SCARP Hälsostudier. Epidemiologisk och experimentell design. Effekter relaterade till kort- och långtidsexponering

Save this PDF as:
 WORD  PNG  TXT  JPG

Size: px
Start display at page:

Download "SCARP Hälsostudier. Epidemiologisk och experimentell design. Effekter relaterade till kort- och långtidsexponering"

Transcription

1 SCARP Hälsostudier Epidemiologisk och experimentell design Effekter relaterade till kort- och långtidsexponering 12 studier från Göteborg, Stockholm och Umeå

2 SCARP hälsostudier i Stockholm Exponering för trafikrelaterade luftföroreningar, lungfunktion, astma och allergi hos barn Korttidseffekter av luftföroreningar hos känsliga grupper i relation till källspecifik exponering Kohortstudie rörande hälsoeffekter av långtidsexponering för luftföroreningar Långtidsexponering för luftföroreningar och genetisk känslighet i relation till hjärtinfarkt Göran Pershagen 15 november

3 Long term exposure to air pollution Residential history for study subjects Geocoding and linking coordinates to dispersion models SO 2 from heating (µg/m 3 ) NO 2 from traffic (µg/m 3 ) Mean (area) Mean (population) 10th to 90th percentile (population) Year PM Mean (area) 5 Mean (population) 10th to 90th percentile (population) Year Linearinterpolation for yearsbetween EDBs Emission databases (EDB) 1960, 1970, 1980, 1990, 2000 NO 2 CO SO 2 10

4 NOx Göran Pershagen 15 november

5 NOx Göran Pershagen 15 november

6 NOx Göran Pershagen 15 november

7 NOx Göran Pershagen 15 november

8 NOx Göran Pershagen 15 november

9 Air pollution and airway disease in preschool children Exposure questionnaire and dust % 1 year symptom questionnaire % 4 year follow up Questionnaire % Dust % PEF % Blood % and spec IgE Peak Expiratory Flow 2 year symptom questionnaire % Transient wheeze Late onset wheeze Persistent wheeze Sensitisation to specific IgE s Göran Pershagen 15 november Stockholm Centre for Public Health and Institute of Environmental Medicine, Karolinska Institutet

10 Wheeze in relation to air pollution exposure Odds Ratio (95% CI) Exposure 1:st year of life. Outcome up to 4 yrs of age.6 any wheeze - PM10 any wheeze - NOx persistent wheeze - PM10 persistent wheeze - NOx Adjusted for municipality, socioeconomic status, heredity, mother s smoking during pregnancy and in infancy, year that house was built, damp or mould in the home at birth and sex of the child Göran Pershagen 15 november Stockholm Centre for Public Health and Institute of Environmental Medicine, Karolinska Institutet

11 Peak Expiratory Flow in relation to air pollution exposure Mean PEF: 169 l/min, SD 29 l/min Effect on PEF (l/m) Traffic-PM 10 Traffic-NO x Point estimate (95%CI)* (-10.67, -0.05) (-6.84, 0.68) *Adjusted for sex, age, height and municipality Göran Pershagen 15 november Stockholm Centre for Public Health and Institute of Environmental Medicine, Karolinska Institutet

12 Sensitization in relation to air pollution exposure Exposure 1:st year of life. Outcome up to 4 yrs of age any sens - PM10Odds Ratio (95% CI) any sens - Nox sens to inhalant all. - PM10 sens to inhalant all. - NOx sens to pollen - PM10 sens to pollen - NOx Adjusted for municipality, socioeconomic status, heredity, mother s smoking during pregnancy and in infancy, year that house was built, damp or mould in the home at birth and sex of the child Göran Pershagen 15 november Stockholm Centre for Public Health and Institute of Environmental Medicine, Karolinska Institutet

13 Cohort study on total public health burden related to long-term air pollution exposure A total of 11,000 12,000 subjects from 3 existing cohorts in Stockholm county Assessment of long-term exposure to air pollution using residential history, emission data bases and dispersion modelling Detailed follow-up of cardiovascular events, cancer, cause of death etc Prospective longitudinal information available on various risk factors based on interviews, questionnaires etc Biologic material stored for all study subjects Göran Pershagen 15 november

14 Long-term exposure to air pollution and cardiac effects is based on SHEEP Population-based case-control study in Stockholm County All first-time MI-cases years old. Controls matched on age, sex, and hospital catchment area. Risk factors for MI from questionnaire, telephone interview and health examination (n=4,067). Source-specific air pollution exposure during each year between Göran Pershagen 15 november

15 Air pollution exposure, blood marker levels, genetics and myocardial infarction Suggested associations between short-term exposure to traffic related air pollution exposure and several blood markers (IL-6, TNF-α, fibrinogen, PAI-1) Strong association between long-term exposure to air pollution and IL-6 Analyses ongoing on gene-environment interactions Göran Pershagen 15 november

16 Relative risk for MI and air pollution exposure Source-specific air pollution exposure NO 2 from traffic CO from traffic PM 10 from traffic SO 2 from heating All cases OR (95% CI) 0.99 ( ) 1.04 ( ) 1.00 ( ) 1.03 ( ) Fatal cases OR (95% CI) 1.51 ( ) 1.22 ( ) 1.39 ( ) 1.24 ( ) ORs calculated for a change in pollution level from the 5th-95th percentile. Adjusted for age, sex, hospital, smoking, physical inactivity, diabetes, socioeconomic status. PM 10 assessed only for the year 2000, ie assuming constant levels Göran Pershagen 15 november

17 Risk of non-fatal MI, fatal MI in or outside hospital in relation to air pollution exposure 4 NO 2 from traffic 4 CO from traffic OR (95% CI) 2 1 Nonfatal Fatal in hospital Fatal outside hospital PM 10 from traffic Nonfatal Fatal in hospital Fatal outside hospital SO 2 from heating *Adjusted for age, sex, hospital, smoking, socioeconomic status, physical inactivity, diabetes Göran Pershagen 15 november

18 Air pollution guidelines in relation to exposure-response relationships in epidemiological studies MKN for PM10, WHO 2006 Long-term exposure and death WHO 2006 EP 2015 US-EPA 2010 EC 2010 Short-term exposure and death in cardiovascular disease US-EPA PM2.5 Fine particles (PM2.5) Dockery et al, NEJM 1993 Fine and coarse particles (PM10) Daniels et al, Am J Epidemiology 2000

19 Conclusions Air pollution exposure assessment Complex mixtures, exposure characterisation difficult Short-term effects Mortality, previous cardiac disease marks increased susceptibility, inflammation, arrythmia Long-term effects on lung cancer Long induction-latency period Long-term cardiac effects Cardiac death, myocardial infarction Long-term respiratory effects in adults and children Lung function, symptoms, sensitisation Guidelines and limit values WHO, US-EPA, EU Göran Pershagen 15 november

Long term exposure to air pollution

Long term exposure to air pollution SCARP hälsostudier i Stockholm SCARP Hälsostudier Epidemiologisk och experimentell design Effekter relaterade till kort- och långtidsexponering studier från Göteborg, Stockholm och Umeå Exponering för

More information

5 Risk factors for the persistence of wheeze during childhood

5 Risk factors for the persistence of wheeze during childhood 5 Risk factors for the persistence of wheeze during childhood Asthma has a variable natural history, with onset and remission occurring at any age. Longitudinal studies suggest that the pattern of asthma

More information

Environmental Factors in Cardiovascular Disease

Environmental Factors in Cardiovascular Disease From the Institute of Environmental Medicine Karolinska Institutet, Stockholm, Sweden Environmental Factors in Cardiovascular Disease Doctoral Thesis Mats Rosenlund Stockholm 2005 Doctoral thesis: Environmental

More information

Challenges in assessing disease latency for cancer in environmental epidemiology

Challenges in assessing disease latency for cancer in environmental epidemiology Challenges in assessing disease latency for cancer in environmental epidemiology Peggy Reynolds, Ph.D. Case-only Clustering in Mobile Populations Workshop - November 11-12, 2010 Ann Arbor, Michigan Outline

More information

Abatement Strategies for Reduction of PM in Stockholm Optimal Efficiency for Health and/or Air Quality Limit Values

Abatement Strategies for Reduction of PM in Stockholm Optimal Efficiency for Health and/or Air Quality Limit Values Abatement Strategies for Reduction of PM in Stockholm Optimal Efficiency for Health and/or Air Quality Limit Values Christer Johansson Environmental Health Administration of Stockholm & Department of Applied

More information

Air Pollution and Public Health

Air Pollution and Public Health Air Pollution and Public Health Where have we been? Where are we going? Joel Schwartz Harvard School of Public Health Meuse Valley Disaster December 1 5 1930 Intense Fog in valley between Liege and

More information

Executive summary. Definition of concepts

Executive summary. Definition of concepts Executive summary Asthma and allergy are very common disorders, which have major effects on an individual s quality of life. Increases in asthma and allergy were reported during the final decades of the

More information

Adverse Health Effects of Air Pollution in India

Adverse Health Effects of Air Pollution in India Health Impacts of Air in India in India in India JN Pande Sitaram Bhartia Institute of Science and Research, New Delhi Well documented in developed countries using several epidemiological study designs.

More information

Spirometry, COPD and lung cancer

Spirometry, COPD and lung cancer Spirometry, COPD and lung cancer Associate Professor Robert Young BMedSc, MBChB, DPhil (Oxon), FRACP, FRCP University of Auckland, New Zealand Spirometry for those with smoking and dust exposures Risk

More information

Air Quality: Public Health Impacts and Local Actions

Air Quality: Public Health Impacts and Local Actions Air Quality: Public Health Impacts and Local Actions This briefing is to inform public health professionals of the public health impacts of air pollution, the sources of air pollution and measures available

More information

Background information

Background information Background information Asthma Asthma is a complex disease affecting the lungs that can be managed but cannot be cured. 1 Asthma can be controlled well in most people most of the time, although some people

More information

Which filter class for supply air is required in a typical HVAC system?

Which filter class for supply air is required in a typical HVAC system? Which filter class for supply air is required in a typical HVAC system? Thomas Carlsson, Technical Director, Magnus Johnsson, Vokes Air Table of Contents: Background 2 Energy Demand 2 Air Quality and PM

More information

Indoor air quality. Chapter 5. At a glance. Indoor air quality 47

Indoor air quality. Chapter 5. At a glance. Indoor air quality 47 Chapter 5 Indoor air quality At a glance Household fuel-burning is a significant contributor to both ambient and indoor air pollutant concentrations. Suspended particulate concentrations were found to

More information

WHO strategy for prevention and control of chronic respiratory diseases

WHO strategy for prevention and control of chronic respiratory diseases WHO/MNC/CRA/02.1 Original: English WHO strategy for prevention and control of chronic respiratory diseases World Health Organization Management of Noncommunicable Diseases Department Chronic Respiratory

More information

An Overview of Asthma - Diagnosis and Treatment

An Overview of Asthma - Diagnosis and Treatment An Overview of Asthma - Diagnosis and Treatment Asthma is a common chronic disorder of the airways that is complex and characterized by variable and recurring symptoms, airflow obstruction, bronchial hyperresponsiveness,

More information

Prognosis of Patients With Breast Cancer: Causes of Death and Effects of Time Since Diagnosis, Age, and Tumor Characteristics

Prognosis of Patients With Breast Cancer: Causes of Death and Effects of Time Since Diagnosis, Age, and Tumor Characteristics Prognosis of Patients With Breast Cancer: Causes of Death and Effects of Time Since Diagnosis, Age, and Tumor Characteristics Edoardo Colzani, M.D., M.P.H. Department of Medical Epidemiology and Biostatistics

More information

COPD and Asthma Differential Diagnosis

COPD and Asthma Differential Diagnosis COPD and Asthma Differential Diagnosis Chronic Obstructive Pulmonary Disease (COPD) is the third leading cause of death in America. Learning Objectives Use tools to effectively diagnose chronic obstructive

More information

Air Pollution in Ulaanbaatar: Public Health Impacts and Research Opportunities

Air Pollution in Ulaanbaatar: Public Health Impacts and Research Opportunities Air Pollution in Ulaanbaatar: Public Health Impacts and Research Opportunities Ryan W. Allen, PhD Associate Professor Faculty of Health Sciences Simon Fraser University Burnaby, BC, Canada allenr@sfu.ca

More information

The Public Health Management of Chemical Incidents Case Study

The Public Health Management of Chemical Incidents Case Study The Public Health Management of Chemical Incidents Case Study Professor David Russell, The WHO Collaborating Centre for Chemical Incidents, Cardiff, Wales, UK Location http://www.wales-calling.com/wales-buttons-maps/wales-town-map.gif

More information

Haze and Health Effects

Haze and Health Effects 22 May 2014 Haze and Health Effects Image source: http://www.straitstimes.com 1. What is Haze? Haze is an aggregation in the atmosphere of very fine, widely dispersed, solid or liquid particles, or both,

More information

Health effects of particulate matter and implications for policy in Europe

Health effects of particulate matter and implications for policy in Europe Health effects of particulate matter and implications for policy in Europe Marie-Eve Héroux Technical Officer, Air Quality and Noise WHO European Centre for Environment and Health Bonn, Germany Presentation

More information

GSK Medicine: Study Number: Title: Rationale: Study Period: Objectives Indication: Study Investigators/Centers: Research Methods Data Source:

GSK Medicine: Study Number: Title: Rationale: Study Period: Objectives Indication: Study Investigators/Centers: Research Methods Data Source: GSK Medicine: Study Number: 08257 Title: OCSIGEN study Longitudinal follow-up of a cohort of patients with asthma treated with inhaled corticosteroids in primary care Rationale: In the Post-Licensing File

More information

Noise and Health. Bilfri dag 22. september Gunn Marit Aasvang, PhD Department of Air Pollution and Noise Norwegian Insitute of Public Health

Noise and Health. Bilfri dag 22. september Gunn Marit Aasvang, PhD Department of Air Pollution and Noise Norwegian Insitute of Public Health Noise and Health Bilfri dag 22. september 2011 Gunn Marit Aasvang, PhD Department of Air Pollution and Noise Norwegian Insitute of Public Health Environmental noise in Norway Approximately 1.6 million

More information

What is meant by "randomization"? (Select the one best answer.)

What is meant by randomization? (Select the one best answer.) Preview: Post-class quiz 5 - Clinical Trials Question 1 What is meant by "randomization"? (Select the one best answer.) Question 2 A. Selection of subjects at random. B. Randomization is a method of allocating

More information

STROKE April 2011 Dr Amer Jafar A delay in recognizing early warning signs (WS) and risk factors (RF) of ischemic stroke causes a delay in treatment Evaluated: knowledge of RF and WS and the impact of

More information

National Environment Protection (Ambient Air Quality) Measure. Appendix 6

National Environment Protection (Ambient Air Quality) Measure. Appendix 6 SOCO National Environment Protection (Ambient Air Quality) Measure Report of the Risk Assessment Taskforce 2 Appendix 6 Pb NO 2 Possible use of Health Risk Assessment in the Review of NEPM Pollutants Specified

More information

Asthma. When do these symptoms arise? What triggers make asthma worse?

Asthma. When do these symptoms arise? What triggers make asthma worse? Asthma Asthma is the term which describes a specific type of breathing problem that arises due to narrowing of the airways. This narrowing is caused when certain natural chemicals within the body are released,

More information

Impact Assessment of Dust, NOx and SO 2

Impact Assessment of Dust, NOx and SO 2 Impact Assessment of Dust, NOx and SO 2 By Pat Swords Content of the Presentation Historical Basis for Air Pollution Control Impacts of air pollutants on human health, etc. Impact Pathway Approach to assessing

More information

CARDIOVASCULAR PROBLEMS IN SURVIVORS OF CHILDHOOD CANCER AND THEIR SIBLINGS

CARDIOVASCULAR PROBLEMS IN SURVIVORS OF CHILDHOOD CANCER AND THEIR SIBLINGS Swiss Childhood Cancer Registry (SCCR) CARDIOVASCULAR PROBLEMS IN SURVIVORS OF CHILDHOOD CANCER AND THEIR SIBLINGS Julien Caccia, Corina S. Rueegg, Eva-Maria Hau, Nicolas X. von der Weid, Gisela Michel,

More information

The Air. Problem, impacts, reasons, solutions.

The Air. Problem, impacts, reasons, solutions. The Air in Problem, impacts, reasons, solutions www.krakowskialarmsmogowy.pl THE problem Krakovians breathe the most polluted air of all European cities. The limit values for particulate matter (PM 10

More information

WILDFIRE RESTORATION OR DEVASTATION?

WILDFIRE RESTORATION OR DEVASTATION? WILDFIRE RESTORATION OR DEVASTATION? PART I HEALTH HAZARDS There is a flip side to every coin. There are beneficial outcomes from wildfire. We are hearing a flood of commentaries from the environmental

More information

Quantifying Life expectancy in people with Type 2 diabetes

Quantifying Life expectancy in people with Type 2 diabetes School of Public Health University of Sydney Quantifying Life expectancy in people with Type 2 diabetes Alison Hayes School of Public Health University of Sydney The evidence Life expectancy reduced by

More information

The Adverse Health Effects of Cannabis

The Adverse Health Effects of Cannabis The Adverse Health Effects of Cannabis Wayne Hall National Addiction Centre Kings College London and Centre for Youth Substance Abuse Research University of Queensland Assessing the Effects of Cannabis

More information

Things you might want to ask about asthma

Things you might want to ask about asthma Things you might want to ask about asthma This information is from Asthma UK. We are a charity that helps people with asthma. EasyRead version What is asthma? If you have asthma your airways do not work

More information

Diabetes Complications

Diabetes Complications Managing Diabetes: It s s Not Easy But It s s Worth It Presenter Disclosures W. Lee Ball, Jr., OD, FAAO (1) The following personal financial relationships with commercial interests relevant to this presentation

More information

Measurement in Epidemiology: Frequency, Association, and Impact

Measurement in Epidemiology: Frequency, Association, and Impact Measurement in Epidemiology: Frequency, Association, and Impact Mayfong Mayxay M.D., Ph.D. (Trop Med) GFMER - WHO - UNFPA - LAO PDR Training Course in Reproductive Health Research Vientiane, 12 October

More information

HLA-Cw*0602 associates with a twofold higher prevalence. of positive streptococcal throat swab at the onset of

HLA-Cw*0602 associates with a twofold higher prevalence. of positive streptococcal throat swab at the onset of 1 HLA-Cw*0602 associates with a twofold higher prevalence of positive streptococcal throat swab at the onset of psoriasis: a case control study Lotus Mallbris, MD, PhD, Katarina Wolk, MD, Fabio Sánchez

More information

Leanne M Poulos Patricia K Correll Brett G Toelle Helen K Reddel Guy B Marks Woolcock Institute of Medical Research, University of Sydney, NSW

Leanne M Poulos Patricia K Correll Brett G Toelle Helen K Reddel Guy B Marks Woolcock Institute of Medical Research, University of Sydney, NSW Lung disease in Australia Leanne M Poulos Patricia K Correll Brett G Toelle Helen K Reddel Guy B Marks Woolcock Institute of Medical Research, University of Sydney, NSW Prepared for Lung Foundation Australia

More information

Logistics. Registration for free continuing education (CE) hours or certificate of attendance through TRAIN at: https://tx.train.

Logistics. Registration for free continuing education (CE) hours or certificate of attendance through TRAIN at: https://tx.train. . DSHS Grand Rounds Logistics Registration for free continuing education (CE) hours or certificate of attendance through TRAIN at: https://tx.train.org Streamlined registration for individuals not requesting

More information

ASTHMA THE FACTS. During an asthma attack your airways become smaller and breathing is more difficult.

ASTHMA THE FACTS. During an asthma attack your airways become smaller and breathing is more difficult. Smoking & asthma ASTHMA THE FACTS = Asthma is a very common illness affecting around 15% of children and 11% of adults. = Asthma is one of the most common causes of hospitalisation of children in Australia.

More information

AIR QUALITY ACTION PLAN

AIR QUALITY ACTION PLAN AIR QUALITY ACTION PLAN FINAL VERSION APRIL 2006 SUMMARY In November 2003 Winchester City Council declared an Air Quality Management Area (AQMA) within Winchester city centre for the pollutants nitrogen

More information

Long-term air pollution exposure and cardio- respiratory mortality: a review

Long-term air pollution exposure and cardio- respiratory mortality: a review Hoek et al. Environmental Health 2013, 12:43 REVIEW Long-term air pollution exposure and cardio- respiratory mortality: a review Gerard Hoek 1*, Ranjini M Krishnan 2, Rob Beelen 1, Annette Peters 3, Bart

More information

October 29, Probable Link Evaluation for Chronic Kidney Disease

October 29, Probable Link Evaluation for Chronic Kidney Disease 1 October 29, 2012 Probable Link Evaluation for Chronic Kidney Disease Conclusion: On the basis of epidemiological and other data available to the C8 Science Panel, we conclude that there is not a probable

More information

Carbon monoxide. General information

Carbon monoxide. General information Carbon monoxide General information Key Points Fire Flammable gas May react violently with other substances Use fine water spray with normal fire-fighting clothing and breathing apparatus Health Toxic

More information

The Role of Insurance in Providing Access to Cardiac Care in Maryland. Samuel L. Brown, Ph.D. University of Baltimore College of Public Affairs

The Role of Insurance in Providing Access to Cardiac Care in Maryland. Samuel L. Brown, Ph.D. University of Baltimore College of Public Affairs The Role of Insurance in Providing Access to Cardiac Care in Maryland Samuel L. Brown, Ph.D. University of Baltimore College of Public Affairs Heart Disease Heart Disease is the leading cause of death

More information

1. NAME 2. SOCIAL SECURITY NUMBER # 4. PRESENT OCCUPATION 5. PLANT 6. ADDRESS 8. TELEPHONE NUMBER 9. INTERVIEWER

1. NAME 2. SOCIAL SECURITY NUMBER # 4. PRESENT OCCUPATION 5. PLANT 6. ADDRESS 8. TELEPHONE NUMBER 9. INTERVIEWER ASBESTOS INITIAL MEDICAL QUESTIONNAIRE 1. NAME 2. SOCIAL SECURITY NUMBER # 3. CLOCK NUMBER 4. PRESENT OCCUPATION 5. PLANT 6. ADDRESS 7. (Zip Code) 8. TELEPHONE NUMBER 9. INTERVIEWER 10. DATE 11. Date of

More information

Air Pollution Challenges and Solutions

Air Pollution Challenges and Solutions Environment and Sustainable Development Headquarter Tehran Municipality Health and Air Pollution Air Pollution Challenges and Solutions Dr. Zohreh Hesami Environment and Sustainable Development Headquarter

More information

Lesson 14 14 Outline Outline

Lesson 14 14 Outline Outline Lesson 14 Confidence Intervals of Odds Ratio and Relative Risk Lesson 14 Outline Lesson 14 covers Confidence Interval of an Odds Ratio Review of Odds Ratio Sampling distribution of OR on natural log scale

More information

COMMUNITIES FOR A BETTER ENVIRONMENT

COMMUNITIES FOR A BETTER ENVIRONMENT COMMUNITIES FOR A BETTER ENVIRONMENT Children s Exposure to Diesel Engine Exhaust: Important Facts For Consideration How Bad is Diesel Exhaust? Diesel exhaust is a sooty cocktail containing 40 different

More information

Abnormalities Consistent with Asbestos-Related Disease Among Long-Term Demolition Workers

Abnormalities Consistent with Asbestos-Related Disease Among Long-Term Demolition Workers Abnormalities Consistent with Asbestos-Related Disease Among Long-Term Demolition Workers Stephen M. Levin, M.D. Mount Sinai School of Medicine New York, New York November 1994 The Center to Protect Workers

More information

United Lung & Sleep Clinic Asbestos Questionnaire

United Lung & Sleep Clinic Asbestos Questionnaire Date United Lung & Sleep Clinic Asbestos Questionnaire 1. Name,, Last First M.I. 2. Address 3. Home Phone: ( ) - Area Code,, City State Zip Code 4. Social Security # : - - 5. Birthdate: / / Month Day Year

More information

What are the causes of air Pollution

What are the causes of air Pollution What are the causes of air Pollution Pollutant Particulate Matter (PM-PM 10 and PM 2.5 ) Description and main UK sources Particulate Matter is generally categorised on the basis of the size of the particles

More information

Childhood Asthma and Adolescent Academic Outcome

Childhood Asthma and Adolescent Academic Outcome Department of Medical Epidemiology and Biostatistics Soren Afshar Study Program in Medicine KI Degree project 30 credits Spring 2015 Childhood Asthma and Adolescent Academic Outcome - A combined twin and

More information

WATCH COMMITTEE. Health significance of occupationally-induced declines in FEV 1

WATCH COMMITTEE. Health significance of occupationally-induced declines in FEV 1 WATCH COMMITTEE PAPER Meeting date: 10 June 2004 Open Govt. Status: Type of paper: Paper File Ref: Exemptions: WATCH/2004/11 Fully Open WATCH COMMITTEE Health significance of occupationally-induced declines

More information

Table E1: Antibiotic use in infancy and wheeze and asthma: longitudinal studies until January 2010

Table E1: Antibiotic use in infancy and wheeze and asthma: longitudinal studies until January 2010 Table E1: Antibiotic use in infancy and wheeze and asthma: longitudinal studies until January 2010 Mai 2010, Sweden [32] Dom 2010, Belgium [33] Su 2010, USA [34] Sobko 2010, Sweden [49] Schmitt 2009, Germany

More information

OSHA INITIAL ASBESTOS MEDICAL QUESTIONNAIRE

OSHA INITIAL ASBESTOS MEDICAL QUESTIONNAIRE OSHA INITIAL ASBESTOS MEDICAL QUESTIONNAIRE 1. NAME 2. SOCIAL SECURITY NUMBER # 3. CLOCK NUMBER FULL TIME PART TIME 4. PRESENT OCCUPATION 5. PLANT / Department 6. ADDRESS (City, ST Zip) 8. TELEPHONE NUMBER

More information

The Canadian Longitudinal Study on Aging (CLSA): Understanding the complexity of aging and health through interdisciplinary research

The Canadian Longitudinal Study on Aging (CLSA): Understanding the complexity of aging and health through interdisciplinary research The Canadian Longitudinal Study on Aging (): Understanding the complexity of aging and health through interdisciplinary research Parminder Raina, PhD Associate Professor, Department of Clinical Epidemiology

More information

Big data size isn t enough! Irene Petersen, PhD Primary Care & Population Health

Big data size isn t enough! Irene Petersen, PhD Primary Care & Population Health Big data size isn t enough! Irene Petersen, PhD Primary Care & Population Health Introduction Reader (Statistics and Epidemiology) Research team epidemiologists/statisticians/phd students Primary care

More information

Prevention of Cardiovascular Disease in Children with Diabetes

Prevention of Cardiovascular Disease in Children with Diabetes Prevention of Cardiovascular Disease in Children with Diabetes Stephen R. Daniels, MD, PhD Department of Pediatrics University of Colorado School of Medicine The Children s Hospital Anschutz Medical Campus

More information

Always Start with PECO

Always Start with PECO Goals of This Course Be able to understand a study design (very basic concept) Be able to understand statistical concepts in a medical paper Be able to perform a data analysis Understanding: PECO study

More information

Mortality Assessment Technology: A New Tool for Life Insurance Underwriting

Mortality Assessment Technology: A New Tool for Life Insurance Underwriting Mortality Assessment Technology: A New Tool for Life Insurance Underwriting Guizhou Hu, MD, PhD BioSignia, Inc, Durham, North Carolina Abstract The ability to more accurately predict chronic disease morbidity

More information

2) Relevance for environmental policy... 2. 4) Data sources and reporting... 5 5) References at the international level... 6

2) Relevance for environmental policy... 2. 4) Data sources and reporting... 5 5) References at the international level... 6 A- 2: Ambient air quality in urban areas 1) General description... 2 1.1) Brief definition... 2 1.2) Units of measurement... 2 1.3) Context...2 2) Relevance for environmental policy... 2 2.1) Purpose...

More information

compact Population-based Studies

compact Population-based Studies Different Pathomechanisms for Asthma and Allergies (NEJM 363:121ff) Genetics of Complex Diseases Unraveled by Combining GWAS and Metabolomics (Nature Genetics 42:137. PLoS Genetics 4:1) Disease Management

More information

Main Effect of Screening for Coronary Artery Disease Using CT

Main Effect of Screening for Coronary Artery Disease Using CT Main Effect of Screening for Coronary Artery Disease Using CT Angiography on Mortality and Cardiac Events in High risk Patients with Diabetes: The FACTOR-64 Randomized Clinical Trial Joseph B. Muhlestein,

More information

Yes. Do you breathe clean air? Blueair Aware The Intelligent Air Quality Monitor

Yes. Do you breathe clean air? Blueair Aware The Intelligent Air Quality Monitor Yes Do you breathe clean air? No Blueair Aware The Intelligent Air Quality Monitor Blueair Aware Puts you in control of the air you breathe Connect with your clean air Knowing what s in the air you breathe

More information

What can be learned about survey non-response through record linkage? Examples from health examination surveys

What can be learned about survey non-response through record linkage? Examples from health examination surveys What can be learned about survey non-response through record linkage? Examples from health examination surveys Hanna Tolonen 1, Juha Karvanen 2, Päivikki Koponen 1, Erkki Vartiainen 1, and Kari Kuulasmaa

More information

The birth of the population-based cohort studies in preventive medicine From Framingham to Värmland

The birth of the population-based cohort studies in preventive medicine From Framingham to Värmland EpiScania Symposium Medicon Village, Lund 2 nd September 2015 The birth of the population-based cohort studies in preventive medicine From Framingham to Värmland Peter M Nilsson, MD, PhD Department of

More information

Chronic Diseases. Between 2005 and 2007 there were no significant changes in any of the adult behaviors reported through the BRFSS.

Chronic Diseases. Between 2005 and 2007 there were no significant changes in any of the adult behaviors reported through the BRFSS. Chronic Diseases Chronic diseases and conditions, such as heart disease, cancer, diabetes and obesity, are the leading causes of death and disability in the United States. Chronic diseases account for

More information

What are observational studies and how do they differ from clinical trials?

What are observational studies and how do they differ from clinical trials? What are observational studies and how do they differ from clinical trials? Caroline A. Sabin Dept. Infection and Population Health UCL, Royal Free Campus London, UK Experimental/observational studies

More information

Burden of Chronic Diseases COPD. Dr Randeep Guleria M.D, D.M. (Pulmonary Medicine) Professor Department of Medicine A.I.I.M.S

Burden of Chronic Diseases COPD. Dr Randeep Guleria M.D, D.M. (Pulmonary Medicine) Professor Department of Medicine A.I.I.M.S Burden of Chronic Diseases COPD Dr Randeep Guleria M.D, D.M. (Pulmonary Medicine) Professor Department of Medicine A.I.I.M.S Definition Chronic Obstructive Pulmonary Disease (COPD) is a preventable and

More information

Basic Study Designs in Analytical Epidemiology For Observational Studies

Basic Study Designs in Analytical Epidemiology For Observational Studies Basic Study Designs in Analytical Epidemiology For Observational Studies Cohort Case Control Hybrid design (case-cohort, nested case control) Cross-Sectional Ecologic OBSERVATIONAL STUDIES (Non-Experimental)

More information

Statistical Report on Health

Statistical Report on Health Statistical Report on Health Part II Mortality Status (1996~24) Table of Contents Table of Contents...2 List of Tables...4 List of Figures...5 List of Abbreviations...6 List of Abbreviations...6 Introduction...7

More information

Mepolizumab (Nucala ) for Treatment of Severe Asthma with Eosinophilic Inflammation: Effectiveness, Value, and Value-Based Price Benchmarks

Mepolizumab (Nucala ) for Treatment of Severe Asthma with Eosinophilic Inflammation: Effectiveness, Value, and Value-Based Price Benchmarks Mepolizumab (Nucala ) for Treatment of Severe Asthma with Eosinophilic Inflammation: Effectiveness, Value, and Value-Based Price Benchmarks Final Background and Scope November 18, 2015 Background: The

More information

Life expectancy and mortality

Life expectancy and mortality Life expectancy and mortality 6 109 Key points Life expectancy In 2010 2012, estimated life expectancy at birth was: 69.1 years for Indigenous males 10.6 years lower than for non-indigenous males (79.7

More information

Family life courses and later life health

Family life courses and later life health Family life courses and later life health Emily Grundy with Sanna Read, Oystein Kravdal and Doug Wolf. http://pathways.lshtm.ac.uk pathways@lshtm.ac.uk @PathwaysNCRM Family life courses and health in mid

More information

STATEMENT ON ESTIMATING THE MORTALITY BURDEN OF PARTICULATE AIR POLLUTION AT THE LOCAL LEVEL

STATEMENT ON ESTIMATING THE MORTALITY BURDEN OF PARTICULATE AIR POLLUTION AT THE LOCAL LEVEL COMMITTEE ON THE MEDICAL EFFECTS OF AIR POLLUTANTS STATEMENT ON ESTIMATING THE MORTALITY BURDEN OF PARTICULATE AIR POLLUTION AT THE LOCAL LEVEL SUMMARY 1. COMEAP's report 1 on the effects of long-term

More information

Survey on the Mortality from Malignant Tumors of Female Asbestos Spinning Workers

Survey on the Mortality from Malignant Tumors of Female Asbestos Spinning Workers Table of Contents WS-E-12 Xing Zhang Survey on the Mortality from Malignant Tumors of Female Asbestos Spinning Workers Xing Zhang 1, Tong-da Sun 2, Nan-feng Shi 2, Li-qiu Zhu 1, Kenji Morinaga 3 1 Institute

More information

Virginia Tech Departmental Policy 27 Sports Medicine Key Function:

Virginia Tech Departmental Policy 27 Sports Medicine Key Function: Virginia Tech Departmental Policy 27 Sports Medicine Key Function: Review: Yearly Director of Athletic Training Title: Management of Asthma in Athletes Section: Treatment S-A Safety POLICY STATEMENT: This

More information

Air pollution. 1 Key Findings

Air pollution. 1 Key Findings AIR POLLUTION: KEY FINDINGS Air pollution 1 Key Findings Air pollution in Cambridgeshire: There are levels of air pollution in Cambridgeshire that impact health, even though most annual average concentrations

More information

Noise Effects on Health in the Context of Air Pollution Exposure

Noise Effects on Health in the Context of Air Pollution Exposure Int. J. Environ. Res. Public Health 2015, 12, 12735-12760; doi:10.3390/ijerph121012735 Review International Journal of Environmental Research and Public Health ISSN 1660-4601 www.mdpi.com/journal/ijerph

More information

POLLEN ALLERGEN CONCENTRATIONS IN A PRE-SCHOOL BUILDING AND A DAY-CARE CENTRE

POLLEN ALLERGEN CONCENTRATIONS IN A PRE-SCHOOL BUILDING AND A DAY-CARE CENTRE POLLEN ALLERGEN CONCENTRATIONS IN A PRE-SCHOOL BUILDING AND A DAY-CARE CENTRE U Matson, M Kvernes and LE Ekberg Dept. of Building services Engineering, Chalmers University of Technology, Sweden ABSTRACT

More information

Role of elevated heart rate in the development of cardiovascular disease in hypertension

Role of elevated heart rate in the development of cardiovascular disease in hypertension ONLINE SUPPLEMENT Role of elevated heart rate in the development of cardiovascular disease in By Palatini P Department of Clinical and Experimental Medicine University of Padova, Padua, Italy Running title:

More information

Camilla Andersson, SMHI. ACCEPTED-projektet och resultat från andra Europeiska studier

Camilla Andersson, SMHI. ACCEPTED-projektet och resultat från andra Europeiska studier Camilla Andersson, SMHI ACCEPTED-projektet och resultat från andra Europeiska studier ACCEPTED ACCEPTED is a research program that aims to improve our understanding of future exposure situations in cities

More information

No sign of decrease in mortality rates in persons with severe mental disorder in Sweden: a cohort study of 12 103 individuals

No sign of decrease in mortality rates in persons with severe mental disorder in Sweden: a cohort study of 12 103 individuals No sign of decrease in mortality rates in persons with severe mental disorder in Sweden: a cohort study of 12 103 individuals Dag Tidemalm 1 *, Margda Waern 2, Claes-Göran Stefansson 3, Stig Elofsson 4,

More information

COPD IN THE UK. Peter Barnes FRS, FMedSci National Heart & Lung Institute Imperial College London, UK

COPD IN THE UK. Peter Barnes FRS, FMedSci National Heart & Lung Institute Imperial College London, UK COPD IN THE UK Peter Barnes FRS, FMedSci National Heart & Lung Institute Imperial College London, UK MRC-ICMR Workshop on Chronic Diseases Delhi November 2009 Imperial College Royal Brompton Hospital Ischaemic

More information

Department of Health Budget Hearing. November 24, 2014

Department of Health Budget Hearing. November 24, 2014 Department of Health Budget Hearing November 24, 2014 Customer-Focused Government Goals Primary Prevention Tobacco Substance Abuse America s Health Rankings Key Operational Goals Increasing the number

More information

Investigation of the effectiveness of national clean cookstove program in Nepal in reducing ARI in 5 children

Investigation of the effectiveness of national clean cookstove program in Nepal in reducing ARI in 5 children Investigation of the effectiveness of national clean cookstove program in Nepal in reducing ARI in 5 children Partnerships for Enhanced Engagement for Research (PEER) Health Project PEER HEALTH-KAVRE,

More information

Special Conditions That May Have an Impact on Asthma

Special Conditions That May Have an Impact on Asthma Special Conditions That May Have an Impact on Asthma When asthma is not optimally controlled, there may be issues with compliance or adherence to the therapeutic program or issues with proper medication

More information

Department of Surgery

Department of Surgery What is emphysema? 2004 Regents of the University of Michigan Emphysema is a chronic disease of the lungs characterized by thinning and overexpansion of the lung-like blisters (bullae) in the lung tissue.

More information

Prognostic impact of uric acid in patients with stable coronary artery disease

Prognostic impact of uric acid in patients with stable coronary artery disease Prognostic impact of uric acid in patients with stable coronary artery disease Gjin Ndrepepa, Siegmund Braun, Martin Hadamitzky, Massimiliano Fusaro, Hans-Ullrich Haase, Kathrin A. Birkmeier, Albert Schomig,

More information

Measures of disease frequency

Measures of disease frequency Measures of disease frequency Madhukar Pai, MD, PhD McGill University, Montreal Email: madhukar.pai@mcgill.ca 1 Overview Big picture Measures of Disease frequency Measures of Association (i.e. Effect)

More information

Louisiana Report 2013

Louisiana Report 2013 Louisiana Report 2013 Prepared by Louisiana State University s Public Policy Research Lab For the Department of Health and Hospitals State of Louisiana December 2015 Introduction The Behavioral Risk Factor

More information

5. LOCATION: 6. STREET ADDRESS: 7. CITY, STATE, AND ZIP CODE:

5. LOCATION: 6. STREET ADDRESS: 7. CITY, STATE, AND ZIP CODE: This mandatory form contains the medical questionnaire that must be administered to all personnel who are exposed to asbestos above the permissible exposure limit, and who will therefore be included in

More information

TRACKS GENETIC EPIDEMIOLOGY

TRACKS GENETIC EPIDEMIOLOGY Dr. Priya Duggal, Director In the post-genomic era where larger amounts of genetic data are now readily available, it has become increasingly important to design studies and use analytical techniques that

More information

ASTHMA< Observation about treatment and education of patients in San Pablo Clinic, Heredia Costa Rica

ASTHMA< Observation about treatment and education of patients in San Pablo Clinic, Heredia Costa Rica ASTHMA< Observation about treatment and education of patients in San Pablo Clinic, Heredia Costa Rica Rachel Borovina, MSIV Lisa Troeger, MSIV University of California San Francisco IHCAI FOUNDATION 2001

More information

Wildfire Smoke and Your Health

Wildfire Smoke and Your Health PUBLIC HEALTH DIVISION http://public.health.oregon.gov Wildfire Smoke and Your Health When smoke levels are high, even healthy people may have symptoms or health problems. The best thing to do is to limit

More information

Asthma Diagnosis and Management

Asthma Diagnosis and Management Asthma Diagnosis and Management Asthma is a condition characterized by narrowing and inflammation of the airways. This inflammation causes the airways to be very sensitive and react to a variety of stimuli

More information

The challenge of cardiovascular disease in Russia

The challenge of cardiovascular disease in Russia The challenge of cardiovascular disease in Russia David Leon david.leon@lshtm.ac.uk The 21st Norwegian Conference on Epidemiology Tromsø, October 30 November 1, 2013 Major changes in society. Brehznev

More information

Social inequalities in all cause and cause specific mortality in a country of the African region

Social inequalities in all cause and cause specific mortality in a country of the African region Social inequalities in all cause and cause specific mortality in a country of the African region Silvia STRINGHINI 1, Valentin Rousson 1, Bharathi Viswanathan 2, Jude Gedeon 2, Fred Paccaud 1, Pascal Bovet

More information

Research Skills for Non-Researchers: Using Electronic Health Data and Other Existing Data Resources

Research Skills for Non-Researchers: Using Electronic Health Data and Other Existing Data Resources Research Skills for Non-Researchers: Using Electronic Health Data and Other Existing Data Resources James Floyd, MD, MS Sep 17, 2015 UW Hospital Medicine Faculty Development Program Objectives Become more

More information