheumatoid factor, unspecified shoulder M Rheumatoid arthritis without rheumatoid factor, right elbow M Rheumatoid arthritis without rheumatoid factor, left elbow M Rheumatoid arthritis without rheumatoid factor, unspecified elbow M Rheumatoid arthritis without rheumatoid factor, right wrist M Rheumatoid arthritis without rheumatoid factor, left wrist M Rheumatoid arthritis without rheumatoid factor, unspecified wrist M Rheumatoid arthritis without rheumatoid factor, right hand M Rheumatoid arthritis without rheumatoid factor, left hand M Rheumatoid arthritis without rheumatoid factor, unspecified hand M Rheumatoid arthritis without rheumatoid factor, right hip M Rheumatoid arthritis without rheumatoid factor, left hip M Rheumatoid arthritis without rheumatoid factor, unspecified hip M Rheumatoid arthritis without rheumatoid factor, right knee M Rheumatoid arthritis without rheumatoid factor, left knee M Rheumatoid arthritis without rheumatoid factor, unspecified knee M Rheumatoid arthritis without rheumatoid factor, right ankle and foot M Rheumatoid arthritis without rheumatoid factor, left ankle and foot M Rheumatoid arthritis without rheumatoid factor, unspecified ankle and foot 6
7 M06.08 Rheumatoid arthritis without rheumatoid factor, vertebrae M06.09 Rheumatoid arthritis without rheumatoid factor, multiple sites M06.1 Adult-onset Still's disease M06.80 Other specified rheumatoid arthritis, unspecified site M Other specified rheumatoid arthritis, right shoulder M Other specified rheumatoid arthritis, left shoulder M Other specified rheumatoid arthritis, unspecified shoulder M Other specified rheumatoid arthritis, right elbow M Other specified rheumatoid arthritis, left elbow M Other specified rheumatoid arthritis, unspecified elbow M Other specified rheumatoid arthritis, right wrist M Other specified rheumatoid arthritis, left wrist M Other specified rheumatoid arthritis, unspecified wrist M Other specified rheumatoid arthritis, right hand M Other specified rheumatoid arthritis, left hand M Other specified rheumatoid arthritis, unspecified hand M Other specified rheumatoid arthritis, right hip M Other specified rheumatoid arthritis, left hip M Other specified rheumatoid arthritis, unspecified hip M Other specified rheumatoid arthritis, right knee M Other specified rheumatoid arthritis, left knee M Other specified rheumatoid arthritis, unspecified knee M Other specified rheumatoid arthritis, right ankle and foot M Other specified rheumatoid arthritis, left ankle and foot M Other specified rheumatoid arthritis, unspecified ankle and foot M06.88 Other specified rheumatoid arthritis, vertebrae M06.89 Other specified rheumatoid arthritis, multiple sites M06.9 Rheumatoid arthritis, unspecified M08.00 Unspecified juvenile rheumatoid arthritis of unspecified site M Unspecified juvenile rheumatoid arthritis, right shoulder M Unspecified juvenile rheumatoid arthritis, left shoulder M Unspecified juvenile rheumatoid arthritis, unspecified shoulder M Unspecified juvenile rheumatoid arthritis, right elbow M Unspecified juvenile rheumatoid arthritis, left elbow M Unspecified juvenile rheumatoid arthritis, unspecified elbow M Unspecified juvenile rheumatoid arthritis, right wrist M Unspecified juvenile rheumatoid arthritis, left wrist M Unspecified juvenile rheumatoid arthritis, unspecified wrist M Unspecified juvenile rheumatoid arthritis, right hand M Unspecified juvenile rheumatoid arthritis, left hand M Unspecified juvenile rheumatoid arthritis, unspecified hand M Unspecified juvenile rheumatoid arthritis, right hip M Unspecified juvenile rheumatoid arthritis, left hip M Unspecified juvenile rheumatoid arthritis, unspecified hip M Unspecified juvenile rheumatoid arthritis, right knee M Unspecified juvenile rheumatoid arthritis, left knee M Unspecified juvenile rheumatoid arthritis, unspecified knee M Unspecified juvenile rheumatoid arthritis, right ankle and foot M Unspecified juvenile rheumatoid arthritis, left ankle and foot M Unspecified juvenile rheumatoid arthritis, unspecified ankle and foot M08.08 Unspecified juvenile rheumatoid arthritis, vertebrae 7
8 M08.09 Unspecified juvenile rheumatoid arthritis, multiple sites M08.20 Juvenile rheumatoid arthritis with systemic onset, unspecified site M Juvenile rheumatoid arthritis with systemic onset, right shoulder M Juvenile rheumatoid arthritis with systemic onset, left shoulder M Juvenile rheumatoid arthritis with systemic onset, unspecified shoulder M Juvenile rheumatoid arthritis with systemic onset, right elbow M Juvenile rheumatoid arthritis with systemic onset, left elbow M Juvenile rheumatoid arthritis with systemic onset, unspecified elbow M Juvenile rheumatoid arthritis with systemic onset, right wrist M Juvenile rheumatoid arthritis with systemic onset, left wrist M Juvenile rheumatoid arthritis with systemic onset, unspecified wrist M Juvenile rheumatoid arthritis with systemic onset, right hand M Juvenile rheumatoid arthritis with systemic onset, left hand M Juvenile rheumatoid arthritis with systemic onset, unspecified hand M Juvenile rheumatoid arthritis with systemic onset, right hip M Juvenile rheumatoid arthritis with systemic onset, left hip M Juvenile rheumatoid arthritis with systemic onset, unspecified hip M Juvenile rheumatoid arthritis with systemic onset, right knee M Juvenile rheumatoid arthritis with systemic onset, left knee M Juvenile rheumatoid arthritis with systemic onset, unspecified knee M Juvenile rheumatoid arthritis with systemic onset, right ankle and foot M Juvenile rheumatoid arthritis with systemic onset, left ankle and foot M Juvenile rheumatoid arthritis with systemic onset, unspecified ankle and foot M08.28 Juvenile rheumatoid arthritis with systemic onset, vertebrae M08.29 Juvenile rheumatoid arthritis with systemic onset, multiple sites M08.3 Juvenile rheumatoid polyarthritis (seronegative) M08.40 Pauciarticular juvenile rheumatoid arthritis, unspecified site M Pauciarticular juvenile rheumatoid arthritis, right shoulder M Pauciarticular juvenile rheumatoid arthritis, left shoulder M Pauciarticular juvenile rheumatoid arthritis, unspecified shoulder M Pauciarticular juvenile rheumatoid arthritis, right elbow M Pauciarticular juvenile rheumatoid arthritis, left elbow M Pauciarticular juvenile rheumatoid arthritis, unspecified elbow M Pauciarticular juvenile rheumatoid arthritis, right wrist M Pauciarticular juvenile rheumatoid arthritis, left wrist M Pauciarticular juvenile rheumatoid arthritis, unspecified wrist M Pauciarticular juvenile rheumatoid arthritis, right hand M Pauciarticular juvenile rheumatoid arthritis, left hand M Pauciarticular juvenile rheumatoid arthritis, unspecified hand M Pauciarticular juvenile rheumatoid arthritis, right hip M Pauciarticular juvenile rheumatoid arthritis, left hip M Pauciarticular juvenile rheumatoid arthritis, unspecified hip M Pauciarticular juvenile rheumatoid arthritis, right knee M Pauciarticular juvenile rheumatoid arthritis, left knee M Pauciarticular juvenile rheumatoid arthritis, unspecified knee M Pauciarticular juvenile rheumatoid arthritis, right ankle and foot M Pauciarticular juvenile rheumatoid arthritis, left ankle and foot M Pauciarticular juvenile rheumatoid arthritis, unspecified ankle and foot M08.48 Pauciarticular juvenile rheumatoid arthritis, vertebrae M08.80 Other juvenile arthritis, unspecified site M Other juvenile arthritis, right shoulder 8
9 M Other juvenile arthritis, left shoulder M Other juvenile arthritis, unspecified shoulder M Other juvenile arthritis, right elbow M Other juvenile arthritis, left elbow M Other juvenile arthritis, unspecified elbow M Other juvenile arthritis, right wrist M Other juvenile arthritis, left wrist M Other juvenile arthritis, unspecified wrist M Other juvenile arthritis, right hand M Other juvenile arthritis, left hand M Other juvenile arthritis, unspecified hand M Other juvenile arthritis, right hip M Other juvenile arthritis, left hip M Other juvenile arthritis, unspecified hip M Other juvenile arthritis, right knee M Other juvenile arthritis, left knee M Other juvenile arthritis, unspecified knee M Other juvenile arthritis, right ankle and foot M Other juvenile arthritis, left ankle and foot M Other juvenile arthritis, unspecified ankle and foot M08.88 Other juvenile arthritis, other specified site M08.89 Other juvenile arthritis, multiple sites M08.90 Juvenile arthritis, unspecified, unspecified site M Juvenile arthritis, unspecified, right shoulder M Juvenile arthritis, unspecified, left shoulder M Juvenile arthritis, unspecified, unspecified shoulder M Juvenile arthritis, unspecified, right elbow M Juvenile arthritis, unspecified, left elbow M Juvenile arthritis, unspecified, unspecified elbow M Juvenile arthritis, unspecified, right wrist M Juvenile arthritis, unspecified, left wrist M Juvenile arthritis, unspecified, unspecified wrist M Juvenile arthritis, unspecified, right hand M Juvenile arthritis, unspecified, left hand M Juvenile arthritis, unspecified, unspecified hand M Juvenile arthritis, unspecified, right hip M Juvenile arthritis, unspecified, left hip M Juvenile arthritis, unspecified, unspecified hip M Juvenile arthritis, unspecified, right knee M Juvenile arthritis, unspecified, left knee M Juvenile arthritis, unspecified, unspecified knee M Juvenile arthritis, unspecified, right ankle and foot M Juvenile arthritis, unspecified, left ankle and foot M Juvenile arthritis, unspecified, unspecified ankle and foot M08.98 Juvenile arthritis, unspecified, vertebrae M08.99 Juvenile arthritis, unspecified, multiple sites Description Autoantibodies directed against cyclic citrullinated proteins (anti-ccp) are found in many patients with rheumatoid arthritis (RA). In patients with RA and active joint inflammation, levels of anti-ccp are higher 9
10 in the synovial fluid than in the peripheral circulation. Anti-CCP found in the serum is thought to be a result of diffusion of these antibodies from the synovial fluid into the general circulation. Autoantibodies against CCP have been recognized and measured for several decades.. However, older tests were performed by a cumbersome immunofluorescence assay and were not commonly used in routine clinical practice. Therefore, attention turned toward measuring anti-ccp antibodies. Serum anti- CCP levels are currently measured using an ELISA assay. Examples of anti-ccp testing for RA include the QUANTA Lite CCP IgG ELISA from INOVA Diagnostics and the Diastat anti-ccp ELISA test from Axis-Shield Diagnostics All anti-ccp tests for RA are considered investigational regardless of the commercial name, the manufacturer or FDA approval status except when used for the medically necessary indications that are consistent with the policy statement. Summary Extensive evidence has established that anti-ccp has a moderately high sensitivity, a high specificity, and is a strong predictor of future erosive arthritis. The test is useful in confirming the diagnosis of RA in patients with early disease, especially when the criteria for a diagnosis of RA are not met by other clinical or laboratory measures. Early identification of patients with RA is important since timely treatment with DMARDs can prevent progression of destructive arthritis and improve functional status. The extensive evidence of the usefulness of the test for diagnosing RA supports its medically necessary designation. The evidence suggests that anti-ccp is not useful as a measure of disease activity and/or response to treatment. As a result, the use of anti-ccp is considered investigational for monitoring disease activity in RA. Policy History Date Action 6/2014 Updated Coding section with ICD10 procedure and diagnosis codes, effective 10/ /2011- Medical policy ICD 10 remediation: Formatting, editing and coding updates. 4/2012 No changes to policy statements. 6/2011 Reviewed - Medical Policy Group Orthopedics, Rehabilitation Medicine and Rheumatology. No changes to policy statements. 7/2010 Reviewed - Medical Policy Group Orthopedics, Rehabilitation Medicine and Rheumatology.No changes to policy statements. 11/01/09 Medical Policy 142 effective 11/01/09 created. Information Pertaining to All Blue Cross Blue Shield Medical Policies Click on any of the following terms to access the relevant information: Medical Policy Terms of Use Managed Care Guidelines Indemnity/PPO Guidelines Clinical Exception Process Medical Technology Assessment Guidelines References 1. Arnett FC, Edworthy SM, Bloch DA et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31(3): Kaarela K, Kauppi MJ, Lehtinen KE. The value of the ACR 1987 criteria in very early rheumatoid arthritis. Scand J Rheumatol 1995; 24(5):
11 3. Saraux A, Berthelot JM, Chales G et al. Ability of the American College of Rheumatology 1987 criteria to predict rheumatoid arthritis in patients with early arthritis and classification of these patients two years later. Arthritis Rheum 2001; 44(11): Visser H, le Cessie S, Vos K et al. How to diagnose rheumatoid arthritis early: a prediction model for persistent (erosive) arthritis. Arthritis Rheum 2002; 46(2): Aletaha D, Neogi T, Silman AJ et al rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis 2010; 69(9): Guidelines for the management of rheumatoid arthritis: 2002 Update. Arthritis Rheum 2002; 46(2): Whiting PF, Smidt N, Sterne JA et al. Systematic review: accuracy of anti-citrullinated Peptide antibodies for diagnosing rheumatoid arthritis. Ann Intern Med 2010; 152(7):456-64; W Avouac J, Gossec L, Dougados M. Diagnostic and predictive value of anti-cyclic citrullinated protein antibodies in rheumatoid arthritis: a systematic literature review. Ann Rheum Dis 2006; 65(7): Qin X, Deng Y, Xu J et al. Meta-analysis: diagnostic value of serum anti-mutated citrullinated vimentin antibodies in patients with rheumatoid arthritis. Rheumatol Int 2011; 31(6): Syversen SW, Gaarder PI, Goll GL et al. High anti-cyclic citrullinated peptide levels and an algorithm of four variables predict radiographic progression in patients with rheumatoid arthritis: results from a 10-year longitudinal study. Ann Rheum Dis 2008; 67(2): Bukhari M, Thomson W, Naseem H et al. The performance of anti-cyclic citrullinated peptide antibodies in predicting the severity of radiologic damage in inflammatory polyarthritis: results from the Norfolk Arthritis Register. Arthritis Rheum 2007; 56(9): Yamane T, Hashiramoto A, Tanaka Y et al. Easy and accurate diagnosis of rheumatoid arthritis using anti-cyclic citrullinated peptide 2 antibody, swollen joint count, and C-reactive protein/rheumatoid factor. J Rheumatol 2008; 35(3): Wagner E, Skoumal M, Bayer PM et al. Antibody against mutated citrullinated vimentin: a new sensitive marker in the diagnosis of rheumatoid arthritis. Rheumatol Int 2009; 29(11): Shidara K, Inoue E, Tanaka E et al. Comparison of the second and third generation anti-cyclic citrullinated peptide antibody assays in the diagnosis of Japanese patients with rheumatoid arthritis. Rheumatol Int 2011; 31(5): Ryu HJ, Takeuchi F, Kuwata S et al. The diagnostic utilities of anti-agalactosyl IgG antibodies, anticyclic citrullinated peptide antibodies, and rheumatoid factors in rheumatoid arthritis. Rheumatol Int 2011; 31(3): Hwang SM, Kim JO, Yoo YM et al. Performance analysis of the ARCHITECT anti-cyclic citrullinated peptide antibody in the diagnosis of rheumatoid arthritis. Clin Chem Lab Med 2010; 48(2): Bongi SM, Manetti R, Melchiorre D et al. Anti-cyclic citrullinated peptide antibodies are highly associated with severe bone lesions in rheumatoid arthritis anti-ccp and bone damage in RA. Autoimmunity 2004; 37(6-7): Raza K, Breese M, Nightingale P et al. Predictive value of antibodies to cyclic citrullinated peptide in patients with very early inflammatory arthritis. J Rheumatol 2005; 32(2): Landmann T, Kehl G, Bergner R. The continuous measurement of anti-ccp-antibodies does not help to evaluate the disease activity in anti-ccp-antibody-positive patients with rheumatoid arthritis. Clin Rheumatol 2010; 29(12): Zendman AJ, van Venrooij WJ, Pruijn GJ. Use and significance of anti-ccp autoantibodies in rheumatoid arthritis. Rheumatology (Oxford) 2006; 45(1): Ronnelid J, Wick MC, Lampa J et al. Longitudinal analysis of citrullinated protein/peptide antibodies (anti-cp) during 5 year follow up in early rheumatoid arthritis: anti-cp status predicts worse disease activity and greater radiological progression. Ann Rheum Dis 2005; 64(12): Dejaco C, Duftner C, Klotz W et al. Third generation anti-cyclic citrullinated peptide antibodies do not predict anti-tnf-alpha treatment response in rheumatoid arthritis. Rheumatol Int 2010; 30(4): National Collaborating Centre for Chronic Conditions. Rheumatoid Arthritis: the management of rheumatoid arthritis in adults. National Institute for Health and Clinical Excellence (NICE) 2009; Feb 35p. (NICE clinical guideline no 79). 11
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