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1 SP IMPLICATIONS OF VERTEBRAL ENDPLATE DEFECTS AND OSSIFICATION PHENOMENA Rothschild Bruce, Jonhan Ho, Youssef Masharawi Northeast Ohio Medical University, Rootstown, OH, 7 USA Department of Dermatopathology, University of Pittsburgh, Pittsburgh, Pennsylvania, U.S.A Spinal Research Lab, The Stanley Steyer School of Health Professions, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel 6999 bmr@ku.edu Category scientific abstract Relevant author disclosures - none

2 OBJECTIVE Clarification of character and implications of vertebral endplate alterations BACKGROUND Vertebral endplates alterations are of unclear clinical significance (,) Endplate abnormalities (on MRI) have been suggested as causes of pain () Endplate abnormalities are uncommon in asymptomatic individuals (,) Precedence exists, as disk abnormalities have also been recognized as asymptomatic (-7). Nosikova et al. J Anat 0;: Resnick. Diagnosis of Bone and Joint Disorders, 00. Weishaupt et al. Radiology 00;8:0-7. Weishaupt et al. Radiology 998;09: Boden et al. J Bone Jt Surg 990;7A: Jensen et al. N Engl J Med 99;: Stadnik et al. Radiology 998;06:9-

3 Endplate alterations have been attributed (,) to Trauma Neoplasm Infection Paget s disease Stress, Enthesitis Vascular alterations Schmorl s nodes have been attributed to Congenitally weak areas of cartilage plate () passage of blood vessels degenerating notochord (0) Osteochondrosis (). Martel et al. Amer J Roentgenol 976;7:7-6.. Sauser et al. J Can Assoc Radiol 978;9:-0.. McFadden & Taylor. Spine 989;: Kelley. Amer J Phys Anthropol Amer J Phys 98;9:7-79.

4 METHODS Vertebral endplates from a 0 year birth cohort (80 individuals born between 9 and 9) of the human skeletal component of the Hamann-Todd Collection were macroscopically evaluated for Vertebral endplate defects Variation of adjacent vertebra size and shape Bone density* Associated pathologies Findings correlated with other present diseases/phenomenon * Osteoporosis can only indirectly be recognized in defleshed bones on the basis of loss of vertebral height (). Therefore, anterior and posterior vertebral heights were compared and lateral compression noted (,).. Rothschild. Lumbar spondylosis (Spondylosis deformans). emedicine 0 Resnick. Diagnosis of Bone and Joint Disorders, 00.. Rothschild & Martin (00): Skeletal Impact of Disease. New Mexico Museum of Natural History, 00.

5 Vertebral endplate defects Schmorl s nodes were recognized as defined by Pfirrmann & Resnick () & Schmorl and Junghanns () as focal irregular or hemispherical bone defect in vertebral endplates view of L vertebral endplate. Irregular defect with smooth margins and remodeled exposed trabeculae within.. Pfirrmann & Resnick. Radiology 0;9: Schmorl & Junghanns, The Human Spine in Health and Disease. Grune and Stratton, 97

6 Vertebral endplate defects defects were recognized as non-hemispherical, elongated endplate defects. (A) L linear crack with no remodeling (B) T0 transverse linear defect (C) T linear defect (D) T0 linear crack with slight remodeling (E) T0 irregular defect with smooth edges and base, communicating with spinal canal (F) T multiple linear defects

7 RESULTS Defects were found in the vertebral endplates of 8 individuals: Schmorl s nodes in.0 defects in 0.6 Both in. Vertebral abnormalities at all levels (cervical, thoracic and lumbar) were more common on the inferior endplate, independent of type Correlations with presence of vertebral defects in an individual Vertebral centra osteophytes, more common (Chi square = 6.9) Diffuse Idiopathic Skeletal Hyperostosis, more common (Chi square = 0.96) Vertebral compression, less common

8 Vertebral level of endplate defects and elevations/deposits Level Aspect < mm Schmorl s node # < mm = or > mm Schmorl s Node # = or > Defect # Defect C C C C 8 C6 7 C7

9 Vertebral level of endplate defects and elevations/deposits Level Aspect < mm = or > mm Schmorl s Node # = or > Defect # Defect < mm Schmorl s node # T T T T T 6 T

10 Vertebral level of endplate defects and elevations/deposits Level Aspect < mm Schmorl s node # < mm = or > mm Schmorl s Node # = or > Defect # Defect T T T T T T

11 Vertebral level of endplate defects and elevations/deposits Level Aspect < mm Schmorl s node # < mm = or > mm Schmorl s Node # = or > Defect # Defect L L L L L 6 6

12 Distribution of endplate defects and surface elevations Vertebral section Schmorl s nodes # Schmorl s nodes defect # Defect Elevation Elevation Both Both # # Cervical Cervical Thoracic Thoracic Lumbar Lumbar Lumbar Number surfaces 8 0 7

13 RESULTS Defects were found in the vertebral endplates of 8 individuals: Schmorl s nodes in.0 defects in 0.6 Both in. Vertebral abnormalities at all levels (cervical, thoracic and lumbar) were more common on the inferior endplate, independent of type Correlations with presence of vertebral defects in an individual Vertebral centra osteophytes, more common (Chi square = 6.9) Diffuse Idiopathic Skeletal Hyperostosis, more common (Chi square = 0.96) Vertebral compression, less common

14 Schmorl s nodes Predominantly limited to single or (of 6) endplate segments (Chi square =.60, p < 0.000) Anterior (Chi square = 6.8 Middle (Chi square = 7.07) Posterior (Chi square =.90) Correlation with presence of Schmorl s nodes in an individual Absent of any increased frequency of Rheumatoid arthritis Calcium pyrophosphate deposition disease Cancer Hypertrophic osteoarthropathy compression fractures Present Spondyloarthropathy (Chi square =.9, p < 0.000) Osteophytes (adjacent) to present almost six times more commonly among vertebrae with defects mm in depth than in those with deeper defects (Chi square = 6.9, p < 0.000). Inverse Tuberculosis (Chi square = 7.90, p < 0.000)

15 Locationofdefectsonendplatesurface Typeofdefect # Schmorl snode # Schmorl snode Anterior Anteriorand Middle Anterior,Middle, Posterior 0 9 Middleand Posterior Middle Posterior 6

16 defects Found in 9 (0.6) of 88 individuals Character Predominately isolated phenomena on a given endplate Orientation - anterior-posteriorly or transverse.

17 defects Character Occasionally Multiple on a given endplate Connected with the spinal (neural) canal Occasionally a crack-like appearance with or without remodeling, but actual fracture through the endplate was rare ( instances Connected with spinal canal Fracture Compared with Schmorl s nodes Location on endplate surface Interior and posterior on (Chi square = 0.77, p < 0.00), or affecting all three regions - anterior to posterior (Chi square =.0) More disseminated throughout the vertebral column More commonly affected areas of endplate involved three (of 6) endplate segments (Chi square =.89, p < 0.0) Both interior and posterior (Chi square = 0.77), or Extended from anterior to posterior (Chi square =.0).

18 Locationofdefectsonendplatesurface Typeofdefect # Schmorl snode # Anterior AnteriorandMiddle Anterior,Middle,Posterior 0 9 MiddleandPosterior 7 Middle 0 0 Posterior 6

19 Surfacedimensionsofvertebraldefects Numberofzones (of6)involved # Schmorl snode #

20 Elevations on vertebral endplates Contrasted with surface disruptions (e.g., cavities/depressions) Co-occurred with vertebral defects in 98 individuals, affecting 7 vertebrae All but one occurred in association with Schmorl s node Compared with presence of surface defects, increased frequency of DISH (Chi square =.8, p < 0.000) Spondyloarthropathy (Chi square =.97, p < 0.000) Rheumatoid arthritis (Chi square =.97, p < 0.000) Calcium pyrophosphate deposition disease (Chi square = 6.77, p < 0.000) Tuberculosis (Chi square = 8.70, p < 0.000) Hypertrophic osteoarthropathy (Chi square = 7.0, p < 0.000)

21 Schmorl s nodes Frequency 8 of 80 individuals in this study Difficult to relate to frequencies reported in the literature Variable definitions () Schmorl and Junghanns () - 8 Batts () - 0. Coventry et al. () - radiographically, on macroscopic examination and a majority with microscopic evidence Williams et al. () - One third radiologically, but many more on MRI frequencies reported from 8 to 8 of 79, localized especially in the lower thoracic spine Localization More frequently on the inferior surface of vertebrae Counter-intuitive, as inferior 0 stronger than superior endplate (6,7) More focal and less centrally localized than assumed by Katz et al.(8). Dar, et al. Eur Spine J 00;9: Schmorl & Junghanns. The Human Spine in Health and Disease. Grune and Stratton, 97. Batts, J Bone Jt Surg 99;:-6. Coventry et al. J Bone Jt Surg 9;7:60-7. Williams et al. Arthritis Rheum 007;7: Grant et al. Spine 00;6: Perey. Acta Orthop Scand 97; (Suppl):-0 8. Katz et al. Invest Radiol 998;:7-

22 Depthofendplatedefects Depth Schmorl snode # defect # <mm 70 6 mm 889 >mm 96 9

23 What are the Implications of Schmorl s Nodes and Defects? Hypotheses Repetitive mechanical stresses produce damage to endplate vascularity (,) Endplate fractures, from trauma and additional stress (,) These are not seen by radiography, only observed pathologically () However current study found no association with Tendency to enthesial calcification (e.g., DISH) Periosteal reaction (e.g., hypertrophic osteoarthropathy) Vertebral compression Diseases which can compromise vertebral integrity* Osteoporosis thus does not allow endplate penetration Tuberculosis Cancer Correlation of endplate defects with vertebral centra osteophytes raises an intriguing question: Are endplate defects simply a manifestation of aging, as has been suggested for vertebral centra osteophytes (,6)? * There were only surface fractures. Peng et al. J Bone Jt Surg 00;8B: Revel et al. Clin Orthop 99;79:0-09. Fahey et al. Spine 998;:7-7.. Schmorl and Junghanns. The Human Spine in Health and Disease. Grune and Stratton, 97. Rothschild. Lumbar spondylosis (Spondylosis deformans). emedicine, Rothschild & Martin. Skeletal Impact of Disease. New Mexico Museum of Natural History, 006.

24 Derivation of Schmorl s nodes Potentially weak area of cartilaginous endplate adjacent to nucleus pulposus residual indentation from regression of chorda dorsalis (). But One mm deep perforations of pig endplate with a. mm wire resulted in only a single Schmorl s node () Therefore, a defect in the vertebral endplate is not sufficient for the development of a Schmorl s node Minimal remodeling suggests that at least some of the cracks represent a congenital anomaly. defects appear to represent a different phenomenon than Schmorl s nodes and should be assessed separately in the future... Resnick & Niwayama. Radiology 978;6:7-6. Cinotti et al. Spine 00;0:7-80

25 Elevations Represent calcified cartilage either residual in life () or residual from the maceration process Linked to surface defect phenomenon (Schmorl s nodes) Does deposition imply disk disease? Does an intact disk prevent deposition? Possibly previously unrecognized alteration of calcified cartilage? Possibly a manifestation of calcium pyrophosphate deposition disease that often complicates other forms of arthritis? Possibly a response to increased in intravertebral pressure? Association with many clinical diseases and phenomena. Oda et al. Spine 988;:0-.

26 If Schmorl s nodes are present, look for: Spondyloarthropathy but not vertebral compression or osteoporosis If surface elevations are present, look for: DISH Infammatory arthritis Spondyloarthropathy Rheumatoid arthritis Calcium pyrophosphate deposition disease Tuberculosis Hypertrophic osteoarthropathy If linear defects are present, look for: Associations, as not characterized to date

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