Florence Janody, Ph.D. Curriculum Vitae

Transcription

1 Florence Janody, Ph.D. Curriculum Vitae Present Position: PRINCIPAL INVESTIGATOR Domain of specialization: Cell biology, Development and Cancer Instituto Gulbenkian de Ciência (IGC) Nationality: French Rua da Quinta Grande, 6- Apartado 14 Birth date: 19/08/1970 P OEIRAS - Portugal Birth place: Ambilly, France Telephone: Fax: [email protected] Education Oct to Dec 1999 Ph.D. in Cell biology, Structural biology and Microbiology Université de la Méditerranée; France. Supervised by Dr. Nathalie Dostatni. Funded by the French government. Oct to July 1995 MSc in Cell biology, Structural biology and Microbiology Université de la Méditerranée; France. Supervised by Dr. Michele Delaage. Oct to July 1993 BSc in Developmental Biology. Université de Besancon; France. Research Since July 2006 Principal Investigator - Actin Dynamics Lab Research Fellowship from July 2006 to March Since April 2008: 5 years salary contract from the Portuguese government. Research Focus: In my lab, we are studying how signalling pathways regulate cytoskeletal organization in distinct epithelia and what is the role of specialized filamentous actin-based structures in transducing signalling pathways using the genetically tractable system Drosophila melanogaster. My project addresses a fundamental aspect of cell biology but also aims to broaden our understanding of pathogenesis associated with actin dynamics. Aug to May 2006 Research Associate - Group leaded by Dr. Michel Semeriva. Founded by the Association pour la Recherche sur le Cancer (ARC). Research Focus: I have analyzed the tissue-specific function of the two cytoskeletal genes Capping Protein and which regulate actin polymerization, in signalling pathways. May to July 2004 Research Associate - Group leaded by Dr. Jessica Treisman. Founded by the Association pour la Recherche sur le Cancer (ARC) and NIH RO1 EY and RO1 GM Research Focus: We carried out mosaic genetic screens in the differentiating Drosophila eye for novel genes involved in signalling pathways. We identified two unexpected categories of genes: Polycomb and Trithorax group genes, including skuld (skd) and kohtalo (kto) and actin cytoskeletal genes that I have characterized. Oct to April 2004 Ph.D. Student - Group leaded by Dr. Nathalie Dostatni. Founded by the French government. Research Focus: I used the early Drosophila embryo to understand how the signal transduction cascade of the Receptor Tyrosine Kinase (RTK) Torso can modify the activity of the Bicoid (Bcd) transcription factor and promote the development of the anterior region of the embryo. I have also participated in the development of two Internet databases, FlyNets and GIF-DB that focus on Drosophila melanogaster molecular interactions.

2 Prizes and Awards Postdoctoral Fellowship From Fundação para a Ciência e a Tecnologia (FCT) Postdoctoral Fellowship From Association pour la Recherche sur le Cancer (ARC) Postdoctoral Fellowship From Association pour la Recherche sur le Cancer (ARC) Predoctoral Fellowship From Fondation pour la Recherche Médicale (FRM) Graduate Student Fellowship From Association pour la Recherche sur le Cancer (ARC) Graduate Student Fellowship From the French government. Membership of Editorial Boards of International Journal From July Member of the Editorial Board of TheScientificWorldJOURNAL. From December Member of the Editorial Board of PLoS ONE. Experiences in Supervision Master Thesis graduation from my lab: * Sofia Rebelo: Defended on February 28, 2008 Universidade de Lisboa. * Pedro Gaspar: Defended on November 25, 2008 Universidade de Lisboa. * Mauricia Vinhas: Defended on June 17, 2009 Universidade do Algarve. * Cláudia Mendes: Defended on November 15, 2010 Universidade de Lisboa. Ph.D. Thesis graduation from my lab: * Barbara Jezowska Defended on May 4 th, Current Supervision as a Principal Investigator 2 Ph.D. Students: * Pedro Gaspar (since May 2009, until May 2013) * Sandra Tavares (since February 2012, until September 2015) 3 Postdocs: * Beatriz García Fernández (since May 2007, until October 2014) * Catarina Brás-Pereira (since July 2008 until January 2013) * Barbara Jezowska (since May until January 2013). 1 technician: * Ana Rita Amândio (since Nov. 2009, until January 2015). Past supervision as a Research Associate 2 Master Students : * Faye Williams * Delphine Pages 2 Ph.D. Students : * Grant Muira * William Hu 1 technician: * Neal Jahren Experiences in Post-Graduate Education Since 2006, I participate annually in Postgraduate courses for the Doctoral Program of the Instituto Gulbenkian de Ciência (PGD) and the Programa Gulbenkian de Formacao Medica Avançada for Medical Doctor. Moreover, I have been involved into the EMBO Practical Course organized in Lisbon (March ). Honors, Boards and Committees * I am a Member of the Editorial Board of TheScientificWorldJOURNAL since * I am a Member of the Editorial Board of PLoS ONE since * I am part of 4 Ph.D. committees: * Clara Peirera Since (Laboratory: Vasco Barreto, IGC-Portugal) * Tânia Ferreira Since (Laboratory: Rui Martinho, IGC-Portugal)

3 * Marco Antunes Since (Laboratory: Antonio Jacinto, IMM-Portugal) * Rita Mateus Since (Laboratory: Antonio Jacinto, IMM-Portugal) * Ana Rita Aires Since March 2012 (Laboratory: Moises Mallo. IGC-Portugal) * I have argued 5 Ph.D. Theses: * Karolina K. M. Lada - June 23, 2009, Cambridge University. Ph.D adviser: Dr. Alfonso Martinez Arias - Department of Genetics, University of Cambridge, UK. * Beatriz García Fernández - January 22, 2007, Universidade Nova de Lisboa. Ph.D adviser: Dr. Antonio Jacinto - Instituto Gulbenkian de Ciência (IGC) - Portugal * César S. Mendes - November 17, 2006, Universidade Nova de Lisboa. Ph.D adviser: Dr. Bertand Mollereau and Dr. Hermann Steller - The Rockefeller University, New York, USA. * Ricardo Miguel Neto da Silva - June, 14, 2010-Universidade Nova de Lisboa. Ph.D. adviser: Dr. Laura A. Johnston - Columbia University - New York, USA. * Catarina Sofia Goncalves Pimentel- July, 16, 2010-Universidade de Coimbra Ph.D. adviser: Dr. Andreas Prokop - University of Manchester, United Kingdom. * I reviewed manuscript for a variety of Journals (Development; Journal of Cell Biology; Developmental Biology; PLOS one...). Invited Lectures and Speaker to peer-reviewed international conferences I have been invited to give Seminar in different Institutions (Ecole Normale Superieure Lyon - France; University of Cambridge - UK; Skirball Institute - UK; Instituto de Medicina Molecular - Portugal). and in peer-reviewed international conferences, including Barcelona BioMed Conferences (Modelling Cancer in Drosophila September 2009) and EMBO Workshop (Biophysical Mechanism of Development. Lisbon May 2011). Collaborations I am collaborating with various scientists: * Dr. Nicolas Tapon (Cancer Research UK, London) * Dr. Raquel Seruca (IPATIMUP, Porto) * Dr. Jochen Guck (University of Cambridge-UK) * Dr. Fernando Casares (Universidad pablo de Olavide-Sevilla-Spain) * Dr. Jose Pereira Leal (Instituto Gulbenkian de Ciência-Portugal) * Dr. Laurent Perrin (Technological Advances for Genomics and Clinics; TAGC; INSERM U928, Marseille-France). Funding ID Present Funding 02/ /2015: PTDC/BIA-BCM/121455/ ,00 Euros Title of the research project: Characterization of distinct actin filament structures in Drosophila larval tissues. This project overlap with the project presented here on the characterization of the expression pattern of each actin isoform. Past Funding 10/ /2010: PTDC/BIA-BCM/71674/ ,00 Euros Title of the research project: Molecular control of actin dynamics and change in cell shape in the morphogenetic furrow during Drosophila eye development. 01/ /2010: PTDC/SAU-OBD/7391/ ,00 Euros Title of the research project: Using Drosophila to understand the molecular control of actin dynamics in aberrant active cell migration 01/ /2011: Centro de Biologia do Desenvolvimento (CBD) ,00 Euros.

4 Title of the research project: Molecular Control of Actin Dynamics and Function during Morphogenesis of Epithelia in Drosophila.. Original Publications (h index: 12; total of 444 citations) Publications submitted in which I am the corresponding author. Name of present and past members of my own lab at IGC are underlined. Brás-Pereira C., Casares F. and Janody F. The retinal determination gene dachshund, a promoterspecific inhibitor of Yorkie function. Submitted to Development. Publications as an independent researcher in which I am the corresponding author. Name of present and past members of my own lab at IGC are underlined. García Fernández B., Jezowska B and Janody F. (2013) Drosophila actin Capping Protein limits JNK activation by the Src proto-oncogene. Accepted for publication in Oncogene on March 31, Jezowska B; García Fernández B.; Amândio A.R.; Duarte P.; Mendes C; Brás-Pereira C. and Janody F (2011). A dual function of Drosophila Capping Protein on DE-Cadherin maintains epithelium integrity and prevents JNK-mediated apoptosis. Developmental Biology (360), Brás-Pereira C., Zhang T., Pignoni F. and Janody F. (2011). Homeostasis of the Drosophila adult retina by Capping Protein and the Hippo pathway. Communicative & Integrative Biology. Sep/Oct.: García Fernández B.; Gaspar P.; Brás-Pereira C.; Jezowska B.; Rebelo S.R.; and Janody F (2011). Actin-Capping Protein and the Hippo pathway regulate actin accumulation and tissue growth in Drosophila. Development 138, Janody F. and Treisman J.E. (2006). Actin Capping Protein alpha maintains vestigial-expressing cells within the Drosophila wing disc epithelium. Development 133: Others original Publications Janody F. and Treisman J.E. (2011). Requirements for mediator complex subunits distinguish three classes of notch target genes at the Drosophila wing margin. Developmental Dynamics 240(9): Roignant JY, Legent K, Janody F and Treisman JE (2010). The transcriptional co-factor Chip acts with LIM-homeodomain proteins to set the boundary of the eye field in Drosophila. Development. 137(2): Gates J, Nowotarski SH, Yin H, Mahaffey JP, Bridges T, Herrera C, Homen CC, Janody F, Montel DJ, Peifer M. (2009). Enabled and Capping Protein play important roles in shaping cell behavior during Drosophila oogenesis. Developmental Biology Sep 1; 333(1):

5 Carrera I., Janody F., Leeds N., Duveau F. and Treisman J.E. (2008). Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13. Proc. Natl. Acad., Sci. USA May 6; 105 (18): Roignant J.Y., Hamel S., Janody F. and Treisman J.E. (2006). The novel SAM domain protein Aveugle is required for Raf activation in the Drosophila EGF receptor signaling pathway. Genes and Development 20: Janody F.; Lee J.D., Jahren N., Hazelett D.J., Benlali A., Muira G.I., Draskovic I. and Treisman J.E. (2004). A mosaic genetic screen reveals distinct roles for trithorax and polycomb group genes in Drosophila eye development. Genetics 166, Janody F.; Martirosyan Z., Benlali A. and Treisman J.E. (2003) Two subunits of the Drosophila mediator complex act together to control cell affinity. Development, 130: Janody F., Sturny R., Schaeffer V., Azou Y. and Dostatni N. (2001). Two distinct domains of Bicoid mediate its transcriptional downregulation by the Torso pathway. Development 128: Janody F., Reischl J. and Dostatni N. (2000a). Persistence of hunchback in the terminal region of the Drosophila blastoderm embryo impairs anterior development. Development, 127: Janody F., Sturny R., Catala F., Desplan C. and Dostatni N. (2000 b). Phosphorylation of Bicoid on MAP-kinase sites: contribution to its interaction with the Torso pathway. Development, 127: Schaeffer V., Janody F., Loss C., Desplan C. and Wimmer E. (1999). Bicoid functions without its TATA-binding protein-associated factor interaction domains. Proc. Natl. Acad., Sci. USA. Vol. 96: Sanchez C., Lachaize C., Janody F., Bellon B., Röder L., Euzenat J., Rechenmann F. and Jacq B. (1999). Grasping at molecular interactions and genetic networks in Drosophila melanogaster using FlyNets, an Internet database. Nucleic Acids Research Vol. 27, No. 1: Mohr E., Horn F., Janody F., Sanchez C., Pillet V., Bellon B., Röder L., Jacq B. (1998). FlyNets and GIF-DB, two Internet databases for molecular interactions in Drosophila melanogaster. Nucleic Acids Research Vol. 26, No. 1: Jacq B., Horn F., Janody F., Gompel N., Serralbo O., Mohr E., Leroy C., Bellon B., Fasano L., Laurenti P., and Röder L. (1997). GIF-DB a WWW databaseon gene interactions involved in Drosophila melanogaster development. Nucleic Acids Research Vol. 25, No. 1: Published comments The Node. The community site for Developmental Biologists. When F-actin dynamics and Hippo signalling activity meet to regulate tissue growth. May 11, 2011.