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1 _ Abstract 1. Basic underlying view

2 Mycobacterium tuberculosis

3 Table 1 2. LTBI treatment subjects 1. Basic view

4

5 2. TB development risk factors and infection diagnosis i. HIV/AIDS ii. Hemodialysis for chronic renal failure, and kidney transplant recipients iii. Recipients of other transplanted organs and stem cell transplants iv. Diabetes

6 i. Biologics

7 ii. Corticosteroids iii. Other immunosuppressants i. Healed TB lesions in chest radiography ii. Silicosis iii. Weight iv. Smoking

8 v. Being from a high-prevalence country vi. Healthcare workers 3. Actual application of treatment 4. Topics for future investigation

9 3. Treatment 1. Drugs and administration periods a. Effects of INH for immunocompetent individuals b. Effects of INH for immunosuppressed individuals Table 2

10 Table 3 a. Effects of RFP b. Use of INH versus RFP 2. Irregular administration of treatment

11 3. Daily dose 4. Contact with INH- and RFP-resistant TB 5. Managing side effects 6. Monitoring of TB development during treatment 7. Health education

12 8. Medication adherence support 9. Post-treatment risk of TB development, and approaches to follow-up observation Reference material Mycobacterium tuberculosis

13 10. LTBI retreatment 11. Future topics related to treatment 4. Related systems

14 References Mycobacterium tuberculosis

15 M.tuberculosis Mycobacterium tuberculosis

16 Mycobacterium tuberculosis

17

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